LOCUS       NM_052839               3052 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.
ACCESSION   NM_052839
VERSION     NM_052839.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Zhang,K., Luo,W., Liu,H. and Gong,J.
  TITLE     PANX2 promotes malignant transformation of colorectal cancer and
            5-Fu resistance through PI3K-AKT signaling pathway
  JOURNAL   Exp Cell Res 442 (2), 114269 (2024)
   PUBMED   39389335
  REMARK    GeneRIF: PANX2 promotes malignant transformation of colorectal
            cancer and 5-Fu resistance through PI3K-AKT signaling pathway.
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   He,Z., Zhao,Y., Rau,M.J., Fitzpatrick,J.A.J., Sah,R., Hu,H. and
            Yuan,P.
  TITLE     Structural and functional analysis of human pannexin 2 channel
  JOURNAL   Nat Commun 14 (1), 1712 (2023)
   PUBMED   36973289
  REMARK    GeneRIF: Structural and functional analysis of human pannexin 2
            channel.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Zhang,H., Wang,S., Zhang,Z., Hou,M., Du,C., Zhao,Z., Vogel,H.,
            Li,Z., Yan,K., Zhang,X., Lu,J., Liang,Y., Yuan,S., Wang,D. and
            Zhang,H.
  TITLE     Cryo-EM structure of human heptameric pannexin 2 channel
  JOURNAL   Nat Commun 14 (1), 1118 (2023)
   PUBMED   36869038
  REMARK    GeneRIF: Cryo-EM structure of human heptameric pannexin 2 channel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Xu,X., Hao,Y., Xiong,S. and He,Z.
  TITLE     PANX2 and brain lower grade glioma genesis: A bioinformatic
            analysis
  JOURNAL   Sci Prog 104 (2), 368504211011836 (2021)
   PUBMED   33913372
  REMARK    GeneRIF: PANX2 and brain lower grade glioma genesis: A
            bioinformatic analysis.
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Ray,S.L., Coulson,D.J., Yeoh,M.L.Y., Tamara,A., Latief,J.S.,
            Bakhashab,S. and Weaver,J.U.
  TITLE     The Role of miR-342 in Vascular Health. Study in Subclinical
            Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory
            Cytokines and PANX2
  JOURNAL   Int J Mol Sci 21 (19), 7217 (2020)
   PUBMED   33003647
  REMARK    GeneRIF: The Role of miR-342 in Vascular Health. Study in
            Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma,
            Inflammatory Cytokines and PANX2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Litvin,O., Tiunova,A., Connell-Alberts,Y., Panchin,Y. and
            Baranova,A.
  TITLE     What is hidden in the pannexin treasure trove: the sneak peek and
            the guesswork
  JOURNAL   J Cell Mol Med 10 (3), 613-634 (2006)
   PUBMED   16989724
  REMARK    GeneRIF: According to brain cancer gene expression database
            REMBRANDT, PANX2 expression levels can predict post diagnosis
            survival for patients with glial tumors.
            Review article
REFERENCE   7  (bases 1 to 3052)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   8  (bases 1 to 3052)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 3052)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
REFERENCE   10 (bases 1 to 3052)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA127683.1, AK096019.1,
            AK123508.1, BC101023.2 and BU732466.1.
            
            On May 17, 2019 this sequence version replaced NM_052839.3.
            
            Summary: The protein encoded by this gene belongs to the innexin
            family. Innexin family members are the structural components of gap
            junctions. This protein and pannexin 1 are abundantly expressed in
            central nervous system (CNS) and are coexpressed in various
            neuronal populations. Studies in Xenopus oocytes suggest that this
            protein alone and in combination with pannexin 1 may form cell
            type-specific gap junctions with distinct properties. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299910.1, AK096019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395842.3/ ENSP00000379183.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DA127683.1         1-111
            112-1514            AK096019.1         96-1498
            1515-1855           AK123508.1         305-645
            1856-2295           BC101023.2         1735-2174
            2296-2605           AK096019.1         2280-2589
            2606-3051           AK123508.1         1395-1840
            3052-3052           BU732466.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..3052
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /note="pannexin 2"
                     /db_xref="GeneID:56666"
                     /db_xref="HGNC:HGNC:8600"
                     /db_xref="MIM:608421"
     CDS             1..2034
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="pannexin-2 isoform 1"
                     /protein_id="NP_443071.2"
                     /db_xref="CCDS:CCDS14085.2"
                     /db_xref="GeneID:56666"
                     /db_xref="HGNC:HGNC:8600"
                     /db_xref="MIM:608421"
                     /translation="MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQL
                     KLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE
                     LRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQE
                     IDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRG
                     RSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVR
                     VSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRR
                     QWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHD
                     ATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIM
                     RVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKK
                     HARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAP
                     LPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHP
                     LLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF"
     exon            1..226
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1690
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..3052
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3030..3035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="PANX2"
                     /gene_synonym="hPANX2; PX2"
                     /note="major polyA site"
ORIGIN      
        1 atgcaccacc tcctggagca gtcggcggac atggcgaccg cgctgctggc gggagagaag
       61 ctgcgggagc tgatcctgcc gggcgcgcag gacgacaagg cgggcgcgct ggccgcgctg
      121 cttctgcagc tgaagctgga gctgccgttc gaccgggtgg tcaccatcgg caccgtgctg
      181 gtgcccatcc tgctggtcac cctggtcttc accaagaact tcgcagagga acccatttac
      241 tgttacaccc cgcacaactt cacgcgcgac caggcgctgt acgcccgcgg ctactgctgg
      301 acggagctgc gggacgcgct gcccggcgtg gacgccagcc tgtggccgtc gctgtttgag
      361 cacaagttcc tgccctacgc gctgctggcc ttcgccgcca tcatgtacgt gcccgcgctg
      421 ggctgggagt tcctggcctc cacgcgcctc acctccgagc tcaacttcct gctgcaggag
      481 atcgacaact gttaccaccg ggcggccgag ggccgcgcgc ccaagatcga gaagcagatc
      541 cagtccaagg gcccgggcat cacggagcgc gagaagcgcg agatcatcga gaacgcggag
      601 aaggagaaga gcccggagca gaacctgttc gagaagtacc tggagcgccg cggccgcagc
      661 aacttcctgg ccaagctgta cctggcgcgg cacgtgctga tcctgctgct gagcgccgtg
      721 cccatctcct acctgtgcac ctactacgcc acgcagaagc agaacgagtt cacctgcgcg
      781 ctgggcgcgt ccccggacgg ggcggcaggt gcggggcccg cggtgcgcgt gagctgcaag
      841 ctcccgtccg tgcaactgca gcgcatcatc gcgggcgtgg acatcgtgct gctgtgcgtc
      901 atgaacctca tcatcctcgt caacctcatc cacctcttca tcttccgcaa gagcaacttc
      961 atcttcgaca agctgcacaa ggtgggcatc aagacgcgcc ggcagtggcg ccgctcgcag
     1021 ttctgcgaca tcaacatcct ggccatgttc tgcaacgaga accgcgacca catcaagtcg
     1081 ctcaaccggc tggacttcat caccaacgag agcgacctca tgtacgacaa cgtggtccgg
     1141 cagctgctgg cggcgctggc gcagtccaac cacgacgcca cccccacggt gcgcgactcg
     1201 ggggtgcaga ccgtggaccc cagcgccaac cccgccgagc ccgacggcgc cgccgagccg
     1261 cccgtggtca agcggccgcg caagaagatg aagtggatcc ccaccagcaa cccgcttccg
     1321 cagcccttca aggagccgct ggccatcatg cgcgtggaga acagcaaggc ggagaagccg
     1381 aagcccgcgc gcaggaagac ggccacggac acgctgatcg cgccgctgct ggaccgctcc
     1441 gcccaccact acaagggcgg agggggcgac ccgggccccg gccccgcccc tgcccccgcc
     1501 ccgccgcccg cccctgacaa gaagcacgcg cgccacttct ccctggacgt gcacccctac
     1561 atcctcggca ccaagaaggc caaggccgag gcggtgcccg ccgccctgcc cgcctcccgg
     1621 agccaggagg ggggcttcct gtcccaggcg gaggactgtg ggctaggcct ggccccggcg
     1681 cccatcaaag atgctccgct ccccgagaag gaaatcccgt accccacaga gccagcccgg
     1741 gcagggcttc cctcgggggg cccgttccac gtccgctcac ctcccgccgc ccctgctgtg
     1801 gcccctctga caccagccag cctgggcaag gcggagcccc tcaccatcct gagccgaaac
     1861 gccacacacc cgctgctgca catcaacacg ctgtacgagg cccgggagga ggaggacggg
     1921 ggcccccgcc tgccgcagga cgtgggggac ctcatcgcca tccctgcccc acagcagatc
     1981 ctcatcgcca ccttcgacga gccgagaacg gtcgtgagta ctgtggagtt ttgagggatg
     2041 gcaccgtcca ggccgccgag agcccctctg cctgtgtcgt gtggcctggc cagcctcccg
     2101 gtggacacca gccctgcgtg gacgtggcct gtgcttcgcc cgcactgcgc gcatccccaa
     2161 cctctgtccg catgcctggg gccttcgccc ccacgtgctc gacaggggaa cccgcccgga
     2221 cggcatcgcc aggcactggc tggggtgggg aaaggtggcc cagtggagcc ggtggccagg
     2281 aaggctgaag cccgcttccc atgctcctgc atcaggtgcc cagccgtggg tgggggccct
     2341 gaggtgaaga gtttattttt ttagtccgtt tcgtcctggc cccgggctgt ggcgagacag
     2401 cccaactccc ccagcccagc tcccccagcc cagagccagg gaagaggaag gtggggccag
     2461 tcccaccagt ggggtggcca cgcccatggg gtcacatgct caggggtcac cccctgcagg
     2521 gacctgatgc cctcgggtgg gagggaccga ggtccaccct cgggtcaaag gtcaacgtgc
     2581 actttctcct tgtcgcctga cagacatttt attttactaa gactgctgta ccgaacaagc
     2641 atatttatca tcaggagaca ggatgggttt aaagcaggat ggtgtgtgtg tgaacgggca
     2701 tgagcagagg tgagcgtgag cgagcgggtg tgtatgtacg agtgtgcacg tgtgtgcgtg
     2761 tgcacagagg gtgtggtgcc agcttgagtg ggagtgtgtg agtgtgagca ggcgggcgag
     2821 tgcgtgagtg cacgccagcg cgtggcccat gtatgaggag tgaaggggcc caacgcaata
     2881 accacgtccc ccacccgggc cccccgccgc ggctgaggcc acatggcttc ctgtgggagc
     2941 cccggccggc acccggctgg tcccacccca aatacctcag ccatggagac catgtcatgc
     3001 agaattaaca aggtagcacc gagcatatca ataaatatta ttctgataat ca
//
