LOCUS       NM_015368               2852 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens pannexin 1 (PANX1), mRNA.
ACCESSION   NM_015368
VERSION     NM_015368.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2852)
  AUTHORS   Zhou,J., Mao,R., Wang,M., Long,R., Gao,L., Wang,X., Jin,L. and
            Zhu,L.
  TITLE     A novel heterozygous missense variant of PANX1 causes human oocyte
            death and female infertility
  JOURNAL   J Ovarian Res 17 (1), 180 (2024)
   PUBMED   39232764
  REMARK    GeneRIF: A novel heterozygous missense variant of PANX1 causes
            human oocyte death and female infertility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2852)
  AUTHORS   Fierro-Arenas,A., Landskron,G., Camhi-Vainroj,I., Basterrechea,B.,
            Parada-Venegas,D., Lobos-Gonzalez,L., Dubois-Camacho,K.,
            Araneda,C., Romero,C., Dominguez,A., Vasquez,G., Lopez-K,F.,
            Alvarez,K., Gonzalez,C.M., Hager Ribeiro,C., Balboa,E., Eugenin,E.,
            Hermoso,M.A. and De la Fuente Lopez,M.
  TITLE     Pannexin-1 expression in tumor cells correlates with colon cancer
            progression and survival
  JOURNAL   Life Sci 351, 122851 (2024)
   PUBMED   38897345
  REMARK    GeneRIF: Pannexin-1 expression in tumor cells correlates with colon
            cancer progression and survival.
REFERENCE   3  (bases 1 to 2852)
  AUTHORS   Xiong,Y., Luo,J., Hong,Z.Y., Zhu,W.Z., Hu,A. and Song,B.L.
  TITLE     Hyperactivation of SREBP induces pannexin-1-dependent lytic cell
            death
  JOURNAL   J Lipid Res 65 (7), 100579 (2024)
   PUBMED   38880128
  REMARK    GeneRIF: Hyperactivation of SREBP induces pannexin-1-dependent
            lytic cell death.
REFERENCE   4  (bases 1 to 2852)
  AUTHORS   Hu,C.Q., Hou,T., Xiang,R., Li,X., Li,J., Wang,T.T., Liu,W.J.,
            Hou,S., Wang,D., Zhao,Q.H., Yu,X.X., Xu,M., Liu,X.K., Chi,Y.J. and
            Yang,J.C.
  TITLE     PANX1-mediated ATP release confers FAM3A's suppression effects on
            hepatic gluconeogenesis and lipogenesis
  JOURNAL   Mil Med Res 11 (1), 41 (2024)
   PUBMED   38937853
  REMARK    GeneRIF: PANX1-mediated ATP release confers FAM3A's suppression
            effects on hepatic gluconeogenesis and lipogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2852)
  AUTHORS   Salgado,M., Marquez-Miranda,V., Ferrada,L., Rojas,M.,
            Poblete-Flores,G., Gonzalez-Nilo,F.D., Ardiles,A.O. and Saez,J.C.
  TITLE     Ca2+ permeation through C-terminal cleaved, but not full-length
            human Pannexin1 hemichannels, mediates cell death
  JOURNAL   Proc Natl Acad Sci U S A 121 (25), e2405468121 (2024)
   PUBMED   38861601
  REMARK    GeneRIF: Ca[2+] permeation through C-terminal cleaved, but not
            full-length human Pannexin1 hemichannels, mediates cell death.
REFERENCE   6  (bases 1 to 2852)
  AUTHORS   Locovei,S., Bao,L. and Dahl,G.
  TITLE     Pannexin 1 in erythrocytes: function without a gap
  JOURNAL   Proc Natl Acad Sci U S A 103 (20), 7655-7659 (2006)
   PUBMED   16682648
  REMARK    GeneRIF: Data show that erythrocytes express the gap junction
            protein pannexin 1.
REFERENCE   7  (bases 1 to 2852)
  AUTHORS   Bao,L., Locovei,S. and Dahl,G.
  TITLE     Pannexin membrane channels are mechanosensitive conduits for ATP
  JOURNAL   FEBS Lett 572 (1-3), 65-68 (2004)
   PUBMED   15304325
REFERENCE   8  (bases 1 to 2852)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   9  (bases 1 to 2852)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
REFERENCE   10 (bases 1 to 2852)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003966.2, BC016931.1,
            AF398509.1, AK074897.1, AY359023.1 and CA418094.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015368.3.
            
            Summary: The protein encoded by this gene belongs to the innexin
            family. Innexin family members are the structural components of gap
            junctions. This protein and pannexin 2 are abundantly expressed in
            central nerve system (CNS) and are coexpressed in various neuronal
            populations. Studies in Xenopus oocytes suggest that this protein
            alone and in combination with pannexin 2 may form cell
            type-specific gap junctions with distinct properties. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.81357.1,
                                           SRR1660809.236064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227638.8/ ENSP00000227638.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AP003966.2         50009-50095
            88-108              BC016931.1         1-21
            109-261             AF398509.1         20-172
            262-486             AK074897.1         120-344
            487-1763            AY359023.1         161-1437
            1764-2845           AK074897.1         1622-2703
            2846-2852           CA418094.1         18-24               c
FEATURES             Location/Qualifiers
     source          1..2852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2852
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="pannexin 1"
                     /db_xref="GeneID:24145"
                     /db_xref="HGNC:HGNC:8599"
                     /db_xref="MIM:608420"
     exon            1..653
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1753
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="innexin"
                     /codon_start=1
                     /product="pannexin-1"
                     /protein_id="NP_056183.2"
                     /db_xref="CCDS:CCDS8296.1"
                     /db_xref="GeneID:24145"
                     /db_xref="HGNC:HGNC:8599"
                     /db_xref="MIM:608420"
                     /translation="MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVG
                     LPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLP
                     LWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSA
                     RDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRL
                     LTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLL
                     SVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLF
                     LEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQ
                     GNQTAELQGMNIDSETKANNGEKNARQRLLDSSC"
     exon            654..793
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1017
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1673
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..2852
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="hexamer: AATAAA"
     polyA_site      1865
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="major polyA site"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="hexamer: TATAAA"
     polyA_site      2852
                     /gene="PANX1"
                     /gene_synonym="MRS1; OOMD7; OZEMA7; PX1; UNQ2529"
                     /note="major polyA site"
ORIGIN      
        1 gtacttggtt tccccgcatg gttccggaag agcgcggcgc agctggctgt gagcgcaggg
       61 ctatcccggc ggccgcttcg gcagccaggg cggcgcggag gggcagggcc agagggaagc
      121 gctttgttcc gcgcgtggtt cccgcgcctg ggggtgcgcg ggagaggcgc gaatccgagt
      181 gccgcgcgcg gcccggggac ttgcacgggc gtgcggggtg gaaccgcagg aagcggagct
      241 ctcgggttcc cgccccgccc cgccccgccg gcggcggagg cagcgagcgc gagagcccag
      301 cggagtcgct gggagcctga ggcaccgaga cacaaaggca ggcgggatgc gggagcaggc
      361 aaagggaaag cgaaagccgc gcgcccggcc ggtgactggg tgaaggcgcc gcgcagcttt
      421 cccgacgccg gctgtacccg gacctcctgg tcgagcctgg cgcgccgcag ccatggccat
      481 cgctcaactg gccacggagt acgtgttctc ggatttcttg ctgaaggagc ccacggagcc
      541 caagttcaag gggctgcgac tggagctggc tgtggacaag atggtcacgt gcattgcggt
      601 ggggctgccc ctgctgctca tctcgctggc cttcgcgcag gagatctcga ttggtacaca
      661 gataagctgt ttctctccaa gttctttctc ctggcgtcag gctgcctttg tggattcata
      721 ttgctgggcg gctgttcagc agaagaactc actgcagagc gagtctggaa acctcccact
      781 gtggctgcat aagtttttcc cctacatcct gctgctcttt gcgatcctcc tgtacctgcc
      841 cccgctgttc tggcgtttcg cagctgctcc tcatatttgc tcagacttga agtttatcat
      901 ggaagaactt gacaaagttt acaaccgtgc aattaaggct gcaaagagtg cgcgtgacct
      961 tgacatgaga gatggagcct gctcagttcc aggtgttacc gagaacttag ggcaaagttt
     1021 gtgggaggta tctgaaagcc acttcaagta cccaattgtg gagcagtact tgaagacaaa
     1081 gaaaaattct aataatttaa tcatcaagta cattagctgc cgcctgctga cactcatcat
     1141 tatactgtta gcgtgtatct acctgggcta ttacttcagc ctctcctcac tctcagacga
     1201 gtttgtgtgc agcatcaaat cagggatcct gagaaacgac agcaccgtgc ccgatcagtt
     1261 tcagtgcaaa ctcattgccg tgggcatctt ccagttgctc agtgtcatta accttgtggt
     1321 ttatgtcctg ctggctcccg tggttgtcta cacgctgttt gttccattcc gacagaagac
     1381 agatgttctc aaagtgtacg aaatcctccc cacttttgat gttctgcatt tcaaatctga
     1441 agggtacaac gatttgagcc tctacaatct cttcttggag gaaaatataa gtgaggtcaa
     1501 gtcatacaag tgtcttaagg tactggagaa tattaagagc agtggtcagg ggatcgaccc
     1561 aatgctactc ctgacaaacc ttggcatgat caagatggat gttgttgatg gcaaaactcc
     1621 catgtctgca gagatgagag aggagcaggg gaaccagacg gcagagctcc aaggtatgaa
     1681 catagacagt gaaactaaag caaataatgg agagaagaat gcccgacaga gacttctgga
     1741 ttcttcttgc tgatgatttt tttccttgag ctgtaaatct gtgacttctg cgacatggga
     1801 tttaatttgg ctaaagcacc cctgttggtt tcacagctgg tttgcaataa atggttcttg
     1861 gtggagatac tgagcatgtc ttattgagtc cctaatggaa atggtgatca acaaaaggtt
     1921 atggaagaat ggtttatgaa cttcccatag gaagcacctg agagatagta aactgcagca
     1981 agtaactatg tgtaagtcct catcaaatga aaagcagaaa gacaagaaca attagtcaag
     2041 agcagtagcc ctgtcagagc ctcggagcaa tacctttctg tacccgtggt gagacaagac
     2101 ccagagctac tggaaaacaa gcactttgga agatttgttt tgttttcatg gaataataat
     2161 atgtcagggt ataatttaac gtgagtttct tatgtgccct taaagactgt tagacaagaa
     2221 aagcattcac tggctaataa tccataggtc gacctatgtc ctaagttagg tgtaaggtcc
     2281 gatgccttgg cccacactcg agctctcttt acattgttag ttgtcaacct tggctgatgg
     2341 aaatcccgta accactattt gttgcactgt gccttgaagg gcagcaggcc caagtgctgc
     2401 tctgactgaa aactgagtta acaagatgaa atctaaagga tattcacagt gacttcaatt
     2461 caggaagaat gcttccaaaa gagcccagtg gggaaatctg acatcacaga agacattaat
     2521 tcagtcactt tcaaagagtt tgtctacagg cggtttctct gttatcaaag gcatttgaaa
     2581 taggatttta cttaaacaat aatggaacac aggagtattt aaagtgaaga acactttgcc
     2641 tgaatgtgat cagggcacat aagtgacatt ggcatgcttc atatggcgtg cttggagcca
     2701 gaaaaactta gcggtttatt ttgtttatat ttaagcacag ctttaaaaaa ttcattatcg
     2761 tttattcagt gtccgaattg aggccatttg ggaagaaaat tctagcactg gtggagaatt
     2821 atagaataaa gattataaat ggttggataa ga
//
