LOCUS       NM_018216               2641 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens pantothenate kinase 4 (inactive) (PANK4), mRNA.
ACCESSION   NM_018216
VERSION     NM_018216.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Vella,V., Ditsiou,A., Chalari,A., Eravci,M., Wooller,S.K.,
            Gagliano,T., Bani,C., Kerschbamer,E., Karakostas,C., Xu,B.,
            Zhang,Y., Pearl,F.M.G., Lopez,G., Peng,L., Stebbing,J., Klinakis,A.
            and Giamas,G.
  TITLE     Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator
            of Temozolomide Resistance in Glioblastoma
  JOURNAL   Adv Sci (Weinh) 11 (15), e2306027 (2024)
   PUBMED   38353396
  REMARK    GeneRIF: Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a
            Modulator of Temozolomide Resistance in Glioblastoma.
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Yao,J., Subramanian,C., Rock,C.O. and Jackowski,S.
  TITLE     Human pantothenate kinase 4 is a pseudo-pantothenate kinase
  JOURNAL   Protein Sci 28 (6), 1031-1047 (2019)
   PUBMED   30927326
  REMARK    GeneRIF: The human PANK4 is a pseudo-pantothenate kinase-a
            catalytically deficient variant of the catalytically active PANK4
            found in plants and fungi.
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Sun,M., Chen,C., Hou,S., Li,X., Wang,H., Zhou,J., Chen,X., Liu,P.,
            Kijlstra,A., Lin,S. and Ye,J.
  TITLE     A novel mutation of PANK4 causes autosomal dominant congenital
            posterior cataract
  JOURNAL   Hum Mutat 40 (4), 380-391 (2019)
   PUBMED   30585370
  REMARK    GeneRIF: the association of a new entity of an autosomal dominant
            cataract with mutations in PANK4, which influences cell
            proliferation, apoptosis of lens epithelial cells, crystallin
            abnormalities, and fiber cell derangement, subsequently induces
            cataract.
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Huang,L., Khusnutdinova,A., Nocek,B., Brown,G., Xu,X., Cui,H.,
            Petit,P., Flick,R., Zallot,R., Balmant,K., Ziemak,M.J.,
            Shanklin,J., de Crecy-Lagard,V., Fiehn,O., Gregory,J.F. 3rd,
            Joachimiak,A., Savchenko,A., Yakunin,A.F. and Hanson,A.D.
  TITLE     A family of metal-dependent phosphatases implicated in metabolite
            damage-control
  JOURNAL   Nat Chem Biol 12 (8), 621-627 (2016)
   PUBMED   27322068
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Li,Y., Chang,Y., Zhang,L., Feng,Q., Liu,Z., Zhang,Y., Zuo,J.,
            Meng,Y. and Fang,F.
  TITLE     High glucose upregulates pantothenate kinase 4 (PanK4) and thus
            affects M2-type pyruvate kinase (Pkm2)
  JOURNAL   Mol Cell Biochem 277 (1-2), 117-125 (2005)
   PUBMED   16132722
  REMARK    GeneRIF: PanK4 interacts with Pkm2 and thereby may modulate the
            glucose metabolism through regulating the activity of Pkm2.
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Robishaw,J.D. and Neely,J.R.
  TITLE     Coenzyme A metabolism
  JOURNAL   Am J Physiol 248 (1 Pt 1), E1-E9 (1985)
   PUBMED   2981478
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC316156.1 and AK001644.1.
            
            On May 17, 2019 this sequence version replaced NM_018216.3.
            
            Summary: This gene encodes a protein belonging to the pantothenate
            kinase family. Pantothenate kinase is a key regulatory enzyme in
            the biosynthesis of coenzyme A (CoA) in bacteria and mammalian
            cells. It catalyzes the first committed step in the universal
            biosynthetic pathway leading to CoA and is itself subject to
            regulation through feedback inhibition by CoA. This family member
            is most abundant in muscle but is expressed in all tissues.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043496.1, BK000012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378466.9/ ENSP00000367727.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               DC316156.1         14-415
            403-2641            AK001644.1         403-2641
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..2641
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /note="pantothenate kinase 4 (inactive)"
                     /db_xref="GeneID:55229"
                     /db_xref="HGNC:HGNC:19366"
                     /db_xref="MIM:606162"
     exon            1..133
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2331
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /EC_number="2.7.1.33"
                     /note="pantothenic acid kinase 4; inactive pantothenic
                     acid kinase 4"
                     /codon_start=1
                     /product="4'-phosphopantetheine phosphatase"
                     /protein_id="NP_060686.3"
                     /db_xref="CCDS:CCDS42.3"
                     /db_xref="GeneID:55229"
                     /db_xref="HGNC:HGNC:19366"
                     /db_xref="MIM:606162"
                     /translation="MAECGASGSGSSGDSLDKSITLPPDEIFRNLENAKRFAIDIGGS
                     LTKLAYYSTVQHKVAKVRSFDHSGKDTEREHEPPYEISVQEEITARLHFIKFENTYIE
                     ACLDFIKDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLK
                     NIPHEAFVYQKDSDPEFRFQTNHPHIFPYLLVNIGSGVSIVKVETEDRFEWVGGSSIG
                     GGTFWGLGALLTKTKKFDELLHLASRGQHSNVDMLVRDVYGGAHQTLGLSGNLIASSF
                     GKSATADQEFSKEDMAKSLLHMISNDIGQLACLHARLHSLDRVYFGGFFIRGHPVTMR
                     TITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAGSSGLMSA
                     SPELGPAQRARSGTFDLLEMDRLERPLVDLPLLLDPPSYVPDTVDLTDDALARKYWLT
                     CFEEALDGVVKRAVASQPDSVDAAERAEKFRQKYWNKLQTLRQQPFAYGTLTVRSLLD
                     TREHCLNEFNFPDPYSKVKQRENGVALRCFPGVVRSLDALGWEERQLALVKGLLAGNV
                     FDWGAKAVSAVLESDPYFGFEEAKRKLQERPWLVDSYSEWLQRLKGPPHKCALIFADN
                     SGIDIILGVFPFVRELLLRGTEVILACNSGPALNDVTHSESLIVAERIAGMDPVVHSA
                     LQEERLLLVQTGSSSPCLDLSRLDKGLAALVRERGADLVVIEGMGRAVHTNYHAALRC
                     ESLKLAVIKNAWLAERLGGRLFSVIFKYEVPAE"
     exon            134..216
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            217..431
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            432..615
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            709..862
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1044
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1126
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1227
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1383
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1496
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1584
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1736
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1792
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1842
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1947
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2048
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2117
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2641
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2623..2628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /note="hexamer: AATAGA"
     polyA_site      2641
                     /gene="PANK4"
                     /gene_synonym="CTRCT49"
                     /note="major polyA site"
ORIGIN      
        1 actttcaaaa tggcggagtg tggagcgagc ggcagcggga gcagcgggga cagtctggac
       61 aagagcatca cgctgccccc cgacgagatc ttccgcaacc tggagaacgc caagcgcttc
      121 gccatcgaca taggcgggtc gttaaccaag ctggcctact attcaacggt acagcacaaa
      181 gtcgccaagg tgcggtcttt cgaccactcc ggaaaggaca cagaacgtga acatgagccg
      241 ccctatgaga tttcagttca agaagagatc actgctcgac tgcacttcat taagtttgag
      301 aatacctaca tcgaagcctg cctggacttc atcaaagacc atctcgtcaa cacagagacc
      361 aaggtcatcc aggcgaccgg gggcggggcc tacaagttca aagacctcat cgaagagaag
      421 ctgcggctga aagtcgacaa ggaggacgtg atgacgtgcc tgattaaggg gtgcaacttc
      481 gtgctcaaga acatccccca tgaggccttc gtgtaccaga aggattccga ccctgagttc
      541 cggttccaga ccaaccaccc ccacattttc ccctatcttc ttgtcaatat cggctctgga
      601 gtctccatcg tgaaggtgga gacggaggac aggttcgagt gggtcggcgg cagctccatt
      661 ggaggcggca ccttctgggg gcttggcgct ctgctcacca aaacgaagaa gtttgacgag
      721 ctcctgcacc tggcctcgag gggccagcac agcaatgtgg acatgctggt gcgggacgtc
      781 tacggcggcg cccaccagac tctcgggctg agcgggaacc tcatcgccag cagcttcggg
      841 aagtcggcca ccgccgacca agagttctcc aaagaagaca tggcgaagag cctgctgcac
      901 atgatcagca acgacattgg gcagctggcc tgcctccacg cacggctgca cagcctggac
      961 cgcgtgtact ttggaggctt ctttatccgg ggccaccccg tgaccatgcg caccatcacc
     1021 tatagcatca acttcttctc caagggggaa gtgcaggcgc tgtttctgag gcacgaaggc
     1081 tacctgggag ccatcggagc gttcctgaaa ggagctgagc aggacaatcc taaccagtac
     1141 agctggggag agaactatgc aggcagctcc gggctgatga gtgcatcacc cgagctcggc
     1201 ccggcgcagc gggcgcggag tggcactttt gacttgctgg aaatggaccg gctggagagg
     1261 ccactggttg acctgccgct cctcctggac ccgccctcct acgtgcccga cacggtggac
     1321 ctcaccgatg acgctctggc ccgaaaatac tggctcacct gctttgagga ggccctggac
     1381 ggggtagtga agcgcgcagt ggcgagccag ccagactctg tggatgcagc cgagagggcg
     1441 gagaagttcc ggcagaagta ctggaacaag cttcagaccc tgaggcagca gcccttcgcc
     1501 tatgggaccc tgaccgtgcg cagcctgctg gacaccaggg agcactgtct gaacgagttc
     1561 aacttcccgg atccctactc caaagtgaag cagcgggaga atggcgtggc gctgaggtgc
     1621 ttccccgggg tcgtgcgctc cctggacgcg ctgggctggg aggaacggca gctggcgctg
     1681 gtgaaaggcc tcctggcggg gaatgtcttc gactgggggg ccaaagccgt gtctgctgtc
     1741 cttgaatccg acccctactt tgggtttgaa gaagcaaaga ggaagttaca agaaagaccc
     1801 tggctcgtgg attcctacag cgagtggctt cagagattaa aggggccccc tcataaatgt
     1861 gccttaattt tcgcagataa cagtggaata gacatcattt tgggagtctt cccctttgtc
     1921 agggagctac tccttagagg gacagaggtc atcctggcgt gcaactcagg ccccgccctg
     1981 aacgacgtga cccacagcga gtccctcatc gtggcagagc gtattgcggg catggaccct
     2041 gtcgtgcact ctgcgctcca ggaagagagg ctgctgctgg tgcagacggg ctccagctcc
     2101 ccgtgcctcg acctcagccg cctggataag gggctggccg cactggtgcg ggagcgtggc
     2161 gcggatctgg tggtcatcga gggcatgggc cgtgctgtcc acacaaacta ccacgcagcc
     2221 ctgcgctgcg agagcctcaa gctggccgtc atcaagaacg cgtggctggc cgagcggctg
     2281 ggcggccggc tcttcagcgt catcttcaag tacgaggtcc cagccgagtg aggcgctgca
     2341 gctgccggac tcttctgctt gtcacttgtc aggaatgtgt ttttaccacc acagggaaac
     2401 tgcgttcaaa tcaacgtatt tatatggtac tgctgtgacg cggcacatac accccagccg
     2461 cacagatgcg tgtgacccag aggcgagacg cagctttgtc ctgggagacg ttcatattgg
     2521 aatctattta actgctaaag aaccttttat atatatatat atataaatag agagatctat
     2581 acaggtatgt ctgacgggac gcagcaccgt gggcacgcac caaatagagt ttttaaaaga
     2641 g
//
