LOCUS       NM_024594              10274 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens pantothenate kinase 3 (PANK3), mRNA.
ACCESSION   NM_024594
VERSION     NM_024594.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10274)
  AUTHORS   Yao,J., Subramanian,C., Rock,C.O. and Jackowski,S.
  TITLE     Human pantothenate kinase 4 is a pseudo-pantothenate kinase
  JOURNAL   Protein Sci 28 (6), 1031-1047 (2019)
   PUBMED   30927326
REFERENCE   2  (bases 1 to 10274)
  AUTHORS   Subramanian,C., Yun,M.K., Yao,J., Sharma,L.K., Lee,R.E.,
            White,S.W., Jackowski,S. and Rock,C.O.
  TITLE     Allosteric Regulation of Mammalian Pantothenate Kinase
  JOURNAL   J Biol Chem 291 (42), 22302-22314 (2016)
   PUBMED   27555321
  REMARK    GeneRIF: Biochemical analyses showed that the transition between
            the inactive and active conformations, as assessed by the binding
            of either ATP.Mg(2+) or acyl-CoA to PANK3, is highly cooperative
            indicating that both protomers move in concert.
REFERENCE   3  (bases 1 to 10274)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   4  (bases 1 to 10274)
  AUTHORS   Leonardi,R., Zhang,Y.M., Yun,M.K., Zhou,R., Zeng,F.Y., Lin,W.,
            Cui,J., Chen,T., Rock,C.O., White,S.W. and Jackowski,S.
  TITLE     Modulation of pantothenate kinase 3 activity by small molecules
            that interact with the substrate/allosteric regulatory domain
  JOURNAL   Chem Biol 17 (8), 892-902 (2010)
   PUBMED   20797618
REFERENCE   5  (bases 1 to 10274)
  AUTHORS   Hong,B.S., Senisterra,G., Rabeh,W.M., Vedadi,M., Leonardi,R.,
            Zhang,Y.M., Rock,C.O., Jackowski,S. and Park,H.W.
  TITLE     Crystal structures of human pantothenate kinases. Insights into
            allosteric regulation and mutations linked to a neurodegeneration
            disorder
  JOURNAL   J Biol Chem 282 (38), 27984-27993 (2007)
   PUBMED   17631502
  REMARK    GeneRIF: analysis of the homodimeric structures of the catalytic
            cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the
            the structural effects of the PanK2 mutations that have been
            implicated in neurodegeneration
REFERENCE   6  (bases 1 to 10274)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
REFERENCE   7  (bases 1 to 10274)
  AUTHORS   Kayano,T., Burant,C.F., Fukumoto,H., Gould,G.W., Fan,Y.S.,
            Eddy,R.L., Byers,M.G., Shows,T.B., Seino,S. and Bell,G.I.
  TITLE     Human facilitative glucose transporters. Isolation, functional
            characterization, and gene localization of cDNAs encoding an
            isoform (GLUT5) expressed in small intestine, kidney, muscle, and
            adipose tissue and an unusual glucose transporter pseudogene-like
            sequence (GLUT6)
  JOURNAL   J Biol Chem 265 (22), 13276-13282 (1990)
   PUBMED   1695905
REFERENCE   8  (bases 1 to 10274)
  AUTHORS   Robishaw,J.D. and Neely,J.R.
  TITLE     Coenzyme A metabolism
  JOURNAL   Am J Physiol 248 (1 Pt 1), E1-E9 (1985)
   PUBMED   2981478
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB045475.1, BC013705.1,
            AC020894.5 and AA831520.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024594.3.
            
            Summary: This gene encodes a protein belonging to the pantothenate
            kinase family. Pantothenate kinase is a key regulatory enzyme in
            the biosynthesis of coenzyme A (CoA) in bacteria and mammalian
            cells. It catalyzes the first committed step in the universal
            biosynthetic pathway leading to CoA and is itself subject to
            regulation through feedback inhibition by CoA. This family member
            is expressed most abundantly in the liver. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.11331.1,
                                           SRR3476690.841492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239231.7/ ENSP00000239231.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               CB045475.1         239-424
            187-1815            BC013705.1         402-2030
            1816-3139           AC020894.5         111565-112888       c
            3140-3146           AA831520.1         18-24               c
            3147-10274          AC020894.5         104430-111557       c
FEATURES             Location/Qualifiers
     source          1..10274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..10274
                     /gene="PANK3"
                     /note="pantothenate kinase 3"
                     /db_xref="GeneID:79646"
                     /db_xref="HGNC:HGNC:19365"
                     /db_xref="MIM:606161"
     exon            1..113
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1198
                     /gene="PANK3"
                     /EC_number="2.7.1.33"
                     /note="hPanK3; pantothenic acid kinase 3"
                     /codon_start=1
                     /product="pantothenate kinase 3"
                     /protein_id="NP_078870.1"
                     /db_xref="CCDS:CCDS4368.1"
                     /db_xref="GeneID:79646"
                     /db_xref="HGNC:HGNC:19365"
                     /db_xref="MIM:606161"
                     /translation="MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVES
                     LKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDK
                     NFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAEC
                     YYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTF
                     LGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMI
                     YKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLL
                     AYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS"
     exon            114..466
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..720
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..897
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1021
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1147
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..10274
                     /gene="PANK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANK3"
                     /note="hexamer: ATTAAA"
     polyA_site      1819
                     /gene="PANK3"
                     /note="major polyA site"
     regulatory      10250..10255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANK3"
                     /note="hexamer: AATAAA"
     polyA_site      10274
                     /gene="PANK3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggccca gccacctccg gagtcgccgc ctctgctctc agtgccccgg atcggaggcc
       61 gtccatcgcc cctcgggccg acgccatgaa gatcaaagat gccaagaaac cctctttccc
      121 atggtttggc atggacattg ggggaactct agtaaagctc tcgtactttg aacctattga
      181 tatcacagca gaggaagagc aagaagaagt tgagagttta aaaagtattc ggaaatattt
      241 gacttctaac gtggcatatg gatccaccgg cattcgggat gtacaccttg aactgaaaga
      301 tttaacactt tttggccgaa gagggaactt gcactttatc aggtttccaa cccaggacct
      361 gcctactttt atccaaatgg gaagagataa aaacttctca acattgcaga cggtgctatg
      421 tgctacagga ggtggtgctt acaagtttga aaaagatttt cgcacaattg gaaacctcca
      481 cctgcacaaa ctggatgaac ttgactgcct tgtaaagggc ttgctgtata tagactctgt
      541 cagtttcaat ggacaagccg agtgctatta ttttgctaat gcctcagaac ctgagcgatg
      601 ccaaaagatg ccttttaacc tggatgatcc ctatccactg cttgtagtga acattggctc
      661 aggagtcagt attttagcag tccattccaa agacaactat aaacgagtga ctgggacaag
      721 ccttggaggg ggtacctttc tgggtttatg cagtttattg actggctgtg aaagttttga
      781 agaggctctt gaaatggcat ccaaaggtga tagcacacaa gctgacaagc tggtccgtga
      841 tatttatgga ggagattatg aaagatttgg tttgccaggt tgggctgtag catctagttt
      901 tgggaatatg atttataagg agaagcgaga atctgttagt aaagaagatc tggcaagagc
      961 tactttagtt actatcacca ataacattgg ttctgtggca cgaatgtgtg ctgttaatga
     1021 gaaaataaac agagttgtct ttgttggaaa ctttttacgt gtcaataccc tctcaatgaa
     1081 acttttggca tatgcactgg attactggtc aaaaggtcaa ctaaaagcat tgtttctaga
     1141 acatgagggt tactttggag cagttggtgc acttcttggg ctgccaaatt tcagctaaag
     1201 catcaggtct ctctctctgc taataaatgt catccaagag gaactaaaac cagaggcatt
     1261 attactgcat tgtttgtcac tgggaaccaa aggataaaag agtagcataa gctgctgaat
     1321 gttgccatat taaaggagag aacttggtaa cgtgaagtat ttctcattga aatgctttcc
     1381 cttttgtata tagccagtgt taaatcctta aatgcaatac agcctctgat tattgagctt
     1441 cctcttaaaa agattttttt attttatgta gccaacattg cagtactgta tgctcaaaca
     1501 caaatcttaa agtatcggaa ctgtttagct tatgaaaata atcgactctg aatatttgtt
     1561 acaagtctgt tttatgtgtt ttgattacta gtgagcagaa aataacatac cctgtattca
     1621 aaattactga aatggcaatc aaagatgatc atttttatgt gattttagaa atgttaaggc
     1681 aatactacta attattgtag gtttttttaa cgtatcaccc aaagcatgta tgtgatcttt
     1741 ccccattagt atctttttct caaatgccat aattaactga aatactatta ttaaattttc
     1801 atgagaattc taaaatgaat cctgggaaat gcacgtttgg tgatgttgca ctttctgtat
     1861 tttacaggaa ttagtcaata catgttgaaa tgtttaacat tttaagattg gaggcttaat
     1921 tactgggagt ctgtctaatg aagtcctggg actattgtaa tggaatatga tttgagttca
     1981 ctgtgctctt tttgtttgtt tgttttggtc atatatacat tcagaacttt tattttaaaa
     2041 caaccacaat aacattaata atagaaaatt catctgtaaa tattcacagt ctagtcactg
     2101 aaaaatggga aaacctctac catgccttat tattaccctt tgctgtttga ggagccagaa
     2161 atagaggtgc agttagagga cggtcacttt ttccaacaaa acccactcca tagccatgtg
     2221 gatttttatc caaaggctca acaaccagag ggaatggtga gacctgataa ctaaaatact
     2281 gttattggca agggtttgaa atgtgtaaga acctaggagg gaaaggaaga ttgagcaaca
     2341 taggaaaagg ggaagagagg ctgagtgtca ccaaggtcca aactccattt ataaaaatac
     2401 tgcaaaacca ggagttgatg gtagaaatgc atatgatcca tggcaggagt aaatctctcc
     2461 acctcctcta actctctgaa aactctagag ttggagcaag tcttccattt gcttcttatc
     2521 cccttaaaag aatgccttcc acttcccaac agcccccatc aagggacccc aagaggccac
     2581 catgctctta tctcgcactt tctttcctat tccccttgcc tgaatctgga gtggggttga
     2641 gccctctgcc ttcaacctta agatttagga agttctttcc ccaactgtct aacttggaaa
     2701 ggtagatgag tctgaatttt gaagtaacga atgcaaattc cactcagcag aggcaatgtt
     2761 atttatgtac atagggatag tggaatgagt tttaatagat tctgtccaaa aggggtttgt
     2821 tcctcttatt tcctctatgt aggaagttgt gtcttaggca actttatcag tatcaatgga
     2881 aaaatgatag gcactacaat gaaatggcag gatgccaata tgagatattt caggaataat
     2941 aagaaataca gtttgtttgt ataaaataaa ctatctcaag aaagttttca acgacagtga
     3001 tagtgttcat ttgtaagaga gagttctaga acttcgatgt ccagtgcagt agccactacc
     3061 catatgtagc tgttgagcat ttgaaatatg gttagtccaa attgagatgt gctctaaagg
     3121 acaataaaag gttaaatatc tcctaatttt ttgtattgat tacatgttga aatgttaaca
     3181 ttggaaatat tgggttaaag aaaaatacac aattaaaatg aatcttggcc aggcgcagtg
     3241 gctcacgcct ctaatcccag cactttgaga ggccagggtg ggcaggtcac ctgaggtcag
     3301 gagttcgaga ccagcctggc cagtgtggca aaaccctgcc tactaaaaat acaaaaatta
     3361 gccaggcatg gtggtgcgca cctgtagtcc cagctacttg ggaggctgag gcaggagaat
     3421 tgcttgaacc caggaggagg aggctgcagt gagctgagat tgtgccactg cactccagcc
     3481 tgggcgacag agtgagactc tgtctcaaaa aaaagaatca tctgtttcca attattttta
     3541 aatgtgctta ctagaaaaga taaaatcaca catggtttac attttatttc tattaagaca
     3601 gcaccgttaa gaacatagag ctttgaggaa ttgtggtatt agaaccaaat ctatttacca
     3661 cagtgagctt acagggagtt actcgagatc ttaataaaaa attataatct ttggcagcct
     3721 tcattatgat tttgtgttct tattattcca gtacctctag attacatatg ggaaaagcta
     3781 aagagccaca gtggtgagat ggttgctcac tctagcaggt aatttcagtt tgaaaggata
     3841 aaatatatga atcatagttc acattaacca aagtacagtg atgaaataac ttagactctg
     3901 accattccat tttttcttaa agattgccct aaatctatag atgctaatac agtatttgcc
     3961 acaggtataa aacttgtagt tactgtcatt caattaagat tcttatctgt acagatatac
     4021 aaatcagaaa cttttaaaat aaattgaact aatggaattt tggctccaat atttagtcac
     4081 tacaatggaa atattaaagc aaggaacatg aagtcattgt agggttttaa aatggctact
     4141 gactgacatg aattcagagt ttcaaacagt ctaaattcta aaaacttaac tttacacgct
     4201 tttcctccta aataaccact ctaataattc atacattcat atcttcaggt aaagaaaact
     4261 gaattttaaa caattgaggc tgggtgcagt ggctcatgcc tgtaatcgaa tataaggact
     4321 tgagtataaa atttgaaaac tacatgggga aatgtcttta tcatgcatct cttgatagtc
     4381 tactgaaaac tattaagtaa acctgcggtc tgtaaacaaa aaaacccata gtgatactta
     4441 ccttgtgtaa tgtaaacaat tttttaagct ctttaaagta catctagatt tactggtaat
     4501 gtatagaagt caattttatc cccaagcatt tctacttcct aaaccattag caagagtctc
     4561 aaaacaactt cactaaacta ttggacctcc agtgttaact tgccaacata aaaatctgaa
     4621 aaactttgta atcactatca aaaatacaaa agagagaata aattcccagg taaaaggctt
     4681 tacaaatttt ggaactatta tgcttttgtt tactaaacac tgatcctttt agtaattctg
     4741 cagtattgcc tcagactccc acaaagtttc aaaatagctc atctattaga ttcctgtaac
     4801 atttatttgg gataaacgtg gttttgttgc cgttgttcat aatagaataa aatatttagc
     4861 tttgatggtt cagatgtaat acaaagaaat aactaagttt gggcctgaga taaatgtggt
     4921 aaagcaagaa tgcagagatg ctgtaatgat gagtgagttt tatagcatta ctgaggacct
     4981 gaaaacttgc tgccaaggac actttgaagg ttttgttggc tggaagaagt gtctctggaa
     5041 tcccactcct agctcttctt gaatatttga aaagaattag ataagggcca tggggaccca
     5101 ggtcacccca cctcttcttt tcagtttggc tacaacattg gagtcatcag tgctcctgag
     5161 acagtcatac aggactttct cagttacact ttgaaagaga ggtcagaaga ctctccctct
     5221 gaggttttgc tcatgtcccc ctggcccttg tctgtggcca tcttccccaa tggtgatatg
     5281 attggctcct ttctgttgca ctctttgtca accactttgg caggtgcagt tcaatgctta
     5341 tcataatttg ttggctatta ctggttgcct tatgggattc tgcagacaag ctgagttggt
     5401 tgaaatgctg atcctgggcc actagattac tggcttgtaa tgcggactct gcacaagttt
     5461 tgtgcccatg tacattggag agatctcgcc tactcccctt tggggtacct ttagtgctct
     5521 caaccagctg gacgtcgttg gtattctgga gatccagatc tttggtctgg agttcatctt
     5581 ggggtctgaa gagctatgcc cagtgatact gggctttacc atccttccag ctgtcctata
     5641 aagtgtagcc cttccatttt gccctggaag tcgtaagttt ttgctcatta acagaaagga
     5701 agagtactaa tgagatcctt cagcaattgt aggggactca ggatgtgtcc caggacatct
     5761 aggagataag agtgctagga tgatacaaga aaagcaagtc actacactgg cgctctttag
     5821 agtacccagc taccaacaac ccactgtcat ttccatcatg ctccagctct ctcagtagct
     5881 ctctggaatc aatgttgtct tctattactc aatgagaatc ttcaaggatg caggtgttga
     5941 gaagccaatc tatagattag tgcaggagtg gttaatatta tcttcttgac tgtagtctct
     6001 ctgtttgtgg ttgaaagggc aggaaggact ttacatatga taggtcttga ggcatggcgt
     6061 tttgttctgt cctcatgatt gtttctttgt tattaaagga tgagtatggt gggatgagct
     6121 ttgtctgtag tggggctatc ttggtctttg tggccttctc tgaagttgga ccagactccg
     6181 ttccctggaa tactgtggcc acactcttca gtttgcaata gcagtggctg gttgctccaa
     6241 ctggacctcc aactttctag ttggattgct cttcctgaac aattattatc tagtttaagt
     6301 gtgttgttgc tttagggtca tggcatgctt atgtatttct gttaccatct gaccatggta
     6361 ctatgccaag ttctcttagg ggacctgaat ctttccagta gaccacattt gagagagtat
     6421 gagtcaactg ggcatagttc ccaacaaccc aaaatacata cgtacttcac tgaagcagat
     6481 ctcatgattc cattgacttc atttctaaaa ttggactttg agcagccaat ttctaaggat
     6541 taaaaagaaa ctttaatgca ttgtagacct ctgtacacag aaaaatcttt gtaacttttg
     6601 ggcttaattt tcattcttaa aaaatctggt aactttttca aatgcaacca ctgtcagttt
     6661 gctgtgaggc taggcaaaca acacaaggta tagaatttcc catcaccacc accctgaccc
     6721 cgcgagaaga ttgcctttta attagagact tgtagaacta gtgcctttta agttctacac
     6781 tcatcttttc caaagactat tagtaaactt gccatgtaat ttgacatggc agttccttgc
     6841 tcagctactc taaataaagt tggaaattag gtggtctctt agtttgggta aagtcagtac
     6901 tattgccagt aatatacatg gtaattgaaa gcccttaaag tggttcagat tatttgccaa
     6961 atattagact ctataaaaat ttctgaggtt ttttttcttt tacctttgag tgtacatgtg
     7021 attgctataa tgtaaatacc agtcccttaa agactgtttc tataagcaga atgatgcagc
     7081 acaaagtgga aaggttttcc tcttattcca gcagtattct tgccttcaaa gagtagtcca
     7141 tcttgccttg atttttaagg ttgttttctt ggatggaaag cttaactgga tagtaatttc
     7201 catatgttct ttataaccac tctgtatatt ataagcaaag ttttttcata ttgtatcttt
     7261 ttctgttgag cactttatgc attttagtct attgcatttg agaatgtagt ttagaaattc
     7321 actgtttaaa gccatgtgaa aactgataga ggataatgaa aatgagtgta cattattttg
     7381 aatttaactt aactgttttg tggtgggtgt gaacaaaaca ttagaaatat attatctttt
     7441 tgtgataata ctctctgacc tcacttaaag tgatctgcca tgaggtatcc atgatcaagt
     7501 ttatgtttat tctaatacct aaggaattca gccaactttg tttctatcat cagataatct
     7561 cagaaaatag tgtgttttat ctatattact gcctcttttc aatatttaag agaataattg
     7621 tcttctggtt tctactgagc ctagtaataa tcactaaaga cctaaaaaag gaattccttc
     7681 tgttaagagt atttggatag cccattcacg ataatggtgg tgtgaaaatc aatcatccca
     7741 gcttttctga catatctaaa ttttgaataa ttaatttcca cttccaaaaa attcaaatgt
     7801 tttctcaaag cagtcactac ttatttgcat tattcctgca tattcagtga atgtgaggtc
     7861 atatttggta ttgtattaga agtagtgttg gtcactggtc ttgcctcttt gaacattatt
     7921 tttatttgta aaatgaggga gttggtttgt tatgatggga aatgagtcag ttttcagggt
     7981 cctgagaaaa ttgcttcatt catggctgtg tttgagataa ctaaagtaaa ttttttttca
     8041 ggtatttggt gtcatgtttt ggagttaata tttagtgctt atataatttt aagttattac
     8101 ataattttta ttggtatata tttgataggt actaggtatt ggattctcac caaaccagta
     8161 gaatggtatt ctctcttaat atgtgattgc ctgtaatggc caggtagata taccttaaag
     8221 taatatgaaa ggttttatat gtatattaaa atgtttgtac ttttaaatct gtaaaggtta
     8281 tctggaattt ttactgtgtt aacttcagaa ttatatgggc attatgactt tttcattgta
     8341 caaaaaatta ttcataaatg ttagaataca gatgttcctt gacttacaat agggttatgt
     8401 tccagtagac ccattgtaaa ttgaaaatac cgtaagttga aaatacattt aatacgccta
     8461 acctactgaa catcccagct tagcctagcc tatcttaaat gtgttctgaa cacttaacgt
     8521 tggcctttag ctgggcaaaa tcatctaata caaaacctat tttataatga agtgtttaat
     8581 atctcaaata agagtattgt accacatatc gttatcccag gataatatca gagtacaaaa
     8641 tttgaagtac agtttttaac tgaatgtgta ttgcttttgc cccattataa agttgaaaaa
     8701 ccataagtca aaccattgtt aagtcggact gtttgtgtta catatatttg ggatttttta
     8761 gtggcccttt ttaaaaagct gtttcttatt tctgatcatt gtgagtgggg atagatgtgg
     8821 gaagaaccat gtctctacta aaaatacaaa aaatagccag gcttgttggc acacacctat
     8881 agtcccagct actcgggaga ccgaggcagg agaatcactt gaaccgggag gcagagggca
     8941 gatcatgcca ctgtattcca gcctgggcaa cagagtaaga ctctgtctca aaaatgaatg
     9001 aatgaatgaa tgaacgaatg aatgtactat gagctgatac tgggatttca ggtaccgcag
     9061 tttgtgctga atgatatgtt tggggtaaat cagttttttt cttatagaat ttcggcgttt
     9121 ttgctgcaac tgccactaat tttgcattta aaagaacaaa agaggaatgt atttttcaaa
     9181 ggagtgaatg aggttaaaat caagattttg aatggtataa atatgcaact aattcagttg
     9241 taggatatta ttaaattttt tattgctaaa tatgtttctt tcatacgttg cagtgcttac
     9301 agttccaaca gctttccaag aaaacatttc catatttgtg ttatttgtaa agtatacata
     9361 aataatgtaa aataatttgg gattatttca actttacatt gtatgtctga atttcatcga
     9421 tgttgtacct ggctcagtca atagttgtca caggtattaa gccattttgg aatttgccac
     9481 ttttttctgg gtaacctgtt ttagtttagt ttacagcatt tagaaacaga aggtaacttt
     9541 atagaagtaa caccaatatc ctagtctgct tgccccgaat ataactaata gtattaggat
     9601 gtaagcaata ttaagatggt ttttattatt ttttatacac tgtgtgcttt tactttttat
     9661 ttaaactaca gcaaaaaact gattttttaa ctaaaattga atggcgttta tcttaatgac
     9721 cagttattga ccaaagtgta ctcagaagat gttattatgt cccaatctaa ggaatccttt
     9781 aatttgggga ttaattttac ttacacatgc catttcagtt tcagttgcct cattctatta
     9841 catcattctt gtcaagtcta agctttatca tgtctgaatt cttttaacac tgaatctgtg
     9901 atgtaaaaat gtatgatgtg ccataaattt tattcataat aaactaagtt atagcctatt
     9961 gtaatctgta aaacatttct tgtaaattac ctaatttatt ttttcattta tgtacagtat
    10021 cttatgtaaa tttgaaaaat gtttgccatg gcgcattctg taaacattcc cgtattcttt
    10081 tccttaatgc ttatttgcat gaaggtaact tgggttttgc ttgtttgtat tggataacca
    10141 ttaagccaac ttcagtttct ctgccttttt ttctgtagtt taaccatttc taattttgtt
    10201 catattctaa atagatgtta gaatcatact ttttattttc tactttctaa ataaattatc
    10261 taagttgttt acta
//
