LOCUS       NM_148977               3155 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens pantothenate kinase 1 (PANK1), transcript variant
            alpha, mRNA.
ACCESSION   NM_148977
VERSION     NM_148977.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3155)
  AUTHORS   Zhao,Z., Xu,X., Ma,S. and Li,L.
  TITLE     Expression and Prognostic Role of PANK1 in Glioma
  JOURNAL   Comb Chem High Throughput Screen 27 (5), 715-724 (2024)
   PUBMED   37138430
  REMARK    GeneRIF: Expression and Prognostic Role of PANK1 in Glioma.
REFERENCE   2  (bases 1 to 3155)
  AUTHORS   Cavestro,C., Diodato,D., Tiranti,V. and Di Meo,I.
  TITLE     Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms,
            and Treatments
  JOURNAL   Int J Mol Sci 24 (6), 5951 (2023)
   PUBMED   36983025
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3155)
  AUTHORS   Zi,Y., Gao,J., Wang,C., Guan,Y., Li,L., Ren,X., Zhu,L., Mu,Y.,
            Chen,S.H., Zeng,Z., Cao,Z., Rong,Z., Chen,P., Zhang,X., Chen,T.,
            Xin,H., Li,X., Li,Z., Sun,L., Deng,Y., Li,N. and Nie,Y.
  TITLE     Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular
            Carcinoma by Negatively Regulating Wnt/beta-catenin Signaling
  JOURNAL   Int J Biol Sci 18 (4), 1539-1554 (2022)
   PUBMED   35280671
  REMARK    GeneRIF: Pantothenate Kinase 1 Inhibits the Progression of
            Hepatocellular Carcinoma by Negatively Regulating Wnt/beta-catenin
            Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3155)
  AUTHORS   Wang,S.J., Yu,G., Jiang,L., Li,T., Lin,Q., Tang,Y. and Gu,W.
  TITLE     p53-Dependent regulation of metabolic function through
            transcriptional activation of pantothenate kinase-1 gene
  JOURNAL   Cell Cycle 12 (5), 753-761 (2013)
   PUBMED   23343762
  REMARK    GeneRIF: p53 plays an important role in regulating energy
            homeostasis through transcriptional control of PANK1.
REFERENCE   5  (bases 1 to 3155)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   6  (bases 1 to 3155)
  AUTHORS   Bohlig,L., Friedrich,M. and Engeland,K.
  TITLE     p53 activates the PANK1/miRNA-107 gene leading to downregulation of
            CDK6 and p130 cell cycle proteins
  JOURNAL   Nucleic Acids Res 39 (2), 440-453 (2011)
   PUBMED   20833636
REFERENCE   7  (bases 1 to 3155)
  AUTHORS   Ramaswamy,G., Karim,M.A., Murti,K.G. and Jackowski,S.
  TITLE     PPARalpha controls the intracellular coenzyme A concentration via
            regulation of PANK1alpha gene expression
  JOURNAL   J Lipid Res 45 (1), 17-31 (2004)
   PUBMED   14523052
  REMARK    GeneRIF: PPARalpha transcription factor as a major factor governing
            hepatic CoA levels by specific modulation of PANK1alpha gene
            expression
REFERENCE   8  (bases 1 to 3155)
  AUTHORS   Ni,X., Ma,Y., Cheng,H., Jiang,M., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human pantothenate kinase
            gene
  JOURNAL   Int J Biochem Cell Biol 34 (2), 109-115 (2002)
   PUBMED   11809413
  REMARK    GeneRIF: molecular cloning and characterization of a new human PanK
            gene
REFERENCE   9  (bases 1 to 3155)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
REFERENCE   10 (bases 1 to 3155)
  AUTHORS   Robishaw,J.D. and Neely,J.R.
  TITLE     Coenzyme A metabolism
  JOURNAL   Am J Physiol 248 (1 Pt 1), E1-E9 (1985)
   PUBMED   2981478
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157400.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 16, 2021 this sequence version replaced NM_148977.2.
            
            Summary: This gene encodes a member of the pantothenate kinase
            family. Pantothenate kinases are key regulatory enzymes in the
            biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the
            first and rate-limiting enzymatic reaction in CoA biosynthesis and
            is regulated by CoA through feedback inhibition. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. This gene and an intronic miRNA on the same
            strand are co-regulated by the tumor suppressor p53 (see PMID
            20833636). [provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (alpha) represents the longest
            transcript and encodes the longest isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027661.1, SRR11853567.4014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307534.10/ ENSP00000302108.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-643               AL157400.8         79074-79716         c
            644-996             AL157400.8         46170-46522         c
            997-1250            AL157400.8         33726-33979         c
            1251-1427           AL157400.8         28287-28463         c
            1428-1551           AL157400.8         27671-27794         c
            1552-1677           AL157400.8         23126-23251         c
            1678-3155           AL157400.8         17462-18939         c
FEATURES             Location/Qualifiers
     source          1..3155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..3155
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /note="pantothenate kinase 1"
                     /db_xref="GeneID:53354"
                     /db_xref="HGNC:HGNC:8598"
                     /db_xref="MIM:606160"
     exon            1..643
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1737
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /EC_number="2.7.1.33"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; pantothenic acid kinase 1"
                     /codon_start=1
                     /product="pantothenate kinase 1 isoform alpha"
                     /protein_id="NP_683878.2"
                     /db_xref="CCDS:CCDS31244.2"
                     /db_xref="GeneID:53354"
                     /db_xref="HGNC:HGNC:8598"
                     /db_xref="MIM:606160"
                     /translation="MGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPPH
                     VCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWF
                     GMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKN
                     LTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIAD
                     LQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLV
                     NMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNV
                     DKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSI
                     ARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGA
                     LLELFKMTDDK"
     exon            644..996
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1250
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1427
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1551
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1677
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3155
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3133..3138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /note="hexamer: AATAAA"
     polyA_site      3155
                     /gene="PANK1"
                     /gene_synonym="PANK"
                     /note="major polyA site"
ORIGIN      
        1 agtctgggag gcgaggaagc cgcgtttgaa gtcgcgcggc ctggggatca ggggaaggcg
       61 ggcggcggga gccccggctg ggggtgcgcg gggatccccg attccgcgcc cggggctggc
      121 gtgctccagg ccggcgccgt ggggccggcg cgcggggggc agggcgcaga ggaggtgggg
      181 gagtcggcag gaggagggga ggagcgccgg gttcgccatc cccaggcgcc ggctctgcgg
      241 ctgctgaatc ggaagccgca gggaggatcc ggggaaataa agacgccgga gaatgacctc
      301 cagcgaggcc gcctgagccg gggcccgcgc acagccccgc cagcccccgg catgggcgac
      361 cgcagcgggc agcaggagcg ctcggtcccg cactctccag gggcccccgt gggcaccagc
      421 gccgccgctg tgaacgggct gctgcacaac ggcttccatc cgccgccagt ccagccgccg
      481 cacgtctgca gccggggtcc agtgggcggc agcgacgcgg cgccccagcg cctcccgctc
      541 ctgccggagc tgcagccgca gccactgctc cctcagcatg actccccggc caagaaatgc
      601 cggctgcgga ggaggatgga ctcggggaga aagaacaggc cgccattccc atggtttggc
      661 atggacatcg gtggaacgct ggttaaattg gtgtatttcg agccgaagga tattacagcc
      721 gaagaggagc aagaggaagt ggagaacctg aagagcatcc ggaagtattt gacttctaat
      781 actgcttatg ggaaaactgg gatccgagac gtccacctgg aactgaaaaa cctgaccatg
      841 tgtggacgca aagggaacct gcacttcatc cgctttccca gctgtgctat gcacaggttc
      901 attcagatgg gcagcgagaa gaacttctct agccttcaca ccaccctctg tgccacagga
      961 ggcggggctt tcaaattcga agaggacttc agaatgattg ctgacctgca gctgcataaa
     1021 ctggatgaac tggactgtct gattcagggc ctgctttatg tcgactctgt tggcttcaac
     1081 ggcaagccag aatgttacta ttttgaaaat cccacaaatc ctgaattgtg tcaaaaaaag
     1141 ccgtactgcc ttgataaccc ataccctatg ttgctggtta acatgggctc aggtgtcagc
     1201 attctagccg tgtactccaa ggacaactat aaaagagtta cagggaccag tcttggaggt
     1261 ggaacattcc taggcctatg ttgcttgctg actggttgtg agacctttga agaagctctg
     1321 gaaatggcag ctaaaggcga cagcaccaat gttgataaac tggtgaagga catttacgga
     1381 ggagactatg aacgatttgg ccttcaagga tctgctgtag catcaagctt tggcaacatg
     1441 atgagtaaag aaaagcgaga ttccatcagc aaggaagacc tcgcccgggc cacattggtc
     1501 accatcacca acaacattgg ctccattgct cggatgtgcg cgttgaatga gaacatagac
     1561 agagttgtgt ttgttggaaa ttttctcaga atcaatatgg tctccatgaa gctgctggca
     1621 tatgccatgg atttttggtc caaaggacaa ctgaaagctc tgtttttgga acatgagggt
     1681 tattttggag ccgttggggc actgttggaa ctgttcaaaa tgactgatga caagtagaga
     1741 cgagcagtgg aggaaacagc ctcccaaaag gacagagaac taaaaaattg ctgctggaga
     1801 aggtgaaagt cgctttggga cggaagccaa gccattatgg cagatgaacc tgctggattt
     1861 gtaaataatt taaaatcctt ccagatgatc ttttactctt aggttttgag ctaatgattc
     1921 aaaacggggg aatataaaag gttttttttc tgtatactgt atttttttaa aaaaatggtg
     1981 cagcgtggcc aaacctacca attgtatgca ttaactttga aaagttgttt gatgtttaag
     2041 aaggacctga tatgtaagcg ctggtcattt ttcttctggg gtttactgat cagtgtggtg
     2101 attttaactt catttagtaa ttactctagg agattttacc ttgacttata tttttcatga
     2161 cgtttcatga tttgctgttg gtttcaaatg aaactacaaa tctggcatgt tttactgtga
     2221 acacttttgt tatttgtttt gtaccctttt ttgtcttgtt tttctgtttt agttgtcttc
     2281 tgaaaaaaga gtcgttccct ctgtttctgt cctcagatga tgtccctccc cctacctgta
     2341 acctttcttt gacataattg ttcatatcaa tgaaggtgct gaccagctca atacaaagtt
     2401 aagcacaaga tctaaagctc ttgaaaatgc ccgtgaagag aagactgaat gtgttaatga
     2461 atttaatgag tctggcaaaa gttgcaaatt atatgcaagt ttgtcctatc gcttataaat
     2521 gtagtgtttc attggattta ttttatgcta ggttatatta agttgaaata gtctgtgatt
     2581 aaatgtcctc atccatgcac agaatatgaa tggcagcaaa tctttgtgca agaaatttga
     2641 aacttattgg gaaaagcctc ccagtagatt aattgttcat atcaggagat ttagggtaag
     2701 tcatgggttg aggtgtcaga tagtaatatc tatttgtttt gtacatgtat atatctagga
     2761 actttgtaac aacacatctt taataatgtt aaaggttttt tcatttttaa tattttaaac
     2821 taaaaactgt acttcaatct cagtttctaa aattaaaaat aatttatact gatctatata
     2881 ttttttcttt ttgaaagatt tcattaagac tgatgggtaa ctttcaaatg agggtcatgt
     2941 acaaatattg ggatgcatga gatcccatga tcttgtgtat tgagcttatt gttgaaaggg
     3001 atttttgaag gacagaacaa ttactccatg atgaatcttc ctttctctgc cttctgagca
     3061 ccgtctttaa tttccatatc ttcaagtctt gaagaagttg atgttaattg aagaattcac
     3121 ttgtctggtt gaaataaagc ctgtttctgt tgtga
//
