LOCUS       NM_175854               5590 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens poly(A) specific ribonuclease subunit PAN3 (PAN3),
            mRNA.
ACCESSION   NM_175854 NM_001168251
VERSION     NM_175854.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5590)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5590)
  AUTHORS   Shang,J., Chen,W.M., Liu,S., Wang,Z.H., Wei,T.N., Chen,Z.Z. and
            Wu,W.B.
  TITLE     CircPAN3 contributes to drug resistance in acute myeloid leukemia
            through regulation of autophagy
  JOURNAL   Leuk Res 85, 106198 (2019)
   PUBMED   31401408
  REMARK    GeneRIF: the present study revealed that circPAN3 is most likely a
            key modulator for acquired drug resistance of AML, which may
            facilitate drug resistance in AML cells by regulating autophagy as
            an autophagy inducer via the AMPK/mTOR pathway.
REFERENCE   3  (bases 1 to 5590)
  AUTHORS   Chen,C.A., Zhang,Y., Xiang,Y., Han,L., Chang,J.T. and Shyu,A.B.
  TITLE     Antagonistic actions of two human Pan3 isoforms on global mRNA
            turnover
  JOURNAL   RNA 23 (9), 1404-1418 (2017)
   PUBMED   28559491
  REMARK    GeneRIF: These results reveal a new fundamental step governing
            mammalian mRNA metabolism. We propose that the first phase of
            deadenylation, coordinated through the interplay among the two Pan3
            isoforms, Pan2, and PABP, represents a cytoplasmic mRNA maturation
            step important for proper mRNA turnover.
            Erratum:[RNA. 2018 Nov;24(11):1607-1612. doi:
            10.1261/rna.068387.118.. PMID: 30327423]
REFERENCE   4  (bases 1 to 5590)
  AUTHORS   Yamagishi,R., Hosoda,N. and Hoshino,S.
  TITLE     Arsenite inhibits mRNA deadenylation through proteolytic
            degradation of Tob and Pan3
  JOURNAL   Biochem Biophys Res Commun 455 (3-4), 323-331 (2014)
   PUBMED   25446091
  REMARK    GeneRIF: arsenite-induced oxidative stress inhibits deadenylation
            of mRNA primarily through downregulation of Tob and Pan3, both of
            which mediate the recruitment of deadenylases to mRNA
REFERENCE   5  (bases 1 to 5590)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   6  (bases 1 to 5590)
  AUTHORS   Huang,K.L., Chadee,A.B., Chen,C.Y., Zhang,Y. and Shyu,A.B.
  TITLE     Phosphorylation at intrinsically disordered regions of PAM2
            motif-containing proteins modulates their interactions with PABPC1
            and influences mRNA fate
  JOURNAL   RNA 19 (3), 295-305 (2013)
   PUBMED   23340509
REFERENCE   7  (bases 1 to 5590)
  AUTHORS   Braun,J.E., Huntzinger,E., Fauser,M. and Izaurralde,E.
  TITLE     GW182 proteins directly recruit cytoplasmic deadenylase complexes
            to miRNA targets
  JOURNAL   Mol Cell 44 (1), 120-133 (2011)
   PUBMED   21981923
REFERENCE   8  (bases 1 to 5590)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   9  (bases 1 to 5590)
  AUTHORS   Siddiqui,N., Mangus,D.A., Chang,T.C., Palermino,J.M., Shyu,A.B. and
            Gehring,K.
  TITLE     Poly(A) nuclease interacts with the C-terminal domain of
            polyadenylate-binding protein domain from poly(A)-binding protein
  JOURNAL   J Biol Chem 282 (34), 25067-25075 (2007)
   PUBMED   17595167
REFERENCE   10 (bases 1 to 5590)
  AUTHORS   Uchida,N., Hoshino,S. and Katada,T.
  TITLE     Identification of a human cytoplasmic poly(A) nuclease complex
            stimulated by poly(A)-binding protein
  JOURNAL   J Biol Chem 279 (2), 1383-1391 (2004)
   PUBMED   14583602
  REMARK    GeneRIF: hPan2 and hPan3 have roles in mRNA decay and exhibit
            cytoplasmic co-localization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK296435.1, AB109552.1, AL138712.19 and BE671612.1.
            
            On Nov 22, 2018 this sequence version replaced NM_175854.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380958.8/ ENSP00000370345.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               AK296435.1         40-590
            552-2679            AB109552.1         1-2128
            2680-5094           AL138712.19        60138-62552
            5095-5590           BE671612.1         15-510              c
FEATURES             Location/Qualifiers
     source          1..5590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..5590
                     /gene="PAN3"
                     /note="poly(A) specific ribonuclease subunit PAN3"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
     exon            1..543
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2777
                     /gene="PAN3"
                     /EC_number="3.1.13.4"
                     /note="PABP-dependent poly(A) nuclease 3; PAB-dependent
                     poly(A)-specific ribonuclease subunit 3; PABP1-dependent
                     poly A-specific ribonuclease subunit PAN3; PAN3 poly(A)
                     specific ribonuclease subunit homolog; PAB1P-dependent
                     poly(A)-nuclease; PAN deadenylation complex subunit 3;
                     PAB-dependent poly(A)-specific ribonuclease subunit PAN3;
                     PAB1P-dependent poly(A)-specific ribonuclease;
                     poly(A)-nuclease deadenylation complex subunit 3"
                     /codon_start=1
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3"
                     /protein_id="NP_787050.6"
                     /db_xref="CCDS:CCDS9329.2"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
                     /translation="MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGV
                     KLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLALAGAPVAGFPPGA
                     VAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIPGMDGGALTDTSLTDS
                     YFSTSFIGVNGFGSPVETKYPLMQRMTNSSSSPSLLNDSAKPYSAHDPLTSPASSLFN
                     DFGALNISQRRKPRKYRLGMLEERLVPMGSKARKAKNPIGCLADRCKSGVPINMVWWN
                     RVTENNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPG
                     MSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQV
                     IQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELR
                     QELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYK
                     AVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLV
                     FAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQL
                     SSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQY
                     QQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMR
                     SVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQK
                     DPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
                     EKSVLVVTYSDLKRCFENTFQELIAAANGQL"
     exon            544..665
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..732
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..803
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..965
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1113
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1361
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1466
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1524
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1686
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1803
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1905
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2071
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2162
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2302
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2432
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2497
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2636
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..5590
                     /gene="PAN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5569..5574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAN3"
                     /note="hexamer: AATAAA"
     polyA_site      5590
                     /gene="PAN3"
                     /note="major polyA site"
ORIGIN      
        1 acccgcccag gcttttatcc ggcaccggca gcgtcttcct ttcctccccc gtctatggtg
       61 gtggcggcgg cggctcctcg ggcggcggcg gaagacgagg ctgcggcgtt gccatgaaca
      121 gtggcggcgg cctcccgccc ccctcggccg ccgcctcccc ttcctcctcc tcgctggcgg
      181 cggcggtggc ggtggtggcc ccgccggggg tcgggggtgt ccccggcggg gcggcggtag
      241 gagtgaagct gaagtactgc cgctactacg ctaaggataa gacttgcttc tacggggagg
      301 agtgtcagtt cctgcatgag gaccctgccg ccggggctgc cccgggcctc ggcctccata
      361 gcaacagcgt ccccctggct ctggctggtg cacccgtggc cggctttccg ccgggagccg
      421 tcgcgggcgg gggagctggg ccgccccccg ggcccaagaa gccggacctg ggggacccgg
      481 ggaccggagc cgcagccggc ggaggaggca gtagcggggg actcgatgga ccgcggctgg
      541 caattccagg aatggatgga ggtgctttaa ctgatacaag tctcacagat tcctatttta
      601 gcaccagctt tattggagtc aatggatttg gaagccctgt agaaacaaaa tatcccctga
      661 tgcagagaat gactaatagt agcagctccc caagccttct aaatgacagt gccaagccat
      721 attcagccca tgatcctcta acatcacctg cttcatcctt gtttaatgac tttggtgccc
      781 tcaacatctc tcagagacga aagccaagga agtatcgcct ggggatgctg gaggagaggc
      841 tagttccgat gggatcaaag gcacgaaaag caaagaaccc tattggctgc cttgctgaca
      901 ggtgtaaatc aggagtaccc atcaatatgg tttggtggaa cagagtcaca gaaaacaatt
      961 tacagacacc aaatcctact gcaagcgagt ttattcctaa aggaggatca acctccaggc
     1021 tgagtaacgt gtcccagtca aatatgtctg ccttctctca agttttctct cacccatcca
     1081 tgggaagccc tgctactgct ggattagcgc caggaatgtc gttgtctgct gggtcttccc
     1141 ctcttcattc ccccaagatt actccacata cttctcctgc tcccagaaga agaagtcaca
     1201 ctccaaatcc agcaagttac atggtgcctt ctagtgcctc tacatctgtt aataatcctg
     1261 tttctcagac tccgtcttct ggtcaggtga tccaaaagga aactgttggt gggacgactt
     1321 acttctatac agacacaact ccagcacctt tgactggaat ggtgtttcca aactatcata
     1381 tttatcctcc aactgcacct cacgttgctt atatgcaacc gaaagcaaac gcaccttcct
     1441 tcttcatggc tgatgaactc cgacaggagc tgatcaacag acatttaata acaatggctc
     1501 aaattgatca agcagatatg ccagcagttc ctacagaggt tgacagctac catagcctat
     1561 tccctctaga accactgcca cctcccaacc ggatacagaa atcaagtaat tttggatata
     1621 ttacatcttg ctacaaagct gtaaacagca aagatgatct gccatattgc cttcggagga
     1681 tacatggttt tcgtcttgtt aacacaaagt gcatggtgtt ggtcgacatg tggaagaaaa
     1741 ttcaacactc aaatatcgta actttgcgtg aagtatttac cactaaagca tttgctgagc
     1801 cctctcttgt gtttgcatat gatttccatg ctggaggaga aactatgatg agcagacact
     1861 ttaatgaccc taatgctgat gcctacttca ccaagagaaa gtggggtcag cacgagggac
     1921 cattgcccag gcagcatgct ggattattgc cagaatctct tatttgggca tatattgtcc
     1981 aactaagttc tgcattgcgt accattcata cagcaggttt ggcatgtcga gttatggatc
     2041 caacaaagat tctgataact ggcaaaacaa ggttgcgagt aaattgtgtt ggagtttttg
     2101 atgttttaac atttgataac agtcaaaata ataatccatt ggcattaatg gcccagtacc
     2161 agcaagcaga tctgatatca ttaggaaaag ttgtgttggc tttggcttgc aactctttgg
     2221 caggaattca gcgagagaat ttacagaaag ccatggaact ggtgacaatc aactattcct
     2281 ctgacctgaa gaatctgatt ttgtatttgt tgactgacca aaacaggatg cgaagtgtaa
     2341 atgacatcat gcccatgatt ggtgctcgat tttatactca attggatgct gctcaaatga
     2401 gaaatgatgt catagaggaa gaccttgcaa aggaggttca aaatggaaga ctgtttaggc
     2461 tcctagcaaa attgggaaca atcaatgaga ggccggagtt tcagaaggat cccacttggt
     2521 cagagactgg agaccgttat ctgttgaaac tctttaggga tcatcttttt catcaggtga
     2581 cagaagcagg tgctccctgg attgacctca gtcatataat ttcttgtctt aacaagctag
     2641 atgctggtgt gccagaaaaa ataagcctga tttccagaga tgagaagagt gtacttgtgg
     2701 tgacctacag tgacttaaag cgctgctttg aaaatacttt tcaagaactg attgcagctg
     2761 caaatggtca gttgtagtat ttgctaaaaa agcacgcagg acatggctaa agaccttaac
     2821 caatagcaaa ttgcactaca gctgaacttt tcatcatctc attcacattt gggaaacgaa
     2881 caggagatga gcaaagctgc ttgcacttca gtcaggtaca ctgttacttg aaaggaagaa
     2941 tgtttcactt acccaagagc tatggctgcc attggaggct gttatctgtg aagaatttat
     3001 tttagattta ggagcaccat caggtgaatg atgttcctgc ttttgttttt tccacttgta
     3061 tatgcactaa ttttaatttt ttaaagactt tttctgatct ttgaactttt gccacattgt
     3121 atacttataa tgggaaactt tgcaaggaca tttttgggaa gcaatgctgg gcagcgtttt
     3181 tgccattgag ggttgcagaa tttgctcttt ttgggatggg ttgccctgaa taacattacg
     3241 gaccaggtaa ataatttcat agaagttcag tatagtacgt aattcttgta agagtatcgt
     3301 atgcaagctc tctgtatgcc acccactgtt agttcaaatt gagatttttg ttttgttttg
     3361 ttcttaagaa cataccaaga aaataccagt gaattgttgg atatgaattc cctgttagtt
     3421 gatttaaatc ctttctgaat aaagatcaga taaacagtaa ctgaaggagc atgtatagct
     3481 ctttccttca aattcaacta gagccttttt aaaaagacat ttgcctgcta gtcagataca
     3541 tttacattta tgcaaatttt ttaaatagga gaaaattaag aaattgtgtt aaaggcctaa
     3601 agttcaggag tgtattactt taggttcttt ccagtttgct ggtttttttt tttttttttt
     3661 tttttttttt tgggcggggg ggaggtttat gaagttttgc tctttgaacc acagctttat
     3721 tatggtcctt tacactggag acagacacag agacactgtt cagaagatga actaaactca
     3781 gcagtggtct ggtatcaaga gctttctgat gttttacagc ctgaatttgg agggataacg
     3841 atctgctgtg cctttgcagt cactgcttag cccaaagtaa tagtactttt gataataact
     3901 cactctgtgc gatattcctg aataagtcca tctcaaaagt ttgggatttt cctcctctta
     3961 actttcttaa tatttggaca tgcagttgtc gccaaacttg ggtattcatg gaatttctag
     4021 taaatgaaat acctatactt tgatactgaa gactgccaaa tacataggaa ttttctttct
     4081 taaaaaacag taatgaagac tatatctcct ttcccagcac tgaatgtttt actagcactg
     4141 ggtgctcacc atgcaactga agaaaatgtg gaaactcaaa aggtcaggac agacttccaa
     4201 gcacttgcaa ctgatgttac tgtcttcaat tttaataatt acacatattt gtatatttca
     4261 gagaagtttt taatatttct ctgtccactt tttataagct ttaaaatgat tttctctgcc
     4321 ttgagatttg catcaagaaa aagcacctct cttcacctga aagctttgaa gactagagac
     4381 acgctttaca cgttttaaca agtatattga gtccacgttt ggtagcatca gttgttgagt
     4441 taaaaagaaa attattgcat ttgatctgga tggattttaa aagaatataa tgttcaatat
     4501 taaaaggata attcacattt gccaccataa tgttcttttt tatgtaaaaa gaagaacttg
     4561 gagacattaa catgaaaaag tcttttatca ttagctcatg tatttgagga agagcagctg
     4621 tctttttata tgttttttga caaatcatat tgtattcttt tgtacaaaaa agaactactt
     4681 gtattctaga agaaatatga aatgcttaat ttataagcgg gctggagatt ttttccaata
     4741 ttgttttctt tgaaaatgaa aggggatcat ctattttagt tttggggtct gggaactttt
     4801 tgaaaattta atttgtggac caatgttttg tgaaagctaa agagggcagg ggttaaaata
     4861 gggcttgaat ttctcattct gtatagacca gcaaacttcc ctgtgcaagg caagtttaca
     4921 tcacaaatcc aagaatgttt gcatcctaaa tgctagtttg cttcagcccc tagttaacct
     4981 caggacttgg tttgcatata aaaggtagac agctgatatg ttttcatgaa taaatattgt
     5041 cagccagaaa aggttggtgt caggtaatgc atattttttt aagctttgtt ttatatttat
     5101 ttttcattta gtttttattg ggaatggttt tcaaagaact ctcagttctg cctaggtgtt
     5161 tttgggggag ccctgttttc catagtgtaa ttccatttaa gaggttgtct aaaagtcttt
     5221 ttaattaata gaaagatttt aatatccaag agtagtcaaa ttaaggatat aaactttcca
     5281 caccttcctg tcgtgacaga taaaagcaca gaaaggacaa cccttgaaat catgtaacgt
     5341 tggtcatttc aatattttgt acctgtttta aattctgtta gtgtatttac ttcattgtaa
     5401 atatttttga gggtaccttt gtattttgct tttgaccttg gttctgtgat ttggatgtca
     5461 acaacttccc taaaaagcac cagtgtgtta ggttctaatg tcatgaccca atttgtgtta
     5521 ttcatcttta atcctgtttt cagtctctat gtgtacagca gtatttttaa taaagaatta
     5581 cagagataaa
//
