LOCUS       XM_024446075            5697 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens peptidylglycine alpha-amidating
            monooxygenase (PAM), transcript variant X16, mRNA.
ACCESSION   XM_024446075
VERSION     XM_024446075.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024446075.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..5697
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /note="peptidylglycine alpha-amidating monooxygenase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 215 ESTs, 1086 long SRA reads, 1
                     Protein, and 98% coverage of the annotated genomic feature
                     by RNAseq alignments, including 49 samples with support
                     for all annotated introns"
                     /db_xref="GeneID:5066"
                     /db_xref="HGNC:HGNC:8596"
                     /db_xref="MIM:170270"
     CDS             940..3657
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /codon_start=1
                     /product="peptidyl-glycine alpha-amidating monooxygenase
                     isoform X14"
                     /protein_id="XP_024301843.1"
                     /db_xref="GeneID:5066"
                     /db_xref="HGNC:HGNC:8596"
                     /db_xref="MIM:170270"
                     /translation="MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLG
                     TTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVH
                     HMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSK
                     YFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNS
                     DISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPV
                     DVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVA
                     PDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYS
                     LLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGN
                     AILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGARREDMKCFQCKEM
                     ISVQDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQ
                     IGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLD
                     PNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGK
                     FITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREI
                     KHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
                     MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKGKGSGGLNLG
                     NFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS"
ORIGIN      
        1 attttcctct gcttctctca gggcagctgg cgtggccacc tcgcaaggct gcttctaggg
       61 acacgagact cgggagggtc agagactttc aggccgggcc ttcactccct tccccggggc
      121 acttgggcaa gagttccagc tcttggctac ctctggcccg cgcgtgagtt cagacaccca
      181 gcacacgcga cccccgcagg gaaaccccgg gaagctgcgc gcaatcgctg gggactcgcc
      241 agggctccac ttcccaagct ccgcgccccc tgcgcccaaa gaggcagggc ggagcagagg
      301 ccgccggcgt ggaggaggcg agcgcggggc tggcccggga gccgcccccg gggagggact
      361 gagacctgcc ccaggagtcg agggcgagcg gcggacccgg ctgggcccgg cgcacgccga
      421 ggagagggag cccccgccac cgccgctgcc tccgcgtgct cagcctgtcc ccgcccaggg
      481 agccggagcc tccaactaac tccgcccgcc gctccgccgc ccgcaggctc cggcttccgt
      541 cccggacaga gcccgtggtc gcgcaggttc tgaatgatga ctgacgcggg tttgggtgat
      601 acccctcaca gcccctgtca ttccggagtc ataaggcacc cgcgcgtcta gccccagcgc
      661 cagggcacgc gagcggcgct ggagggagga aagcttccgc ctgcgggccg gacaaaagtc
      721 ccgcctgccc acggcttttt gcccgccgct cgtgaccgag acgcctcgcc gcggccagct
      781 cgctgctctc gctggcggat ggtgtgtggc cgccgcagga cgcccgccgt gcccgggcca
      841 tgaagtagcg gctgctggcg gcgccgctgc ccaaccgcca gccccagccc cgcgctgcgc
      901 tgcccggtcc tctcccggcg gggtcgtatc ggcgtggaca tggctggccg cgtccctagc
      961 ctgctagttc tccttgtttt tccaagcagc tgtttggctt tccgaagccc actttctgtc
     1021 tttaagaggt ttaaagaaac taccagacca ttttccaatg aatgtcttgg taccaccaga
     1081 cccgtagttc ctattgattc atcagatttt gcattggata ttcgcatgcc tggggttaca
     1141 cctaaacagt ccgatacata cttctgcatg tctatgcgaa taccagtgga tgaggaagcc
     1201 ttcgtgattg acttcaagcc tcgagccagc atggatactg tccatcacat gttacttttt
     1261 ggatgcaata tgccttcatc cactggaagt tactggtttt gtgatgaagg aacctgtaca
     1321 gataaagcca atattctgta tgcctgggcg agaaatgctc cccctacccg gctccccaaa
     1381 ggtgttggat tcagagttgg aggagagact ggaagtaaat actttgtact acaggtacac
     1441 tatggggata ttagtgcttt tagagataat aacaaggact gttctggtgt gtccttacac
     1501 ctcacacgtc tgccacagcc tttaattgct ggcatgtacc ttatgatgtc tgttgacact
     1561 gttatcccag caggagaaaa agtggtgaat tctgacattt catgccatta taaaaattat
     1621 ccaatgcatg tctttgccta tagagttcac actcaccatt taggtaaggt agtaagtgga
     1681 tacagagtaa gaaatggaca gtggacactg attggacggc agagccctca gctgccacag
     1741 gctttctacc ctgtggggca tccagttgat gtaagttttg gtgacctact ggctgcaaga
     1801 tgtgtattca ctggtgaagg aaggacagaa gccacacaca ttggtggcac gtctagtgat
     1861 gaaatgtgca acttatacat tatgtattac atggaagcca agcatgcagt ttctttcatg
     1921 acctgtaccc agaatgtagc tccagatatg ttcagaacca taccaccaga ggccaacatt
     1981 ccaattcccg tgaagtctga tatggttatg atgcatgaac atcataaaga aacagaatat
     2041 aaagataaga ttcctttact acagcagcca aaacgagaag aagaagaagt gttagaccag
     2101 ggtgatttct attcactact ttccaagctg ctaggagaaa gggaagatgt tgttcatgtg
     2161 cacaaatata atcctacaga aaaggcagaa tcagagtcag acctggtagc tgagattgca
     2221 aatgtagtcc aaaaaaagga tcttggtcga tctgatgcca gagagggtgc agaacatgag
     2281 aggggtaatg ctattcttgt cagagacaga attcacaaat tccacagact agtatctacc
     2341 ttgaggccac cagagagcag agttttctca ttacagcagc ccccacctgg tgaaggcacc
     2401 tgggaaccag aacacacagg agctagaaga gaagatatga aatgtttcca gtgcaaagaa
     2461 atgataagtg ttcaagattt ccacatggaa gaggcactgg attggcctgg agtatacttg
     2521 ttaccaggcc aggtttctgg ggtggctcta gaccctaaga ataacctggt gattttccac
     2581 agaggtgacc atgtctggga tggaaactcg tttgacagca agtttgttta ccagcaaata
     2641 ggactcggac caattgaaga agacactatt cttgtcatag atccaaataa tgctgcagta
     2701 ctccagtcca gtggaaaaaa tctgttttac ttgccacatg gcttgagtat agataaagat
     2761 gggaattatt gggtcacaga cgtggctctc catcaggtgt tcaaactgga tccaaacaat
     2821 aaagaaggcc ctgtattaat cctgggaagg agcatgcaac caggcagtga ccagaatcac
     2881 ttctgtcaac ccactgatgt ggctgtggat ccaggcactg gagccattta tgtatcagat
     2941 ggttactgca acagcaggat tgtgcagttt tcaccaagtg gaaagttcat cacacagtgg
     3001 ggagaagagt cttcagggag cagtcctctg ccaggccagt tcactgttcc tcacagcttg
     3061 gctcttgtgc ctcttttggg ccaattatgt gtggcagacc gggaaaatgg tcggatccag
     3121 tgttttaaaa ctgacaccaa agaatttgtg agagagatta agcattcatc atttggaaga
     3181 aatgtatttg caatttcata tataccaggc ttgctctttg cagtgaatgg gaagcctcat
     3241 tttggggacc aagaacctgt acaaggattt gtgatgaact tttccaatgg ggaaattata
     3301 gacatcttca agccagtgcg caagcacttt gatatgcctc atgatattgt tgcatctgaa
     3361 gatgggactg tgtacattgg agatgctcat accaacaccg tgtggaagtt caccttgact
     3421 gagaaattgg aacatcgatc agttaaaaag gctggcattg aggtccagga aatcaaagga
     3481 aagggaagtg gaggcttaaa ccttggtaat ttctttgcaa gccgtaaggg ctacagtcga
     3541 aaagggtttg accggcttag cactgagggc agtgaccaag agaaagagga tgatggaagt
     3601 gaatcagaag aggagtattc agcacctctg cctgcgctcg caccttcctc ctcctgaaaa
     3661 ccaagctttg atttagattg agtaagattt acccagaatg tcagattcct ttccctttag
     3721 cacgtttaaa gttctgtgta tttaattgta aactgtacta gtctgtgtgg gactgtacac
     3781 actttattta cttcgttttg gttaagttgg cttctgtttc tagttgagga gtttcctaaa
     3841 agttcataac agtgccattg tctttatatg aacatagact agagaaaccg tcctcttttt
     3901 ccatcataat tctaatctaa caatggaaga tttgcccatt tacacttttg agactttttg
     3961 gtggatgtaa ataaccccat tctttgcttg aacacagtat tttcccaata gcactttcat
     4021 tgccagtgtc tttctttggt gcctttcctg ttcagcattc ttagcctgtg gcagtaaaga
     4081 gaaactttgt gctacatgac gacaaagctg ctaaatctcc tattttttta aaatcactaa
     4141 cattatattg caatgaagga aataaaaaag tctctattta aattcttttt taaattttct
     4201 tcagttggtg tgtttttggg atgtcttatt tttagatggt tacactgtta gaacactatt
     4261 ttcagaatct gaatgtaatt tgtgtaataa agtgttttca gagcattagc tgtcagtgta
     4321 ttttccagtt tttgcgtatt tgcagatttt acatacaact tttataataa ttacacaaac
     4381 ccacaaatat tagtgaaact tactcgatgt cttcaactaa aagaaatgtg tgtattgtac
     4441 aaaatttaga agatacttta gccaatataa attaaaaacc agcctgagtt tacataaatt
     4501 tgtaaagtca ggctcttcta aaatccaaag agggtttttg cctatatatc aatcagagga
     4561 taaatacttt aataaaaggt aatcacagct aagtggatac ctgtgtctca aattacatat
     4621 gcaaatgatc catcagtagg gatcactaat aatagttttc cttttaaaaa ataatttcag
     4681 ggcaggtaca gtggctcaag cctatacttc caggactttg ggaggccaag cagaaggatt
     4741 gtgggaggcc aagcagaagg attgtttgag cccagaaatt caaggctgca gtgagctatg
     4801 atcaatccac tgtactccag cctaggctac agagtgagat cctttctcta aaataaaata
     4861 caatttccat gtatccatag gaatatattc atcttttaca gtgattgcag attagtttta
     4921 aaacgtcttt ttcgtaattc gtcaatgcaa gttagtaaga accagataat tttccatttt
     4981 aaaatgatag gaatctaaaa ctctttttca aaaatgccaa cctgtttttc cggcatcata
     5041 gtagttggaa taatacagat ataattgact aatcataaag tacatgagag tacagaaggg
     5101 aaatttggaa acggtaagtc tgctagggca ttacaatcct gtcctagcac tccaccttta
     5161 ttctgccaac ctgggttaat taaagatggt agcctggaaa gtaatgaatg acattgactt
     5221 caggcaatct ttccactgat tattcttggc tgaacttcat ttatcgagtc agagaatgca
     5281 ctgcctgaga aatgtcccag aggagtgaat cctaggcctg gccacagtag aatcgcctgg
     5341 agaatttaag aaaaaaattg ttgggcactc actctttcca gtgatcttta tttagttggc
     5401 ttacaatgga atacaggtat ggttcatgtt tttaaatttg tccaggtgtt tctattgtgc
     5461 agtcacagtt gaaaaccatt gtcttcgaga atagctattc tatcttgcca gttacaataa
     5521 gtggatagct atattttcac ataaattata gtttacagat gtttggaggg ggaagacagg
     5581 atctgaggtg ttttgatatg actgttagca ccaaaatctg aatgccttaa ttgttgaatg
     5641 tgttaaattg gataattaaa atgggcataa atgacttatt aaaaaagcaa agggaaa
//
