LOCUS       NM_001177306            3990 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens peptidylglycine alpha-amidating monooxygenase (PAM),
            transcript variant 5, mRNA.
ACCESSION   NM_001177306 XM_024446068
VERSION     NM_001177306.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   De Sousa,S.M.C., Shen,A., Yates,C.J., Clifton-Bligh,R.,
            Santoreneos,S., King,J., Toubia,J., Trivellin,G., Lania,A.G.,
            Stratakis,C.A., Torpy,D.J. and Scott,H.S.
  TITLE     PAM variants in patients with thyrotrophinomas, cyclical Cushing's
            disease and prolactinomas
  JOURNAL   Front Endocrinol (Lausanne) 14, 1305606 (2023)
   PUBMED   38075079
  REMARK    GeneRIF: PAM variants in patients with thyrotrophinomas, cyclical
            Cushing's disease and prolactinomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Goetze,J.P., Voiosu,A., Wiese,S., Schulte,J., Kaufmann,P.,
            Bergmann,A., Bartels,E.D. and Moller,S.
  TITLE     Peptidylglycine alpha-amidating monooxygenase and adrenomedullin
            measurement in patients with hepatic cirrhosis
  JOURNAL   Biomark Med 17 (13), 577-583 (2023)
   PUBMED   37812053
  REMARK    GeneRIF: Peptidylglycine alpha-amidating monooxygenase and
            adrenomedullin measurement in patients with hepatic cirrhosis.
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Sheng,B., Wei,H., Li,Z., Wei,H. and Zhao,Q.
  TITLE     PAM variants were associated with type 2 diabetes mellitus risk in
            the Chinese population
  JOURNAL   Funct Integr Genomics 22 (4), 525-535 (2022)
   PUBMED   35394266
  REMARK    GeneRIF: PAM variants were associated with type 2 diabetes mellitus
            risk in the Chinese population.
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Barchiesi,A., Bazzani,V., Tolotto,V., Elancheliyan,P.,
            Wasilewski,M., Chacinska,A. and Vascotto,C.
  TITLE     Mitochondrial Oxidative Stress Induces Rapid Intermembrane
            Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1
            Protein through TIM23 Complex
  JOURNAL   J Mol Biol 432 (24), 166713 (2020)
   PUBMED   33197464
  REMARK    GeneRIF: Mitochondrial Oxidative Stress Induces Rapid Intermembrane
            Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1
            Protein through TIM23 Complex.
REFERENCE   5  (bases 1 to 3990)
  AUTHORS   Chen,Y.C., Mains,R.E., Eipper,B.A., Hoffman,B.G., Czyzyk,T.A.,
            Pintar,J.E. and Verchere,C.B.
  TITLE     PAM haploinsufficiency does not accelerate the development of diet-
            and human IAPP-induced diabetes in mice
  JOURNAL   Diabetologia 63 (3), 561-576 (2020)
   PUBMED   31984442
  REMARK    GeneRIF: PAM haploinsufficiency does not accelerate the development
            of diet- and human IAPP-induced diabetes in mice.
            Erratum:[Diabetologia. 2020 May;63(5):1090. doi:
            10.1007/s00125-020-05119-2.. PMID: 32172312]
REFERENCE   6  (bases 1 to 3990)
  AUTHORS   Vos,M.D., Jones,J.E. and Treston,A.M.
  TITLE     Human peptidylglycine alpha-amidating monooxygenase transcripts
            derived by alternative mRNA splicing of an unreported exon
  JOURNAL   Gene 163 (2), 307-311 (1995)
   PUBMED   7590286
REFERENCE   7  (bases 1 to 3990)
  AUTHORS   Tsukamoto,T., Noguchi,M., Kayama,H., Watanabe,T., Asoh,T. and
            Yamamoto,T.
  TITLE     Increased peptidylglycine alpha-amidating monooxygenase activity in
            cerebrospinal fluid of patients with multiple sclerosis
  JOURNAL   Intern Med 34 (4), 229-232 (1995)
   PUBMED   7606087
REFERENCE   8  (bases 1 to 3990)
  AUTHORS   Mains,R.E., Milgram,S.L., Keutmann,H.T. and Eipper,B.A.
  TITLE     The NH2-terminal proregion of peptidylglycine alpha-amidating
            monooxygenase facilitates the secretion of soluble proteins
  JOURNAL   Mol Endocrinol 9 (1), 3-13 (1995)
   PUBMED   7760848
REFERENCE   9  (bases 1 to 3990)
  AUTHORS   Ouafik,L.H., Stoffers,D.A., Campbell,T.A., Johnson,R.C.,
            Bloomquist,B.T., Mains,R.E. and Eipper,B.A.
  TITLE     The multifunctional peptidylglycine alpha-amidating monooxygenase
            gene: exon/intron organization of catalytic, processing, and
            routing domains
  JOURNAL   Mol Endocrinol 6 (10), 1571-1584 (1992)
   PUBMED   1448112
REFERENCE   10 (bases 1 to 3990)
  AUTHORS   Glauder,J., Ragg,H., Rauch,J. and Engels,J.W.
  TITLE     Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning
            and functional expression of a truncated form in COS cells
  JOURNAL   Biochem Biophys Res Commun 169 (2), 551-558 (1990)
   PUBMED   2357221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008501.5, AC008779.5,
            AC113373.2 and AC010250.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Oct 5, 2020 this sequence version replaced
            XM_024446068.1, NM_001177306.1.
            
            Summary: This gene encodes a multifunctional protein. The encoded
            preproprotein is proteolytically processed to generate the mature
            enzyme. This enzyme includes two domains with distinct catalytic
            activities, a peptidylglycine alpha-hydroxylating monooxygenase
            (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating
            lyase (PAL) domain. These catalytic domains work sequentially to
            catalyze the conversion of neuroendocrine peptides to active
            alpha-amidated products. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (5) encodes isoform e.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.22577.1,
                                           SRR1803617.139710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438793.8/ ENSP00000396493.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC008501.5         82319-82362
            45-506              AC008779.5         57188-57649         c
            507-627             AC008779.5         56079-56199         c
            628-685             AC008779.5         22059-22116         c
            686-773             AC008779.5         9451-9538           c
            774-859             AC113373.2         32883-32968
            860-943             AC113373.2         34511-34594
            944-992             AC113373.2         54763-54811
            993-1060            AC113373.2         56304-56371
            1061-1141           AC113373.2         57463-57543
            1142-1218           AC113373.2         57828-57904
            1219-1322           AC113373.2         58643-58746
            1323-1507           AC113373.2         67801-67985
            1508-1579           AC113373.2         69084-69155
            1580-1900           AC113373.2         82042-82362
            1901-2030           AC113373.2         98198-98327
            2031-2147           AC010250.7         81985-82101         c
            2148-2220           AC010250.7         79908-79980         c
            2221-2431           AC010250.7         78123-78333         c
            2432-2632           AC010250.7         77477-77677         c
            2633-2748           AC010250.7         75268-75383         c
            2749-2848           AC010250.7         67701-67800         c
            2849-2902           AC010250.7         65291-65344         c
            2903-3106           AC010250.7         59800-60003         c
            3107-3160           AC010250.7         56896-56949         c
            3161-3990           AC010250.7         55418-56247         c
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..3990
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /note="peptidylglycine alpha-amidating monooxygenase"
                     /db_xref="GeneID:5066"
                     /db_xref="HGNC:HGNC:8596"
                     /db_xref="MIM:170270"
     exon            1..44
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            45..506
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..3339
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /EC_number="1.14.17.3"
                     /EC_number="4.3.2.5"
                     /note="isoform e preproprotein is encoded by transcript
                     variant 5; peptidyl alpha-amidating enzyme;
                     peptidylglycine 2-hydroxylase; peptidylglycine
                     alpha-hydroxylating monooxygenase;
                     peptidyl-alpha-hydroxyglycine alpha-amidating lyase;
                     pancreatic peptidylglycine alpha-amidating monooxygenase;
                     peptidylamidoglycolate lyase"
                     /codon_start=1
                     /product="peptidyl-glycine alpha-amidating monooxygenase
                     isoform e preproprotein"
                     /protein_id="NP_001170777.1"
                     /db_xref="CCDS:CCDS54885.1"
                     /db_xref="GeneID:5066"
                     /db_xref="HGNC:HGNC:8596"
                     /db_xref="MIM:170270"
                     /translation="MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLG
                     TTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVH
                     HMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSK
                     YFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNS
                     DISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPV
                     DVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVA
                     PDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYS
                     LLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGN
                     AILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVY
                     LLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNN
                     AAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPG
                     SDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQ
                     FTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGL
                     LFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDA
                     HTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKL
                     IKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFR
                     GKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSS
                     S"
     exon            507..627
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            628..685
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            686..773
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            774..859
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            860..943
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            944..992
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1060
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1141
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1218
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1322
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1507
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1579
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1900
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2030
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2147
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2220
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2431
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2632
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2748
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2848
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2902
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3106
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3160
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3990
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3968..3973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /note="hexamer: AATAAA"
     polyA_site      3990
                     /gene="PAM"
                     /gene_synonym="PAL; PAM-1; PHM"
                     /note="major polyA site"
ORIGIN      
        1 gcaggctccg gcttccgtcc cggacagagc ccgtggtcgc gcaggttctg aatgatgact
       61 gacgcgggtt tgggtgatac ccctcacagc ccctgtcatt ccggagtcat aaggcacccg
      121 cgcgtctagc cccagcgcca gggcacgcga gcggcgctgg agggaggaaa gcttccgcct
      181 gcgggccgga caaaagtccc gcctgcccac ggctttttgc ccgccgctcg tgaccgagac
      241 gcctcgccgc ggccagctcg ctgctctcgc tggcggatgg tgtgtggccg ccgcaggacg
      301 cccgccgtgc ccgggccatg aagtagcggc tgctggcggc gccgctgccc aaccgccagc
      361 cccagccccg cgctgcgctg cccggtcctc tcccggcggg gtcgtatcgg cgtggacatg
      421 gctggccgcg tccctagcct gctagttctc cttgtttttc caagcagctg tttggctttc
      481 cgaagcccac tttctgtctt taagaggttt aaagaaacta ccagaccatt ttccaatgaa
      541 tgtcttggta ccaccagacc cgtagttcct attgattcat cagattttgc attggatatt
      601 cgcatgcctg gggttacacc taaacagtcc gatacatact tctgcatgtc tatgcgaata
      661 ccagtggatg aggaagcctt cgtgattgac ttcaagcctc gagccagcat ggatactgtc
      721 catcacatgt tactttttgg atgcaatatg ccttcatcca ctggaagtta ctggttttgt
      781 gatgaaggaa cctgtacaga taaagccaat attctgtatg cctgggcgag aaatgctccc
      841 cctacccggc tccccaaagg tgttggattc agagttggag gagagactgg aagtaaatac
      901 tttgtactac aggtacacta tggggatatt agtgctttta gagataataa caaggactgt
      961 tctggtgtgt ccttacacct cacacgtctg ccacagcctt taattgctgg catgtacctt
     1021 atgatgtctg ttgacactgt tatcccagca ggagaaaaag tggtgaattc tgacatttca
     1081 tgccattata aaaattatcc aatgcatgtc tttgcctata gagttcacac tcaccattta
     1141 ggtaaggtag taagtggata cagagtaaga aatggacagt ggacactgat tggacggcag
     1201 agccctcagc tgccacaggc tttctaccct gtggggcatc cagttgatgt aagttttggt
     1261 gacctactgg ctgcaagatg tgtattcact ggtgaaggaa ggacagaagc cacacacatt
     1321 ggtggcacgt ctagtgatga aatgtgcaac ttatacatta tgtattacat ggaagccaag
     1381 catgcagttt ctttcatgac ctgtacccag aatgtagctc cagatatgtt cagaaccata
     1441 ccaccagagg ccaacattcc aattcccgtg aagtctgata tggttatgat gcatgaacat
     1501 cataaagaaa cagaatataa agataagatt cctttactac agcagccaaa acgagaagaa
     1561 gaagaagtgt tagaccaggg tgatttctat tcactacttt ccaagctgct aggagaaagg
     1621 gaagatgttg ttcatgtgca caaatataat cctacagaaa aggcagaatc agagtcagac
     1681 ctggtagctg agattgcaaa tgtagtccaa aaaaaggatc ttggtcgatc tgatgccaga
     1741 gagggtgcag aacatgagag gggtaatgct attcttgtca gagacagaat tcacaaattc
     1801 cacagactag tatctacctt gaggccacca gagagcagag ttttctcatt acagcagccc
     1861 ccacctggtg aaggcacctg ggaaccagaa cacacaggag atttccacat ggaagaggca
     1921 ctggattggc ctggagtata cttgttacca ggccaggttt ctggggtggc tctagaccct
     1981 aagaataacc tggtgatttt ccacagaggt gaccatgtct gggatggaaa ctcgtttgac
     2041 agcaagtttg tttaccagca aataggactc ggaccaattg aagaagacac tattcttgtc
     2101 atagatccaa ataatgctgc agtactccag tccagtggaa aaaatctgtt ttacttgcca
     2161 catggcttga gtatagataa agatgggaat tattgggtca cagacgtggc tctccatcag
     2221 gtgttcaaac tggatccaaa caataaagaa ggccctgtat taatcctggg aaggagcatg
     2281 caaccaggca gtgaccagaa tcacttctgt caacccactg atgtggctgt ggatccaggc
     2341 actggagcca tttatgtatc agatggttac tgcaacagca ggattgtgca gttttcacca
     2401 agtggaaagt tcatcacaca gtggggagaa gagtcttcag ggagcagtcc tctgccaggc
     2461 cagttcactg ttcctcacag cttggctctt gtgcctcttt tgggccaatt atgtgtggca
     2521 gaccgggaaa atggtcggat ccagtgtttt aaaactgaca ccaaagaatt tgtgagagag
     2581 attaagcatt catcatttgg aagaaatgta tttgcaattt catatatacc aggcttgctc
     2641 tttgcagtga atgggaagcc tcattttggg gaccaagaac ctgtacaagg atttgtgatg
     2701 aacttttcca atggggaaat tatagacatc ttcaagccag tgcgcaagca ctttgatatg
     2761 cctcatgata ttgttgcatc tgaagatggg actgtgtaca ttggagatgc tcataccaac
     2821 accgtgtgga agttcacctt gactgagaaa ttggaacatc gatcagttaa aaaggctggc
     2881 attgaggtcc aggaaatcaa agaagccgag gcagttgttg aaaccaaaat ggagaacaaa
     2941 cccacctcct cagaattgca gaagatgcaa gagaaacaga aactgatcaa agagccaggc
     3001 tcgggagtgc ctgttgttct cattacaacc cttctggtta ttccggtggt tgtcctgctg
     3061 gccattgcca tatttattcg gtggaaaaaa tcaagggcct ttggagattc tgaacacaaa
     3121 ctcgagacga gttcaggaag agtactggga agatttagag gaaagggaag tggaggctta
     3181 aaccttggta atttctttgc aagccgtaag ggctacagtc gaaaagggtt tgaccggctt
     3241 agcactgagg gcagtgacca agagaaagag gatgatggaa gtgaatcaga agaggagtat
     3301 tcagcacctc tgcctgcgct cgcaccttcc tcctcctgaa aaccaagctt tgatttagat
     3361 tgagtaagat ttacccagaa tgtcagattc ctttcccttt agcacgttta aagttctgtg
     3421 tatttaattg taaactgtac tagtctgtgt gggactgtac acactttatt tacttcgttt
     3481 tggttaagtt ggcttctgtt tctagttgag gagtttccta aaagttcata acagtgccat
     3541 tgtctttata tgaacataga ctagagaaac cgtcctcttt ttccatcata attctaatct
     3601 aacaatggaa gatttgccca tttacacttt tgagactttt tggtggatgt aaataacccc
     3661 attctttgct tgaacacagt attttcccaa tagcactttc attgccagtg tctttctttg
     3721 gtgcctttcc tgttcagcat tcttagcctg tggcagtaaa gagaaacttt gtgctacatg
     3781 acgacaaagc tgctaaatct cctatttttt taaaatcact aacattatat tgcaatgaag
     3841 gaaataaaaa agtctctatt taaattcttt tttaaatttt cttcagttgg tgtgtttttg
     3901 ggatgtctta tttttagatg gttacactgt tagaacacta ttttcagaat ctgaatgtaa
     3961 tttgtgtaat aaagtgtttt cagagcatta
//
