LOCUS       NM_001303037            8346 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein associated with LIN7 2, MAGUK p55 family
            member (PALS2), transcript variant 2, mRNA.
ACCESSION   NM_001303037
VERSION     NM_001303037.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8346)
  AUTHORS   Chen,R.X., Xu,S.D., Deng,M.H., Hao,S.H., Chen,J.W., Ma,X.D.,
            Zhuang,W.T., Cao,J.H., Lv,Y.R., Lin,J.L., Li,S.Y., Qiao,G.B.,
            Xie,D. and Wang,F.W.
  TITLE     Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes
            colorectal cancer progression by inhibiting autophagy
  JOURNAL   Signal Transduct Target Ther 9 (1), 80 (2024)
   PUBMED   38565536
  REMARK    GeneRIF: Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex
            promotes colorectal cancer progression by inhibiting autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8346)
  AUTHORS   Cheng,Q., Wang,W., Liu,J., Lv,Z., Ji,W., Yu,J., Zhang,W. and
            Yang,Y.
  TITLE     Elevated MPP6 expression correlates with an unfavorable prognosis,
            angiogenesis and immune evasion in hepatocellular carcinoma
  JOURNAL   Front Immunol 14, 1173848 (2023)
   PUBMED   37207207
  REMARK    GeneRIF: Elevated MPP6 expression correlates with an unfavorable
            prognosis, angiogenesis and immune evasion in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8346)
  AUTHORS   Fujiwara,N., Shigemoto,M., Hirayama,M., Fujita,K.I., Seno,S.,
            Matsuda,H., Nagahama,M. and Masuda,S.
  TITLE     MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of
            MTR4-sensitive substrates in the human nucleus
  JOURNAL   Nucleic Acids Res 50 (15), 8779-8806 (2022)
   PUBMED   35902094
  REMARK    GeneRIF: MPP6 stimulates both RRP6 and DIS3 to degrade a specified
            subset of MTR4-sensitive substrates in the human nucleus.
REFERENCE   4  (bases 1 to 8346)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8346)
  AUTHORS   Khoury,S., Wang,Q.P., Parisien,M., Gris,P., Bortsov,A.V.,
            Linnstaedt,S.D., McLean,S.A., Tungate,A.S., Sofer,T., Lee,J.,
            Louie,T., Redline,S., Kaunisto,M.A., Kalso,E.A., Munter,H.M.,
            Nackley,A.G., Slade,G.D., Smith,S.B., Zaykin,D.V., Fillingim,R.B.,
            Ohrbach,R., Greenspan,J.D., Maixner,W., Neely,G.G. and
            Diatchenko,L.
  TITLE     Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6
            as a novel gene that functions in sleep center neurons
  JOURNAL   Sleep 44 (3) (2021)
   PUBMED   33034629
  REMARK    GeneRIF: Multi-ethnic GWAS and meta-analysis of sleep quality
            identify MPP6 as a novel gene that functions in sleep center
            neurons.
REFERENCE   6  (bases 1 to 8346)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
REFERENCE   7  (bases 1 to 8346)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   8  (bases 1 to 8346)
  AUTHORS   Tseng,T.C., Marfatia,S.M., Bryant,P.J., Pack,S., Zhuang,Z.,
            O'Brien,J.E., Lin,L., Hanada,T. and Chishti,A.H.
  TITLE     VAM-1: a new member of the MAGUK family binds to human Veli-1
            through a conserved domain
  JOURNAL   Biochim Biophys Acta 1518 (3), 249-259 (2001)
   PUBMED   11311936
REFERENCE   9  (bases 1 to 8346)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
REFERENCE   10 (bases 1 to 8346)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF162130.2, AC005084.2, BM685172.1 and AC003093.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001303037.1.
            
            Summary: Members of the peripheral membrane-associated guanylate
            kinase (MAGUK) family function in tumor suppression and receptor
            clustering by forming multiprotein complexes containing distinct
            sets of transmembrane, cytoskeletal, and cytoplasmic signaling
            proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided
            into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see
            TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like
            (see CASK; MIM 300172), based on their size and the presence of
            additional domains. MPP6 is a member of the p55-like MAGUK
            subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM,
            Mar 2008].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.262274.1,
                                           SRR1803613.239911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222644.10/ ENSP00000222644.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AF162130.2         48-312
            266-266             AC005084.2         126057-126057
            267-1998            AF162130.2         314-2045
            1999-7232           AC005084.2         172183-177416
            7233-7856           BM685172.1         11-634              c
            7857-8346           AC003093.1         146-635
FEATURES             Location/Qualifiers
     source          1..8346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..8346
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="protein associated with LIN7 2, MAGUK p55 family
                     member"
                     /db_xref="GeneID:51678"
                     /db_xref="HGNC:HGNC:18167"
                     /db_xref="MIM:606959"
     exon            1..142
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..261
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1767
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="MAGUK protein p55T; VELI-associated MAGUK 1; MAGUK
                     p55 subfamily member 6; protein associated with Lin7 2;
                     membrane protein, palmitoylated 6 (MAGUK p55 subfamily
                     member 6); membrane palmitoylated protein 6; protein
                     associated with LIN7 2, MAGUK family member"
                     /codon_start=1
                     /product="protein PALS2"
                     /protein_id="NP_001289966.1"
                     /db_xref="CCDS:CCDS5388.1"
                     /db_xref="GeneID:51678"
                     /db_xref="HGNC:HGNC:18167"
                     /db_xref="MIM:606959"
                     /translation="MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERL
                     EDSKLEAVSDNNLELVNEILEDITPLINVDENVAELVGILKEPHFQSLLEAHDIVASK
                     CYDSPPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHG
                     GMIDRQGLLHVGDIIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTITPQQV
                     FVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPS
                     QFLEEKRKAFVRRDWDNSGPFCGTISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMP
                     PFQRKTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSR
                     SEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFM
                     PYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLII
                     INDNLDKAFEKLQTAIEKLRMEPQWVPISWVY"
     exon            262..414
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..567
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..795
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..927
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1027
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1096
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1258
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1461
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1590
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..8346
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5182..5187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="hexamer: AATAAA"
     polyA_site      5211
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="major polyA site"
     regulatory      7813..7818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="hexamer: AATAAA"
     polyA_site      7856
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
     regulatory      8324..8329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="hexamer: AATAAA"
     polyA_site      8346
                     /gene="PALS2"
                     /gene_synonym="MPP6; p55T; VAM-1; VAM1"
                     /note="major polyA site"
ORIGIN      
        1 gcatttccag ttctcaacta cgagccacga gtttgcagat ggggctgctc ggcggcgcct
       61 gtggctgagg gagagcagcg gcggcgggga gcgaccggga gcggcggcag cggcggcgcg
      121 gaggcggctg aggtgcgagc cgcaatgcag caagtcttgg aaaaccttac ggagctgccc
      181 tcgtctactg gagcagaaga aatagaccta attttcctca agggaattat ggagaatcct
      241 attgtaaaat cacttgctaa ggctcatgag aggctagaag attccaaact agaagctgtc
      301 agtgacaata acttggaatt agtcaatgaa attcttgaag acatcactcc tctaataaat
      361 gtggatgaaa atgtggcaga attggttggt atactcaaag aacctcactt ccagtcactg
      421 ttggaggccc atgatattgt ggcatcaaag tgttatgatt cacctccatc aagcccagaa
      481 atgaataatt cttctatcaa taatcagtta ttaccagtag atgccattcg tattcttggt
      541 attcacaaaa gagctgggga accactgggt gtgacattta gggttgaaaa taatgatctg
      601 gtaattgccc gaatcctcca tgggggaatg atagatcgac aaggtctact tcatgtggga
      661 gatataatta aagaagtcaa tggccatgag gttggaaata atccaaagga attacaagaa
      721 ttactgaaaa atattagtgg aagtgtcacc ctaaaaatct taccaagtta tagagatacc
      781 attactcctc aacaggtatt tgtgaagtgt cattttgatt ataatccata caatgacaac
      841 ctaatacctt gcaaagaagc aggattgaag ttttccaaag gagagattct tcagattgta
      901 aatagagaag atccaaattg gtggcaggct agccatgtaa aagagggagg aagcgctggt
      961 ctcattccaa gccagttcct ggaagagaag agaaaggcat ttgttagaag agactgggac
     1021 aattcaggac ctttttgtgg aactataagt agcaaaaaaa agaaaaagat gatgtatctc
     1081 acaaccagaa atgcagaatt tgatcgtcat gaaatccaga tatatgagga ggtagccaaa
     1141 atgcctccct tccagagaaa aacattagta ttgataggag ctcaaggtgt aggccgaaga
     1201 agcttgaaaa acaggttcat agtattgaat cccactagat ttggaactac ggtgccattt
     1261 acttcacgga aaccaaggga agatgaaaaa gatggccagg catataagtt tgtgtcacga
     1321 tctgagatgg aagcagatat taaagctgga aagtatttgg aacatgggga atatgaagga
     1381 aatctctatg gaaccaaaat tgattctatt cttgaggttg tccaaactgg acggacttgc
     1441 attctggatg tcaacccaca agcactgaaa gtattgagga catcagagtt tatgccctat
     1501 gtggtattta ttgcggctcc ggagctagag acgttacgtg ccatgcacaa ggctgtggtg
     1561 gatgcaggaa tcactaccaa gcttctgacc gactctgact tgaagaaaac agtggatgaa
     1621 agtgcacgga ttcagagagc atacaaccac tattttgatt tgatcatcat aaatgataat
     1681 ctagacaaag cctttgaaaa actgcaaact gccatagaga aactgagaat ggaaccacag
     1741 tgggtcccaa tcagctgggt ttactgatga ttcagtaagg ttaacaatga aaattaaact
     1801 cttaaaaagt gactgcaaca aataaacctt ctactgagaa aatacatcac agatagaaga
     1861 ttatctgcta agtccaggca tttttatggt gtagattgaa ataatagtac acttctgaat
     1921 ttttatataa aatgtggttg gaaggtgtac taatatataa tttatcttaa tttttctaac
     1981 tttgtatgga taatctttct attcatatca cataaagaaa tgcgttgaag cattttgtat
     2041 atgttttgat ttagtaccct tgcctttttc atcaaaggaa ttttcaaatc attcactcta
     2101 acattggtct catattttca ctgtgataat gaatattact tgaaatagtt ttgtaaagct
     2161 gtcatttagt tcagtattca aatagtgaag ggttagtctt aatagaagaa aatatagtta
     2221 ttgaccttcc ttcttataaa tttcttacaa aagcagaatt ttaagtcagt gttatagcta
     2281 gtctactacc atctaaatct gacatcaaaa gtctgatcag tttacgtatt ttcattattt
     2341 cggagatgta tggctatcca ttctaattta tacagctata ttagttttgt ctcttcattt
     2401 ctatctttac tgaaaaattg aagagcaata ccttgcactc tcttttgagg ttattctttt
     2461 tatttgttgc agtgatatga tgctaactaa tttaacatgt acacagtaag ctctggggct
     2521 ggaagcaagg tcatgcagac tgagagagtg ccttatcctg taaaacctta cagcaaaatg
     2581 acacttgaag aaagtttatt ttcacatgta aaattttgac tgacaaaagg aacctactac
     2641 tttaaacaat ggttttatta gaacatggtc agcaaatgta tcatgcctct gcaaatttta
     2701 gtgatgttta gagatgcctc taagtttgca gttggaggtt tttgtgcttt tagaaatgtg
     2761 atgtgatcct tagggtacct gttttgtctg ttgtgttgag aaccaaaccc attgaacaac
     2821 ttaaaaaatt gggaaataat tgtcagctat tttgtataca tacacacaaa atatatacat
     2881 tatataatat gtatattatg tattatataa tatatataaa atgttttgta tattttttac
     2941 atatctgtta aaaaatgtac tttgtttttt tgtttgtttg ttttgagatg gagtctctct
     3001 ctgtcaccca tgctggagta cagtggcgcg atctcagccc gctgcaacct ctgcctcctg
     3061 ggttcatgcg actctcgtgc ctcagcctcc caagtaattg agattacagt tgggtgccac
     3121 catgtccggc taatttttgt atttttagta cagatggggt ttcaccatgt tggccagggt
     3181 ggtctcgagc tcctgacctc aagtgatcca cccaccttgg cctcccaaag tgctgagatt
     3241 acaagcatga gccactgcac ctagccaaga agtgtacttt ttgtttaatg attaccgaaa
     3301 gaagttctcc tttagaagca ttgacttata caaattccca cattcacctc agttaatatc
     3361 ttcctttagg attcttggat aatagaaatt cttcctaaaa catactcaga gatgcagctc
     3421 attattaaat taaggtaacc acattctgta ttgttgctag cttttcatgt aaacattatt
     3481 cacactttaa aggattaggt gtttaaatat tgatggtcat ctttgtctgg tgttaggtgc
     3541 cagacacctg gctgctgaat ttgttttttc cctcaccaaa gttgtcattt ggaacgccag
     3601 ctgggaggac tttgaaggaa aagaaaatat atgacaatag gcagtattga cacattgttt
     3661 aaaatctttt tcacaataaa acaaaacacc caagttgtca tattgttaaa gttggaaatc
     3721 tataggtttt tctttttttt tttttttttc tttttttgat tctagatttc atggccagaa
     3781 cacaaattca cgtttcttgt cctaggacag ggaattggtg acaaaatgga ttatactatt
     3841 ttaataacag tggaaacttt caaactacat gtgtttacac caaattcttg gcttctcaaa
     3901 gcaacatgaa ttaaagcaca gtatcaaggt gatgccctat gacaatgttt caacacacac
     3961 ttgaaatttt aagagaaatt tcagttcttc actcaggaaa tgtgctgtat tctctaatgt
     4021 actttcatgc tgcagcatgg agcctcttta aacagctttg ggataattat agcagcacaa
     4081 gaagtttatc tgcaaaatat ttcaatcatc ttggtacaat agatgacttt tacatcatgt
     4141 atattagcct tatgtgatat aaaatgtatt acttagaaaa tatacttaaa ggaattattt
     4201 ctattataaa tggtattcat gattgactac ttaattaatg cacattagat ttctcctaat
     4261 ataaaatgaa atgatgcagt ttagttcatt tcagtctaga tgcccgtact aacaagaata
     4321 cagttagata agttcattgt atctcaatga agaatcattg aacttgaaac ccaagtccca
     4381 aatgaatctg caggaatgag cagtgctctg cgggggcaaa cagccccaga ggtcccaggg
     4441 ttcttcctag gtaatgagag tatagctgtg atcaaggaaa tgtgaacttc tcttttggga
     4501 agatctgcga taattagctt tatggaagcg aaaatggttt agagtggtgt tgagcaattg
     4561 ttaagagttg aaatagacac acacatgcat gtgcttttgg gaaacatgat gtgccaacgt
     4621 attaatgtgc ctgagggctc cttgtggata ggtcagtgtc cacatttcag cactcagggc
     4681 atgactgtac acaacctaag actatatata tattttttca ttttcaaatg tacaaatacc
     4741 catagaggtg atgtgcctgg ataagtcatt taaccatagc ttagtgaaat aaatgtgatg
     4801 gccctaaaaa gtagaatttt cactttcatt acagccatgc ctttattatg cagtctccat
     4861 ttctgtgtga tatttggtaa tatcacatgt caaatacatc aggactttgt ttattttggc
     4921 taactctaac tatacaattg ctgaacatag ctttctgaaa tagaaattat aagagaaacc
     4981 cagtatgcct acagcattag tagcctaaat cctagattct agaatccaat aaatttatag
     5041 tagttcttaa gaagtttcct ttaaagcaac aaatagatta ttaaggcaaa tttagataat
     5101 aacccaagtt agcaataaaa ccatgtgaca ttatagatta tgtccagata ctaactgctt
     5161 tgaccataat atcccaatga caataaaaaa tgatccttgg tttaaaaatt attaaatggt
     5221 acttattttt atgtataaca agtgtcatga tcccagtgac tggagttgat tttcaaggtg
     5281 gatagccata gagttaggta aaattatttt gaattggcaa actaaagata acaattttga
     5341 aaattgctca aaataataat ctacttaaat tttacttttg taacttctga aacagtactc
     5401 cattatccag aaatcacagg ctagagagcc aataattttg tagtaatgaa ccttaactaa
     5461 acatgaaaaa ggcaatcctg aagttttatg tacatagata gcagttcatt ttttaaatgt
     5521 tcgagttgcc atatattatg tatgtgtgtg tgtgtgtgta tatatatata tatatatata
     5581 tatatatata tatatataca gctatgtgta taatatgtaa aattctccca aaatgtatga
     5641 atataaaact gaatgtattc attcatgtaa ttataactag cattctaaaa tttttaatta
     5701 ctcccatttc tttgacattc tgaaactttt tttagattgt tttaaaacgc tctggttcca
     5761 ccttgaagct gataatcttt ctgaaaaata tatgagaaac tcagaaagta gtcattatta
     5821 taataaattt aattttctta gggaaaaagg gcagggttct ggatggaaac ccctttggaa
     5881 attcttattt aaacttttga atgaatcttt aatatgattc aggctgagat tatgatacct
     5941 gcccttgtct tatttcaaga ggtttgctgt gagaattcat gtaataacat ctgtaatgta
     6001 tttggaattt ttgggagaaa ttcattcttt taaataatgg gattattgta tatagtacaa
     6061 atgaatactc acaaaattta agaatacatt tgactaataa ttgagcatct tgtcagtttt
     6121 tatgcaagca tatattgtat acctgaggaa gatgacagtt ctataatttt tttaaggtaa
     6181 ggttattttt aaattgcatt tttgttctaa cgttttgcaa tttatattct ttttaaaata
     6241 tttcccataa ttcatcatgc tagcttctgt gttcttggaa tagtttttga aaaatgcaga
     6301 gattcgaaca tgagtcctta atatactaaa cagtgaaaga atgatgatat ctcatttcta
     6361 aagtaagcat ggttcacacc actttggcaa tacactgcag tactttttaa aaaatattct
     6421 ctagtgataa aagtaaagac agggtactgg ccaagatcct aattctgact tctgactgtg
     6481 tgatcttcga tgaaatttat atttcccttt atcattacta ttctacttgt taagtaaggc
     6541 taagttaata tttgtcttcg ccttaaattc tgatttgtaa tttgtaactc tgatgtggta
     6601 gctgtgatat ggtgaactga aaaatcctta ttaggctact ttatctgttc tcttttagtt
     6661 attttaaagt gtacctgttt ctgaagtaat gtagtgaatg gtgaatactt ttcaggaatt
     6721 cttccagttt taaaatagcc ccaaagatac agtttcagct ggtggaaggt ctgttctgct
     6781 ctcttagtcc taatcagaaa gtccctttta tcttataatc ccatactaaa tccaaaccct
     6841 tagcaaatcc ttgctgccaa ccagaccact cacaaatcaa acaaaatgta agcaagcaat
     6901 ccagtactcg gttacaccag aagactctga tctttgcccc cgaaaactgt cctactttat
     6961 ccttatacct gaaatcactg catacctgaa atcactgcag ccctactgtt ttacccatac
     7021 cattaattta aaaaggcatc tatttcttta tagaaagaaa cattcacagt gaggtcttag
     7081 tttgtgaacc tcaaaatcca gatattaatc cactttagtt attactttgt aattgcttct
     7141 cagtcattgg ctgataatgc aatggtgtga taaatttgac ttatctccac atacaaaagt
     7201 cgatcagaag ggatagttct cttccttttt ttcccctcct actggctctt actgttttct
     7261 aatctccagt gtaaatggaa tgaacacatc tatagttaag gtaaatgcca ccaatcagaa
     7321 gattgagtga tttactgctt gtaaagcaac tgtctttgaa tcttatgaaa taggtggtgt
     7381 tgctaccaca gaagccaaaa aggtcttaaa attggaaata gatgtcttta ttgtacttca
     7441 gccaacagca agccagggga aggaacatac ataaatatga caggtcatat atgaaatttg
     7501 gctctcctcc tatcaaagta gcctaggagc ttggaggaag cctaattaac taaaacagga
     7561 aaaaagcata ctcatctgat gtaaaaactc atcagctgta aattaccaac attaaaccag
     7621 aagtcattac cagttaaaat gtgtggtttt catcttattc ttaaatagga gaggtggaca
     7681 gtagtgtaag taacattgct ttaaagacat aaagcttgtc ctggtaaaca tggtctaaat
     7741 gagaaatgcc tccatctttt caggtagaac cagatttcag gcatagctca gctacatctg
     7801 tatttgaaat acaataaaaa tatttcttat gtctctgtat tctcttttaa aaagaactgc
     7861 tgactggctc ctgtctcttc agtaacactg attttttttt aaagaagtga tatgttggac
     7921 tctgttgtag aagaatgagc actagtattc agcaacaagt gcaatttctc catgttatgt
     7981 tgagctctgt tggagcctat ggtgagtatt tgatgtgaaa accttgctgt gggaattttt
     8041 tattcttcct tttcccccca cgccagttcg ttttggtaag tcttttattt gaacacaaga
     8101 cgcatgcttt tttaaacctc tagtttttga agtaactgta gaagagaatc tttaaaaaaa
     8161 aaaatggagg gcagaatgct tgttagcaat ctgaaaatca aagctgaaca agctgcttaa
     8221 agtttctgat taagaagttt aaaaagaaaa attaattgct actgctttcc aggtaattgt
     8281 attattagtt tctgtataaa agaaacatta ttgctgttgt ataaataaaa ttttcctgtg
     8341 gtacaa
//
