LOCUS       NM_017734               2334 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens palmdelphin (PALMD), mRNA.
ACCESSION   NM_017734
VERSION     NM_017734.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Su,Y., Du,Y., Ye,S., Jia,G., Ding,B. and Yu,J.
  TITLE     Clinical importance and PI3K/Akt pathway-dependent
            anti-proliferative role of PALMD and DPT in breast cancer
  JOURNAL   Pathol Res Pract 249, 154717 (2023)
   PUBMED   37556876
  REMARK    GeneRIF: Clinical importance and PI3K/Akt pathway-dependent
            anti-proliferative role of PALMD and DPT in breast cancer.
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Wang,S., Yu,H., Gao,J., Chen,J., He,P., Zhong,H., Tan,X.,
            Staines,K.A., Macrae,V.E., Fu,X., Jiang,L. and Zhu,D.
  TITLE     PALMD regulates aortic valve calcification via altered glycolysis
            and NF-kappaB-mediated inflammation
  JOURNAL   J Biol Chem 298 (5), 101887 (2022)
   PUBMED   35367413
  REMARK    GeneRIF: PALMD regulates aortic valve calcification via altered
            glycolysis and NF-kappaB-mediated inflammation.
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Sainz-Jaspeado,M., Smith,R.O., Plunde,O., Pawelzik,S.C., Jin,Y.,
            Nordling,S., Ding,Y., Aspenstrom,P., Hedlund,M., Bastianello,G.,
            Ascione,F., Li,Q., Demir,C.S., Fernando,D., Daniel,G.,
            Franco-Cereceda,A., Kroon,J., Foiani,M., Petrova,T.V.,
            Kilimann,M.W., Back,M. and Claesson-Welsh,L.
  TITLE     Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in
            the Endothelium
  JOURNAL   Circulation 144 (20), 1629-1645 (2021)
   PUBMED   34636652
  REMARK    GeneRIF: Palmdelphin Regulates Nuclear Resilience to Mechanical
            Stress in the Endothelium.
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Li,Z., Gaudreault,N., Arsenault,B.J., Mathieu,P., Bosse,Y. and
            Theriault,S.
  TITLE     Phenome-wide analyses establish a specific association between
            aortic valve PALMD expression and calcific aortic valve stenosis
  JOURNAL   Commun Biol 3 (1), 477 (2020)
   PUBMED   32859967
  REMARK    GeneRIF: Phenome-wide analyses establish a specific association
            between aortic valve PALMD expression and calcific aortic valve
            stenosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Dashzeveg,N., Taira,N., Lu,Z.G., Kimura,J. and Yoshida,K.
  TITLE     Palmdelphin, a novel target of p53 with Ser46 phosphorylation,
            controls cell death in response to DNA damage
  JOURNAL   Cell Death Dis 5 (5), e1221 (2014)
   PUBMED   24810057
  REMARK    GeneRIF: findings define palmdelphin as a target of
            serine-46-phosphorylated p53 that controls cell death in response
            to DNA damage.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Andreu,N., Escarceller,M., Feather,S., Devriendt,K., Wolf,A.S.,
            Estivill,X. and Sumoy,L.
  TITLE     PALML, a novel paralemmin-related gene mapping on human chromosome
            1p21
  JOURNAL   Gene 278 (1-2), 33-40 (2001)
   PUBMED   11707320
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Hu,B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kilimann,M.W.
  TITLE     The paralemmin protein family: identification of paralemmin-2, an
            isoform differentially spliced to AKAP2/AKAP-KL, and of
            palmdelphin, a more distant cytosolic relative
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1369-1376 (2001)
   PUBMED   11478809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF262379.1 and AL390970.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017734.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000278.1, AF262379.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263174.9/ ENSP00000263174.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2301              AF262379.1         170-2470
            2302-2334           AL390970.1         1569-1601
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..2334
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="palmdelphin"
                     /db_xref="GeneID:54873"
                     /db_xref="HGNC:HGNC:15846"
                     /db_xref="MIM:610182"
     exon            1..250
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1861
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="paralemnin-like protein; paralemmin-like protein"
                     /codon_start=1
                     /product="palmdelphin"
                     /protein_id="NP_060204.1"
                     /db_xref="CCDS:CCDS758.1"
                     /db_xref="GeneID:54873"
                     /db_xref="HGNC:HGNC:15846"
                     /db_xref="MIM:610182"
                     /translation="MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKK
                     ALREKWLLDGISSGKEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTK
                     EEAILKKLKSIERTTEDIIRSVKVEREERAEESIEDIYANIPDLPKSYIPSRLRKEIN
                     EEKEDDEQNRKALYAMEIKVEKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVY
                     AVSSNHSAAYNGTDGLAPVEVEELLRQASERNSKSPTEYHEPVYANPFYRPTTPQRET
                     VTPGPNFQERIKIKTNGLGIGVNESIHNMGNGLSEERGNNFNHISPIPPVPHPRSVIQ
                     QAEEKLHTPQKRLMTPWEESNVMQDKDAPSPKPRLSPRETIFGKSEHQNSSPTCQEDE
                     EDVRYNIVHSLPPDINDTEPVTMIFMGYQQAEDSEEDKKFLTGYDGIIHAELVVIDDE
                     EEEDEGEAEKPSYHPIAPHSQVYQPAKPTPLPRKRSEASPHENTNHKSPHKNSISLKE
                     QEESLGSPVHHSPFDAQTTGDGTEDPSLTALRMRMAKLGKKVI"
     exon            251..331
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            332..456
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            457..571
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            572..605
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            606..719
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1817
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2334
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="hexamer: AATAAA"
     polyA_site      2173
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="major polyA site"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
     regulatory      2311..2316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
                     /note="hexamer: AATAAA"
     polyA_site      2334
                     /gene="PALMD"
                     /gene_synonym="C1orf11; PALML"
ORIGIN      
        1 attacatgtg tctgtctggc ctgatctgtg catctgctcg gagacgctcc tgacaagtcg
       61 ggaatttctc tatttctcca ctggtgcaaa gagcggattt ctccctgctt ctcttctgtc
      121 acccccgctc ctctccccca ggaggctcct tgatttatgg tagctttgga cttgcttccc
      181 cgtctgactg tccttgactt ctagaatgga agaagctgag ctggtgaagg gaagactcca
      241 ggccatcaca gataaaagaa aaatacagga agaaatctca cagaagcgtc tgaaaataga
      301 ggaagacaaa ctaaagcacc agcatttgaa gaaaaaggcc ttgagggaga aatggcttct
      361 agatggaatc agcagcggaa aagaacagga agagatgaag aagcaaaatc aacaagacca
      421 gcaccagatc caggttctag aacaaagtat cctcaggctt gagaaagaga tccaagatct
      481 tgaaaaagct gaactgcaaa tctcaacgaa ggaagaggcc attttaaaga aactaaagtc
      541 aattgagcgg acaacagaag acattataag atctgtgaaa gtggaaagag aagaaagagc
      601 agaagagtca attgaggaca tctatgctaa tatccctgac cttccaaagt cctacatacc
      661 ttctaggtta aggaaggaga taaatgaaga aaaagaagat gatgaacaaa ataggaaagc
      721 tttatatgcc atggaaatta aagttgaaaa agacttgaag actggagaaa gtacagttct
      781 gtcttcaata cctctgccat cagatgactt taaaggtaca ggaataaaag tttatgatga
      841 tgggcaaaag tcagtgtatg cagtaagttc taatcacagt gcagcataca atggcaccga
      901 tggcctggca ccagttgaag tagaggaact tctaagacaa gcctcagaga gaaactctaa
      961 atccccaaca gagtatcatg agcctgtata tgccaatccc ttttacaggc ctacaacccc
     1021 acagagagaa acggtgaccc ctggaccaaa ctttcaagaa aggataaaga ttaaaactaa
     1081 tggactgggt attggtgtaa atgaatccat acacaatatg ggcaatggtc tttcagagga
     1141 aaggggaaac aacttcaatc acatcagtcc cattccgcca gtgcctcatc cccgatcagt
     1201 gattcaacaa gcagaagaga agcttcacac cccgcaaaaa aggctaatga ctccttggga
     1261 agaatcgaat gtcatgcagg acaaagatgc accctctcca aagccaaggc tgagccccag
     1321 agagacaata tttgggaaat ctgaacacca gaattcttca cccacttgtc aggaggacga
     1381 ggaagatgtc agatataata tcgttcattc cctgcctcca gacataaatg atacagaacc
     1441 ggtgacaatg attttcatgg ggtatcagca ggcagaagac agtgaagaag ataagaagtt
     1501 tctgacagga tatgatggga tcatccatgc tgagctggtt gtgattgatg atgaggagga
     1561 ggaggatgaa ggagaagcag agaaaccgtc ctaccacccc atagctcccc atagtcaggt
     1621 gtaccagcca gccaaaccaa caccacttcc tagaaaaaga tcagaagcta gtcctcatga
     1681 aaacacaaat cataaatccc cccacaaaaa ttccatatct ctgaaagagc aagaagaaag
     1741 cttaggcagc cctgtccacc attccccatt tgatgctcag acaactggag atgggactga
     1801 ggatccatcc ttaacagctt taaggatgag aatggcaaag ctgggaaaaa aggtgatcta
     1861 agagttgtac cacctatata aacatccttt gaagaagaaa ctaagaagca tttgcaaatt
     1921 tctcttctgg atattttgtt tattttttct gaagtccaaa aaattatcat tacagtgtac
     1981 catattaagc catgtgaata agtagtagtc attatttgtg aaaaattccc aaaaagctgg
     2041 ggaaaacaaa tgtgtaactt ttccagttac ttgacacgat tcagtggggg aaaaccagca
     2101 ttttttattc tattgatacc aaagcatttc taataagagc ttgttaaatt taagaataaa
     2161 gttatttaaa atattctgag tatagtatat taactggcat tgtaattttg atgatacaaa
     2221 gattgaaaga tcataggaaa gcattgccct tcatcacaga agtattcaac tctgacaaat
     2281 aaatatgtca tcctgaatta ataatgcctt aataaaagta catcctcctg ctaa
//
