LOCUS       NM_001367327            2422 bp    mRNA    linear   PRI 20-DEC-2024
DEFINITION  Homo sapiens paralemmin 3 (PALM3), transcript variant 2, mRNA.
ACCESSION   NM_001367327
VERSION     NM_001367327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Chen,X., Wu,X., Zhao,Y., Wang,G., Feng,J., Li,Q. and Qian,G.
  TITLE     A novel binding protein of single immunoglobulin IL-1
            receptor-related molecule: Paralemmin-3
  JOURNAL   Biochem Biophys Res Commun 404 (4), 1029-1033 (2011)
   PUBMED   21187075
  REMARK    GeneRIF: These results suggest that PALM3 may function as an
            adaptor in the LPS- Toll-like receptor 4 signaling and the
            interaction of SIGIRR with PALM3 may partly account for the
            mechanism of the negatively regulatory effect of SIGIRR.
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022098.9.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to variant 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.75011.1,
                                           ERR3218373.96074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474, SAMEA2159912
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC022098.9         94728-95015         c
            289-431             AC022098.9         94039-94181         c
            432-516             AC022098.9         93806-93890         c
            517-562             AC022098.9         92757-92802         c
            563-2422            AC022098.9         90744-92603         c
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2422
                     /gene="PALM3"
                     /note="paralemmin 3"
                     /db_xref="GeneID:342979"
                     /db_xref="HGNC:HGNC:33274"
                     /db_xref="MIM:621051"
     exon            1..288
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..431
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..2184
                     /gene="PALM3"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="paralemmin-3 isoform 2"
                     /protein_id="NP_001354256.1"
                     /db_xref="CCDS:CCDS92540.1"
                     /db_xref="GeneID:342979"
                     /db_xref="HGNC:HGNC:33274"
                     /db_xref="MIM:621051"
                     /translation="MDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQL
                     QLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPP
                     ESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGE
                     AKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKE
                     DRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPE
                     GDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTG
                     GGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKL
                     GTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATK
                     EPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAG
                     PPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQ
                     PAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKTCQCCAVM"
     exon            432..516
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..562
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..2422
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALM3"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="PALM3"
                     /note="major polyA site"
ORIGIN      
        1 actccgcccg ccgctgagtc agcgcctccg cagccccctc cccgccctgg gtgcagaccc
       61 gcgctgggcc acccccgccg ggctcgctgc ctcgggagcc ccgggagctc cggtgagccc
      121 cgcggaggag ggaggggaaa gggagggaag aggaggtggt ggaggccgcg cccggccggc
      181 gggcagctcc gggtcctctg tgcgcaggag aagcggcggc tgcaggagga gatccgcgcc
      241 gcgcgccggg aggtggagga ggagaaactc cgcgtggagc gtctcaagag gaagtctctc
      301 cgggaacgtt ggctaatgga tggggcagct gcagtgccag agccatccga agaccccacc
      361 tcgaaggacc cccagtcacc cgagggccag gctcaggccc gaatccggaa cctggaagac
      421 agtttgttca cactccagtc ccagctgcaa ctgttgcaaa gtgcttccac aggtgcccag
      481 cacaagccct caggcaggcc cagctggcgc agacagggtc accgtcctct ctcccagtcc
      541 attgtcgagg caggttctgt aggccagact gatctgaaca agagagcctc cctgccggct
      601 ggactagtgg gcacgcctcc agagtccccc tctgagccca gggaggatgt cttggggttt
      661 ctgccaggcc cgaggcaggt ccccggggca gcaggagact cctcagaagc caatggccca
      721 tgccccagcc ccatccccac tccagagcag gggctaagtc agagggcagt gccatccgaa
      781 gggcgggtgg gtgaggccaa aggagggggc gtggtgagtg tggtgtggga agggctgagg
      841 gccacagagg actgtgccac aggggccacg ggccccgagc tggaggctaa ggtggaggaa
      901 gtggtgctgg aagccatcgg agacaggaag ggagctggta gcctggagct cccggcctgg
      961 gtgaaggagg acaggggcat cgtggaggtg gtctgggagg gggtgggtgg cagtgatgca
     1021 gaggccatgg gggagatagg cagggtccct gaggtcgtgc agactagctc gcctaggctc
     1081 caggagagat tagaggcagc agcttccata gaaggggaag atgtgcccca gggcagccct
     1141 gagggtgatg ggcagggagg ctctggagga gaggagggat ccttcatttg ggtggagaga
     1201 gtgaccctca gtgaagagtg ggaggagctg ctggtggagg ggttggaagg gcccgaggtg
     1261 gcagggaggg agagaggaga tgaaagcccg ctgggggccg agggggccaa gacgggagga
     1321 ggcgaggaga cctgggaggc agagaagaga aaagcggaag aatccatggg aataggaagt
     1381 gaggaaaagc cagggacagg gagggatgaa gcggagatgt caccagtggt agagaggaaa
     1441 ggaggagaga agaagttgga gctggagagc agaggaagtg cagaaaagct gggaacagag
     1501 agggaaggag gtgaggaacc actgggcata gagagaaaag ttgagggaca tttgagggca
     1561 gagaaggaag gagatgagga aaagcgaggg gcagaggagg aggaggtaga agaaccattg
     1621 ggagtagaga agaaaggagg tgaggaagag ccagaggcaa ccaaagaacc actggaggca
     1681 gagagaaagg gaggggagga gacactggag gcagagaaaa ggggaggtga ggaatcattg
     1741 gagacagaga agacccaagg gacggaggga gatctgaatc tagaacaagg gtctagggaa
     1801 ggaagtgaat cccaggcaga ggagatgaat gaggcagggc ctccccttga ggctaacacg
     1861 gagacaaggc cagagaagga aggaccccag ccccaggaga agccagtagg agccctggag
     1921 gaggaaggag tgaagcccca aaccgctgct gagggccaag gccccttggg ggatgccaca
     1981 cctcttctgg cagagacccc agccccagag cagcccgccg aatgccagcc actgcttcag
     2041 ggggaggggc ccagcgccaa ccccagtgcc caccctgtgc ccacctacgc gcctgcccgg
     2101 cagcctgagc catctgcccc caccgagggt gaagaggcaa gtggccctaa gcaaaagacg
     2161 tgccagtgtt gtgcggtcat gtgaacccat gcccctccac cccatgtcca gctcctctca
     2221 cagctacctc ggcctcttgg cacccagaag agggtcccag gcacagacag ggaccacagg
     2281 actggccatg gcacctggga gccagctagc ctgcacgtcc acctaaacct gggcttccag
     2341 accccttgcc cactgcctgt aaccctggcc tccttctgcg atgaagcctt tatacttgaa
     2401 aataaaatgt gaaagcactc aa
//
