LOCUS       NM_001145028            2401 bp    mRNA    linear   PRI 20-DEC-2024
DEFINITION  Homo sapiens paralemmin 3 (PALM3), transcript variant 1, mRNA.
ACCESSION   NM_001145028 XM_001726585 XM_005259891 XM_292820 XM_937298
VERSION     NM_001145028.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2401)
  AUTHORS   Chen,X., Wu,X., Zhao,Y., Wang,G., Feng,J., Li,Q. and Qian,G.
  TITLE     A novel binding protein of single immunoglobulin IL-1
            receptor-related molecule: Paralemmin-3
  JOURNAL   Biochem Biophys Res Commun 404 (4), 1029-1033 (2011)
   PUBMED   21187075
  REMARK    GeneRIF: These results suggest that PALM3 may function as an
            adaptor in the LPS- Toll-like receptor 4 signaling and the
            interaction of SIGIRR with PALM3 may partly account for the
            mechanism of the negatively regulatory effect of SIGIRR.
REFERENCE   2  (bases 1 to 2401)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022098.9.
            
            On or before Nov 21, 2018 this sequence version replaced
            XM_005259891.4, NM_001145028.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2152474,
                              SAMEA2159912 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000669674.2/ ENSP00000499271.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC022098.9         99317-99453         c
            138-186             AC022098.9         96492-96540         c
            187-267             AC022098.9         94728-94808         c
            268-410             AC022098.9         94039-94181         c
            411-495             AC022098.9         93806-93890         c
            496-541             AC022098.9         92757-92802         c
            542-2401            AC022098.9         90744-92603         c
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2401
                     /gene="PALM3"
                     /note="paralemmin 3"
                     /db_xref="GeneID:342979"
                     /db_xref="HGNC:HGNC:33274"
                     /db_xref="MIM:621051"
     exon            1..137
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2163
                     /gene="PALM3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="paralemmin-3 isoform 1"
                     /protein_id="NP_001138500.2"
                     /db_xref="CCDS:CCDS46001.2"
                     /db_xref="GeneID:342979"
                     /db_xref="HGNC:HGNC:33274"
                     /db_xref="MIM:621051"
                     /translation="MALQSQVWSLATPMPMAESSLYRQRLEVIAEKRRLQEEIRAARR
                     EVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDS
                     LFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLP
                     AGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAV
                     PSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSL
                     ELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGE
                     DVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPL
                     GAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELE
                     SRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGG
                     EEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQ
                     AEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLL
                     AETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKTC
                     QCCAVM"
     exon            138..186
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            187..267
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            268..410
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..495
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..541
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..2401
                     /gene="PALM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2380..2385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALM3"
                     /note="hexamer: AATAAA"
     polyA_site      2401
                     /gene="PALM3"
                     /note="major polyA site"
ORIGIN      
        1 actccaggca gccaagtcac agcctccggg gcaccttcag gcaagcgggt ggtgggtcca
       61 gaactcggag accagaaagt gaacttctgg gcagagatgg ccctgcagag ccaggtgtgg
      121 tctctggcca cacccatgcc catggcggag agctccctct accggcagcg gctagaagtc
      181 atcgctgaga agcggcggct gcaggaggag atccgcgccg cgcgccggga ggtggaggag
      241 gagaaactcc gcgtggagcg tctcaagagg aagtctctcc gggaacgttg gctaatggat
      301 ggggcagctg cagtgccaga gccatccgaa gaccccacct cgaaggaccc ccagtcaccc
      361 gagggccagg ctcaggcccg aatccggaac ctggaagaca gtttgttcac actccagtcc
      421 cagctgcaac tgttgcaaag tgcttccaca ggtgcccagc acaagccctc aggcaggccc
      481 agctggcgca gacagggtca ccgtcctctc tcccagtcca ttgtcgaggc aggttctgta
      541 ggccagactg atctgaacaa gagagcctcc ctgccggctg gactagtggg cacgcctcca
      601 gagtccccct ctgagcccag ggaggatgtc ttggggtttc tgccaggccc gaggcaggtc
      661 cccggggcag caggagactc ctcagaagcc aatggcccat gccccagccc catccccact
      721 ccagagcagg ggctaagtca gagggcagtg ccatccgaag ggcgggtggg tgaggccaaa
      781 ggagggggcg tggtgagtgt ggtgtgggaa gggctgaggg ccacagagga ctgtgccaca
      841 ggggccacgg gccccgagct ggaggctaag gtggaggaag tggtgctgga agccatcgga
      901 gacaggaagg gagctggtag cctggagctc ccggcctggg tgaaggagga caggggcatc
      961 gtggaggtgg tctgggaggg ggtgggtggc agtgatgcag aggccatggg ggagataggc
     1021 agggtccctg aggtcgtgca gactagctcg cctaggctcc aggagagatt agaggcagca
     1081 gcttccatag aaggggaaga tgtgccccag ggcagccctg agggtgatgg gcagggaggc
     1141 tctggaggag aggagggatc cttcatttgg gtggagagag tgaccctcag tgaagagtgg
     1201 gaggagctgc tggtggaggg gttggaaggg cccgaggtgg cagggaggga gagaggagat
     1261 gaaagcccgc tgggggccga gggggccaag acgggaggag gcgaggagac ctgggaggca
     1321 gagaagagaa aagcggaaga atccatggga ataggaagtg aggaaaagcc agggacaggg
     1381 agggatgaag cggagatgtc accagtggta gagaggaaag gaggagagaa gaagttggag
     1441 ctggagagca gaggaagtgc agaaaagctg ggaacagaga gggaaggagg tgaggaacca
     1501 ctgggcatag agagaaaagt tgagggacat ttgagggcag agaaggaagg agatgaggaa
     1561 aagcgagggg cagaggagga ggaggtagaa gaaccattgg gagtagagaa gaaaggaggt
     1621 gaggaagagc cagaggcaac caaagaacca ctggaggcag agagaaaggg aggggaggag
     1681 acactggagg cagagaaaag gggaggtgag gaatcattgg agacagagaa gacccaaggg
     1741 acggagggag atctgaatct agaacaaggg tctagggaag gaagtgaatc ccaggcagag
     1801 gagatgaatg aggcagggcc tccccttgag gctaacacgg agacaaggcc agagaaggaa
     1861 ggaccccagc cccaggagaa gccagtagga gccctggagg aggaaggagt gaagccccaa
     1921 accgctgctg agggccaagg ccccttgggg gatgccacac ctcttctggc agagacccca
     1981 gccccagagc agcccgccga atgccagcca ctgcttcagg gggaggggcc cagcgccaac
     2041 cccagtgccc accctgtgcc cacctacgcg cctgcccggc agcctgagcc atctgccccc
     2101 accgagggtg aagaggcaag tggccctaag caaaagacgt gccagtgttg tgcggtcatg
     2161 tgaacccatg cccctccacc ccatgtccag ctcctctcac agctacctcg gcctcttggc
     2221 acccagaaga gggtcccagg cacagacagg gaccacagga ctggccatgg cacctgggag
     2281 ccagctagcc tgcacgtcca cctaaacctg ggcttccaga ccccttgccc actgcctgta
     2341 accctggcct ccttctgcga tgaagccttt atacttgaaa ataaaatgtg aaagcactca
     2401 a
//
