LOCUS       NM_007203               7618 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens PALM2 and AKAP2 fusion (PALM2AKAP2), transcript
            variant 3, mRNA.
ACCESSION   NM_007203
VERSION     NM_007203.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7618)
  AUTHORS   Delaunay,M., Paterek,A., Gautschi,I., Scherler,G. and Diviani,D.
  TITLE     AKAP2-anchored extracellular signal-regulated kinase 1 (ERK1)
            regulates cardiac myofibroblast migration
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (3), 119674 (2024)
   PUBMED   38242328
  REMARK    GeneRIF: AKAP2-anchored extracellular signal-regulated kinase 1
            (ERK1) regulates cardiac myofibroblast migration.
REFERENCE   2  (bases 1 to 7618)
  AUTHORS   Deng,D.X., Li,C.Y., Zheng,Z.Y., Wen,B., Liao,L.D., Zhang,X.J.,
            Li,E.M. and Xu,L.Y.
  TITLE     Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell
            Carcinoma Cells Through Activating Ezrin
  JOURNAL   Mol Cell Proteomics 22 (8), 100593 (2023)
   PUBMED   37328063
  REMARK    GeneRIF: Prenylated PALM2 Promotes the Migration of Esophageal
            Squamous Cell Carcinoma Cells Through Activating Ezrin.
REFERENCE   3  (bases 1 to 7618)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7618)
  AUTHORS   Li,X., Wang,C., Zhang,G., Liang,M. and Zhang,B.
  TITLE     AKAP2 is upregulated in ovarian cancer, and promotes growth and
            migration of cancer cells
  JOURNAL   Mol Med Rep 16 (4), 5151-5156 (2017)
   PUBMED   28849175
  REMARK    GeneRIF: expression of AKAP2 was elevated in ovarian cancer.
            Furthermore, overexpression of AKAP2 promoted the growth and
            migration of ovarian cancer cells, whereas knockdown of AKAP2
            expression reduced the growth and migration of ovarian cancer
            cells.
REFERENCE   5  (bases 1 to 7618)
  AUTHORS   Hultqvist,G., Ocampo Daza,D., Larhammar,D. and Kilimann,M.W.
  TITLE     Evolution of the vertebrate paralemmin gene family: ancient origin
            of gene duplicates suggests distinct functions
  JOURNAL   PLoS One 7 (7), e41850 (2012)
   PUBMED   22855693
REFERENCE   6  (bases 1 to 7618)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 7618)
  AUTHORS   Alto,N.M., Soderling,S.H., Hoshi,N., Langeberg,L.K., Fayos,R.,
            Jennings,P.A. and Scott,J.D.
  TITLE     Bioinformatic design of A-kinase anchoring protein-in silico: a
            potent and selective peptide antagonist of type II protein kinase A
            anchoring
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4445-4450 (2003)
   PUBMED   12672969
REFERENCE   8  (bases 1 to 7618)
  AUTHORS   Kammerer,S., Burns-Hamuro,L.L., Ma,Y., Hamon,S.C., Canaves,J.M.,
            Shi,M.M., Nelson,M.R., Sing,C.F., Cantor,C.R., Taylor,S.S. and
            Braun,A.
  TITLE     Amino acid variant in the kinase binding domain of dual-specific A
            kinase-anchoring protein 2: a disease susceptibility polymorphism
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4066-4071 (2003)
   PUBMED   12646697
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7618)
  AUTHORS   Hu,B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kilimann,M.W.
  TITLE     The paralemmin protein family: identification of paralemmin-2, an
            isoform differentially spliced to AKAP2/AKAP-KL, and of
            palmdelphin, a more distant cytosolic relative
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1369-1376 (2001)
   PUBMED   11478809
REFERENCE   10 (bases 1 to 7618)
  AUTHORS   Dong,F., Feldmesser,M., Casadevall,A. and Rubin,C.S.
  TITLE     Molecular characterization of a cDNA that encodes six isoforms of a
            novel murine A kinase anchor protein
  JOURNAL   J Biol Chem 273 (11), 6533-6541 (1998)
   PUBMED   9497389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158829.14, AJ303079.1,
            AL158823.11 and AL353598.12.
            
            On May 31, 2019 this sequence version replaced NM_007203.4.
            
            Summary: This gene belongs to the paralemmin downstream gene (PDG)
            family defined in PMID:22855693. Paralemmin downstream genes may
            have evolved contiguously with the paralemmin genes and are
            associated with other paralemmin paralogs in humans and several
            other taxa. The gene encodes three distinct protein isoforms, the
            PALM2 isoform, the AKAP2 isoform and the PALM2-AKAP2 isoform. The
            biological significance of the PALM2-AKAP2 isoforms is yet unknown.
            Earlier, PALM2 and AKAP2 were annotated as separate genes and
            PALM2-AKAP2 was annotated as a readthrough gene. [provided by
            RefSeq, May 2019].
            
            Transcript Variant: This variant (3) encodes isoform 3
            (PALM2-AKAP2), the longest isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ303079.1, AB023137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374530.8/ ENSP00000363654.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AL158829.14        38307-38417
            112-3339            AJ303079.1         1-3228
            3340-3340           AL158823.11        168711-168711
            3341-5154           AJ303079.1         3230-5043
            5155-6178           AL353598.12        8830-9853
            6179-7618           AJ303079.1         6071-7510
FEATURES             Location/Qualifiers
     source          1..7618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..7618
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /note="PALM2 and AKAP2 fusion"
                     /db_xref="GeneID:445815"
                     /db_xref="HGNC:HGNC:33529"
                     /db_xref="MIM:604582"
     exon            1..336
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..3603
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /note="isoform 3 (PALM2-AKAP2) is encoded by transcript
                     variant 3; protein kinase A anchoring protein 2; protein
                     kinase A2; A kinase (PRKA) anchor protein 2; A-kinase
                     anchor protein 2; A-kinase anchoring protein 2; paralemmin
                     2; PALM2-AKAP2 fusion; PALM2-AKAP2 readthrough; paralemmin
                     A kinase anchor protein; PALM2-AKAP2 fusion protein"
                     /codon_start=1
                     /product="PALM2-AKAP2 protein isoform 3 (PALM2-AKAP2)"
                     /protein_id="NP_009134.1"
                     /db_xref="CCDS:CCDS35100.1"
                     /db_xref="GeneID:445815"
                     /db_xref="HGNC:HGNC:33529"
                     /db_xref="MIM:604582"
                     /translation="MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSK
                     VLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQIS
                     AKEQIILEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDG
                     TSRAAGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLL
                     EPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESL
                     DNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPT
                     ERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRC
                     SSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELE
                     KERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQ
                     LLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMEN
                     SRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKS
                     PGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDDD
                     HGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNET
                     TNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLE
                     YQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFE
                     PPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSK
                     YSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQ
                     VLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQ
                     RPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALR
                     WEAGIYANQEEEDNE"
     exon            337..417
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..548
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..663
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..685
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..787
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..873
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..3286
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3465
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3504
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..7618
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7586..7591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /note="hexamer: ATTAAA"
     polyA_site      7592
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /note="major polyA site"
     polyA_site      7618
                     /gene="PALM2AKAP2"
                     /gene_synonym="AKAP-KL; AKAP2; AKAPKL; MISP2; PALM2;
                     PALM2-AKAP2; PRKA2"
                     /note="major polyA site"
ORIGIN      
        1 gtcccacgtc ctcggctggc gcggccggcg gcggcggcga ccgggagatg cagtgagcgg
       61 cggcgctggg gcgcagccag gcggccggga gggcgggggc cagaggctga gcccgggcga
      121 gcccgccgtg cgcacagctc tgcccgccgc ccctggagcg gatccccagc cgtccctggg
      181 cgttctcccg ggttctagca aagccccccg gggtgcccat cagtttcctt gggtgactac
      241 agcgtgtgtt ttttctttcc tctttcccct gcctgtgtgc ccttctccag gatggcagag
      301 gcggaattgc acaaggaaag gctgcaagcc atagcagaaa aaagaaagag gcagactgaa
      361 atagaaggca agcgacaaca gcttgacgag cagatacttc tgctgcagca ttccaagtcc
      421 aaagtgcttc gggagaaatg gctgctgcag ggcatacccg ctggaactgc cgaagaggag
      481 gaagccagga ggcggcagtc tgaagaggat gagttcagag tcaagcaact tgaagataac
      541 attcagaggc tggagcaaga aatacaaacg ctagaaagtg aagagtccca gatatctgcc
      601 aaagagcaaa tcatcctaga gaaactgaag gaaacagaaa aatccttcaa ggactttcag
      661 aagggtttct ccagtacgga tggagatgca gtaaattaca tttcctccca gcttcccgac
      721 ctgccaatcc tctgttcacg aacagcagaa ccatcacctg ggcaggacgg gaccagcaga
      781 gcggctggag tcgggtggga gaatgtgctg ctaaaggaag gtgagtcagc ctcgaacgcc
      841 acagaaacat ccggcccaga catgactatc aagaagcctc cccagctttc tgaggatgat
      901 atctggctaa aaagcgaggg agacaactat agtgccaccc tcctggagcc tgctgccagc
      961 tctctttccc cagatcacaa aaacatggaa attgaggtgt ctgttgcaga atgtaaaagt
     1021 gttcctggaa tcacctctac cccacatccc atggaccatc cctccgcttt ctattcaccc
     1081 ccgcataatg gcctccttac tgatcaccac gaatccctgg ataatgatgt tgccagagag
     1141 atccgctatc tagatgaggt gctagaggcc aactgctgtg attctgctgt ggatggaacg
     1201 tacaatggaa catcctcccc agagcctggt gcagtggttc tggtgggcgg cctaagcccc
     1261 cctgtccacg aggcgaccca gccagaaccc actgaaagaa cagctagccg gcaggcacct
     1321 cctcacatcg agctcagtaa tagcagccct gaccccatgg cagaggcaga aagaacaaat
     1381 ggccattccc ccagccagcc tagagatgcg ctgggggaca gcctgcaggt gcctgtcagc
     1441 cccagctcca caaccagctc acggtgttct tcccgagatg gagagttcac tctcaccaca
     1501 ctgaaaaagg aggccaagtt tgagctgcgt gccttccatg aggacaagaa gccctccaag
     1561 ctctttgagg atgacgagca tgagaaagaa caatactgca ttagaaaagt gaggccttca
     1621 gaggagatgc tggagctgga aaaggagagg agagagctca tccgcagcca ggccgtcaag
     1681 aagaatcctg gcattgcagc aaaatggtgg aatcccccgc aggaaaaaac catcgaggag
     1741 cagctggacg aggaacatct ggagtcgcac aaaaagtaca aggagcgcaa agagagaagg
     1801 gcacagcagg aacagttgct gctgcagaag cagttacagc agcagcagca gcagccccca
     1861 tcgcagctct gcacagcccc tgcctcttct catgaacgcg caagcatgat tgacaaagca
     1921 aaggaggaca ttgtcacaga gcagatagat ttctctgctg ctcgcaaaca atttcagctg
     1981 atggagaatt ccaggcaagc ggtggccaag ggccagagta cacccaggct gttctccatc
     2041 aagcctttct acaggcctct ggggtcagtc aactcagaca agccactgac taatccgaga
     2101 ccaccttctg tcgggggacc tccagaagac agtggtgcct cagccgccaa gggacagaaa
     2161 tcccccggtg ccctggagac cccatcggca gcaggaagcc agggcaacac agcctctcag
     2221 gggaaggaag ggccctacag cgagccttct aaacgtgggc ccttatctaa actgtgggct
     2281 gaggatggag aatttacgag cgcccgggct gtcctcactg tggtcaagga tgatgaccat
     2341 gggattttgg atcagttctc aagatctgtc aatgtctcct tgacccaaga ggagcttgac
     2401 tctggtctgg acgaattgtc ggtgaggtct caggatacca cagtcctgga gaccctatcc
     2461 aatgatttca gcatggacaa catcagtgac agcggggcat ccaatgagac aaccaatgcc
     2521 ctccaggaaa attcactggc tgatttttct ctgccccaga caccacaaac tgacaacccc
     2581 tcagagggcc gaggagaagg cgtctccaag tcatttagtg atcatggttt ctattcccct
     2641 tcctccacgc tgggggactc tccgttggtt gatgacccct tggagtatca ggctggcctc
     2701 ctggtgcaga atgccattca acaagccata gccgagcagg tggataaagc tgtgtccaaa
     2761 accagcaggg atggagcaga gcaacaggga cctgaagcga ctgtagagga agctgaagct
     2821 gcggctttcg gctcagaaaa gcctcagagc atgtttgagc cacctcaggt gtcttctcct
     2881 gttcaagaga aaagggatgt attaccaaag attctgcctg ctgaagacag ggcgctcagg
     2941 gaaagggggc ccccccagcc actgccagct gtgcagccca gtggcccgat taacatggag
     3001 gagaccaggc ccgaaggaag ctatttcagc aagtactcgg aggcagctga gctgagaagc
     3061 acagcctccc tcctggccac tcaagaatct gacgtgatgg ttgggccttt caagctgagg
     3121 tccaggaaac agcggacttt gtccatgatt gaggaagaga tccgagcagc tcaggaaagg
     3181 gaagaggagc tgaagaggca gagacaagtc ttgcagagta cgcagagccc caggacaaag
     3241 aatgccccat cactgccctc cagaacatgc tacaaaactg ctccagggaa aatagagaaa
     3301 gtcaaacctc ctccatcccc caccactgaa ggccccagct tgcagcctga cttagcccct
     3361 gaagaggctg ccggaaccca gcggcccaag aatctgatgc agaccctcat ggaagactat
     3421 gagacacaca aatctaaaag gcgcgagaga atggatgata gtagttacac ttctaagtta
     3481 ctgtcttgca aggtgacttc cgaggtcctc gaggccacac gggttaatcg aagaaagagc
     3541 gcactggctt tgcgctggga agcagggatc tatgccaacc aggaggaaga agacaacgaa
     3601 taaacttcct tcaacccagg aagcgtcttt ggtgcttggg agaccaagaa accaagaaat
     3661 taacaactga aagcatttta atggactatt tattaaagtg caaacaaact cagcaatcct
     3721 tatgtagacc agaagctgca atatacaatg atgaaaatga aacgaaaagg aagtcccccc
     3781 atcagactct ggacacccag gaatcaaaag agaaaggact tttttggtga ctcaatccca
     3841 gtgtctggtt tggggccaat ctacaatgga tccaaaagga caaaacatgt tacaagcaaa
     3901 tcaacatagt tgctgcaggc ggaactgaga ccagcctctc tgggcgatga aggacaatgg
     3961 tggtagggcc acttagagag cagtagggcc caggctggtg cagcctacat ggcacaggat
     4021 atttccctgc accagtttcc cacctgtcac ttgcagcatc agagggtgtt gcattaactc
     4081 cattttctcc agcagccata aaatgaatgg cgtttctctc catatttgcc cagaagaggc
     4141 agttatgatt ccacttctcc tacatttaat tatttttaat tgagaacaac tcatgatcac
     4201 aattcataaa atccatattt taagacaata gttcttcatg tcacaaacac aatctattct
     4261 acatgaggag gctgagaaag gggaagagaa aaacaaacca aatggatgat gttagcttta
     4321 ggatcgtgtc tgcttataat attcactgat ctgcagttta tgagaacaca ttttcacagt
     4381 tatgtttctt cataggaaaa ctatatttag tgggcaacaa ctatttttat gatgggatgg
     4441 gggagtatat acacgtatag aatctgtacg cgttgaacaa cttggttcaa gatggtgggg
     4501 gcatttttag agcggcaata attgaaaaaa aaggcgaact ctgccttgga gaggtagatg
     4561 ataagaaata aaaaggtgtt tataactatt ttgtattata aagtgggcct tagagatagg
     4621 aagaagaatg atggattcct tttggatcaa tcagaaagga aacacgaaag aaaagtcagg
     4681 aaggtagaga gagaaaaagg gagggaagga gaaagaatgg gaataaaata aggaggtaag
     4741 agatactatt tttgctgagc aaccagtgtg tttcaggatg atacaaagaa aaatatagaa
     4801 tagaaataag tgcaggcttg gaatcagcta caaatcctaa agatggggtg tgtgtggatg
     4861 tgtgtgtgtg tgtgtgtaca ccattgtgtg tttgtaaaat gtgtatgttc atgagtaagg
     4921 gtgtgtgtgt gtgtgtatta aaattccaga gtgaccgtgg cacttgggtg tacaggtaat
     4981 tcctccagag ctgtttgctg gcttcaggag tggagtgaga atttcttttt tatgaaaagg
     5041 gatataaagg caccgagctg atgcagtatt tgtaatatta agttgaccta acaaggtatt
     5101 tgcatgagtc acaattacaa agttttgagc ggttttgtaa tttgacattt aggagagtct
     5161 cctatttatt ctcatacttt acattcatgc ttagtatact atagaggatg ccagctttaa
     5221 tctttctgtc atttaaagca atatgataag ggtattcaat aattgggtgc cctaaatttc
     5281 tggatgagaa aattttcaat tctggccatg agaaagaaaa aaaaataaac agccttcttt
     5341 ttttttcctt tgttttaaaa ctgtggtttt ttaaaaaagc aataattaac tcagacctca
     5401 ctaaaaatca tttttgtttt tatattgtta tgtcataagc tctattatgt tattctaaca
     5461 agtagcaatt tcacaaaatt tgtatgtaga tgttaacgca catttccttt gcttctttta
     5521 ttagactagt gttgactttg gggggggaca tttattcaca aatgagaagt aggcacaaag
     5581 taaaaaatgg aaccatctac taacaaggat cctttaaaac tgccaaggga gctctaactt
     5641 gaagccacat cctacagatg gcagcccaaa tagcacatgg gcaattggca ccatctttat
     5701 atggttgagt ctcctgaata ttttgaatga attctcaaca aaatgtgcta gccactgggg
     5761 acgcaaaaca agtaagatcc ctgttgcaag aaattcattt tatagtgagg gaggttggca
     5821 tggagactaa aattctcagg aaaatgagat ccgtgttaga ttagaagtcc tgatgtgaaa
     5881 tgggaggact caggaaggag gatcgtcttt acctgaggat ttctagccag aggtcccaga
     5941 tgcctgggct gagaacccag cgataagggg gcgttcccaa agcagacaca gggataagaa
     6001 cagaggaggc agcagcattg cacagcccca ggcacagtgg cagttaggat ggctggagag
     6061 taggatagtt ctatgggttg cccaaaaaat gtgatgcgct tcatgttttc tctgactcat
     6121 ggatctggta gagaccatag acatgatata gactaacttc cccatttttc acaagaggaa
     6181 accatcctta tgacttacct taaagttttt tgttctgttt tgaaggaaac catgtgcttc
     6241 atgaaaccta cagttgacaa gagaatgtac agctaagaga aaagcttaag aggccacact
     6301 attcgcggaa tggctttaga ggcagatgaa gtggtctttg accacagttg attgaaccag
     6361 agcacttatt gcttaaagaa taacagagtt ctagagctgg gggttcttgg gccatgctcc
     6421 gtgtgtggat aaggaaagaa atactgtttc tgggactctc ccacagtcac aaagctgttt
     6481 tcactgtggc ccctacatct cttaactttt gctattactc ctatgctgcc ttccggatta
     6541 ctgctgtcta tcttcttgct ccactcactg aagatcctat tataatccca tgaaaatgta
     6601 aattacagtt tacttgggag agccagattt tctctgtgct cttgagtttt ttattcattc
     6661 aagaaacctt gggccaccgc tttgtacata gcaccgtgct aggctctggg atcccaaatg
     6721 gaccctttta actttctgaa gatgggaccg tcccctggag gaaagtcatt cctgcctaat
     6781 ccatcgagag aaagaggctt acgaaaaact ttgcctctga tgctcagccc cacccccaaa
     6841 tagcacacaa gcttgttaac cccacctctt acaaaatgtt tagattctgt aggtgttaaa
     6901 agcctttctg gaagtattgc attctgccgt gtttataggt gttcactttc ctccagagct
     6961 gattaactac tgacatgact tggctttctc atccagaaat tatggaaaca gggtctgtca
     7021 gtggcaggag gccgtgctgt gttttacttg gatgacacaa tgcagtttac ttgcctcttc
     7081 atacccatgc atgctgctca ccctagacaa tgacatataa gccgtatata gatcaatgtc
     7141 cacatatata tacacacaca catatatata tataaagtgt aacaaggaac actaaaacag
     7201 tgttgattct tgtctctgaa gacaaataat taaacctttt ttttcccaac taaagaatgg
     7261 atttaattaa actatgtatt gaaaaaaaag tagcctaagt gttagagatg gtgaatatat
     7321 tccattttag ttaaagaaca aatttcctga attttaagca ttcagtgagc tgccaatttt
     7381 gattttgtgt tgctctttac ccaaattatt ttttctttgt ttttcttttt ttgggggagg
     7441 aggggaaaaa agcagcaata ctgtgtttgg aaattatact ctgtatctgg ttttcctgtg
     7501 tatgttaacc acttaaatgt tattatcctg ctttggtttt agagtgattg tgaggcattc
     7561 aatgcaagta tacagttatt ttctcattaa aatccaatgt gtgttgagtt tttataaa
//
