LOCUS       NM_002579               2891 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens paralemmin (PALM), transcript variant 1, mRNA.
ACCESSION   NM_002579
VERSION     NM_002579.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Basile,M., Lin,R., Kabbani,N., Karpa,K., Kilimann,M., Simpson,I.
            and Kester,M.
  TITLE     Paralemmin interacts with D3 dopamine receptors: implications for
            membrane localization and cAMP signaling
  JOURNAL   Arch Biochem Biophys 446 (1), 60-68 (2006)
   PUBMED   16386234
REFERENCE   3  (bases 1 to 2891)
  AUTHORS   Gauthier-Campbell,C., Bredt,D.S., Murphy,T.H. and
            El-Husseini,Ael.-D.
  TITLE     Regulation of dendritic branching and filopodia formation in
            hippocampal neurons by specific acylated protein motifs
  JOURNAL   Mol Biol Cell 15 (5), 2205-2217 (2004)
   PUBMED   14978216
REFERENCE   4  (bases 1 to 2891)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   5  (bases 1 to 2891)
  AUTHORS   Kutzleb,C., Sanders,G., Yamamoto,R., Wang,X., Lichte,B.,
            Petrasch-Parwez,E. and Kilimann,M.W.
  TITLE     Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in
            neurons and implicated in plasma membrane dynamics and cell process
            formation
  JOURNAL   J Cell Biol 143 (3), 795-813 (1998)
   PUBMED   9813098
REFERENCE   6  (bases 1 to 2891)
  AUTHORS   Burwinkel,B., Miglierini,G., Jenne,D.E., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A., Ring,H.Z., Francke,U. and
            Kilimann,M.W.
  TITLE     Structure of the human paralemmin gene (PALM), mapping to human
            chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding
            mutations in grizzled, mocha, jittery, and hesitant mice
  JOURNAL   Genomics 49 (3), 462-466 (1998)
   PUBMED   9615234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005763.1, BU508077.1,
            BC032449.1, BP199809.1 and BM667870.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002579.2.
            
            Summary: This gene encodes a member of the paralemmin protein
            family. The product of this gene is a prenylated and palmitoylated
            phosphoprotein that associates with the cytoplasmic face of plasma
            membranes and is implicated in plasma membrane dynamics in neurons
            and other cell types. Several alternatively spliced transcript
            variants have been identified, but the full-length nature of only
            two transcript variants has been determined. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032449.1, SRR3476690.240224.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338448.10/ ENSP00000341911.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC005763.1         11874-11891
            19-170              BU508077.1         1-152
            171-1711            BC032449.1         1-1541
            1712-2153           BP199809.1         127-568
            2154-2459           BC032449.1         1984-2289
            2460-2891           BM667870.1         18-449              c
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2891
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /note="paralemmin"
                     /db_xref="GeneID:5064"
                     /db_xref="HGNC:HGNC:8594"
                     /db_xref="MIM:608134"
     exon            1..217
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1376
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paralemmin-1"
                     /codon_start=1
                     /product="paralemmin-1 isoform 1"
                     /protein_id="NP_002570.2"
                     /db_xref="CCDS:CCDS32857.1"
                     /db_xref="GeneID:5064"
                     /db_xref="HGNC:HGNC:8594"
                     /db_xref="MIM:608134"
                     /translation="MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQH
                     LKSKALRERWLLEGTPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGD
                     SAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVD
                     GSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDG
                     TAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGV
                     QAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDA
                     AEPKEPAPPNGSAAEPPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM"
     exon            218..269
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..350
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..481
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..632
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..654
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..714
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..846
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..2891
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /note="hexamer: AATAAA"
     polyA_site      2891
                     /gene="PALM"
                     /gene_synonym="PALM1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcccgccg ccgcccggac aataaacagc agctttgcgc ggggcgatgc ccgagccggt
       61 gccgccgccc ccgcgccgcg cagccccggc cgccaggcct tagcccgccc cggcccccgc
      121 caggccgcgt ccccctcccc tcccctcccc cgcgcgccac ccgcgcccgc ccccgcccgg
      181 caccgcggac ccacccggac ctcggcgggg agatggaggt cctggcggca gagaccacgt
      241 cccagcagga gcggctgcag gccatcgcag agaagcggaa gcggcaggcg gagatcgaga
      301 acaagcgccg gcagctggag gacgagcgga ggcagctgca gcacctgaag tccaaggcac
      361 tgcgggagcg ctggctgctg gaggggacgc cgtcctcggc ctcagagggg gatgaggacc
      421 tgaggaggca gatgcaggac gacgagcaga agacacggct gctggaggac tcggtgtcca
      481 ggttggagaa ggaaattgag gtgctggagc gtggagactc cgccccagcc actgccaagg
      541 agaacgcggc ggccccgagc ccagtccggg ccccagcccc gagtccagcc aaggaggagc
      601 gcaagacaga ggtggtgatg aattcacagc agacgccggt gggcacgccc aaagacaagc
      661 gagtctccaa cacgcccctg aggacggttg acggctcccc catgatgaag gcagccatgt
      721 actcggttga gatcactgtg gagaaggaca aggtgacagg ggagaccagg gtgctgtcca
      781 gcaccacgct gctccctcgg cagccgctcc ctctgggcat caaagtctac gaggacgaga
      841 ccaaagtggt ccatgctgtg gacggcaccg ccgagaacgg gatccacccc ctgagctcct
      901 ccgaggtgga cgaactcatc cacaaagcgg acgaggtcac gctgagcgag gcagggtcca
      961 cggccggggc ggcagagacc cggggggctg tggagggggc agcccggacc acgccctccc
     1021 ggcgggagat caccggtgtg caggcacagc caggcgaggc cacgtccggc ccgccgggga
     1081 tccagcccgg ccaggagccc ccggtcacaa tgatcttcat gggttaccag aacgtggagg
     1141 atgaggccga gaccaagaag gtgctgggcc ttcaagatac catcacggcg gagctggtgg
     1201 tcatcgaaga cgcggctgag cccaaggagc ctgcaccacc caacggcagt gctgccgagc
     1261 ctcccacgga ggccgcctcc agggaagaga atcaggcggg gcccgaggcc accaccagcg
     1321 acccccagga cctcgacatg aagaagcacc gttgtaaatg ctgctccatc atgtgagccg
     1381 gcccccgaga ccccggcccc caccccacac cacagacacc caccagcccg gcccctcccg
     1441 gcgcctgccc accctccacc cacagcctca cgggtccagg acttggcgtg ttgttacatg
     1501 ttccttccga gttttctttc gctggaaaga gggacagggg cccccacccg tcaccacgcc
     1561 ccaacactcc ccccgaacca gagccgtgca cttgtgcctg gtaggagaga gacaggacag
     1621 acccgctttt cccgagacaa ggacccccca tgtcacggca gcttcacaga cgcggctcgc
     1681 gcccaccggg gtcctggcgg gtgggacccg cagcctccac gcggcccagg ccagcctgcc
     1741 accctctggg cctcctacct gtgcctttct ctgaggggac accccgccag agagggcccc
     1801 gggagccggg ggtgggtact gaggcctgct caggccctgg aagtgaggct ctatggggtt
     1861 ccctggccaa ggcgctggcc ccccaatctc aggcagttgg ggtgaggccg tgcctctttg
     1921 ggggctaaag gtcttgggtg gaggacaggc ccctctgctg tgcccctatg ccctgtgtgg
     1981 gcccaaccag tggacaatgg agtctggggg agggggaacc ccggggacat gcccccaccc
     2041 gggaggggcc ggtaacccct gggctatctt ctagacgggg cgaaccaggg gtcattgacc
     2101 tgccccctgc acagggcagg gaccgagtga gccactcctt gtcccgagct cccgccccca
     2161 ctgggccctc cttcctcctg gtgctaattt ggggacccca ggggccgccc ccggcctctt
     2221 ctccatcctg cttggaccag ggtcctgggt cttcccaacc ataccccgag atcaggcccc
     2281 acctgccagc tctactgggc ttggagcacg tccgggcagt ggagggaggg acacagcctg
     2341 ggacaggaag cctcttgggt tggagcagga gaccctcatt tgccacccag accaatgtga
     2401 gcctgccccc agccccctct cattggaagt ggcaaggggc ttccctcctg ggggcagcta
     2461 cactcgtccc cagaggcaca ttcgtgcaca ttctcacaga caccgtctca cacgttggct
     2521 ttggacaacc aggccccaac ttggtccctg ccctagggac ctccagcctg gtgcccagtg
     2581 ctcaggccac ctcctggtcc agtcaccacc tgcagcctcg gcagggcagg tacaggggcc
     2641 acctcggatg ggagcctggg tccctgcctc cgctctgccc ctgggtggct gggaggagag
     2701 gccctctcgg gggtgacctg ggcgtcagcc gtggaacccc ctcctcctcc ctggagtctg
     2761 cctgagtccc tcgagccgcg agccttcgct gaagtgccct tgctataacc ccctctgctt
     2821 ctggtgtgtg acgaggcccc cgatgttctt gattttccca gagaagcaaa taaacagcgt
     2881 gaacagcccc a
//
