LOCUS       NM_001166108            5858 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens palladin, cytoskeletal associated protein (PALLD),
            transcript variant 1, mRNA.
ACCESSION   NM_001166108
VERSION     NM_001166108.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5858)
  AUTHORS   Huang,Z., Zeng,Z., Li,J., Cai,R., He,W. and Hu,S.
  TITLE     [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1371-1378 (2023)
   PUBMED   37712274
  REMARK    GeneRIF: [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4].
REFERENCE   2  (bases 1 to 5858)
  AUTHORS   Shu,X., Chen,M., Liu,S.Y., Yu,L., Sun,L.X., Sun,L.C. and Ran,Y.L.
  TITLE     Palladin promotes cancer stem cell-like properties in lung cancer
            by activating Wnt/Beta-Catenin signaling
  JOURNAL   Cancer Med 12 (4), 4510-4520 (2023)
   PUBMED   36047666
  REMARK    GeneRIF: Palladin promotes cancer stem cell-like properties in lung
            cancer by activating Wnt/Beta-Catenin signaling.
REFERENCE   3  (bases 1 to 5858)
  AUTHORS   Zhang,T., Song,C., Li,H., Zheng,Y. and Zhang,Y.
  TITLE     Different Extracellular beta-Amyloid (1-42) Aggregates
            Differentially Impair Neural Cell Adhesion and Neurite Outgrowth
            through Differential Induction of Scaffold Palladin
  JOURNAL   Biomolecules 12 (12), 1808 (2022)
   PUBMED   36551236
  REMARK    GeneRIF: Different Extracellular beta-Amyloid (1-42) Aggregates
            Differentially Impair Neural Cell Adhesion and Neurite Outgrowth
            through Differential Induction of Scaffold Palladin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5858)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5858)
  AUTHORS   Liotta,L., Lange,S., Maurer,H.C., Olive,K.P., Braren,R., Pfarr,N.,
            Burger,S., Muckenhuber,A., Jesinghaus,M., Steiger,K., Weichert,W.,
            Friess,H., Schmid,R., Algul,H., Jost,P.J., Ramser,J., Fischer,C.,
            Quante,A.S., Reichert,M. and Quante,M.
  TITLE     PALLD mutation in a European family conveys a stromal
            predisposition for familial pancreatic cancer
  JOURNAL   JCI Insight 6 (8), 141532 (2021)
   PUBMED   33764904
  REMARK    GeneRIF: PALLD mutation in a European family conveys a stromal
            predisposition for familial pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5858)
  AUTHORS   Ronty,M.J., Leivonen,S.K., Hinz,B., Rachlin,A., Otey,C.A.,
            Kahari,V.M. and Carpen,O.M.
  TITLE     Isoform-specific regulation of the actin-organizing protein
            palladin during TGF-beta1-induced myofibroblast differentiation
  JOURNAL   J Invest Dermatol 126 (11), 2387-2396 (2006)
   PUBMED   16794588
  REMARK    GeneRIF: These results identify palladin 4Ig as a novel marker of
            myofibroblast conversion in vitro and in vivo.
REFERENCE   7  (bases 1 to 5858)
  AUTHORS   Eberle,M.A., Pfutzer,R., Pogue-Geile,K.L., Bronner,M.P.,
            Crispin,D., Kimmey,M.B., Duerr,R.H., Kruglyak,L., Whitcomb,D.C. and
            Brentnall,T.A.
  TITLE     A new susceptibility locus for autosomal dominant pancreatic cancer
            maps to chromosome 4q32-34
  JOURNAL   Am J Hum Genet 70 (4), 1044-1048 (2002)
   PUBMED   11870593
REFERENCE   8  (bases 1 to 5858)
  AUTHORS   Mykkanen,O.M., Gronholm,M., Ronty,M., Lalowski,M., Salmikangas,P.,
            Suila,H. and Carpen,O.
  TITLE     Characterization of human palladin, a microfilament-associated
            protein
  JOURNAL   Mol Biol Cell 12 (10), 3060-3073 (2001)
   PUBMED   11598191
REFERENCE   9  (bases 1 to 5858)
  AUTHORS   Bang,M.L., Mudry,R.E., McElhinny,A.S., Trombitas,K., Geach,A.J.,
            Yamasaki,R., Sorimachi,H., Granzier,H., Gregorio,C.C. and Labeit,S.
  TITLE     Myopalladin, a novel 145-kilodalton sarcomeric protein with
            multiple roles in Z-disc and I-band protein assemblies
  JOURNAL   J Cell Biol 153 (2), 413-427 (2001)
   PUBMED   11309420
REFERENCE   10 (bases 1 to 5858)
  AUTHORS   Parast,M.M. and Otey,C.A.
  TITLE     Characterization of palladin, a novel protein localized to stress
            fibers and cell adhesions
  JOURNAL   J Cell Biol 150 (3), 643-656 (2000)
   PUBMED   10931874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079926.7, AF464873.1,
            BC144666.1, AK025843.1, AF077041.1 and AI418424.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001166108.1.
            
            Summary: This gene encodes a cytoskeletal protein that is required
            for organizing the actin cytoskeleton. The protein is a component
            of actin-containing microfilaments, and it is involved in the
            control of cell shape, adhesion, and contraction. Polymorphisms in
            this gene are associated with a susceptibility to pancreatic cancer
            type 1, and also with a risk for myocardial infarction. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505667.6/ ENSP00000425556.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC079926.7         108773-108786       c
            15-52               AF464873.1         1-38
            53-3689             BC144666.1         1-3637
            3690-3922           AK025843.1         1170-1402
            3923-5654           AF077041.1         1925-3656
            5655-5858           AI418424.1         27-230              c
FEATURES             Location/Qualifiers
     source          1..5858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..5858
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /note="palladin, cytoskeletal associated protein"
                     /db_xref="GeneID:23022"
                     /db_xref="HGNC:HGNC:17068"
                     /db_xref="MIM:608092"
     exon            1..143
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            144..1133
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3597
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myoneurin; sarcoma antigen NY-SAR-77"
                     /codon_start=1
                     /product="palladin isoform 1"
                     /protein_id="NP_001159580.1"
                     /db_xref="CCDS:CCDS54818.1"
                     /db_xref="GeneID:23022"
                     /db_xref="HGNC:HGNC:17068"
                     /db_xref="MIM:608092"
                     /translation="MSGTSSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLD
                     LARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPV
                     QPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQR
                     KGGPQSQLCDKAANLIEELTSIFKAAKPRNRSPNGESSSPDSGYLSPKNQPSALLSAS
                     ASQSPMEDQGEMEREVKSPGARHCYQDNQDLAVPHNRKSHPQPHSALHFPAAPRFIQK
                     LRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEA
                     FEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTTS
                     VSLTIGSSSPKTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVFTKELQNT
                     AVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVI
                     AETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNNDHFQHFPPPP
                     PILETSSLELASKKPSEIQQVNNPELGLSRAALQMQFNAAERETNGVHPSRGVNGLIN
                     GKANSNKSLPTPAVLLSPTKEPPPLLAKPKLGFPKKASRTARIASDEEIQGTKDAVIQ
                     DLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQDIGSPHA
                     SVGSPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEM
                     KLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTT
                     ASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDS
                     GDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDS
                     AHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFI
                     EKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLI
                     QGATKEDAGWYTVSAKNEAGIVSCTARLDVYISRH"
     exon            1134..1312
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1379
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1485
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1560
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1702
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1726
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1846
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2189
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2325
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2424
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2475
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2697
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2847
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2942
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3075
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3283
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3449
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3583
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3629
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..5858
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5815..5820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /note="hexamer: AATAAA"
     polyA_site      5834
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
                     /note="major polyA site"
     polyA_site      5858
                     /gene="PALLD"
                     /gene_synonym="CGI-151; CGI151; MYN; PNCA1; SIH002"
ORIGIN      
        1 acagttgcct caaagtgacc acggaccagg cagtctctaa tgaataggca aggccacaac
       61 ctccattctc ccagaaaaga agaaatgctc atctgaaatt catcacctct ctggagtctt
      121 caaactgacc aagcattgaa aagaacacag tttcagaaaa cagtttccag tgcctctggc
      181 cttcctactg aaagcagaca cagagtgcat gaagaccgtt caaatatgtc agggacctcc
      241 tcccatgagt ccttctatga ctccctctca gacatgcagg aagaaagcaa gaatactgac
      301 ttcttcccgg gcctttctgc tttcctcagc caggaagaga taaacaagag tcttgacctg
      361 gcccggagag ccatagccga ctccgaaaca gaagattttg actcggaaaa ggagatctcg
      421 cagattttca gtacttctcc tgcaagcctc tgtgaacatc cttcccataa ggagaccaaa
      481 ttgggtgaac acgcctcgag gagacctcag gataacaggt caacacctgt ccagcctctg
      541 gcagagaaac aaactaagag tatctcttca cctgtttcaa agaggaaacc tgccatgtca
      601 cccctgctca ccaggcccag ctacatccgg agcctccgaa aggctgaaaa gcgtggtgca
      661 aaaactccca gcacaaacgt aaagcccaaa acgccacatc aaagaaaggg tggcccccag
      721 agccagctgt gtgacaaggc agctaattta attgaggagc taacatccat atttaaagcc
      781 gcaaagccaa gaaacagaag cccaaatggg gagtcctcgt caccagacag tgggtacctg
      841 tctcctaaaa atcagccgtc agccctgctg agtgcctcag ccagccagag ccctatggaa
      901 gaccaagggg agatggaaag agaggtcaag tcccctgggg ccaggcattg ctaccaggac
      961 aaccaggact tggcagtgcc acacaaccgc aagtctcacc cacagcccca cagcgccctc
     1021 cacttcccag ctgcacctcg attcatccaa aagctgagga gccaagaagt agcagaaggg
     1081 agccgagttt atctggagtg tagagtcact ggaaacccca ctcctcgagt cagatggttc
     1141 tgtgaaggga aagaactgca caacactcct gatattcaaa tccactgtga gggaggggac
     1201 ctccataccc tgatcatagc agaggccttt gaggacgaca caggtcgcta cacctgtttg
     1261 gctacgaatc ccagcggctc agacacaaca tctgctgagg tgttcattga aggtgccagt
     1321 tcaacagatt ctgacagtga aagtttagct ttcaaatcaa gagctggagc tatgccacaa
     1381 gctcaaaaga aaacaacttc tgtttccttg acaataggat catcatctcc aaagacaggg
     1441 gtgaccacag ctgtgattca accactgtct gtccctgtgc aacaggttca cagtccaact
     1501 tcatatctct gccgacctga tggaaccact actgcctact ttcctcctgt ttttacaaag
     1561 gaactgcaaa acacagccgt ggcggaaggc caggtggtgg ttctggagtg ccgggtccgt
     1621 ggggcacccc ctctgcaggt ccagtggttt cggcaaggga gtgaaatcca agactctcca
     1681 gatttccgaa ttctacagaa aaaacctaga tctacagctg aacctgagga gatttgcacc
     1741 ctagttatcg ctgagacttt ccctgaagat gcagggatct ttacatgttc agcaagaaat
     1801 gattatggat cagcaaccag cactgcccag ctggttgtca cctcagccaa cactgaaaac
     1861 tgtagttacg agtcaatggg agaatccaac aatgaccact tccaacactt tccacctccc
     1921 cctccaatct tggagacaag ttccttggag ttggcttcaa agaaaccatc tgagatccag
     1981 caggtgaaca accctgagtt aggcctgagc agggcagccc ttcaaatgca attcaatgct
     2041 gctgagaggg aaacgaacgg agtccatccc agccgtggag taaatggact gattaacggc
     2101 aaagctaaca gtaataaatc tcttccaaca ccagctgtcc tgctttcacc cactaaggag
     2161 ccaccacctc tgcttgccaa accaaaacta ggatttccaa agaaggccag tagaactgct
     2221 agaatagcct ccgatgagga aattcaaggc acaaaggatg ctgttattca agacctggaa
     2281 cgaaaacttc gcttcaagga ggacctcctg aacaatggcc agccgaggtt aacatacgaa
     2341 gaaagaatgg ctcgtcgact gctaggtgct gacagtgcaa ctgtctttaa tattcaggag
     2401 ccagaagagg aaacagctaa tcaggacatt ggttctcctc atgcttctgt agggagtcct
     2461 ctggatggtc aaaaggaata caaagtctcc agctgtgaac agagactcat cagtgaaata
     2521 gagtacaggc tagaaaggtc tcctgtggat gaatcaggtg atgaagttca gtatggagat
     2581 gtgcctgtgg aaaatggaat ggcaccattc tttgagatga agctgaaaca ttacaagatc
     2641 tttgagggaa tgccagtaac tttcacatgt agagtggctg gaaatccaaa gccaaagatc
     2701 tattggttta aagatgggaa gcagatctct ccaaagagtg atcactacac cattcaaaga
     2761 gatctcgatg ggacctgctc cctccatacc acagcctcca ccctagatga tgatgggaat
     2821 tatacaatta tggctgcaaa ccctcagggc cgcatcagtt gtactggacg gctaatggta
     2881 caggctgtca accaaagagg tcgaagtccc cggtctccct caggccatcc tcatgtcaga
     2941 aggcctcgtt ctagatcaag ggacagtgga gacgaaaatg aaccaattca ggagcgattc
     3001 ttcagacctc acttcttgca ggctcctgga gatctgactg ttcaagaagg aaaactctgc
     3061 agaatggact gcaaagtcag tgggttacca accccagatc taagctggca actagatgga
     3121 aagcccgtac gccctgacag tgctcacaag atgctggtgc gtgagaacgg ggtgcactct
     3181 ctgatcatag agccagtcac gtcacgtgat gccggcatct acacatgtat agctaccaac
     3241 cgagcaggac agaactcatt cagcctggag cttgtggttg ctgctaaaga agcacacaaa
     3301 ccccctgtgt ttattgagaa gctccaaaac acaggagttg ctgatgggta cccagtgcgg
     3361 ctggaatgtc gtgtattggg agtgccacca cctcagatat tttggaagaa agaaaatgaa
     3421 tcactcactc acagcactga ccgagtgagc atgcaccagg acaaccacgg ctacatctgc
     3481 ctgctcattc agggagccac aaaagaagat gctgggtggt atactgtgtc agccaagaat
     3541 gaagcaggga ttgtgtcctg tactgccagg ctggacgttt acatttctcg acattaatag
     3601 tgaaccacac caggagaaca aatacccaac ccagtggcat cagcagtcac agagcaccaa
     3661 gccaaaaaaa gtacggccct cagccagtcg ctatgcagca ctttcggacc agggactaga
     3721 catcaaagca gcgttccaac ctgaggccaa cccatctcac ctgacactga atactgcctt
     3781 ggtagaaagt gaggacctgt aatccagcat tcttgttaaa gctgaaacac tgaaacagcc
     3841 attgccttga ccaacatatt cctttgtcac attatgtaaa aggcagaaac atacctttga
     3901 ctataagaaa ttaaaaaaaa aacaccaaaa taatattttt cttacttgat ataccaaact
     3961 tagtttaagt agataatgct aatacaaata tacacattgc acagaaaata cacatttact
     4021 gtccaattta aaactttgga attgctgtga ttaaagtgat caaaatgcca aaatactaaa
     4081 ggaaatcaat tgttcacagg taactacaat ttgtattatc tacaagtgcc tttaaacaca
     4141 agatataggt gctgtgtagc ctgatagtgt gaaatgttta atgagggagt tgtaccacaa
     4201 acagtactac aatgattctg aagcacagtg tattcagaca gatacagtga accaagtgca
     4261 atatgtaagg atgaaagaag aagagatgac aaagaaatcc aagtaaatgc cttgtctttg
     4321 caaatgtttt tatattaaat cataaggaag gaactacttg ccttaaatgt taatatcaaa
     4381 agagttttct aacaaggtta ataccttagt tcttaacatt ttttttcttt atgtgtagtg
     4441 ttttcatgct accttggtag gaaacttatt tacaaaccat attaaaaggc taatttaaat
     4501 ataaataata taaagtgctc tgaataaagc agaaatatat tacagttcat tccacagaaa
     4561 gcatccaaac cacccaaatg accaaggcat atatagtatt tggaggaatc aggggtttgg
     4621 aaggagtagg gaggagaatg aaggaaaatg caaccagcat gattatagtg tgttcattta
     4681 gataaaagta gaaggcacag gagaggtagc aaaggccagg cttttctttg gttttcttca
     4741 aacataggtg aaaaaaacac tgccattcac aagtcaagga acccagggcc agctggaagt
     4801 gtggagcaca catgctgtgg agcacacatg ctgtggagat tgcagtgtgt ctgaggtttg
     4861 tgtagtagtg gaagatttta ggtatgtaga gcaagttgaa aatggattga gactgcatgg
     4921 tggcataaat gagaaattgc ctgtagcatc tagtctactt gaaggaagtg gagacataag
     4981 gagagacaaa aacaggtttg tgccataaag tattttttca aagacaccaa gatgtggtaa
     5041 atgaaaatta ttagttcact tccctgctgc catgaaactt tgccttaaga aggtgctgga
     5101 ttccaaggtt tgtaaaggca tctcggtaaa gactgctttt tgaatgcata tgattttgca
     5161 tcagctagac tgagttgatt ctgaccagac ttgatggttt taagtcggaa ccgataaatt
     5221 ttaaaaagga gaaaaaataa tttgacctag tagtataaaa catgaggctt taatggtact
     5281 ttgctatgaa aagaaaacac tgtattcctt atgcaaaaca catgtatctt tcattattta
     5341 taagtggcct ctcttagctc agttactcaa ttcatacgta gtatttttta aaataatttt
     5401 atatctgtgt accaccccat atatttcata ttactgtttc acatgtacag ctttctactt
     5461 ctttgtaaga acaccaacca accaaggttt aagtgattaa taggcttgag caccgggtgg
     5521 cagatgttct atgcagtgtg gttcaagttt ctttgaccgc acttatatgc attgctaata
     5581 tggaatttaa gataccatac acagtctctc atggacctat ctctattgta gaattatgac
     5641 ttatgtctta cttgccaaat ttttctgaat gtgacctttt tttgctgatt tgctgggttt
     5701 gggattaact agcattattt tgccaccttt atattgtatt tataaaaaaa aaagtactat
     5761 caatcaatca tactactttg gattgttgtg ctggtgtaat gtggatttaa catcaataaa
     5821 tatttgacaa ataatagttg cagttttgtg aagcaaaa
//
