LOCUS       NM_014431               4610 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phosphatase domain containing paladin 1 (PALD1), mRNA.
ACCESSION   NM_014431 XM_166125
VERSION     NM_014431.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4610)
  AUTHORS   Sommerer,Y., Dobricic,V., Schilling,M., Ohlei,O., Sabet,S.S.,
            Wesse,T., Fuss,J., Franzenburg,S., Franke,A., Parkkinen,L.,
            Lill,C.M. and Bertram,L.
  TITLE     Entorhinal cortex epigenome-wide association study highlights four
            novel loci showing differential methylation in Alzheimer's disease
  JOURNAL   Alzheimers Res Ther 15 (1), 92 (2023)
   PUBMED   37149695
  REMARK    GeneRIF: Entorhinal cortex epigenome-wide association study
            highlights four novel loci showing differential methylation in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4610)
  AUTHORS   Egana,I., Kaito,H., Nitzsche,A., Becker,L., Ballester-Lopez,C.,
            Niaudet,C., Petkova,M., Liu,W., Vanlandewijck,M., Vernaleken,A.,
            Klopstock,T., Fuchs,H., Gailus-Durner,V., Hrabe de Angelis,M.,
            Rask-Andersen,H., Johansson,H.J., Lehtio,J., He,L., Yildirim,A.O.
            and Hellstrom,M.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Female mice lacking Pald1 exhibit endothelial cell apoptosis and
            emphysema
  JOURNAL   Sci Rep 7 (1), 15453 (2017)
   PUBMED   29133847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4610)
  AUTHORS   Wallgard,E., Nitzsche,A., Larsson,J., Guo,X., Dieterich,L.C.,
            Dimberg,A., Olofsson,T., Ponten,F.C., Makinen,T., Kalen,M. and
            Hellstrom,M.
  TITLE     Paladin (X99384) is expressed in the vasculature and shifts from
            endothelial to vascular smooth muscle cells during mouse
            development
  JOURNAL   Dev Dyn 241 (4), 770-786 (2012)
   PUBMED   22354871
REFERENCE   4  (bases 1 to 4610)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   5  (bases 1 to 4610)
  AUTHORS   Huang,S.M., Hancock,M.K., Pitman,J.L., Orth,A.P. and Gekakis,N.
  TITLE     Negative regulators of insulin signaling revealed in a genome-wide
            functional screen
  JOURNAL   PLoS One 4 (9), e6871 (2009)
   PUBMED   19727444
  REMARK    GeneRIF: PALD (KIAA1274, paladin) has a role in inhibition of
            insulin's ability to down regulate a FOXO1A-driven reporter gene,
            reduce upstream insulin-stimulated AKT phosphorylation, and
            decrease insulin receptor (IR) abundance
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4610)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022532.13, CN335744.1, BC040163.1 and AL355344.20.
            
            On Nov 22, 2018 this sequence version replaced NM_014431.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033100.2, SRR1803615.170526.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263563.7/ ENSP00000263563.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC022532.13        50588-50628         c
            42-625              CN335744.1         26-609
            626-2607            BC040163.1         88-2069
            2608-2608           AL355344.20        36993-36993
            2609-3355           BC040163.1         2071-2817
            3356-3356           AL355344.20        39802-39802
            3357-4169           BC040163.1         2819-3631
            4170-4572           BC040163.1         3634-4036
            4573-4610           BC040163.1         4038-4075
FEATURES             Location/Qualifiers
     source          1..4610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..4610
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /note="phosphatase domain containing paladin 1"
                     /db_xref="GeneID:27143"
                     /db_xref="HGNC:HGNC:23530"
                     /db_xref="MIM:614656"
     exon            1..293
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            294..507
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2893
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /note="palladin"
                     /codon_start=1
                     /product="paladin"
                     /protein_id="NP_055246.2"
                     /db_xref="CCDS:CCDS31215.1"
                     /db_xref="GeneID:27143"
                     /db_xref="HGNC:HGNC:23530"
                     /db_xref="MIM:614656"
                     /translation="MGTTASTAQQTVSAGTPFEGLQGSGTMDSRHSVSIHSFQSTSLH
                     NSKAKSIIPNKVAPVVITYNCKEEFQIHDELLKAHYTLGRLSDNTPEHYLVQGRYFLV
                     RDVTEKMDVLGTVGSCGAPNFRQVQGGLTVFGMGQPSLSGFRRVLQKLQKDGHRECVI
                     FCVREEPVLFLRADEDFVSYTPRDKQNLHENLQGLGPGVRVESLELAIRKEIHDFAQL
                     SENTYHVYHNTEDLWGEPHAVAIHGEDDLHVTEEVYKRPLFLQPTYRYHRLPLPEQGS
                     PLEAQLDAFVSVLRETPSLLQLRDAHGPPPALVFSCQMGVGRTNLGMVLGTLILLHRS
                     GTTSQPEAAPTQAKPLPMEQFQVIQSFLRMVPQGRRMVEEVDRAITACAELHDLKEVV
                     LENQKKLEGIRPESPAQGSGSRHSVWQRALWSLERYFYLILFNYYLHEQYPLAFALSF
                     SRWLCAHPELYRLPVTLSSAGPVAPRDLIARGSLREDDLVSPDALSTVREMDVANFRR
                     VPRMPIYGTAQPSAKALGSILAYLTDAKRRLRKVVWVSLREEAVLECDGHTYSLRWPG
                     PPVAPDQLETLEAQLKAHLSEPPPGKEGPLTYRFQTCLTMQEVFSQHRRACPGLTYHR
                     IPMPDFCAPREEDFDQLLEALRAALSKDPGTGFVFSCLSGQGRTTTAMVVAVLAFWHI
                     QGFPEVGEEELVSVPDAKFTKGEFQVVMKVVQLLPDGHRVKKEVDAALDTVSETMTPM
                     HYHLREIIICTYRQAKAAKEAQEMRRLQLRSLQYLERYVCLILFNAYLHLEKADSWQR
                     PFSTWMQEVASKAGIYEILNELGFPELESGEDQPFSRLRYRWQEQSCSLEPSAPEDLL
                     "
     exon            508..610
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            611..790
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            791..955
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1116
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1192
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1344
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1444
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1549
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1645
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1774
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1891
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2047
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2230
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2371
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2443
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2584
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2740
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..4610
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /note="hexamer: ATTAAA"
     polyA_site      4610
                     /gene="PALD1"
                     /gene_synonym="KIAA1274; PALD"
                     /note="major polyA site"
ORIGIN      
        1 ggcgttgggt agcggggcgc tggggagcag cgcggcgcgc acgggccggg gcgcgcaggt
       61 cccgtcgccg gtgagcacgg gctccctctc gcgtggcctc gccgggtccg cctggcctgc
      121 ccacctccgg agccacctct gcccccgcat gggctggcga agttgggagg agcgagctgg
      181 agccagagcg cgcgccgggc gcgccccgtc gctgcctgac tcggcgcccg cagttcgggc
      241 gcagcacgcc ggccgcagga gcacggatgc cccccggagc cgcgggctgg caggtctggg
      301 gtcctgaggc tgctggcaga ctatgggtac aacggccagc acagcccagc agacggtctc
      361 ggcaggcacc ccatttgagg gcctacaggg cagtggcacg atggacagtc ggcactccgt
      421 cagcatccac tccttccaga gcactagctt gcataacagc aaggccaagt ccatcatccc
      481 caacaaggtg gcccctgttg tgatcacgta caactgcaag gaggagttcc agatccatga
      541 tgagctgctc aaggctcatt acacgttggg ccggctctcg gacaacaccc ctgagcacta
      601 cctggtgcaa ggccgctact tcctggtgcg ggatgtcact gagaagatgg atgtgctggg
      661 caccgtggga agctgtgggg cccccaactt ccggcaggtg cagggtgggc tcactgtgtt
      721 cggcatggga cagcccagcc tctcagggtt caggcgggtc ctccagaaac tccagaagga
      781 cggacatagg gagtgtgtca tcttctgtgt gcgggaggaa cctgtgcttt tcctgcgtgc
      841 agatgaggac tttgtgtcct acacacctcg agacaagcag aaccttcatg agaacctcca
      901 gggccttgga cccggggtcc gggtggagag cctggagctg gccatccgga aagagatcca
      961 cgactttgcc cagctgagcg agaacacata ccatgtgtac cataacaccg aggacctgtg
     1021 gggggagccc catgctgtgg ccatccatgg tgaggacgac ttgcatgtga cggaggaggt
     1081 gtacaagcgg cccctcttcc tgcagcccac ctacaggtac caccgcctgc ccctgcccga
     1141 gcaagggagt cccctggagg cccagttgga cgcctttgtc agtgttctcc gggagacccc
     1201 cagcctgctg cagctccgtg atgcccacgg gcctccccca gccctcgtct tcagctgcca
     1261 gatgggcgtg ggcaggacca acctgggcat ggtcctgggc accctcatcc tgcttcaccg
     1321 cagtgggacc acctcccagc cagaggctgc ccccacgcag gccaagcccc tgcctatgga
     1381 gcagttccag gtgatccaga gctttctccg catggtgccc cagggaagga ggatggtgga
     1441 agaggtggac agagccatca ctgcctgtgc cgagttgcat gacctgaaag aagtggtctt
     1501 ggaaaaccag aagaagttag aaggtatccg accggagagc ccagcccagg gaagcggcag
     1561 ccgacacagc gtctggcaga gggcgctgtg gagcctggag cgatacttct acctgatcct
     1621 gtttaactac taccttcatg agcagtaccc gctggccttt gccctcagtt tcagccgctg
     1681 gctgtgtgcc caccctgagc tgtaccgcct gcccgtgacg ctgagctcag caggccctgt
     1741 ggctccgagg gacctcatcg ccaggggctc cctacgggag gacgatctgg tctccccgga
     1801 cgcgctcagc actgtcagag agatggatgt ggccaacttc cggcgggtgc cccgcatgcc
     1861 catctacggc acggcccagc ccagcgccaa ggccctgggg agcatcctgg cctacctgac
     1921 ggacgccaag aggaggctgc ggaaggttgt ctgggtgagc cttcgggagg aggccgtgtt
     1981 ggagtgtgac gggcacacct acagcctgcg gtggcctggg ccccctgtgg ctcctgacca
     2041 gctggagacc ctggaggccc agctgaaggc ccatctaagc gagcctcccc caggcaagga
     2101 gggccccctg acctacaggt tccagacctg ccttaccatg caggaggtct tcagccagca
     2161 ccgcagggcc tgtcctggcc tcacctacca ccgcatcccc atgccggact tctgtgcccc
     2221 ccgagaggag gactttgacc agctgctgga ggccctgcgg gccgccctct ccaaggaccc
     2281 aggcactggc ttcgtgttca gctgcctcag cggccagggc cgtaccacaa ctgcgatggt
     2341 ggtggctgtc ctggccttct ggcacatcca aggcttcccc gaggtgggtg aggaggagct
     2401 cgtgagtgtg cctgatgcca agttcactaa gggtgaattt caggtagtaa tgaaggtggt
     2461 gcagctgcta cccgatgggc accgtgtgaa gaaggaggtg gacgcagcgc tggacactgt
     2521 cagcgagacc atgacgccca tgcactacca cctgcgggag atcatcatct gcacctaccg
     2581 ccaggcgaag gcagcgaaag aggcgcaaga aatgcggagg ctgcagctgc ggagcctgca
     2641 gtacttggag cgctatgtct gcctgattct cttcaacgcg tacctccacc tggagaaggc
     2701 cgactcctgg cagaggccct tcagcacctg gatgcaggag gtggcatcga aggctggcat
     2761 ctacgagatc cttaacgagc tgggcttccc cgagctggag agcggggagg accagccctt
     2821 ctccaggctg cgctaccggt ggcaggagca gagctgcagc ctcgagccct ctgcccccga
     2881 ggacttgctg tagggggcct tactccctgt ccccccaccc acagggcccc acgcaggcct
     2941 ggggtgtctg aggtgctctt ggctgggagc ggccctgagg ggtgctggcc ttgaaatgat
     3001 tcccccactt cctggagaga ctgagcggag ttgggagcct ttttagaaag aactttttat
     3061 aggacaggga gacagcacag ccatcccttg caaaccacca aggtgtgtgg ctgacctcca
     3121 gggaggagca ctcactggag tgctcacaag gtgcacactg ctgtgtgtac cttgcagaca
     3181 ggccggcgtt cagcctccaa ggggctcact cccccagttg ccaaacactg tggatctctc
     3241 tgtcctcttc tcccctctct cagattggcc tggcagcccc tggcacagag cagacccggc
     3301 cactggtagc tccccacttc cttactcctg ctgctctgcc attgccgctc cccttgttgc
     3361 tgcccaagca ctgccctcgg gcgtctggca gcctgaggtg ggtggagggg acagtgttct
     3421 ggatagatct attatgtgaa aggcagcttc acccagtttt ctggactctc atgcccccat
     3481 ctccgacctg ggagacttca ggaatgacaa cctacccagc ctggtggggc tggcaggatg
     3541 gtggaggttt ctcaaggagc tggagacttc agggagcccc tctcatgggg aggaaagagc
     3601 ttccaggggg cgaacgcagc acagaggaag aggcctgctc cacttgtctg ggaacctggg
     3661 caggaggcac agaggaagcc aaggcctgga gctgcaggtc ccccggcatc tctctctgtc
     3721 ccggcagccc aggatggcct ggtgccccca cctgctgcag caggagcccc aaggagtgct
     3781 agctgagggt ggttgctggg gtggtcctca tggacagtga ggtgtgcaag ggtgcactga
     3841 gggtggtggg aggggatcac ctgggttcca ggccatcctt gctgagcatc tttgagcctg
     3901 ccttccggtg ggagcagaaa aggccagacc ctgctgagtt agaggctgct gggatccact
     3961 gtttccacac agcgggaagg ctgctgggaa caggtggcag agaagtgcca tgtttgcgtt
     4021 gagccttgca gctcttccag ctggggactg gtgcttgctg aaacccagga gctgaacagt
     4081 gaggaggctg tccaccttgc ttggctcact gggaccagga aagcctgtct ttggttaggc
     4141 tcgtgtactt ctgcaggaaa aaaaaaaaag gatgtgtcat tggtcatgat atttgaaaag
     4201 gggaggaggc cgaagttgtt cccatttatc cagtattgga aaatatttga cccccttggc
     4261 tgaattcttt tgcagaacta ctgtgtgtct gttcactacc ttttcaggtt tattgttttt
     4321 atttttgcat gaattaagac gttttaattt ctttgcagac aaggtctaga tgcggagtca
     4381 gagatgggac tgaatgggga gggatccttt gtgttctcat ggttggctct gactttcagc
     4441 tgtgttggga ccactggctg atcacatcac ctctctgcct cagtttcccc atctgtaaaa
     4501 tgggagaata atacttgcct acctacctca caggggtgtt gtgaggattc atttgtgatt
     4561 tttttttttt ttgtacagag cttttaagca ttaaaaacag ctaaatgtga
//
