LOCUS       NM_001395430            4379 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens p21 (RAC1) activated kinase 6 (PAK6), transcript
            variant 2, mRNA.
ACCESSION   NM_001395430
VERSION     NM_001395430.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4379)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 4379)
  AUTHORS   Wang,D., Zhu,J., Yang,Y., Wang,Z., Ying,Z. and Zhang,H.
  TITLE     The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus
            cells in human intervertebral disc degeneration
  JOURNAL   Cell Signal 102, 110528 (2023)
   PUBMED   36423859
  REMARK    GeneRIF: The role of the miR-4306/PAK6 axis in degenerative nucleus
            pulposus cells in human intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 4379)
  AUTHORS   Xue,S.T., Zheng,B., Cao,S.Q., Ding,J.C., Hu,G.S., Liu,W. and
            Chen,C.
  TITLE     Long non-coding RNA LINC00680 functions as a ceRNA to promote
            esophageal squamous cell carcinoma progression through the
            miR-423-5p/PAK6 axis
  JOURNAL   Mol Cancer 21 (1), 69 (2022)
   PUBMED   35255921
  REMARK    GeneRIF: Long non-coding RNA LINC00680 functions as a ceRNA to
            promote esophageal squamous cell carcinoma progression through the
            miR-423-5p/PAK6 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4379)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4379)
  AUTHORS   Wells,C.M. and Jones,G.E.
  TITLE     The emerging importance of group II PAKs
  JOURNAL   Biochem J 425 (3), 465-473 (2010)
   PUBMED   20070256
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4379)
  AUTHORS   Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A.
  TITLE     p21 activated kinase 5 activates Raf-1 and targets it to
            mitochondria
  JOURNAL   J Cell Biochem 105 (1), 167-175 (2008)
   PUBMED   18465753
  REMARK    GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may
            control Raf-1 dependent signaling at mitochondria
REFERENCE   7  (bases 1 to 4379)
  AUTHORS   Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P.,
            Schneider,M.C. and Lu,M.L.
  TITLE     Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38
            MAP kinase
  JOURNAL   J Biol Chem 280 (5), 3323-3330 (2005)
   PUBMED   15550393
  REMARK    GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6
            suggests that PAK6 plays a role in the cellular response to
            stress-related signals.
REFERENCE   8  (bases 1 to 4379)
  AUTHORS   Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and
            Bokoch,G.M.
  TITLE     Mechanism of p21-activated kinase 6-mediated inhibition of androgen
            receptor signaling
  JOURNAL   J Biol Chem 279 (3), 1922-1931 (2004)
   PUBMED   14573606
REFERENCE   9  (bases 1 to 4379)
  AUTHORS   Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and
            Balk,S.P.
  TITLE     AR and ER interaction with a p21-activated kinase (PAK6)
  JOURNAL   Mol Endocrinol 16 (1), 85-99 (2002)
   PUBMED   11773441
REFERENCE   10 (bases 1 to 4379)
  AUTHORS   Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z.
  TITLE     Androgen receptor specifically interacts with a novel p21-activated
            kinase, PAK6
  JOURNAL   J Biol Chem 276 (18), 15345-15353 (2001)
   PUBMED   11278661
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020658.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of a family of p21-stimulated
            serine/threonine protein kinases, which contain an amino-terminal
            Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal
            kinase domain. These kinases function in a number of cellular
            processes, including cytoskeleton rearrangement, apoptosis, and the
            mitogen-activated protein (MAP) kinase signaling pathway. The
            protein encoded by this gene interacts with androgen receptor (AR)
            and translocates to the nucleus, where it is involved in
            transcriptional regulation. Changes in expression of this gene have
            been linked to prostate cancer. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2322734.1,
                                           SRR14038195.398186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000560346.6/ ENSP00000453858.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-740               AC020658.6         77438-78177
            741-823             AC020658.6         78974-79056
            824-935             AC020658.6         91553-91664
            936-1144            AC020658.6         103156-103364
            1145-1798           AC020658.6         104217-104870
            1799-2296           AC020658.6         110599-111096
            2297-2430           AC020658.6         111241-111374
            2431-2557           AC020658.6         111721-111847
            2558-2683           AC020658.6         111926-112051
            2684-2818           AC020658.6         112517-112651
            2819-4379           AC020658.6         114302-115862
FEATURES             Location/Qualifiers
     source          1..4379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4379
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /note="p21 (RAC1) activated kinase 6"
                     /db_xref="GeneID:56924"
                     /db_xref="HGNC:HGNC:16061"
                     /db_xref="MIM:608110"
     exon            1..740
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            741..823
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..935
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1144
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             941..2986
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     p21(CDKN1A)-activated kinase 6; serine/threonine-protein
                     kinase PAK 6; p21 protein (Cdc42/Rac)-activated kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 6 isoform 1"
                     /protein_id="NP_001382359.1"
                     /db_xref="GeneID:56924"
                     /db_xref="HGNC:HGNC:16061"
                     /db_xref="MIM:608110"
                     /translation="MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL
                     DTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRG
                     RSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPW
                     PEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMK
                     AAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSS
                     SKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLR
                     TAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKA
                     ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLF
                     NEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCE
                     AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY
                     WMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS
                     HKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC"
     exon            1145..1798
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2296
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2430
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2557
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2683
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2818
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..4379
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /note="hexamer: ATTAAA"
     polyA_site      4379
                     /gene="PAK6"
                     /gene_synonym="PAK5"
                     /note="major polyA site"
ORIGIN      
        1 aagcaacgtt ggagcagctc ggcgccccaa acgagcaggt cgatgcctga ggatttaatg
       61 gagaaatccc aaagtgagcc ggggcgcgcg gtggaggagg ggcgcgccgc agccggggcc
      121 gctgggccct gatgggcggg agcggggtgg agcggcctcg cctgccaggc agccctgggc
      181 gcggggctcg gcggccacac tctggagaca gccacggtcc aggcaggtgg gggagggcgc
      241 tgctcccgtc ctgatgtgcc aggagccgcc agcagccatc caggtgacta agccggccca
      301 ctagcactga gtcaccgccc gcctcgagct gttcttgctt ctcctttgca tctgattatt
      361 ttgggagctg gaaacttgga gctgcacctg agtcccgccc cttctagctc tcccctccct
      421 accttgggct ccaggaagat gggacttgct gtgagtctgc tgccaccccc taaagatatg
      481 gaagacgctg tgggggccag aagtgcccgg ggggctgtgg cagcaggcag agtgcaatag
      541 cagatatggt ggtcaggctg cctgtgtgtg tcctctggag gtgttgggac agaagggcag
      601 tcttgtccga gctgactgga gtcctcccgg gctggctctg aactcatctc ccacggggat
      661 gtttcggtaa aggagtggct tctggggtcg gagtggcatt tggagagcga ggctggattg
      721 gcttaggctg gcctgggcag ggagtgccgc ttcctgggct agagacaagc accagcctgc
      781 agtggagaac gcaggacccc gctgcccaga aggagcagcc acggcctgcg gaggactggc
      841 ccagcaaggt cccaggtctt ccctctcctc agcgcctaag agagaggccc agtgcgggtg
      901 aggagtcgcg aggaagaggc ggaaggcgcc ggaaggcacc atgttccgca agaaaaagaa
      961 gaaacgccct gagatctcag cgccacagaa cttccagcac cgtgtccaca cctccttcga
     1021 ccccaaagaa ggcaagtttg tgggcctccc cccacaatgg cagaacatcc tggacacact
     1081 gcggcgcccc aagcccgtgg tggacccttc gcgaatcaca cgggtgcagc tccagcccat
     1141 gaagacagtg gtgcggggca gcgcgatgcc tgtggatggc tacatctcgg ggctgctcaa
     1201 cgacatccag aagttgtcag tcatcagctc caacaccctg cgtggccgca gccccaccag
     1261 ccggcggcgg gcacagtccc tggggctgct gggggatgag cactgggcca ccgacccaga
     1321 catgtacctc cagagccccc agtctgagcg cactgacccc cacggcctct acctcagctg
     1381 caacgggggc acaccagcag gccacaagca gatgccgtgg cccgagccac agagcccacg
     1441 ggtcctgccc aatgggctgg ctgcaaaggc acagtccctg ggccccgccg agtttcaggg
     1501 tgcctcgcag cgctgtctgc agctgggtgc ctgcctgcag agctccccac caggagcctc
     1561 gccccccacg ggcaccaata ggcatggaat gaaggctgcc aagcatggct ctgaggaggc
     1621 ccggccacag tcctgcctgg tgggctcagc cacaggcagg ccaggtgggg aaggcagccc
     1681 tagccctaag acccgggaga gcagcctgaa gcgcaggcta ttccgaagca tgttcctgtc
     1741 cactgctgcc acagcccctc caagcagcag caagccaggc cctccaccac agagcaagcc
     1801 caactcctct ttccgaccgc cgcagaaaga caacccccca agcctggtgg ccaaggccca
     1861 gtccttgccc tcggaccagc cggtggggac cttcagccct ctgaccactt cggataccag
     1921 cagcccccag aagtccctcc gcacagcccc ggccacaggc cagcttccag gccggtcttc
     1981 cccagcggga tccccccgca cctggcacgc ccagatcagc accagcaacc tgtacctgcc
     2041 ccaggacccc acggttgcca agggtgccct ggctggtgag gacacaggtg ttgtgacaca
     2101 tgagcagttc aaggctgcgc tcaggatggt ggtggaccag ggtgaccccc ggctgctgct
     2161 ggacagctac gtgaagattg gcgagggctc caccggcatc gtctgcttgg cccgggagaa
     2221 gcactcgggc cgccaggtgg ccgtcaagat gatggacctc aggaagcagc agcgcaggga
     2281 gctgctcttc aacgaggtgg tgatcatgcg ggactaccag cacttcaacg tggtggagat
     2341 gtacaagagc tacctggtgg gcgaggagct gtgggtgctc atggagttcc tgcagggagg
     2401 agccctcaca gacatcgtct cccaagtcag gctgaatgag gagcagattg ccactgtgtg
     2461 tgaggctgtg ctgcaggccc tggcctacct gcatgctcag ggtgtcatcc accgggacat
     2521 caagagtgac tccatcctgc tgaccctcga tggcagggtg aagctctcgg acttcggatt
     2581 ctgtgctcag atcagcaaag acgtccctaa gaggaagtcc ctggtgggaa ccccctactg
     2641 gatggctcct gaagtgatct ccaggtcttt gtatgccact gaggtggata tctggtctct
     2701 gggcatcatg gtgattgaga tggtagatgg ggagccaccg tacttcagtg actccccagt
     2761 gcaagccatg aagaggctcc gggacagccc cccacccaag ctgaaaaact ctcacaaggt
     2821 ctccccagtg ctgcgagact tcctggagcg gatgctggtg cgggaccccc aagagagagc
     2881 cacagcccag gagctcctag accacccctt cctgctgcag acagggctac ctgagtgcct
     2941 ggtgcccctg atccagctct accgaaagca gacctccacc tgctgagccc accccaagta
     3001 tgcctgccac ctacgcccac aggcagggca cactgggcag ccagcctgcc ggcaggactt
     3061 gcctgcctcc tcctctcagt attctctcca aagattgaaa tgtgaagccc cagccccacc
     3121 ctctgccctt cagcctactg ggccaggccg gacctgcccc ctcagtgtct ctccctcccg
     3181 agtccccaga tggagacccc tttctacagg atgacccctt gatatttgca cagggatatt
     3241 tctaagaaac gcagaggcca gcgttcctgg cctctgcagc caacacagta gaaaaggctg
     3301 ctgtggtttt ttaaaggcag ttgtccacta gtgtcctagg ccactgcaga gggcagactg
     3361 ctggtctcca cagatacctg ctgttctcag ctccagcttc aaacctcgag tctcgagagg
     3421 gccacggggt ggtttttatg accggaatcc cgcttcctcc ctcacgtctg atgtcctgaa
     3481 ggtgcagtcc cacctgtaca gcccctcccc gcccagaact gtgaatggcc tgctccaggc
     3541 catggctggg ggcagggagt gaggggacaa tttctgagtg aaagagaaag aatggggtcg
     3601 gtggtgaagg tgctctcact ttacagaatg gagagaacat cgtgtgtgtg tgtgtgtgtg
     3661 tgtgtgtgtg tgtgtgtgtg taaggggagg aaagccacct tgacagccca ggtccctcca
     3721 ggtcacccac agccagtttc aggaaggctg cccctctctc ccactaagtt ctggcctgaa
     3781 gggacctgct ttcttggcct ggcttccacc tctccactcc tgtgtctacc tggccagtgg
     3841 agtggtccat gctaagtcta acactcctgg gagctcagga ggcttctgag cttctcctgt
     3901 actgtgcatc gtgagggcca gagacaggaa tgtaaggatt ggcaactgtg ttacctttca
     3961 agtttatctc aataaccagg tcatcaggga cccattgttc tcttcagaac cctatctggg
     4021 agagaaggcg aaccacctcc gggtttccat catgtcaagg tcacaggcat ccatgtgtgc
     4081 aaaccatctg ccccagctgc ctccacagac tgctgtctcc ttgtcctcct cggccctgcc
     4141 ccacttcagg gctgctgtga gatggaattc caggaaagaa cttcaggtgt ctggaccctt
     4201 tctatctaga taatattttt agattcttct gctccctagt gacctacctg ggggcaaaga
     4261 aattgcaagg actttttttt aagggtcaga gttttcaaaa caaaagcatc ttccctagaa
     4321 atttttgtga attgtttgca cttgtgcctg ttttaaatta aattgagtgt tcaaagcca
//
