LOCUS       NM_177990               4728 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens p21 (RAC1) activated kinase 5 (PAK5), transcript
            variant 2, mRNA.
ACCESSION   NM_177990
VERSION     NM_177990.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Liu,X., Pan,Y.J., Kang,M.J., Jiang,X., Guo,Z.Y. and Pei,D.S.
  TITLE     PAK5 potentiates slug transactivation of N-cadherin to facilitate
            metastasis of renal cell carcinoma
  JOURNAL   Cell Signal 110, 110803 (2023)
   PUBMED   37437827
  REMARK    GeneRIF: PAK5 potentiates slug transactivation of N-cadherin to
            facilitate metastasis of renal cell carcinoma.
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Pan,X., Liu,D., Ying,M., Zheng,G., Fan,C., Pan,F. and Ke,Q.
  TITLE     PAK5 is a potential target in myelodysplastic syndrome through
            interacting with LMO2 and GATA1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (9), 77-85 (2022)
   PUBMED   36905268
  REMARK    GeneRIF: PAK5 is a potential target in myelodysplastic syndrome
            through interacting with LMO2 and GATA1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Zeng,H., Tong,F., Bin,Y., Peng,L., Gao,X., Xia,X., Yi,X. and
            Dong,X.
  TITLE     The Predictive Value of PAK7 Mutation for Immune Checkpoint
            Inhibitors Therapy in Non-Small Cell Cancer
  JOURNAL   Front Immunol 13, 834142 (2022)
   PUBMED   35242138
  REMARK    GeneRIF: The Predictive Value of PAK7 Mutation for Immune
            Checkpoint Inhibitors Therapy in Non-Small Cell Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Li,Y., Xing,Y., Wang,X., Hu,B., Zhao,X., Zhang,H., Han,F., Geng,N.,
            Wang,F., Li,Y., Li,J., Jin,F. and Li,F.
  TITLE     PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b
            processing in a kinase-dependent manner in breast cancer
  JOURNAL   Cell Rep 37 (12), 110127 (2021)
   PUBMED   34936874
  REMARK    GeneRIF: PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b
            processing in a kinase-dependent manner in breast cancer.
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Dan,C., Nath,N., Liberto,M. and Minden,A.
  TITLE     PAK5, a new brain-specific kinase, promotes neurite outgrowth in
            N1E-115 cells
  JOURNAL   Mol Cell Biol 22 (2), 567-577 (2002)
   PUBMED   11756552
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Cau,J., Faure,S., Comps,M., Delsert,C. and Morin,N.
  TITLE     A novel p21-activated kinase binds the actin and microtubule
            networks and induces microtubule stabilization
  JOURNAL   J Cell Biol 155 (6), 1029-1042 (2001)
   PUBMED   11733543
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Tan,Y., Demeter,M.R., Ruan,H. and Comb,M.J.
  TITLE     BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and
            cell survival
  JOURNAL   J Biol Chem 275 (33), 25865-25869 (2000)
   PUBMED   10837486
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Scheid,M.P., Schubert,K.M. and Duronio,V.
  TITLE     Regulation of bad phosphorylation and association with Bcl-x(L) by
            the MAPK/Erk kinase
  JOURNAL   J Biol Chem 274 (43), 31108-31113 (1999)
   PUBMED   10521512
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   del Peso,L., Gonzalez-Garcia,M., Page,C., Herrera,R. and Nunez,G.
  TITLE     Interleukin-3-induced phosphorylation of BAD through the protein
            kinase Akt
  JOURNAL   Science 278 (5338), 687-689 (1997)
   PUBMED   9381178
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034427.4, AK315820.1,
            AK307926.1, AB040812.1 and AL031652.4.
            
            On May 21, 2020 this sequence version replaced NM_177990.3.
            
            Summary: The protein encoded by this gene is a member of the PAK
            family of Ser/Thr protein kinases. PAK family members are known to
            be effectors of Rac/Cdc42 GTPases, which have been implicated in
            the regulation of cytoskeletal dynamics, proliferation, and cell
            survival signaling. This kinase contains a CDC42/Rac1 interactive
            binding (CRIB) motif, and has been shown to bind CDC42 in the
            presence of GTP. This kinase is predominantly expressed in brain.
            It is capable of promoting neurite outgrowth, and thus may play a
            role in neurite development. This kinase is associated with
            microtubule networks and induces microtubule stabilization. The
            subcellular localization of this kinase is tightly regulated during
            cell cycle progression. Alternatively spliced transcript variants
            encoding the same protein have been described. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) lacks an internal 5' UTR exon,
            as compared to variant 1. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315820.1, AK291401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353224.10/ ENSP00000322957.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL034427.4         19252-19288         c
            38-202              AK315820.1         2-166
            203-638             AK307926.1         97-532
            639-4708            AB040812.1         543-4612
            4709-4728           AL031652.4         130638-130657       c
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.2"
     gene            1..4728
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /note="p21 (RAC1) activated kinase 5"
                     /db_xref="GeneID:57144"
                     /db_xref="HGNC:HGNC:15916"
                     /db_xref="MIM:608038"
     exon            1..315
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            316..465
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            466..680
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..2636
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /EC_number="2.7.11.1"
                     /note="protein kinase PAK5; p21(CDKN1A)-activated kinase
                     7; serine/threonine-protein kinase PAK7;
                     p21CDKN1A-activated kinase 7; serine/threonine-protein
                     kinase PAK 7; PAK-5; PAK-7; p21-activated kinase 5;
                     p21-activated kinase 7; p21 protein (Cdc42/Rac)-activated
                     kinase 7; p21 (RAC1) activated kinase 7"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 5"
                     /protein_id="NP_817127.1"
                     /db_xref="CCDS:CCDS13107.1"
                     /db_xref="GeneID:57144"
                     /db_xref="HGNC:HGNC:15916"
                     /db_xref="MIM:608038"
                     /translation="MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLA
                     DTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRK
                     ESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYY
                     RGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWE
                     YQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT
                     SPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYD
                     RAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSS
                     QYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLA
                     NFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVD
                     MYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIH
                     RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEV
                     DIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV
                     REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH"
     exon            681..1466
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1958
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2092
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2219
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2345
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2480
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..4728
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4685..4690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /note="hexamer: AATAAA"
     regulatory      4691..4696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /note="hexamer: AATAAA"
     polyA_site      4713
                     /gene="PAK5"
                     /gene_synonym="PAK7"
     polyA_site      4728
                     /gene="PAK5"
                     /gene_synonym="PAK7"
                     /note="major polyA site"
ORIGIN      
        1 ggccgccgct acagcctgcc tcccgccggc tgccacgaaa acccggagca gctgcgtacg
       61 ctcatggaca gtcctccgag gggcgaagcc gggcagctgg gcatgctcag tagctggggg
      121 aggtttgggt ggagagtaga aagctgtggc tctgcctctc accccctccc gctggccccc
      181 gccccccttg cccctaccca gccagtagta gttccccagc gtgcgcccgg ggagaccggg
      241 aacatggcgc tgggagcgct gtagcagctg agaaggggct gaggcaccgc cgcttcgctg
      301 acagccggcc accagaaata cactgtggtg aaatgcttcc acctcttgct aaaatgaaca
      361 ctgaggaaaa atgaagaaga ctgacaagca ccagcgaaaa gttgcagaat agaaatagcc
      421 acactcctct ggagtcttta attcatccac agccatcata taaaggtttt ggcatcatgt
      481 ttgggaagaa aaagaaaaag attgaaatat ctggcccgtc caactttgaa cacagggttc
      541 atactgggtt tgatccacaa gagcagaagt ttaccggcct tccccagcag tggcacagcc
      601 tgttagcaga tacggccaac aggccaaagc ctatggtgga cccttcatgc atcacaccca
      661 tccagctggc tcctatgaag acaatcgtta gaggaaacaa accctgcaag gaaacctcca
      721 tcaacggcct gctagaggat tttgacaaca tctcggtgac tcgctccaac tccctaagga
      781 aagaaagccc acccacccca gatcagggag cctccagcca cggtccaggc cacgcggaag
      841 aaaatggctt catcaccttc tcccagtatt ccagcgaatc cgatactact gctgactaca
      901 cgaccgaaaa gtacagggag aagagtctct atggagatga tctggatccg tattatagag
      961 gcagccacgc agccaagcaa aatgggcacg taatgaaaat gaagcacggg gaggcctact
     1021 attctgaggt gaagcctttg aaatccgatt ttgccagatt ttctgccgat tatcactcac
     1081 atttggactc actgagcaaa ccaagtgaat acagtgacct caagtgggag tatcagagag
     1141 cctcgagtag ctcccctctg gattattcat tccaattcac accttctaga actgcaggga
     1201 ccagcgggtg ctccaaggag agcctggcgt acagtgaaag tgaatgggga cccagcctgg
     1261 atgactatga caggaggcca aagtcttcgt acctgaatca gacaagccct cagcccacca
     1321 tgcggcagag gtccaggtca ggctcgggac tccaggaacc gatgatgcca tttggagcaa
     1381 gtgcatttaa aacccatccc caaggacact cctacaactc ctacacctac cctcgcttgt
     1441 ccgagcccac aatgtgcatt ccaaaggtgg attacgatcg agcacagatg gtcctcagcc
     1501 ctccactgtc agggtctgac acctacccca ggggccctgc caaactacct caaagtcaaa
     1561 gcaaatcggg ctattcctca agcagtcacc agtacccgtc tgggtaccac aaagccacct
     1621 tgtaccatca cccctccctg cagagcagtt cgcagtacat ctccacggct tcctacctga
     1681 gctccctcag cctctcatcc agcacctacc cgccgcccag ctggggctcc tcctccgacc
     1741 agcagccctc cagggtgtcc catgaacagt ttcgggcggc cctgcagctg gtggtcagcc
     1801 caggagaccc cagggaatac ttggccaact ttatcaaaat cggggaaggc tcaaccggca
     1861 tcgtatgcat cgccaccgag aaacacacag ggaaacaagt tgcagtgaag aaaatggacc
     1921 tccggaagca acagagacga gaactgcttt tcaatgaggt cgtgatcatg cgggattacc
     1981 accatgacaa tgtggttgac atgtacagca gctaccttgt cggcgatgag ctctgggtgg
     2041 tcatggagtt tctagaaggt ggtgccttga cagacattgt gactcacacc agaatgaatg
     2101 aagaacagat agctactgtc tgcctgtcag ttctgagagc tctctcctac cttcataacc
     2161 aaggagtgat tcacagggac ataaaaagtg actccatcct cctgacaagc gatggccgga
     2221 taaagttgtc tgattttggt ttctgtgctc aagtttccaa agaggtgccg aagaggaaat
     2281 cattggttgg cactccctac tggatggccc ctgaggtgat ttctaggcta ccttatggga
     2341 cagaggtgga catctggtcc ctcgggatca tggtgataga aatgattgat ggcgagcccc
     2401 cctacttcaa tgagcctccc ctccaggcga tgcggaggat ccgggacagt ttacctccaa
     2461 gagtgaagga cctacacaag gtttcttcag tgctccgggg attcctagac ttgatgttgg
     2521 tgagggagcc ctctcagaga gcaacagccc aggaactcct cggacatcca ttcttaaaac
     2581 tagcaggtcc accgtcttgc atcgtccccc tcatgagaca atacaggcat cactgagcag
     2641 aggattcgtg taggtggcaa agctagatga ggacatgaga ataattcagg agaacaaaag
     2701 gaaacacaga acatgcaaaa ggcctgtgca ttctagacca gccaattggt gggacagcgt
     2761 gatgaccggc agggttcaac agaccagggc atcttcttgt gtcttaaaca ggcatctctc
     2821 cactgacagc cggtgtggtc acttggagca cggctttaat aagtcattat tatatttttc
     2881 agcccttcat ccagcaaatc agaaggactc agtacaaact ccgttatgat atatcctagc
     2941 cacatgcagg gtaacatgta ggattttcta tattgaaaga atacttttct ggcaaaaaaa
     3001 aaaaaaaaag aaagaaagga aaacaaaaag cacttttttc ttaatggtag cagtataatg
     3061 tattttgcaa cgaatttgta atttttctgt acgatagttt tgataattta tagtactttg
     3121 atgtcatgta gccattgtat cagttgaagt aatacttgtt tactagagga gtttgaacaa
     3181 agcctttcct acttttttat ccctttaaga gaaccaatga ttctttagga actttgaata
     3241 ctgaatgact ctcaatcacc gtcagcttta gtaaaatctc tttcttatcc taacaagtgt
     3301 cttatttggt ggaagaagaa ttaagagtga tggtgatggt gtgcacgttt cattaatcca
     3361 accaaaaata atgaaataaa atttgagcca cagtatacca ctccttggga taaagttaaa
     3421 tatttttaaa gatcacattt tccatgaacg cctctagtag caaaccattc ttttgcacac
     3481 cacaatgttt ccctcagtgc cctttctcaa atgggtacaa tgttcccttg tggccaaatt
     3541 tccctcccag ggagcaattt cagtgctagg atcattggat tcagttccca aaatagaatg
     3601 tttcagtgag accatgagaa ttccaggctc acaaagggag aggagagaac agggcaagac
     3661 gtttggtttc atttgtcacc atttttaaaa ctctgtatgc tagcacacca aactcttgtc
     3721 tatatttacc tttgtaccac agtattaatc gctattgttc atgtatcgtg ctggaagtct
     3781 gaactgactc tagaggatga attagcaaga gggtatttta ccaggtatga tctgacttca
     3841 gttgtgccca tgttataatg tgtttccgac ataggagagt cgtgctgctg tctagatctt
     3901 cttgaatgtt gataaaaatg aatgactact acaatacatt ttgtgttgct tgttggatga
     3961 atttgcatgt taactgtagg ccaatataga tttgccttta aaactctgga agagctacat
     4021 agtcatcatt agtttctatt aattatgcat cagacaaaag ccatttgtta ccaaactggg
     4081 aaaacagagg cttttcttaa ctatttcaca tactgtaaca aatatgaatt taaatttgtg
     4141 atagcgctct ggttgctcta agcataatta agaatttttg taattaatag gttgctaatt
     4201 atttatcact gctaaaaagg aaaaaaggca taaaatgacc ttctactgat tagattttca
     4261 gttttctttc aaactggaaa tgcctccata aatatgatct atgattttgc ttcataaaac
     4321 agcaaatcaa tgttttatgt aaaatattaa agcattaata taaatatgtg agaataaaaa
     4381 caatctaaat ccagaaaatg gcagtcctaa atgttcatga gacagattgt attaatttaa
     4441 ccaggactat gtagaagtag aaagaaaaga aaaagaaaat cttttttaaa ccagaataaa
     4501 cattaaaaac tattgcagaa aatagtggat tttggattcc aaacattttc gacagtgtaa
     4561 tggaaatttt tctgtaattt tcttaccatc gggtattttt taaagtattc attgagttta
     4621 ccaaaagtta ctgtagctta aaaggttttg tgagcactaa ctattggcag aaactgcatt
     4681 tgcaaataaa aataaatgtt tgccttttcc ccattgtgtt attggaaa
//
