LOCUS       XM_017029563            9234 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens p21 (RAC1) activated kinase 3 (PAK3),
            transcript variant X18, mRNA.
ACCESSION   XM_017029563
VERSION     XM_017029563.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000023.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017029563.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
     gene            1..9234
                     /gene="PAK3"
                     /gene_synonym="ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3;
                     PAK-3; PAK3beta; XLID30"
                     /note="p21 (RAC1) activated kinase 3; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 16 ESTs, 298 long SRA reads, 4 Proteins, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments"
                     /db_xref="GeneID:5063"
                     /db_xref="HGNC:HGNC:8592"
                     /db_xref="MIM:300142"
     CDS             578..2320
                     /gene="PAK3"
                     /gene_synonym="ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3;
                     PAK-3; PAK3beta; XLID30"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 3 isoform
                     X7"
                     /protein_id="XP_016885052.1"
                     /db_xref="GeneID:5063"
                     /db_xref="HGNC:HGNC:8592"
                     /db_xref="MIM:300142"
                     /translation="MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNK
                     KARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPV
                     TVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLK
                     FYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEE
                     DENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ
                     RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQ
                     MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE
                     TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
                     EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALY
                     LIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTP
                     LIIAAKEAIKNSSR"
ORIGIN      
        1 accgcgggcg ggcagctgtg ccagctaacc gtctgggatc tcgcactggg ggctgcagct
       61 tttccccgcc tcgagccagt gtgcgggggc gggagaagag ccagggggag cgggctgggc
      121 ccggggctgc ggctgcggcc gcggggctgc ggctccccag ccccgccagc tggagcgctc
      181 ggaggtagag gaaaggtctt gacggggtgg ctggatccgt ggcagaatcc agttccagat
      241 tctagacttg agggttctgg gctgttggtc tgtagaagcg aaggagagaa ggactcaaat
      301 ccaggccaag tgtatggctg tctgaggtat tggaacagaa ggaggtccat tcctgttggt
      361 gacaacaccg tggccctgtt ctgggatgag caaggtgtaa aggtttcccc caagaaagag
      421 cagctgagtc cttgcatctt gtggcagctg gtgtgcccag cactgagtct gtaggagctg
      481 aagccagccc ggacccttct catgggcagt gcccacctgt gctgaagtcc tgcagcggtg
      541 gcggtgtgag gagctgtgaa attagttgta actgaaaatg tctgacggtc tggataatga
      601 agagaaaccc ccggctcctc cactgaggat gaatagtaac aaccgggatt cttcagcact
      661 caaccacagc tccaaaccac ttcccatggc ccctgaagag aagaataaga aagccaggct
      721 tcgctctatc ttcccaggag gaggggataa aaccaataag aagaaggaga aagagcgccc
      781 agagatctct cttccttcag actttgagca tacgattcat gtggggtttg atgcagtcac
      841 cggggaattc actaactccc ctttccagac ctctagacct gtgacggtcg cttcaagtca
      901 atcagaggga aaaatgccag atctctatgg ctcacagatg tgcccaggga agctcccaga
      961 gggaattcca gagcaatggg cacgattact ccaaacttcc aacataacaa aattggaaca
     1021 gaagaagaac ccacaagctg ttctagatgt tctcaaattc tatgattcca aagaaacagt
     1081 caacaaccag aaatacatga gctttacatc aggagataaa agtgcacatg gatacatagc
     1141 agcccatcct tcgagtacaa aaacagcatc tgagcctcca ttggcccctc ctgtgtctga
     1201 agaagaagat gaagaggaag aagaagaaga agatgaaaat gagccaccac cagttatcgc
     1261 accaagacca gagcatacaa aatcaatcta tactcgttct gtggttgaat ccattgcttc
     1321 accagcagta ccaaataaag aggtcacacc accctctgct gaaaatgcca attccagtac
     1381 tttgtacagg aacacagatc ggcaaagaaa aaaatccaag atgacagatg aggagatctt
     1441 agagaagcta agaagcattg tgagtgttgg ggacccaaag aaaaaataca caagatttga
     1501 aaaaattggt caaggggcat caggtactgt ttatacagca ctagacattg caacaggaca
     1561 agaggtggcc ataaagcaga tgaaccttca acagcaaccc aagaaggaat taattattaa
     1621 tgaaattctg gtcatgaggg aaaataagaa ccctaatatt gttaattatt tagatagcta
     1681 cttggtgggt gatgaactat gggtagtcat ggaatacttg gctggtggct ctctgactga
     1741 tgtggtcaca gagacctgta tggatgaagg acagatagca gctgtctgca gagagtgcct
     1801 gcaagctttg gatttcctgc actcaaacca ggtgatccat agagatataa agagtgacaa
     1861 tattcttctc gggatggatg gctctgttaa attgactgac tttgggttct gtgcccagat
     1921 cactcctgag caaagtaaac gaagcactat ggtgggaacc ccatattgga tggcacctga
     1981 ggtggtgact cgaaaagctt atggtccgaa agttgatatc tggtctcttg gaattatggc
     2041 aattgaaatg gtggaaggtg aaccccctta ccttaatgaa aatccactca gggcattgta
     2101 tctgatagcc actaatggaa ctccagagct ccagaatcct gagagactgt cagctgtatt
     2161 ccgtgacttt ttaaatcgct gtcttgagat ggatgtggat aggcgaggat ctgccaagga
     2221 gcttttgcag catccatttt taaaattagc caagcctctc tccagcctga ctcctctgat
     2281 tatcgctgca aaggaagcaa ttaagaacag cagccgctaa gactgcaagc cttacacctc
     2341 accatctccc tcatgagtaa gactgaaata aaactctgct gcaggaaaga tggaagaaaa
     2401 gacagtcaaa tggggtgggg gttctttacc tttcaaatga atagaaactt cttataagcc
     2461 tttttcctac tccctcagat tatgtaattt atttgtaagc ctgaatcgca gcccaaacag
     2521 ggcagcaatg ttgaagtgac cataaagtgg tcacttccac cgtgaagcga aagagccagt
     2581 agtgaatccc ctcattttgt gcattcactt tgaagaaaaa ggtttctcaa agatgcacac
     2641 tccctcttca tagtgttgtg tttgttttta agttagagag tagtccctct tgcattcaaa
     2701 cctccttcaa aactccttac ccaatgtgat gtttttcact tgcattgtca ttagatgtcc
     2761 agaaaaaaaa aagatgtcaa aatgtttttc taaaaaaaga aagcaaaaaa agcaaggcaa
     2821 aaaaaaaaaa aaaaacaaac aaaaacaaaa acaaaacaaa aacaagcaaa caaaaaatac
     2881 cagagcaagt actgtgtgaa catgtggaag tccatgccct aatagagttg caatttttta
     2941 ttcttcttct atagtggtgg cttggtttgt gtacctattt ttctgcattt gtattggaaa
     3001 aggtttcttt taagacattt tccaaaagtg gagaggaata tgtgtgttca ggaagggctt
     3061 tcaaaaaact gtatatctaa ataaagctca aacggtgaaa tcctgtcaca ttttcacaat
     3121 gatgcttaaa agataattga gtaaaccagg ttgttaatct ccttaatacc tgaaagagga
     3181 cacactgaaa ctgaaactgt gacatcctgc taggtgagtt caggttctga acctaggaaa
     3241 tcctcatagg agaaaccaca tttaaacaaa gatgggactt tctctgagag ccaaaaccag
     3301 ataaatgtag aatactgaaa tccttgttgg acattaagta aacaaagata atgataccta
     3361 aattaatcct ctcttgtgct tatgaaacat atgcactgta aaataggcat accaggagga
     3421 aatagataca ttaatcatca tttacttatg atacaaatta tttattttga caatttataa
     3481 cgtttaaaaa agttttttaa agatctagag aaaggtgata tagtaaacat tcaactctgt
     3541 aagaaatggg aggtcagtga aggctacatc ccaatcaata tttggctcta agtacctctt
     3601 cccatttttc ctatgtatca cctatttctg tttcggaata tggtgtgttc atgcttagtt
     3661 ctttgggctt ttgaatatca aaagcatatt cataaatgtc ttgaaattct ctccagtgga
     3721 aaataatttt aacttacaat catatcccaa gaaatgtcag tccgacagaa ttccttatat
     3781 gacttgggga aaataacaaa atttgactac tatttcacca tatatctatt tattaaaaaa
     3841 ttcaacagtt ggcacttcct gaatcttctg agagtagaaa aatatctgcg gagtgtctgt
     3901 gtagaaaagg atatgcctct cttttgagtg tattgacaat tttgtaaatt acagaaagtt
     3961 gtttctctaa gcctttgaaa aactaacaat ttgtgttata gaaggcttct taatttgcag
     4021 tataaaagaa tctaaacaga acttatgtac attcagccag aaggggaaag agatcagtta
     4081 cataggcctc tctccttctt tgccaaggta catccatcca tctaaccatc catatatcca
     4141 catcttaaaa tgaaagcact ttctttagag tttcagcaaa ctatatagtg tacgtgttta
     4201 tgttcaggag atgaccccac tggtgtattt cctattttcc ctattgtttt ctttgactgt
     4261 aaaagttggg agaggcttga cctcctcccc ttgaaaatgt ccacagtggg ataaaacaac
     4321 aaatgtgaaa agaaaatgaa acggtaatat taatttgaag catactatgt tatactttgc
     4381 aaaaacgaat ctgggcctgt aatttttaat gccacactgc tctaatgaga gagagaggcc
     4441 ttaattttga tttcatttaa aaataagtac tttaaaaaat ttttcactca tagtgccggg
     4501 aaattcaatg aaatcctggg atgcaaataa aaatcagtac attagtgact gtgtcctgcc
     4561 agtggagaga gcccaatacc tggttaggaa gccctattca ttagttagca tcccttacat
     4621 gttgagaagg cctttttttt gttgttattt tggagacctt ggagcagtga cccttcagat
     4681 cactgtaggc agagaaatgg cttctctctt atgctttcag ttcagcatat taacaatgag
     4741 gagccaggta cttctttact accactttgt accaagattt gataataata tatcccagga
     4801 ggcattactt ttataaattt gtattcatgt aaattttcaa atgagaacag cttctaaagc
     4861 cccttccctg tattggagag ttatgtatat ttctaataag tattagaaag aagctgtttc
     4921 tcatgccaca gtgatgctga aggattcaca tttggtacaa tcgagtaact tgaacgccag
     4981 attgttaaca gtttattctc tttccctgga tttttaagct catcttgaca caggtgagtc
     5041 tatccaaatc tttgatgttg ctagtgtgcc ctgagataac gagggcacat ctttcaatgt
     5101 tgattccaaa atgtcctgag ttaggaatag ggcagtggga aagtcaggga agggtgagaa
     5161 gcacagtaga gattatttat ttaaaaaagg aaagaacgtt aatgttgtta gcaaggatcc
     5221 agtgcgttgt cataatccca tgaggatttt cagatgacac aatcccctca aatcagtcac
     5281 catgttgggt aatgacttcg ttcttgctga tctcgtgtgt gtgtcattgt aaatatttgt
     5341 gtgtccatgt tccattttgg ctactggatg gccaagccat gtaagaagat ttaactcaag
     5401 tatttattct ttatgttatt cagatttctt tcaggcttgt gaactgcacc ccaatgtttg
     5461 agtttaacca cctgatcctt acatctatcc ctccccggtg aagcacattc cattgctaaa
     5521 agaaaaagaa acacgaaatt gcttcctgtt gtctgtataa ctgttttgat agtttgagat
     5581 atttgtctat aaatgatatt tctcagctca aagatcgtgt aaataattat attcctttgc
     5641 tcaatgggtt tatttctaat gaggctgcca gttctgagag attctataat atcactttta
     5701 aataacataa acagggatta caactatgta aaaagaaatg catatggaca aagactggga
     5761 acacagataa ttgaaatcag ttgtgttagg gtggtggaat tatgtgaatt tttttttctt
     5821 tttaaaattt tatttgatat tgttataata ttgctttaca ataaataaac agcagaaagg
     5881 gaactataga cacatagaaa agatgccaga agcagatgcc ttctggccag agcgcagagc
     5941 atgcagggca gagatatttg ctagttacaa ttattccata ggctttatgc ttgcctgggt
     6001 gctgaggttg gcacacgctc gggtatggca cacgctttct taggagacta ttatctataa
     6061 gttaaagcta gggagatgtc actattagaa ctccaaacac actcttctgc tttaaaacag
     6121 gttgtctgcc ctctgctttg gtatggcatt cgggtgtctg ttttgtggtt gctttagatt
     6181 ggaggggtga ccattttatt agcccccttg ataacatctg ttgcagatat tgcctttctg
     6241 gaacgtttta acagactctc aggttgaatt ttggaggact agaaggataa aatccccagc
     6301 tcccaccatt ttcttgtcca acaggatatt actgtatatc attcaggtag gattcttctt
     6361 ttaataacca atagggcaag tcccactaat ttcaatagaa gttatgactt gcaattaaaa
     6421 gctgactttg aaatcattaa acaaatatgt aggactgtct ctgcctgttg gcattcagtt
     6481 atagttctgt taattttggc ttgggatggt ctccatgtgc ttttttctgc ctatttatag
     6541 gttgtttgca gtagttgtga tttttaaaga gcaagggaga ccatctaacc aaaggataac
     6601 ttccttctaa ctcaccaaag aaattttagg tgagaacttt aataatgagg tagtcacctc
     6661 agatatgctg cttagtttca ctaaaagcag accctatacc tagagaagtc actggctttt
     6721 tattggtcat tctcaataca gaaatactta ggggagtctt aaccctgcca tccccggttg
     6781 aatctcttgg tctttatcta agctacttgc agttaatatt cagttaagca aaggtatggc
     6841 cagtagtgca agtatctccc agtctctgag ctctgaacaa gaggactgaa attcagcatt
     6901 tgtaaactga cagtttgatg ggcctgggat ttgaagtgaa ctcagcacac aattctgaac
     6961 gtgtatttgc atgtggactg ggaaggaaat aaatgggaac ttggaaataa tggaatattt
     7021 ctcctatgaa agaatttttc gtagaagatt tgtttttgat ataatctttc tgttggttag
     7081 cttttagtgt tttcattcct tttctgatcc acactccttt aagtgaccaa atgaatataa
     7141 cccaacatgc attgggaatg tgtttaatat taaacaatgt ctaactgaat ctgcaaatgc
     7201 gggaactgag atatcacctc catgtgcaca cctgtgtgta cgagtattct atacaacttg
     7261 tagcatttac tgccacttaa ttgggttgaa cttgcaagat aaacttttgg aaactgctta
     7321 gtgccatcgg agtctccttt agaagctgcc atcaggcaaa tgctatccca taataccagc
     7381 agtaagcctg gcaacatgtt caacagattt agtacccaag aggaaatcaa cagcgatagt
     7441 agagaatgag tcagatgtag tgggataaat actagcctag gaagaaggag ccccggagtc
     7501 taatatgagc tttattacta aattgctatg tgacgctagg caagtcactt aacctctcca
     7561 tggctgtttc ctcatctgta aaataagtgt attggactag atgatcctta gggtctttcc
     7621 aaaagtctaa cattctatgg cattataggt tgccttgcaa attcagcctg ctatagtgat
     7681 ggcaaatatc acgtttaagc ctgagtctct tatgttgcag ttaaataaaa gaactatgta
     7741 agatgatttt taaaattcaa gcaaatgggc cgggtgcggt ggctcatacc tgtaatccca
     7801 gcactttggg aggccaaggc aggcggatca cctgaggtca ggagttcgag accagcctga
     7861 ccaacataga gaaaccccat ctctactaaa aatacaaaat tagccgggtg tggtggcggg
     7921 cgcctgtaat cccagctact tgggaggctg aggtgggaga atcgcttgaa cccaggaggc
     7981 ggaggttgtg gtgagctgag atcatgccat tgcactccag cctcggcaac aagagtgaaa
     8041 cttcgtctcc aaaaaaaaaa actcaagcaa atgaagttca taataatagg ggatgttgat
     8101 aaaacttgtg gcagccttcc aattcattta cagttgtttc gttttgtttt tgttttaatg
     8161 tccattttct gttgactgtt cccagttttc attttccata cagtctgtat gtaaagtctg
     8221 gttttcatta agctgtggcc agtatttgcc actacaacag aaacacactg tcacacttgc
     8281 tagaatataa ctgtacttga gcttctcctt tcctgtgaag tagtgctggg ctttctagag
     8341 tttaattctc aagtggcaca agatagcaga gcccatgcat tttaatggct gagactgcta
     8401 agagtgaacc taaacactta caagttgcag agagaaatga aaaagtaatt acatgctatt
     8461 agcattgaga aatgttgaca aattaatttg ttgggaacca aagatagcat ttctgatgac
     8521 aactcccaca gtgattggcc agttgtatga tgagtacact gctggaaaga gggtaaactg
     8581 ggagttagtg gatggtccca atgccctgcc tacagcagag tgccaaccag ccctgagtgc
     8641 aaaattcaag ttcaatgtgt gtgcttgtgt gtggtgtgct ttatggaccc gcaaatacca
     8701 tattcattat tgatgataag atcttcacag aatcctgtag ctactaatgc attgagtttt
     8761 taatctcagt acatcagcca ggaggagcca gatcacaggg tagtgatgtc tactgggatt
     8821 atactcataa catctacaca aaacaagttg agaaggatcc acgttttcat tgtttatcag
     8881 aattgtatct catttggctg agcattactt ttgtcagaat gtgttatctg taaaccatgt
     8941 gtagtgaaat tcttctgtaa ctttggatta aaggtattta tggtcttttt gtttgtttga
     9001 tttttaagta agttatttct tttgtagacc tgctgatggt atggttccat ccttctgacc
     9061 tcagcatcca atctttttaa ggatttttgt tttcaatatt gttattttaa attgtggttg
     9121 aagcaataga aaattgaaat atggattgtg catgactgtg tcttgagtgt aaaaatattg
     9181 cagtttgaaa cttggaccta aagtattgca aataaaaatg acaaacatca atga
//
