LOCUS       NM_002577               6139 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), mRNA.
ACCESSION   NM_002577 XM_936511
VERSION     NM_002577.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6139)
  AUTHORS   Kervarrec,T., Westphal,D., Pissaloux,D., Legrand,M., Tirode,F.,
            Neuhart,A., Drouot,F., Becker,J.C., Macagno,N., Seris,A.,
            Jouary,T., Beltzung,F., Jullie,M.L., Harms,P.W., Cribier,B.,
            Mourah,S., Jouenne,F., Fromont,G., Louveau,B., Mancini,M.,
            Kazakov,D.V., de la Fouchardiere,A. and Battistella,M.
  TITLE     Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases
  JOURNAL   Histopathology 85 (4), 566-578 (2024)
   PUBMED   38785043
  REMARK    GeneRIF: Porocarcinomas with PAK1/2/3 fusions: a series of 12
            cases.
REFERENCE   2  (bases 1 to 6139)
  AUTHORS   Wu,D., Zuo,Z., Sun,X., Li,X., Yin,F. and Yin,W.
  TITLE     ACSL4 promotes malignant progression of Hepatocellular carcinoma by
            targeting PAK2 transcription
  JOURNAL   Biochem Pharmacol 224, 116206 (2024)
   PUBMED   38615921
  REMARK    GeneRIF: ACSL4 promotes malignant progression of Hepatocellular
            carcinoma by targeting PAK2 transcription.
REFERENCE   3  (bases 1 to 6139)
  AUTHORS   Sannigrahi,M.K., Cao,A.C., Rajagopalan,P., Sun,L., Brody,R.M.,
            Raghav,L., Gimotty,P.A. and Basu,D.
  TITLE     A novel pipeline for prioritizing cancer type-specific therapeutic
            vulnerabilities using DepMap identifies PAK2 as a target in head
            and neck squamous cell carcinomas
  JOURNAL   Mol Oncol 18 (2), 336-349 (2024)
   PUBMED   37997254
  REMARK    GeneRIF: A novel pipeline for prioritizing cancer type-specific
            therapeutic vulnerabilities using DepMap identifies PAK2 as a
            target in head and neck squamous cell carcinomas.
REFERENCE   4  (bases 1 to 6139)
  AUTHORS   Yang,H., Li,Z., Zhu,S., Wang,W., Zhang,J., Zhao,D., Zhang,M.,
            Zhu,W., Xu,W. and Xu,C.
  TITLE     Molecular mechanisms of pancreatic cancer liver metastasis: the
            role of PAK2
  JOURNAL   Front Immunol 15, 1347683 (2024)
   PUBMED   38343537
  REMARK    GeneRIF: Molecular mechanisms of pancreatic cancer liver
            metastasis: the role of PAK2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6139)
  AUTHORS   Kervarrec,T., Pissaloux,D., Paindavoine,S., Tirode,F., Osio,A.,
            Mourah,S., Jouenne,F., Sohier,P., Calonje,E., Pekar,A.,
            Luna,E.V.E., Goto,K., Delalande,F., Frouin,E., Macagno,N.,
            Drouot,F., Faisan,M., Cribier,B., Battistella,M. and de la
            Fouchardiere,A.
  TITLE     Recurrent PAK2 rearrangements in poroma with folliculo-sebaceous
            differentiation
  JOURNAL   Histopathology 83 (2), 310-319 (2023)
   PUBMED   37199682
  REMARK    GeneRIF: Recurrent PAK2 rearrangements in poroma with
            folliculo-sebaceous differentiation.
REFERENCE   6  (bases 1 to 6139)
  AUTHORS   Benner,G.E., Dennis,P.B. and Masaracchia,R.A.
  TITLE     Activation of an S6/H4 kinase (PAK 65) from human placenta by
            intramolecular and intermolecular autophosphorylation
  JOURNAL   J Biol Chem 270 (36), 21121-21128 (1995)
   PUBMED   7673144
REFERENCE   7  (bases 1 to 6139)
  AUTHORS   Martin,G.A., Bollag,G., McCormick,F. and Abo,A.
  TITLE     A novel serine kinase activated by rac1/CDC42Hs-dependent
            autophosphorylation is related to PAK65 and STE20
  JOURNAL   EMBO J 14 (17), 4385 (1995)
   PUBMED   7556080
  REMARK    Correction to:[EMBO J. 1995 May 1;14(9):1970-8. doi:
            10.1002/j.1460-2075.1995.tb07189.x.. PMID: 7744004]
REFERENCE   8  (bases 1 to 6139)
  AUTHORS   Knaus,U.G., Morris,S., Dong,H.J., Chernoff,J. and Bokoch,G.M.
  TITLE     Regulation of human leukocyte p21-activated kinases through G
            protein--coupled receptors
  JOURNAL   Science 269 (5221), 221-223 (1995)
   PUBMED   7618083
REFERENCE   9  (bases 1 to 6139)
  AUTHORS   Martin,G.A., Bollag,G., McCormick,F. and Abo,A.
  TITLE     A novel serine kinase activated by rac1/CDC42Hs-dependent
            autophosphorylation is related to PAK65 and STE20
  JOURNAL   EMBO J 14 (9), 1970-1978 (1995)
   PUBMED   7744004
  REMARK    Erratum:[EMBO J. 1995 Sep 1;14(17):4385. doi:
            10.1002/j.1460-2075.1995.tb00113.x.. PMID: 7556080]
REFERENCE   10 (bases 1 to 6139)
  AUTHORS   Brandon,S.D. and Masaracchia,R.A.
  TITLE     Multisite phosphorylation of a synthetic peptide derived from the
            carboxyl terminus of the ribosomal protein S6
  JOURNAL   J Biol Chem 266 (1), 380-385 (1991)
   PUBMED   1985906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB164364.1, AK291339.1,
            BC069613.1 and AC127904.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 21, 2008 this sequence version replaced NM_002577.3.
            
            Summary: The p21 activated kinases (PAK) are critical effectors
            that link Rho GTPases to cytoskeleton reorganization and nuclear
            signaling. The PAK proteins are a family of serine/threonine
            kinases that serve as targets for the small GTP binding proteins,
            CDC42 and RAC1, and have been implicated in a wide range of
            biological activities. The protein encoded by this gene is
            activated by proteolytic cleavage during caspase-mediated
            apoptosis, and may play a role in regulating the apoptotic events
            in the dying cell. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.141172.1,
                                           SRR1660803.20636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327134.7/ ENSP00000314067.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DB164364.1         1-116
            117-649             AK291339.1         1-533
            650-678             BC069613.1         363-391
            679-2102            AK291339.1         563-1986
            2103-6139           AC127904.8         28592-32628
FEATURES             Location/Qualifiers
     source          1..6139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..6139
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /note="p21 (RAC1) activated kinase 2"
                     /db_xref="GeneID:5062"
                     /db_xref="HGNC:HGNC:8591"
                     /db_xref="MIM:605022"
     exon            1..301
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            302..509
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1897
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /EC_number="2.7.11.1"
                     /note="p21 (CDKN1A)-activated kinase 2; S6/H4 kinase; p58;
                     PAK-2; gamma-PAK; p21-activated kinase 2; p21 protein
                     (Cdc42/Rac)-activated kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 2"
                     /protein_id="NP_002568.2"
                     /db_xref="CCDS:CCDS3321.1"
                     /db_xref="GeneID:5062"
                     /db_xref="HGNC:HGNC:8591"
                     /db_xref="MIM:605022"
                     /translation="MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVP
                     EEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQW
                     ARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAK
                     GTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSL
                     DKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA
                     IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV
                     VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQ
                     ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR
                     ALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSS
                     LTPLIMAAKEAMKSNR"
     exon            510..610
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            611..758
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            759..790
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            791..898
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1031
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1095
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1144
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1257
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1375
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1475
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1672
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1810
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..6139
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4165..4170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /note="hexamer: ATTAAA"
     polyA_site      4192
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
     regulatory      5962..5967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /note="hexamer: AATAAA"
     polyA_site      5980
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /note="major polyA site"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
                     /note="hexamer: GATAAA"
     polyA_site      6139
                     /gene="PAK2"
                     /gene_synonym="KNO2; PAK65; PAKgamma"
ORIGIN      
        1 gtcttcctcc cccagggttg tggccacgcg cagcggcggc ggttgttccg cttcccctcc
       61 ggcccgggcc gtcgccattg ccgaaggctc cctcccctcc cctccctggc gtgcgcagga
      121 ctccgccgcc gctgggccta gcggtagcag cggctgctcc agcgcggcgt ctcttcccgc
      181 cccgcttccc cttccctccc ctcccctccc cgcaccgcgc gctagcccgg ggcggctccg
      241 cagcccgccg ggagctctga ccgaggcgcc tcgctggggc ggggaccttg ccttgcccgg
      301 ggccatttca taattctgaa tcatgtctga taacggagaa ctggaagata agcctccagc
      361 acctcctgtg cgaatgagca gcaccatctt tagcactgga ggcaaagacc ctttgtcagc
      421 caatcacagt ttgaaacctt tgccctctgt tccagaagag aaaaagccca ggcataaaat
      481 catctccata ttctcaggca cagagaaagg aagtaaaaag aaagaaaagg aacggccaga
      541 aatttctcct ccatctgatt ttgagcacac catccatgtt ggctttgatg ctgttactgg
      601 agaattcact ggcatgccag aacagtgggc tcgattacta cagacctcca atatcaccaa
      661 actagagcaa aagaagaatc ctcaggctgt gctggatgtc ctaaagttct acgactccaa
      721 cacagtgaag cagaaatatc tgagctttac tcctcctgag aaagatggct ttccttctgg
      781 aacaccagca ctgaatgcca agggaacaga agcacccgca gtagtgacag aggaggagga
      841 tgatgatgaa gagactgctc ctcccgttat tgccccgcga ccggatcata cgaaatcaat
      901 ttacacacgg tctgtaattg accctgttcc tgcaccagtt ggtgattcac atgttgatgg
      961 tgctgccaag tctttagaca aacagaaaaa gaagactaag atgacagatg aagagattat
     1021 ggagaaatta agaactatcg tgagcatagg tgaccctaag aaaaaatata caagatatga
     1081 aaaaattgga caaggggctt ctggtacagt tttcactgct actgacgttg cactgggaca
     1141 ggaggttgct atcaaacaaa ttaatttaca gaaacagcca aagaaggaac tgatcattaa
     1201 cgagattctg gtgatgaaag aattgaaaaa tcccaacatc gttaactttt tggacagtta
     1261 cctggtagga gatgaattgt ttgtggtcat ggaatacctt gctggggggt cactcactga
     1321 tgtggtaaca gaaacgtgca tggatgaagc acagattgct gctgtatgca gagagtgttt
     1381 acaggcattg gagtttttac atgctaatca agtgatccac agagacatca aaagtgacaa
     1441 tgtacttttg ggaatggaag gatctgttaa gctcactgac tttggtttct gtgcccagat
     1501 cacccctgag cagagcaaac gcagtaccat ggtcggaacg ccatactgga tggcaccaga
     1561 ggtggttaca cggaaagctt atggccctaa agtcgacata tggtctctgg gtatcatggc
     1621 tattgagatg gtagaaggag agcctccata cctcaatgaa aatcccttga gggccttgta
     1681 cctaatagca actaatggaa ccccagaact tcagaatcca gagaaacttt ccccaatatt
     1741 tcgggatttc ttaaatcgat gtttggaaat ggatgtggaa aaaaggggtt cagccaaaga
     1801 attattacag catcctttcc tgaaactggc caaaccgtta tctagcttga caccactgat
     1861 catggcagct aaagaagcaa tgaagagtaa ccgttaacat cactgctgtg gcctcatact
     1921 cttttttcca ttttctacaa gaagcctttt agtatatgaa aattattact ctttttgggg
     1981 tttaaagaaa tggtctgcat aacctgaatg aaagaagcaa atgactattc tctgaagaca
     2041 accaagagaa aattgcaaaa agacaagtat gacttttata tgaacccctt ctttagggtc
     2101 cagaaggaat tgtggactga atcactagcc ttaggtcttt cagcaaacag cctatcaggg
     2161 ccatttatca tgtgtgagat ttgcatttta ctttgctgac tttgttgtaa tagatcccat
     2221 tcattgtccc ctttggggta tttccaatac ttgaatggca gattggagtt tttcagagta
     2281 tgtgtttcat ctgctagtct ttctctcctt catagctttt cttttcctgg acttgctcct
     2341 tttgagttgc ttttgcgttt ctcatgccta ggcaagtgta atagaaatta tgtagctcct
     2401 tatgttggca aaggagctct atatagtttc actttgtata aaagttagga ccagctgttg
     2461 ttacatgtaa tattttagtt cagaacttga cctgaaggaa gggaagaaaa gtatgtgatt
     2521 tttacctttt ttaacaaatg tgaaaaagtc agttttagaa atttcgtggt agtaagttcg
     2581 gcatttgtta catgtataga gagaagacta ataatctcta tttataacta aatcattgag
     2641 atagaaaaag attcccattg actgtagact tcttcccatt ttgtcttccc ttctgcctgt
     2701 ttccccttca ggcttggctc taggaaccaa agtgatttgt tgttgttcca acctgggctt
     2761 tgtgactttg gttagtgcca ctaccttctt ccctcctttc ccccttcaat ttggaaataa
     2821 atttctgtat atgttgcaat tttaggttta ggtttgttct ttttcttttt cattaatcct
     2881 ctctcacctc acagataccc cctcccatgg caaataatat aataaccagt gaattttcag
     2941 gaatttaaaa attagctttt ttccacttaa aggagaaaaa tatttgggac tagcagcaga
     3001 ggcagtaaga gatgtgaacc ttggtgagct ctgatacagt gagaagagat tatactcatg
     3061 aaagagaatg ttagtgttac agagaagcag ccgatagcaa atcgactgta gagacttggc
     3121 ggcggtggca ttgccccagg tcgtcagcag tgtggtatta tctatgagaa cttgagcgac
     3181 agagtatttc ttgatgaatt tatagatcat ttgagatgtt gagttacttt agtttagttt
     3241 tgttttgttt tttcaaataa gtagagacta ttgtaaaaaa cgagaaagga aaatgaaatg
     3301 tgcgtgttga tagcaataat ttgtttcttt taaagattct aaaaggtctg agacctgtag
     3361 cattaattat ttgagtgccc tcccttctcc cctcccctcc cttttctctt ctcttttttc
     3421 ctctcctctt cttctccttt attcattgtt ttgcttttgg agtgggtgtt gttcaagtat
     3481 ctgtggtttg gttctggcat tttgttccca ccatcccctt cccccattaa cttcccccct
     3541 gcttgccatc ctgcagtagt ataaatcatg aataaaaaat aattttgctg ttgtagtata
     3601 cattggagaa actggcaggt tttatttcca ttattttatt tccactatat ctatgataag
     3661 atgcaattat aaggagagaa gtgactgttt tttattgata aggcaagatt ttcagaaaaa
     3721 tgagtaaaat aattaatgaa acatatttag agcacttaat ggtctctgtt ttcaatataa
     3781 ttcttgattt catttttctc tggaatatat tggccttcta cagctattac tgaattatag
     3841 aaactggttt atttctggca gaaagctgca gtgccacctg agttccaaat tttaccattc
     3901 tttgtaaaca gttggatgga ttatgataaa gaagatgcta ccaatgaaat agaaaaccaa
     3961 cgagatgaga agactgtgat cctcatgtac tcagaggcac ttccctccta agtcaaagac
     4021 catcctcact gactatgtgc caacgcctcg tttcaggctt gtgactcaac aaagggcttt
     4081 tccattgata gaagcagttt gggatttgta gttgcgactt cttcgatagt tacctgcacg
     4141 tccattgctg gcaactgact tgtcattaaa acctggctct ttggttaagg gagctacgct
     4201 gtggtttatt cttaagttac gtggataaac taacctctaa cagaaatata ctttggttaa
     4261 ttttgaaatg tgtcattttt aaacaatctt aaaagtaata cagaattgtg atttattaat
     4321 tttaaaacat tcagaacttg ttgaaagaaa aattatatct gaatcaagat tcatgttttt
     4381 tatttttatt ttttttgata cagagtctca ctctgtcact caggctggag tgcagtgaca
     4441 tgatctcagc tcactgcaac ctccgcttcc tgggttcaag caattctcat gcctcagcct
     4501 cctgagtagc tgagaccaca ggcacccgcc accacaccca gctatttttt tgtattttta
     4561 gtagagacag agtctcacca cattgcccag gctggtctcc aactcctgag ctcaggcagt
     4621 ctgcccacct tggcctccca aagtgctgca gttacaggcg tgagccactg cacctggcct
     4681 catgtttttt aaataattgc cttttatatt tacccttttt gtcatcactt tagaatgaaa
     4741 attcccattt aaatctgaaa gttaccttaa tagtcctctt gtgttattag gacagtatta
     4801 ttatagtact tatttatttt attttagatt taaagttatc ttctcttttt cttttttctt
     4861 ctgctgcttt tagggacaat taaaactggg aaactatgaa acatggaaca ttttatccta
     4921 cctgaaagta aacgagtaat tgtgaagcat aagacactga ggctaataca actctgtctt
     4981 catgtgttga ctgcctggca catagtattc attctcttcc ctttaacata gaagtgtcca
     5041 gctgcgtaca gtctagtaac cagcaactgt aaacgaacct gtgcctctaa caagcgattc
     5101 taaaccacct atgagtattt cttttagggc tcacttaaat acatgtttgt atatactgta
     5161 ttctagccag aataatttta gatctgatca ggtagtagct aaaattagaa aaaaacaaaa
     5221 tagatgctta aagaatttgc atccattttt gagtctaaat cttttaaaat atactgagat
     5281 ccacatctag tgaaatgtca gtgtcaaaat attatagatt atagctaaaa tccagattaa
     5341 tactcatttg gggtttttta tagtggaact tcatagtaat acaaaaagca gattgtcttc
     5401 ctgtctccgc tgctcccaca gtaggtattg aaactggtaa aatcagtttt ttgatagtgt
     5461 gtgtatataa gaaaaaatag atacacacat tcttttttct cagtcaacac attgattgaa
     5521 cactctggca aagatgctgt ggtggatgag gttggagttc gaaagaagaa gcaagcgctg
     5581 gcctggcctt gaaagaaccg aagtctttcc cattcacttc tctagaaagc tgccaagaca
     5641 gaggcagaaa gaaatggatg atagttctgt caagcacact tctgttctct tagaacttag
     5701 aagtgtttct aagagaacag aagtaataag agaaacagtt acgtgtggaa ttcaacatct
     5761 ttggttggaa cgcattggct ttttttttct tgttttgata gaaatggaat taagcaaaag
     5821 tagtttttgt cttttctgtt gtcttcaaat tttatgcctt ttatttttaa tttaatcccg
     5881 ttcaattatt taattgttat acattgacat taactgctgt attttgactt tgttcaataa
     5941 ttttgttctt tcagggctag aaataaactt tttaaaaaaa gtgtgcattt ttccctttcc
     6001 taaactttta ttctttcttt tgatcagcgt aaaagaatat tttaatgtct tttgatagca
     6061 taaaagaata tttaaatgtc ttaataggtt ttcaaagaac atttagtatt tttagtgata
     6121 aatgttttaa accttttaa
//
