LOCUS       NM_017906               1523 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens PAK1 interacting protein 1 (PAK1IP1), mRNA.
ACCESSION   NM_017906
VERSION     NM_017906.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1523)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 1523)
  AUTHORS   Williamson,R.C., Cowell,C.A., Hammond,C.L., Bergen,D.J.,
            Roper,J.A., Feng,Y., Rendall,T.C., Race,P.R. and Bass,M.D.
  TITLE     Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1
            and controlling GEF exposure
  JOURNAL   J Cell Sci 127 (Pt 19), 4292-4307 (2014)
   PUBMED   25074804
REFERENCE   4  (bases 1 to 1523)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   5  (bases 1 to 1523)
  AUTHORS   Ross,A.P., Mansilla,M.A., Choe,Y., Helminski,S., Sturm,R.,
            Maute,R.L., May,S.R., Hozyasz,K.K., Wojcicki,P., Mostowska,A.,
            Davidson,B., Adamopoulos,I.E., Pleasure,S.J., Murray,J.C. and
            Zarbalis,K.S.
  TITLE     A mutation in mouse Pak1ip1 causes orofacial clefting while human
            PAK1IP1 maps to 6p24 translocation breaking points associated with
            orofacial clefting
  JOURNAL   PLoS One 8 (7), e69333 (2013)
   PUBMED   23935987
  REMARK    GeneRIF: A mutation in mouse Pak1ip1 causes orofacial clefting
            while human PAK1IP1 maps to 6p24 translocation breaking points
            associated with orofacial clefting.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1523)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 1523)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1523)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 1523)
  AUTHORS   Xia,C., Ma,W., Stafford,L.J., Marcus,S., Xiong,W.C. and Liu,M.
  TITLE     Regulation of the p21-activated kinase (PAK) by a human Gbeta -like
            WD-repeat protein, hPIP1
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6174-6179 (2001)
   PUBMED   11371639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010907.1, AF283303.1, BU618231.1 and AL358777.12.
            
            On Nov 22, 2018 this sequence version replaced NM_017906.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.144436.1,
                                           SRR3476690.927856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379568.4/ ENSP00000368887.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               BC010907.1         22-635
            615-783             AF283303.1         675-843
            784-842             BC010907.1         805-863
            843-1266            AF283303.1         903-1326
            1267-1480           BU618231.1         15-228              c
            1481-1523           AL358777.12        133187-133229
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.2"
     gene            1..1523
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="PAK1 interacting protein 1"
                     /db_xref="GeneID:55003"
                     /db_xref="HGNC:HGNC:20882"
                     /db_xref="MIM:607811"
     exon            1..98
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1193
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="PAK/PLC-interacting protein 1; WD repeat-containing
                     protein 84"
                     /codon_start=1
                     /product="p21-activated protein kinase-interacting protein
                     1"
                     /protein_id="NP_060376.2"
                     /db_xref="CCDS:CCDS34339.1"
                     /db_xref="GeneID:55003"
                     /db_xref="HGNC:HGNC:20882"
                     /db_xref="MIM:607811"
                     /translation="MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTAS
                     LSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAED
                     GLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFI
                     KNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVL
                     AVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKL
                     KQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEP
                     GDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
                     "
     exon            99..261
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            262..382
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            383..457
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            458..510
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            511..656
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            657..754
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            755..854
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            855..978
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1523
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="hexamer: AATAAA"
     regulatory      1479..1484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="hexamer: AATATA"
     polyA_site      1482
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="major polyA site"
     polyA_site      1495
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
     regulatory      1496..1501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
                     /note="hexamer: TATAAA"
     polyA_site      1523
                     /gene="PAK1IP1"
                     /gene_synonym="bA421M1.5; hPIP1; MAK11; PIP1; WDR84"
ORIGIN      
        1 acgtgcgctg ctgaatggag ctggtcgctg gttgctacga gcaggtcctc tttgggttcg
       61 ctgtacaccc ggagcccgag gcttgcggcg accacgagca atggactctt gtggctgact
      121 tcactcacca tgctcacact gcctccttgt cagcagtagc tgtaaatagt cgttttgtgg
      181 tcactgggag caaagatgaa acaattcaca tttatgacat gaaaaagaag attgagcatg
      241 gggctctagt gcatcacagt ggtacaataa cttgcctgaa attctatggc aacaggcatt
      301 taatcagtgg agcggaagat ggactcatct gtatctggga tgcaaagaaa tgggaatgcc
      361 tgaagtcaat taaagctcac aaaggacagg tgaccttcct ttctattcac ccatctggca
      421 agttggccct gtcggttggt acagataaaa ctttaagaac gtggaatctt gtagaaggaa
      481 gatcagcatt cataaaaaat ataaaacaaa atgctcacat agtagaatgg tccccaagag
      541 gagagcagta tgtagttatc atacagaata aaatagacat ctatcagctt gacactgcat
      601 ccattagtgg caccatcaca aatgaaaaga gaatttcctc tgttaaattt ctttcagagt
      661 ctgtccttgc agtggctgga gatgaagaag ttataaggtt ttttgactgt gattcactag
      721 tgtgcctctg cgaatttaaa gctcatgaaa acagggtaaa ggacatgttc agttttgaaa
      781 ttccagagca tcatgttatt gtttcagcat cgagtgatgg tttcatcaaa atgtggaagc
      841 ttaagcagga taagaaagtt cccccatctt tactctgtga aataaacact aatgccaggc
      901 tgacgtgtct tggagtgtgg ctagacaaag tggcagacat gaaagaaagc cttcctccag
      961 ctgcagagcc ttctcctgta agtaaagaac agtccaaaat tggcaaaaag gagcctggtg
     1021 acacagtgca caaagaagaa aagcggtcaa aacctaacac aaagaaacgc ggtttaacag
     1081 gtgacagtaa gaaagcaaca aaagaaagtg gcctgatatc aaccaagaag aggaaaatgg
     1141 tagaaatgtt ggaaaagaag aggaaaaaga agaaaataaa aacaatgcag tgaatcacag
     1201 atgtctcctg aaagaactct tttagatgaa atcattctac tcaaatgtac cttaattttt
     1261 tttttttccc tgagtaaaag caagaaattt cttcctttgg aaaaaatata tatattaaaa
     1321 aaccactttt agatggtttt ttttaaaaaa aaaaaaaaaa ctggtaaaat tacttttggc
     1381 agacagtgtt ttatgaatta tgtatcatgt tgatatataa tatgttaatg tgtcatgtaa
     1441 tttttacttt gtacaaagca aataaagatc tttctcaaaa tatactgtaa aataatataa
     1501 aatattgaac acattcttta tca
//
