LOCUS       XM_047427053            7134 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens p21 (RAC1) activated kinase 1 (PAK1),
            transcript variant X11, mRNA.
ACCESSION   XM_047427053
VERSION     XM_047427053.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..7134
                     /gene="PAK1"
                     /gene_synonym="alpha-PAK; IDDMSSD; p65-PAK; PAKalpha"
                     /note="p21 (RAC1) activated kinase 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 37 ESTs, 1731 long SRA reads, 12 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 21 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5058"
                     /db_xref="HGNC:HGNC:8590"
                     /db_xref="MIM:602590"
     CDS             4240..5877
                     /gene="PAK1"
                     /gene_synonym="alpha-PAK; IDDMSSD; p65-PAK; PAKalpha"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 1 isoform
                     X4"
                     /protein_id="XP_047283009.1"
                     /db_xref="GeneID:5058"
                     /db_xref="HGNC:HGNC:8590"
                     /db_xref="MIM:602590"
                     /translation="MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPN
                     PEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQ
                     WARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALN
                     VKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVA
                     TSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKI
                     GQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY
                     LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKS
                     DNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
                     GIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEK
                     RGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH"
ORIGIN      
        1 gtattaaatg gcatttagaa tccaaaatct ggttcctaga taatgctcat tgttattgga
       61 ccattgctgc tcccaggcct tctcatagac ataatgagga aatgaggttc tgacaccccc
      121 atcacaggct ctccctactg tgtggatgcc ctccttatct tgcttgggct ttggtaccct
      181 atagcagggt gctcttccat gacaactctt tcttaactgt ggttggcttc tgacacacta
      241 caccagggca cccctctctc ctgatacgga tgccttcctt gctatactta gactatgata
      301 ttccacacca gtccacctcc ctgccccaaa tgtggatgct cttttcaccc tgcttgggct
      361 ctgattctcc tcactagact acttgtctct tcctccccct cctgatggac tcaccctgct
      421 taggtctgac cacagtgttg ggctgccctc atcatctctt aactagactt tttttttttt
      481 ttttgagatg gagtcttgtt ctgtcgccca ggctggagtg cagtggtgca atctcggctc
      541 actgcaacct ccgcctccta ggttcatgcc attctcctgc ctcagcctcc cgagtagctg
      601 gggctacagg cgtctgccat catgcccagc taattttttt ctttttttgt atttttagta
      661 gcaacggggt ttcaccgcgc tagccaggat ggtctcgatc tcccgacctt gtgatctgcc
      721 cgcctcggtc tcccaaagtg ctgggattac aggtgtgagc caccgcgcct ggccttaact
      781 agactattat aacacaaagc ctcctaactg atctccttgc tttcaatctt cttatacctt
      841 tcacatttct gcaagagtga tcattctaaa atataagtca aatcatgcca ctgctctgct
      901 taaaaacatt gtaatagttc ccttttgctt agagaataaa tttcaagttc cttgggctgt
      961 cattcaagga tctctagtat ctgacccaaa ggtacctttc gtcctcattt cttattagtt
     1021 ccttggtata ctgtgcactc caactatcgc cactggctac tccttagaca taccccagta
     1081 catttactcc tctggctttt tgcctttatc ctctcctctg tctggcttag ccaactctct
     1141 tcactgtctg ataaaatccc tcagagtcct agttcagatg tctgctatgg atgtcagagc
     1201 ctgaatacag tgaggaagat aacaataaga ggaaggaatt acctggtgaa acctctctga
     1261 cctctatagt cataaacagt cccctttttt tctacttctg atggagtatt tacttcattc
     1321 tctctctttt cacaatcagc tgtttacata tctgttgcct ctgattcatt ggctgctcct
     1381 tgaatgcact caacacaggg cattgcatct agtagaccct cagggaatgc tgatggaact
     1441 tgtcaaggga atgaattttg gatggtgaag ttaccacagc agtgaatctg ttgctttcat
     1501 ttgaagtcca ttcacaggtc ccactgaggt ctgagaggct ctgactacaa gaaagggttt
     1561 ggagtctggc atccttgggt ctagatatct gccctgtgcc agagctcttt ctgagaaaat
     1621 gatatattca cactattctc ctctttagta aattccaaat atgtctttaa aaaaaaatct
     1681 acactgtcat cctaaataaa ataattccta gctacaggaa tataggtatt taaagctgca
     1741 aataatagca gtgacatcat cctactaaaa aagcctgccc caaattgtct gaaggccagc
     1801 attgtgatat gtgtctcctg acagcctatc cctgcagaga ccctcagtct gtctctgcag
     1861 agacacttag gctgaagtgt cagcaaagga gggttttaga ctttctcagt gactttacca
     1921 gtctgcactt tttggagctg tgtgggaagc atcacaggct aggttccttg tagcatgtgg
     1981 gggtttctag aggggaagag aaagatagga gtctgtattt ctttagatcc cactaccaac
     2041 cccatttgct ccagccatag cagcatcttg aacttttctt gttctgatca ttcattcttc
     2101 cggggctttg tccaggtttt cttttctacc ctgagattga actgtctgat ttcaaagcct
     2161 aggctctttt gtgtttcata atcatagcac cgaatttttt tttttttttt ttttaaagat
     2221 tgctcatttt tgcttttcct gtcaggtttt cagtctcatt aaaataattt ctaaattgag
     2281 atcagaatat tttctaatat acagattcaa tttttgcctc cacaggggtt gaatcaaggt
     2341 atacttacct acaagactaa ctcttatttt gatttggcct gagacacagt agaatgttcc
     2401 caatttaaga ttagcactat tccatctgcc tggtgctaat tgaaactgaa gaggaaggaa
     2461 agcttttatt ctataattgt ttggagagca gcatggaaaa ctccttagaa tgtgatgaac
     2521 ttgatattta ctaggtttat aagttttggc aagtgttaag ctctctgtgc cccgattttc
     2581 ttacctgtaa aatgagggta ataaagccaa tttttaaagg gctgttatta ggttaaatga
     2641 tatgattctt gtagggttga ctctggtttt gactttgtca ccaacagtgg gaggtgggag
     2701 tcatcaacct aagcattgtc cctggcttag tatatgccat aatttcacac taaagctacg
     2761 tttacttcca ttatcttata taaccttcat attgtgatca gagaaaaaaa gatggtggtg
     2821 gtggttccca tttgtcaaat aaggaaattg atactcagag aagttgagtg gcttgtctga
     2881 aaacagagac ctctgactcc tagtctgaga ctccttttgt tcttaacaag tcttaggaga
     2941 gggccgtgtg gtgtaaaaaa aaaaaaaaaa aaaaaaagag gccttcaatt gaaaagtcaa
     3001 gaatgggctt ggtgcagtgg ctcaagcttg tagtcccagc actttgggag gctgaggtgg
     3061 gaagattcct tgaacccagg agtatttttt ctttttcaga aacagggtct tgctctgtca
     3121 cccaggctat gtgatcatag cccactgtag ccttgaactt gtgggctcaa gcgatccccc
     3181 tgccttagcc tcccaagtag ctaggattat acgcagaagc cactgcacta agaatatctt
     3241 gattttgtag ttttagctag gataatttgg gaaagtcaac tcagtttcta ccttatttaa
     3301 acagaaatat gaattattct ttttaactca ctttggcaaa taattgtcga gcatttacta
     3361 tgccttacac ggtgctaggc ttgtcccttc tgtcaagctg tttatatttc actaaggata
     3421 agagatacag ataattagtt taagtgaaaa gagttataac aaatgtgtat gtggcagaag
     3481 ataatggtgg ctgtggtggg agtggtccag gagggtgcca cagagatagc cgtggggctg
     3541 ggcattgctt ctgaggagaa atctcaaagg agggtatgta agaattaatt ggataatgga
     3601 tatgaatgtg ctttattagt tgccacataa atgcagcttt ttacaactgt caattcttac
     3661 agaaggtgcc tcttttctag aaaccttggc tgaccgagta gaacaccata gttggagtcc
     3721 aaacttaatt aaagtgagaa gaaagatttt agtagattga gattttatat taaaaaaaaa
     3781 aaaagcaaaa gcctgtgtct gaagtttttg gaatccagga gtccttaaaa tgggatgtgt
     3841 atgcctatta aaattgtctt ctactttgat gacacagtgg acctcagcca cttttgagtt
     3901 tataaaggac ttatttatta tcacttaaaa aaaagccact tgtgctcctg cagcatttta
     3961 gatatttaaa acagccttgc aaacaagtat gtatcctggg gaataaaatg aatcaggaca
     4021 agacaaagag aaattgggcg gctgagccaa agatatgtaa tgtttttatt ttttatattt
     4081 gtttgggttc agtagatgta attattgaga gctttgtatg tgctaggctt tgtatgaagt
     4141 actgagggaa cagagatgaa tgaagcattt cgtaaacaag gggacatata gtctggctgg
     4201 agatacaaga catctgtgta gctgctgctg gtggtgacaa tgtcaaataa cggcctagac
     4261 attcaagaca aacccccagc ccctccgatg agaaatacca gcactatgat tggagccggc
     4321 agcaaagatg ctggaaccct aaaccatggt tctaaacctc tgcctccaaa cccagaggag
     4381 aagaaaaaga aggaccgatt ttaccgatcc attttacctg gagataaaac aaataaaaag
     4441 aaagagaaag agcggccaga gatttctctc ccttcagatt ttgaacacac aattcatgtc
     4501 ggttttgatg ctgtcacagg ggagtttacg ggaatgccag agcagtgggc ccgcttgctt
     4561 cagacatcaa atatcactaa gtcggagcag aagaaaaacc cgcaggctgt tctggatgtg
     4621 ttggagtttt acaactcgaa gaagacatcc aacagccaga aatacatgag ctttacagat
     4681 aagtcagctg aggattacaa ttcttctaat gccttgaatg tgaaggctgt gtctgagact
     4741 cctgcagtgc caccagtttc agaagatgag gatgatgatg atgatgatgc taccccacca
     4801 ccagtgattg ctccacgccc agagcacaca aaatctgtat acacacggtc tgtgattgaa
     4861 ccacttcctg tcactccaac tcgggacgtg gctacatctc ccatttcacc tactgaaaat
     4921 aacaccactc caccagatgc tttgacccgg aatactgaga agcagaagaa gaagcctaaa
     4981 atgtctgatg aggagatctt ggagaaatta cgaagcatag tgagtgtggg cgatcctaag
     5041 aagaaatata cacggtttga gaagattgga caaggtgctt caggcaccgt gtacacagca
     5101 atggatgtgg ccacaggaca ggaggtggcc attaagcaga tgaatcttca gcagcagccc
     5161 aagaaagagc tgattattaa tgagatcctg gtcatgaggg aaaacaagaa cccaaacatt
     5221 gtgaattact tggacagtta cctcgtggga gatgagctgt gggttgttat ggaatacttg
     5281 gctggaggct ccttgacaga tgtggtgaca gaaacttgca tggatgaagg ccaaattgca
     5341 gctgtgtgcc gtgagtgtct gcaggctctg gagttcttgc attcgaacca ggtcattcac
     5401 agagacatca agagtgacaa tattctgttg ggaatggatg gctctgtcaa gctaactgac
     5461 tttggattct gtgcacagat aaccccagag cagagcaaac ggagcaccat ggtaggaacc
     5521 ccatactgga tggcaccaga ggttgtgaca cgaaaggcct atgggcccaa ggttgacatc
     5581 tggtccctgg gcatcatggc catcgaaatg attgaagggg agcctccata cctcaatgaa
     5641 aaccctctga gagccttgta cctcattgcc accaatggga ccccagaact tcagaaccca
     5701 gagaagctgt cagctatctt ccgggacttt ctgaaccgct gtctcgagat ggatgtggag
     5761 aagagaggtt cagctaaaga gctgctacag catcaattcc tgaagattgc caagcccctc
     5821 tccagcctca ctccactgat tgctgcagct aaggaggcaa caaagaacaa tcactaaaac
     5881 cacactcacc ccagcctcat tgtgccaagc cttctgtgag ataaatgcac atttcagaaa
     5941 ttccaactcc tgatgccctc ttctccttgc cttgcttctc ccatttcctg atctagcact
     6001 cctcaagact ttgatccttg gaaaccgtgt gtccagcatt gaagagaact gcaactgaat
     6061 gactaatcag atgatggcca tttctaaata aggaatttcc tcccaattca tggatatgag
     6121 ggtggtttat gattaagggt ttatataaat aaatgtttct agtcttccgt gtgtcaaaat
     6181 cctcacctcc ttcataacca tctcccacaa ttaattcttg actatataaa tttatggttt
     6241 gataatatta tcaatttgta atcaattgag atttctttag tgcttgcttt tctgtgactc
     6301 aactgcccag acacctcatt gtacttgaaa actggaacag cttgggaatg ccatggggtt
     6361 tgataatctg ccagggacat gaagaggctc agcttcctgg accatgactt tggctcagct
     6421 gatcctgaca tgggagaaca accacatttt tctttgtgtg tgcttctagc agctgttcgg
     6481 gaggaccttg acccaatagt gttcccatgc tgtttcttgt gaaatgctct cggctatgta
     6541 gcagcttttg attccctgca taccctaggc tgctgcccct atcctgtccc ttgtttataa
     6601 cattgagagg ttttctaggg cacatactga gtgagagcag tgttgagaag tcggggaaaa
     6661 tggtgactac ttttagagca aggctgggca tcagcacctg tccagctcta cttgtgtgat
     6721 gtttcaggaa ctcagcccct ttttctgcct aggataagga gctgaaagat taacttggat
     6781 cttctaatgg tccaaatctt ttggtcacaa taaagagtct ccaaattaga gactgcatgt
     6841 tagttctgga tggatttggt ggcctgacat gataccctgc cagctgtgag gggaccccgt
     6901 ttttaagatg catggccaag ctctctgcaa atggaaatgc ttacactggg tgttggggat
     6961 gtttgctacc tcctgctatt tttgtggttt tggttctccc actatggtag gacccctggc
     7021 cagcattgtg gcttgtcatg tcagccccat tgactacctt ctcatgctct gaggtactac
     7081 tgcctctgca gcacaaattt ctatttctgt caataaaagg agatgaaaat attc
//
