LOCUS       NM_020459               6300 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens poly(A) binding protein interacting protein 2B
            (PAIP2B), mRNA.
ACCESSION   NM_020459 XM_376062 XM_945908
VERSION     NM_020459.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6300)
  AUTHORS   Tang,H., Wei,P., Chang,P., Li,Y., Yan,D., Liu,C., Hassan,M. and
            Li,D.
  TITLE     Genetic polymorphisms associated with pancreatic cancer survival: a
            genome-wide association study
  JOURNAL   Int J Cancer 141 (4), 678-686 (2017)
   PUBMED   28470677
  REMARK    GeneRIF: Study provides evidence that a low-frequency SNP of the
            translation inhibitor gene PAIP2B with a significant association
            with pancreatic cancer survival.
REFERENCE   2  (bases 1 to 6300)
  AUTHORS   Berlanga,J.J., Baass,A. and Sonenberg,N.
  TITLE     Regulation of poly(A) binding protein function in translation:
            Characterization of the Paip2 homolog, Paip2B
  JOURNAL   RNA 12 (8), 1556-1568 (2006)
   PUBMED   16804161
REFERENCE   3  (bases 1 to 6300)
  AUTHORS   Derry,M.C., Yanagiya,A., Martineau,Y. and Sonenberg,N.
  TITLE     Regulation of poly(A)-binding protein through PABP-interacting
            proteins
  JOURNAL   Cold Spring Harb Symp Quant Biol 71, 537-543 (2006)
   PUBMED   17381337
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA346299.1, AB032981.1, DA247526.1 and AC007881.4.
            
            On or before May 24, 2007 this sequence version replaced
            XM_376062.4, XM_945908.2.
            
            Summary: Most mRNAs, except for histones, contain a 3-prime poly(A)
            tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances
            translation by circularizing mRNA through its interaction with the
            translation initiation factor EIF4G1 (MIM 600495) and the poly(A)
            tail. Various PABP-binding proteins regulate PABP activity,
            including PAIP1 (MIM 605184), a translational stimulator, and
            PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et
            al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.188656.1,
                                           SRR1660803.198078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244221.9/ ENSP00000244221.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DA346299.1         1-189
            190-411             AB032981.1         170-391
            412-593             DA247526.1         413-594
            594-688             AB032981.1         574-668
            689-6300            AC007881.4         149439-155050       c
FEATURES             Location/Qualifiers
     source          1..6300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..6300
                     /gene="PAIP2B"
                     /note="poly(A) binding protein interacting protein 2B"
                     /db_xref="GeneID:400961"
                     /db_xref="HGNC:HGNC:29200"
                     /db_xref="MIM:611018"
     exon            1..176
                     /gene="PAIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            177..325
                     /gene="PAIP2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..559
                     /gene="PAIP2B"
                     /note="PAIP-2B; PABP-interacting protein 2B"
                     /codon_start=1
                     /product="polyadenylate-binding protein-interacting
                     protein 2B"
                     /protein_id="NP_065192.1"
                     /db_xref="CCDS:CCDS46322.1"
                     /db_xref="GeneID:400961"
                     /db_xref="HGNC:HGNC:29200"
                     /db_xref="MIM:611018"
                     /translation="MNGSNMANTSPSVKSKEDQGLSGHDEKENPFAEYMWMENEEDFN
                     RQVEEELQEQDFLDRCFQEMLDEEDQDWFIPSRDLPQAMGQLQQQLNGLSVSEGHDSE
                     DILSKSNLNPDAKEFIPGEKY"
     exon            326..502
                     /gene="PAIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            503..6300
                     /gene="PAIP2B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      732
                     /gene="PAIP2B"
                     /note="major polyA site"
     regulatory      6283..6288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAIP2B"
                     /note="hexamer: AATAAA"
     polyA_site      6300
                     /gene="PAIP2B"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcagt aagagataac ctggcaagtg gtagtggcgc ttctcgggtg ctgtgcttca
       61 cgttttggta ctaaaggccg agactgttgt ggcgacggcg acctctacgg caacggctta
      121 agctctcgga ggagtggcag agtacgatct gaaggagggg cttctggtta gcccaggttc
      181 catcataatg aatggatcca atatggcaaa tacatcaccg agtgtaaaat ccaaagagga
      241 ccaggggtta agtgggcacg atgaaaagga aaacccattt gcagagtaca tgtggatgga
      301 gaatgaagag gatttcaaca gacaggtgga ggaggaactg caggagcaag acttcttgga
      361 ccgctgcttc caagagatgc tggatgaaga agaccaagac tggtttattc cctcacgaga
      421 cctgcctcag gccatgggac agttgcaaca gcagttaaat ggactgtcag tcagtgaagg
      481 tcatgattct gaagatattt tgagcaaaag taacctgaac ccagatgcca aggagtttat
      541 tccaggagag aagtactgag ccgagaaagc tttgaggaag acttgtctgt ccccacatct
      601 ggggatagta atgcacaaaa tggtggagct gaagaggggg atggggcggg cgaggggtgc
      661 acagcgggaa ggggagtggt ggtctcacaa tactgtgact ctgagtaact aatatgctca
      721 gtcttattct aagcctctga gtatttctat tttgttctgc tgacttttgt ttggggagtt
      781 tcctgttttg tttttttaaa tagctctttc gagttaagga aattgcattt tccccccttc
      841 atcagaagtg ttccgcggtg tgtatttaaa caaaataagc tgactaagaa aaactggata
      901 tttaggaaat gcccctctca ccctgctgta tacttatcag ggacagtgag cacctggaga
      961 gctttttgtg gaatctattg agttggatgg gaaaagggac aagcagaaag agcaggtggt
     1021 gcaaactgga atttgaggct cagctgcccc acccccgggg tctcctgcaa tgaactcgga
     1081 taaccaatgt gctgtcaagc ccttgcctgt ttgtcctgaa ccccattcaa gaaaacacag
     1141 acttaaagta cttagtttac agtaactttt gatgattgtt gaaagttgta aatcagaagg
     1201 tagggctgtg atggtggttg tcacttgagt catttagtta ctgttgtcct gttcataagc
     1261 ctgtgttcac caccaccatc agactcacca tttataagta gaagagcact agggttgatc
     1321 tgccacctca tctttcatga agtctattcc ccagcctcct ttttaagaaa agatactgct
     1381 accaaaggca taggggaggc ctgctgtgct ggcaattagc atgagcctgc agaagtcatc
     1441 cttgaatctg ttgtgtctta attttatttg gacagttttt ttttccagcc tcatcaacac
     1501 ttggtcttcc tggtgtctta attccctcag acaagtttat gcactttttt aaggaaatat
     1561 ttttcaggac actagtaaga agctcagttc acagtttgga tatttcttcc cacattacag
     1621 aattatggaa aggaactcaa aatcagccta ggaaagtgag tcctgcttga cccatgtgac
     1681 tgtgtacctg accttctggg atcttttcag ctattaaaac attttactgt tcccacatac
     1741 ccagctttgc aagttttgta gattgacctc ttagggtgtg tttctttgtc tttcctgcct
     1801 ttaacttgct ggggtctttt gttgctaccc ctaaggaact aaactgggtg ccaggagcta
     1861 ccttcgtgta tagagatgta gatggcagtg tggggtacag gagagccatc caggccattc
     1921 tcccagggat gaggaattgg agagccctga agataatagt ggcttctttc tgattgctac
     1981 tgtgctgtgt gataggccta atagggaaaa gatatgtaac ttgaaacaaa gttggtataa
     2041 attcagtatg tggctgtggg acagaggttg gaaggaaagg actagggtat ggaaagctga
     2101 agaaattctc cttatgagct ctcgttgact ttttgaacag tgataagcta atgccagatt
     2161 taaaatacac attttttcct atttgagtct ttaggattat atcatttgaa aaaattgcct
     2221 tccttgttag gtcacatgtc ataggagagt agcttagaga acttgcatta ccagacagac
     2281 acattaattc ccaaagcctc tatgttgaga gaatgaaact gttaactctt tttcagagag
     2341 gactatgaat aaagaaactt ctttattcaa gcttcagctt tcagctgggt tgtttcctct
     2401 aaaagggaaa gggcattgca agtgcataga ggaaatctct cccttctggg actgcttttc
     2461 ctccttcatc ctcgtgagcc tgtccaagct cagaattccg aaggctgtta gaaatgcgtt
     2521 gggattgcag agagaaagga gcttgtcttt ccttctgctg tgctggtctg ttttggatgt
     2581 cagtcttcag gactatgaaa acttcctgcc agtttagcat ggacactgag ggctggcatt
     2641 tctagtcttc ttcagacact gaacatactg actccaggta taggaagcag ctagcaaatt
     2701 gattcttttt taaatgcata ggactctgct tccggcggtt cctcttgtag tccaactctt
     2761 tttgccatct atttatgttg ggaggtaggg gcacaattgt cactcacaac acaggctagt
     2821 tagagtttgc taccttctta gcagaaaatg catgtgtgtc ttgttggacc ttcactgggg
     2881 aaaggctggg agcctctggc tgtcagtgac ttttctcaca gaagaagaac cagcaagcca
     2941 gactggacac ctttaccctt taatggtaag acttgtattt ataaggggta attttgatgt
     3001 tgaatttaag ccactacttt gtttaaactt ttttaaattg gcaactagaa gtttgagaat
     3061 ttgtatagaa atggaacatg tatttctaac agttgccaat ctggctggtc ccaatgttag
     3121 tttattagtg attgatctgt aattattggg attatttatt caactctaaa attccaagat
     3181 gaaaataatt tatctctttc ttttcaaggg aaaaaaccca aatgaatgca ttttcagttt
     3241 ctccaggcct ttgaactgca gcagaaaatt caaggataca gcctaggcct gggcaaatgc
     3301 agccctgggt ctttgggcca gtttctgaca ataatagttg agttttggga atcacataag
     3361 ggtgaaacca gaaacgatcc taaggaaagg cttgaccttt gttaacacct ttagtttcca
     3421 aagtcacagc agctggggtc cctctttttt tttttttttt cttttttttt gagacatagt
     3481 ctcactctgt cacccaggct ggagtgcagt ggtatgacca tagctcactg cagcatcaaa
     3541 ttcctaggct caagcaatcc tcccatctta gcctcccgag tagctgggac aacaggtacg
     3601 caccaccacg gccagctaat tatttttatt atttttattt tttgtagaga ctggatcttg
     3661 ctctatttcc caagctactc ttgaattgtt gtgctcaagt gattctccca tctcagcctc
     3721 ccaaagtgct gggattatag gctgggtgtg gtgagccacc ccagcctggg gtctctttaa
     3781 ttaaggttat aatgctaacc atggcttaaa atactaagca acattttcca aattgtttat
     3841 tactattgct ttgattttgg agaagctggg aagtaaggag gtgaggtgaa tactctgata
     3901 attaacacgt gttagagagg aaagttgtgt gaagaggctg ccaaagtaaa cagcacgaat
     3961 gaatcttctt gtactagggc tgctgcaaac cccaggtaga caaatgacag cccaggctcc
     4021 tgaaccatca ggaacccagg aatctaccca actgtgagga gggggcaggc cttcgtcaat
     4081 aagggtccca ccatcacggg ctaataatct ttctcagttt aggtgatatt gaggtattga
     4141 aactgttaga aatctgacag atttgaccaa gatttggaga cgtccacata attgggaagg
     4201 actgagtgtc cctagccact ctcctctggg ataacgcgga cgtcattagt ttgcgaagtg
     4261 ggtggggaga acaggaggat tgactctaat ttggtgtgta gtgggggcct tgatgtcctt
     4321 ctgcctctgt ccacatttcc ccatgtgact cattgcaccc tgcattgctc acagggatca
     4381 ttagttctcc cggtagacag agcacctctg cagcctctgc tctgctgcct tgtgaatttc
     4441 ctacacagac ttggttagtt acaatttgga aacagttttt ttgggttttt ttcctttgtt
     4501 ttaatcttct cacaatgaag ctgctattgg tgacagggac aggggagcag gaagccaacc
     4561 cagggaaaca tgcgagtttc ctgcacacca cttagtcacc tgccctcact ggccaacccc
     4621 ctactgctgt tcccagtcag tctggttttt agaggcatcg tggcaataga atagctggat
     4681 acactaatct ctacaaggtg tcaggcagga gattcacctt ccccagtccc aggggacagg
     4741 agagaaatct gtaaagggac agatgcacca tctttatttc aaaagaaaaa gctccctcag
     4801 attgtgttac taggagtctc ttttgtgaca tttactgagc tttctcccca atcttacctt
     4861 cctattggct actttttaaa taaaaataaa cattttaggc taatatgaca aaaatgagat
     4921 aaaatcttaa aaacattgta ctagtgtaca gttactaaaa tgtgcttact acaaaacagt
     4981 aaaatatttc actctgtaaa tcatcactaa gtagttattc tgtcctgttg attatgagcc
     5041 tccaaaaatg tttaatgctt gaaggatggt ttgggaggca gggaatcctt ttcttaaaac
     5101 aactttaatg aggcatatgt tacatatcat aaaacaccca tttcaagtgt acatttcagt
     5161 gattttagta acttccctca gtggtgtagc tgtaactatt actcagtttt agaacatttt
     5221 tatccctccc aataagatcc ttcatgctct tttacagtta atcctgttct tacccccggc
     5281 aaccactaat ctactttctc tataaatttg ccctttctgg acagttcaaa tcaatggaat
     5341 catacaatat gtggtccctt gggtctggct tttttactta gctaatgttt ttgaggtttg
     5401 tccatgacag ataacgtctt ggtagtttgt tccttttatt gctgagtaga attctgttga
     5461 tggatgtacc acattttgtc agcagagagc cttttaaact tggattccaa cttcctgttg
     5521 tctaaacgga accctccgaa cgtaggactt ataggggaag ctgctgtgca tgtcaaaaaa
     5581 actactaatc agaatgagct ttgtcatcca gagccagaac tgctgcagaa atttttataa
     5641 ttttgcaact tcttttttta caaggaactt ttgtgctact acacatcagg acttttgaag
     5701 catccaataa atccatttaa taagtatgag catgtgtctg agtggacaag aaagtgaaac
     5761 catccatgct acattggata atttttcctc ccccagactg gacagggaat ctcagctttc
     5821 aaaacagagt aacctggctc cacttacaaa gctgcacagg cattaaagat cgtgctgcct
     5881 ttgttaggca gatttggagg ggaggcccaa cagcaaagat ggagaggaaa aagggagtgg
     5941 agcttgtgga acaggaagcc ccccagggtc tgtgcagggc tgctcagctc ttgaggatgt
     6001 tgtggatggt gaagtggtga tggtgtcccg gagcagccca gcacctccac tgggcccaga
     6061 aggtcttgac ttcggacact tacccctgtt tcacaagtgt ttataaagct gtttttgctt
     6121 tttttcccct aatcattact tggtagttat taatccttct ttgggggagg gacagggctt
     6181 taaaactgaa gaaaataatt ttcataaaaa tatcaaaaat ggaaaaaagt tactttgtaa
     6241 aaaatttgct atacaaacca aatggcagct gttgagaatc tcaataaaat gttaaatgca
//
