LOCUS       NM_016480               1456 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens poly(A) binding protein interacting protein 2 (PAIP2),
            transcript variant 2, mRNA.
ACCESSION   NM_016480
VERSION     NM_016480.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   Wegler,M., Jia,X., Alders,M., Bouman,A., Chen,J., Duan,X.,
            Lauzon,J.L., Mathijssen,I.B., Sticht,H., Syrbe,S., Tan,S., Guo,H.
            and Abou Jamra,R.
  TITLE     De novo variants in the PABP domain of PABPC1 lead to developmental
            delay
  JOURNAL   Genet Med 24 (8), 1761-1773 (2022)
   PUBMED   35511136
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Gouyon,F., Onesto,C., Dalet,V., Pages,G., Leturque,A. and
            Brot-Laroche,E.
  TITLE     Fructose modulates GLUT5 mRNA stability in differentiated Caco-2
            cells: role of cAMP-signalling pathway and PABP
            (polyadenylated-binding protein)-interacting protein (Paip) 2
  JOURNAL   Biochem J 375 (Pt 1), 167-174 (2003)
   PUBMED   12820898
  REMARK    GeneRIF: Role of PAIP2 in modulation of GLUT5 mRNA stability.
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Khaleghpour,K., Kahvejian,A., De Crescenzo,G., Roy,G.,
            Svitkin,Y.V., Imataka,H., O'Connor-McCourt,M. and Sonenberg,N.
  TITLE     Dual interactions of the translational repressor Paip2 with poly(A)
            binding protein
  JOURNAL   Mol Cell Biol 21 (15), 5200-5213 (2001)
   PUBMED   11438674
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Kozlov,G., Trempe,J.F., Khaleghpour,K., Kahvejian,A., Ekiel,I. and
            Gehring,K.
  TITLE     Structure and function of the C-terminal PABC domain of human
            poly(A)-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4409-4413 (2001)
   PUBMED   11287632
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Khaleghpour,K., Svitkin,Y.V., Craig,A.W., DeMaria,C.T., Deo,R.C.,
            Burley,S.K. and Sonenberg,N.
  TITLE     Translational repression by a novel partner of human poly(A)
            binding protein, Paip2
  JOURNAL   Mol Cell 7 (1), 205-216 (2001)
   PUBMED   11172725
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI552800.1, BC039337.1 and BU732743.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016480.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.532927.1,
                                           SRR1660809.145436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265192.9/ ENSP00000265192.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               BI552800.1         28-638
            612-1240            BC039337.1         1382-2010
            1241-1456           BU732743.1         21-236              c
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..1456
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /note="poly(A) binding protein interacting protein 2"
                     /db_xref="GeneID:51247"
                     /db_xref="HGNC:HGNC:17970"
                     /db_xref="MIM:605604"
     exon            1..127
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            128..291
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..537
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /note="PABC1-interacting protein 2; PABP-interacting
                     protein 2; polyA-binding protein-interacting protein 2"
                     /codon_start=1
                     /product="polyadenylate-binding protein-interacting
                     protein 2"
                     /protein_id="NP_057564.3"
                     /db_xref="CCDS:CCDS4211.1"
                     /db_xref="GeneID:51247"
                     /db_xref="HGNC:HGNC:17970"
                     /db_xref="MIM:605604"
                     /translation="MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFN
                     RQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSL
                     EDLVVKSNLNPNAKEFVPGVKYGNI"
     exon            292..471
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            472..1456
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1436..1441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /note="hexamer: AATAAA"
     polyA_site      1456
                     /gene="PAIP2"
                     /gene_synonym="PAIP-2; PAIP2A"
                     /note="major polyA site"
ORIGIN      
        1 gtttgtttgg actggagaag ggaggcggcg ggcgaagcgc acgtcgagcg ggggagcggc
       61 gctgcctgtg gagatccgcg gaggccgaca ggattcgttg gctgccgtcc ccgctgctgt
      121 gcattgggtt aaaaacgaca accaacatca gccatgaaag atccaagtcg cagcagtact
      181 agcccaagca tcatcaatga agatgtgatt attaacggtc attctcatga agatgacaat
      241 ccatttgcag agtacatgtg gatggaaaat gaagaagaat tcaacagaca aatagaagag
      301 gagttatggg aagaagaatt tattgaacgc tgtttccaag aaatgctgga agaggaagaa
      361 gagcatgaat ggtttattcc agctcgagat ctcccacaaa ctatggacca aatccaagac
      421 cagtttaatg accttgttat cagtgatggc tcttctctgg aagatcttgt ggtcaagagc
      481 aatctgaatc caaatgcaaa ggagtttgtt cctggggtga agtacggaaa tatttgagta
      541 gacggggccc tcttttggtg gatgtagcac aatttccaca ctgtgaaggc agtattagaa
      601 gacttaattg taaaagctct cttgtcactg tgttacactt atgcattgcc aaagtttttg
      661 ttagtcttgc atgcttaata aaagtgctga gactgttact aagtaaaaag ctgtcaaaca
      721 tttactgaaa atagaattgg ccccatggct tgatgtgaag acagcaagga aagaagcacc
      781 agtcaagttg tgaacaagca ccaaattaaa agacctaaac cttaccaaat tgtctttttt
      841 tgaggctaat ctatcacttg ttaatgtcta aactttaaaa tcagtacatt taatttgagt
      901 tccaactgtt aagcatattt ctcagactta aatttgatta tgtccccatc aaaaagaatc
      961 tccattttct gaaggtctgt tagttaattt gagataattt gttaaaggca agtatgtcat
     1021 attactgagg ctacaagtta gtcagcagat gagtgccagt ccagcctttt ctggtatgtt
     1081 attgttagaa atattgagtt ctaatgttac atctgaggaa gtatgtaatt tgagaattgt
     1141 aacttctaag ggattcactg catcatagct atgcctgtat ggagtctaac atatgaccaa
     1201 taccaaccca taatccagct gaacaaagat actgtaacat gatttgagtg gtgcttttcc
     1261 ttgctttgtt aaccatcacg agagtctgca gcacaacttt taacaaagct agaacagttt
     1321 tggcttctta aacttcatat ttgggtaggt taagctgcca tacgtgttca gtgtgaatag
     1381 tgtttaagtt gaaaatattg taaaaaaatt atattttttc aaaaatattt aaaaaaataa
     1441 ataatagtag aactga
//
