LOCUS       NM_006451               2780 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens poly(A) binding protein interacting protein 1 (PAIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_006451
VERSION     NM_006451.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Yin,G., Jia,S., Zhang,Y., Xian,Y., Guo,Y. and Liu,Q.
  TITLE     YAP1-activated ZNF131 promotes hepatocellular carcinoma cell
            proliferation through transcriptional regulation of PAIP1
  JOURNAL   Arch Biochem Biophys 754, 109921 (2024)
   PUBMED   38341068
  REMARK    GeneRIF: YAP1-activated ZNF131 promotes hepatocellular carcinoma
            cell proliferation through transcriptional regulation of PAIP1.
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Swarup,N., Hong,K.O., Chawla,K., Choi,S.J., Shin,J.A., Oh,K.Y.,
            Yoon,H.J., Lee,J.I., Cho,S.D. and Hong,S.D.
  TITLE     Effect of PAIP1 on the metastatic potential and prognostic
            significance in oral squamous cell carcinoma
  JOURNAL   Int J Oral Sci 14 (1), 9 (2022)
   PUBMED   35153296
  REMARK    GeneRIF: Effect of PAIP1 on the metastatic potential and prognostic
            significance in oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Deo,R.C., Sonenberg,N. and Burley,S.K.
  TITLE     X-ray structure of the human hyperplastic discs protein: an
            ortholog of the C-terminal domain of poly(A)-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4414-4419 (2001)
   PUBMED   11287654
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   Khaleghpour,K., Svitkin,Y.V., Craig,A.W., DeMaria,C.T., Deo,R.C.,
            Burley,S.K. and Sonenberg,N.
  TITLE     Translational repression by a novel partner of human poly(A)
            binding protein, Paip2
  JOURNAL   Mol Cell 7 (1), 205-216 (2001)
   PUBMED   11172725
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Grosset,C., Chen,C.Y., Xu,N., Sonenberg,N., Jacquemin-Sablon,H. and
            Shyu,A.B.
  TITLE     A mechanism for translationally coupled mRNA turnover: interaction
            between the poly(A) tail and a c-fos RNA coding determinant via a
            protein complex
  JOURNAL   Cell 103 (1), 29-40 (2000)
   PUBMED   11051545
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Gray,N.K., Coller,J.M., Dickson,K.S. and Wickens,M.
  TITLE     Multiple portions of poly(A)-binding protein stimulate translation
            in vivo
  JOURNAL   EMBO J 19 (17), 4723-4733 (2000)
   PUBMED   10970864
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Craig,A.W., Haghighat,A., Yu,A.T. and Sonenberg,N.
  TITLE     Interaction of polyadenylate-binding protein with the eIF4G
            homologue PAIP enhances translation
  JOURNAL   Nature 392 (6675), 520-523 (1998)
   PUBMED   9548260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015937.2, DB089732.1 and
            AC114956.2.
            
            On Nov 22, 2018 this sequence version replaced NM_006451.4.
            
            Summary: The protein encoded by this gene interacts with
            poly(A)-binding protein and with the cap-binding complex eIF4A. It
            is involved in translational initiation and protein biosynthesis.
            Overexpression of this gene in COS7 cells stimulates translation.
            Alternative splicing occurs at this locus and three transcript
            variants encoding three distinct isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136920.1, AF013758.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306846.8/ ENSP00000302768.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               BC015937.2         3-947
            946-977             DB089732.1         530-561
            978-1750            BC015937.2         980-1752
            1751-2780           AC114956.2         52242-53271         c
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..2780
                     /gene="PAIP1"
                     /note="poly(A) binding protein interacting protein 1"
                     /db_xref="GeneID:10605"
                     /db_xref="HGNC:HGNC:16945"
                     /db_xref="MIM:605184"
     exon            1..496
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1671
                     /gene="PAIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PABC1-interacting protein 1; polyadenylate-binding
                     protein-interacting protein 1; PAIP-1; PABP-interacting
                     protein 1"
                     /codon_start=1
                     /product="polyadenylate-binding protein-interacting
                     protein 1 isoform 1"
                     /protein_id="NP_006442.2"
                     /db_xref="CCDS:CCDS3947.1"
                     /db_xref="GeneID:10605"
                     /db_xref="HGNC:HGNC:16945"
                     /db_xref="MIM:605184"
                     /translation="MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQ
                     PPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQD
                     KIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSE
                     YVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMG
                     ARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGE
                     LYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAW
                     KEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPE
                     NDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPY
                     LDDIDDEMDPEIEEAYEKFCLESERKRKQ"
     exon            497..666
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..852
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..965
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1077
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1203
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1310
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1428
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1483
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1577
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..2780
                     /gene="PAIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="PAIP1"
                     /note="major polyA site"
     regulatory      2751..2756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAIP1"
                     /note="hexamer: AATAAA"
     polyA_site      2780
                     /gene="PAIP1"
                     /note="major polyA site"
ORIGIN      
        1 ggaaagccga gggtagccga gcggggcggg cgctctggag cggcgggtgc tcgggctgcc
       61 gtccgctccg ccagaagcac cgagcagccg agccggggcc cgccgccctc ctcctccatg
      121 aggcccgagt gaggcgcggc ggctatagcc gacccgcggc gccttccccc cgcgtcctat
      181 cgcgagcgca gcggcagcgg cccctggagg aggaggcgga ggaggaggag catgtcggac
      241 ggtttcgatc gggccccagg tgctggtcgg ggccggagcc ggggcctggg ccgcggaggg
      301 ggcgggcctg agggcggcgg tttcccgaac ggagcggggc ctgctgagcg ggcgcggcac
      361 cagccgccgc aacccaaagc cccgggcttc ctgcagccac cgccgctgcg ccagcccagg
      421 acgaccccgc cgccaggggc ccagtgcgag gtccccgcca gcccccagcg gccttcccgg
      481 cccggggcgc tcccagagca aacgaggccc ctgagagctc cacctagttc acaggataaa
      541 atcccacagc agaactcgga gtcagcaatg gctaagcccc aggtggttgt agctcctgta
      601 ttaatgtcta agctgtctgt gaatgcccct gaattttacc cttcaggtta ttcttccagt
      661 tacacagaat cctatgagga tggttgtgag gattatccta ctctatcaga atatgttcag
      721 gattttttga atcatcttac agagcagcct ggcagttttg aaactgaaat tgaacagttt
      781 gcagagaccc tgaatggttg tgttacaaca gatgatgctt tgcaagaact tgtggaactc
      841 atctatcaac aggccacatc tatcccaaat ttctcttata tgggagctcg cctgtgtaat
      901 tacctgtccc atcatctgac aattagccca cagagtggca acttccgcca attgctactt
      961 caaagatgtc ggactgaata tgaagttaaa gatcaagctg caaaagggga tgaagttact
     1021 cgaaaacgat ttcatgcatt tgtactcttt ctgggagaac tttatcttaa cctggagatc
     1081 aagggaacaa atggacaggt tacaagagca gatattcttc aggttggtct tcgagaattg
     1141 ctgaatgccc tgttttctaa tcctatggat gacaatttaa tttgtgcagt aaaattgtta
     1201 aagttgacag gatcagtttt ggaagatgct tggaaggaaa aaggaaagat ggatatggaa
     1261 gaaattattc agagaattga aaacgttgtc ctagatgcaa actgcagtag agatgtaaaa
     1321 cagatgctct tgaagcttgt agaactccgg tcaagtaact ggggcagagt ccatgcaact
     1381 tcaacatata gagaagcaac accagaaaat gatcctaact actttatgaa tgaaccaaca
     1441 ttttatacat ctgatggtgt tcctttcact gcagctgatc cagattacca agagaaatac
     1501 caagaattac ttgaaagaga ggactttttt ccagattatg aagaaaatgg aacagattta
     1561 tccggggctg gtgatccata cttggatgat attgatgatg agatggaccc agagatagaa
     1621 gaagcttatg aaaagttttg tttggaatca gagcgtaagc gaaaacagta aagttaaatt
     1681 tcagcatatc agttttataa agcagtttag gtatggtgat ttagcagaac acaagagagc
     1741 aagaaaatgt cacatctata ccaaattaag gatgttgagt tatgttacta atgtatgcaa
     1801 ctttaatttt gtttaacact atctgccaaa ataaacttta ttccctataa cttaaaatgt
     1861 gtatatatat ataatagttt attatgtaca gttaattcta ctgttttggc tgcaataaaa
     1921 tcgattttga aataaatgaa atgttgaaaa ttttgctagt tggttagatg cttatccttt
     1981 aaattctact tttcttgagg ggaaaaagtc ttcttctgga aatacatatt actgcaaaaa
     2041 tgtagcatcc ttttttaggt aggagtatta tagctttcat tttagtttga catttagtgt
     2101 cccaatgaat tgaatttcaa atatgaatca taatcttgaa aatctttagc actaaagtct
     2161 tggaatatat caacaactga tttacatatg cagatgctat ttgataccaa gggcttttta
     2221 aatgtcatgg gggggaaaaa cccaacttgg tgaactccca gctaaacaac caagacttca
     2281 ctgaagattt attccaattc tagaattgtt cttttttatt tttatttttt caactgacta
     2341 acttcattac cttaaaggct agaacattat tctgctttat ttatatggct ttctcacttt
     2401 tattttgtag catgggttgc atcgactttt ttactagaga attttactag atatttgtca
     2461 ttcaagtttt catctgcttt ataattgata caccttgagg gtcacttttc taatactttt
     2521 actataatgt ggtaccacct cagccctaat aaataatatt tttacctaat gtcaaatctt
     2581 tttccagcta actaaaaact gtgtacaaaa ggattgcttg taaatatgca tgtaaatagt
     2641 tctgttaata acccactgtt ttacatttgg tacatctgtg tctgctaata cagttagctt
     2701 tctcactttt ctgcttgttt gttcagtctg aattaaaatt agactttgaa aataaagctt
     2761 aaatagttgt ttcctctaaa
//
