LOCUS       NM_001079524            6371 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens phosphoribosylaminoimidazole carboxylase and
            phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS),
            transcript variant 3, mRNA.
ACCESSION   NM_001079524
VERSION     NM_001079524.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6371)
  AUTHORS   Chou,M.C., Wang,Y.H., Chen,F.Y., Kung,C.Y., Wu,K.P., Kuo,J.C.,
            Chan,S.J., Cheng,M.L., Lin,C.Y., Chou,Y.C., Ho,M.C., Firestine,S.,
            Huang,J.R. and Chen,R.H.
  TITLE     PAICS ubiquitination recruits UBAP2 to trigger phase separation for
            purinosome assembly
  JOURNAL   Mol Cell 83 (22), 4123-4140 (2023)
   PUBMED   37848033
  REMARK    GeneRIF: PAICS ubiquitination recruits UBAP2 to trigger phase
            separation for purinosome assembly.
REFERENCE   2  (bases 1 to 6371)
  AUTHORS   He,J., Zou,L.N., Pareek,V. and Benkovic,S.J.
  TITLE     Multienzyme interactions of the de novo purine biosynthetic protein
            PAICS facilitate purinosome formation and metabolic channeling
  JOURNAL   J Biol Chem 298 (5), 101853 (2022)
   PUBMED   35331738
  REMARK    GeneRIF: Multienzyme interactions of the de novo purine
            biosynthetic protein PAICS facilitate purinosome formation and
            metabolic channeling.
REFERENCE   3  (bases 1 to 6371)
  AUTHORS   Shon,H., Matveeva,E.A., Jull,E.C., Hu,Y., Coupet,T.A. and Lee,Y.S.
  TITLE     Evidence Supporting Substrate Channeling between Domains of Human
            PAICS: A Time-Course Analysis of 13C-Bicarbonate Incorporation
  JOURNAL   Biochemistry 61 (7), 575-582 (2022)
   PUBMED   35285625
  REMARK    GeneRIF: Evidence Supporting Substrate Channeling between Domains
            of Human PAICS: A Time-Course Analysis of (13)C-Bicarbonate
            Incorporation.
REFERENCE   4  (bases 1 to 6371)
  AUTHORS   Tang,X., Wu,Y., Yang,J. and Zhu,W.
  TITLE     Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the
            proliferation of non-small cell lung cancer
  JOURNAL   Bioengineered 12 (1), 4643-4653 (2021)
   PUBMED   34323174
  REMARK    GeneRIF: Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits
            the proliferation of non-small cell lung cancer.
REFERENCE   5  (bases 1 to 6371)
  AUTHORS   Du,B., Zhang,Z., Di,W., Xu,W., Yang,L., Zhang,S., He,G., Yang,R.
            and Wang,M.
  TITLE     PAICS is related to glioma grade and can promote glioma growth and
            migration
  JOURNAL   J Cell Mol Med 25 (16), 7720-7733 (2021)
   PUBMED   34173716
  REMARK    GeneRIF: PAICS is related to glioma grade and can promote glioma
            growth and migration.
REFERENCE   6  (bases 1 to 6371)
  AUTHORS   Zalkin,H. and Dixon,J.E.
  TITLE     De novo purine nucleotide biosynthesis
  JOURNAL   Prog Nucleic Acid Res Mol Biol 42, 259-287 (1992)
   PUBMED   1574589
  REMARK    Review article
REFERENCE   7  (bases 1 to 6371)
  AUTHORS   Barton,J.W., Hart,I.M. and Patterson,D.
  TITLE     Mapping of a locus correcting lack of phosphoribosylaminoimidazole
            carboxylase activity in Chinese hamster ovary cell Ade-D mutants to
            human chromosome 4
  JOURNAL   Genomics 9 (2), 314-321 (1991)
   PUBMED   2004782
REFERENCE   8  (bases 1 to 6371)
  AUTHORS   Minet,M. and Lacroute,F.
  TITLE     Cloning and sequencing of a human cDNA coding for a multifunctional
            polypeptide of the purine pathway by complementation of the
            ade2-101 mutant in Saccharomyces cerevisiae
  JOURNAL   Curr Genet 18 (4), 287-291 (1990)
   PUBMED   2253271
REFERENCE   9  (bases 1 to 6371)
  AUTHORS   Alenin,V.V., Iakovleva,M.F., Bystrova,I.M., Zazerskaia,I.A. and
            Domkin,V.D.
  TITLE     [Testing the activity of enzymes responsible for biosynthesis of
            purine nucleotides AIR-carboxylase and SAICAR-synthetase in human
            cell extracts]
  JOURNAL   Vopr Med Khim 36 (6), 59-63 (1990)
   PUBMED   2075724
REFERENCE   10 (bases 1 to 6371)
  AUTHORS   Schild,D., Brake,A.J., Kiefer,M.C., Young,D. and Barr,P.J.
  TITLE     Cloning of three human multifunctional de novo purine biosynthetic
            genes by functional complementation of yeast mutations
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 2916-2920 (1990)
   PUBMED   2183217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC019255.1, AC114766.5 and
            AA669362.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001079524.1.
            
            Summary: This gene encodes a bifunctional enzyme containing
            phosphoribosylaminoimidazole carboxylase activity in its N-terminal
            region and phosphoribosylaminoimidazole succinocarboxamide
            synthetase in its C-terminal region. It catalyzes steps 6 and 7 of
            purine biosynthesis. The gene is closely linked and divergently
            transcribed with a locus that encodes an enzyme in the same
            pathway, and transcription of the two genes is coordinately
            regulated. The human genome contains several pseudogenes of this
            gene. Multiple transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.208291.1,
                                           SRR1803617.206701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512576.3/ ENSP00000421096.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1457              BC019255.1         109-1565
            1458-2803           AC114766.5         17637-18982
            2804-3161           AA669362.1         12-369              c
            3162-6371           AC114766.5         19341-22550
FEATURES             Location/Qualifiers
     source          1..6371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..6371
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /note="phosphoribosylaminoimidazole carboxylase and
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /db_xref="GeneID:10606"
                     /db_xref="HGNC:HGNC:8587"
                     /db_xref="MIM:172439"
     exon            1..69
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1331
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /EC_number="6.3.2.6"
                     /EC_number="4.1.1.21"
                     /note="isoform 2 is encoded by transcript variant 3; AIR
                     carboxylase; SAICAR synthetase;
                     phosphoribosylaminoimidazole carboxylase;
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase;
                     multifunctional protein ADE2; bifunctional
                     phosphoribosylaminoimidazole
                     carboxylase/phosphoribosylaminoimidazole
                     succinocarboxamide synthetase; multifunctional protein
                     ADE2H1; phosphoribosylaminoimidazole carboxylase,
                     phosphoribosylaminoimidazole succinocarboxamide
                     synthetase"
                     /codon_start=1
                     /product="bifunctional phosphoribosylaminoimidazole
                     carboxylase/phosphoribosylaminoimidazole
                     succinocarboxamide synthetase isoform 2"
                     /protein_id="NP_001072992.1"
                     /db_xref="CCDS:CCDS47061.1"
                     /db_xref="GeneID:10606"
                     /db_xref="HGNC:HGNC:8587"
                     /db_xref="MIM:172439"
                     /translation="MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNA
                     ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRR
                     IATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQT
                     EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
                     SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTS
                     DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
                     LGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFG
                     LSNHLVWSKLRASILNTWISLKQADKKIRECNL"
     exon            70..267
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            268..446
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            447..626
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            627..740
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            741..824
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1005
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1164
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..6371
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /note="hexamer: ATTAAA"
     polyA_site      3154
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /note="major polyA site"
     regulatory      4348..4353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /note="hexamer: AATGAA"
     polyA_site      4374
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
     regulatory      6353..6358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
                     /note="hexamer: AATAAA"
     polyA_site      6371
                     /gene="PAICS"
                     /gene_synonym="ADE2; ADE2H1; AIRC; PAICSD; PAIS"
ORIGIN      
        1 agagttctgc ctcgcttccc ggcgcggtcg cagccctcag cccacttagg ataatggcga
       61 cagctgaggt actgaacatt ggtaaaaaat tatatgaggg taaaacaaaa gaagtctacg
      121 aattgttaga cagtccagga aaagtcctcc tgcagtccaa ggaccagatt acagcaggaa
      181 atgcagctag aaaaaaccac ctggaaggaa aagctgcaat ctcaaataaa atcaccagtt
      241 gtatttttca gttattacag gaagcaggta ttaaaactgc cttcaccaga aaatgtgggg
      301 agacagcttt cattgcaccg cagtgtgaaa tgattccaat tgaatgggtt tgcagaagaa
      361 tagcaactgg ttcttttctc aaaagaaatc ctggtgtcaa ggaaggatat aagttttacc
      421 cacctaaagt ggagttgttt ttcaaggatg atgccaataa tgacccacag tggtctgagg
      481 aacagctgat tgctgcaaaa ttttgctttg ctggacttct tataggccag actgaagtgg
      541 atatcatgag tcatgctaca caggctatat ttgaaatact ggagaaatcc tggttgcccc
      601 agaattgtac actggttgat atgaagattg aatttggtgt tgatgtaacc accaaagaaa
      661 ttgttcttgc tgatgttatt gacaatgatt cctggagact ctggccatca ggagatcgaa
      721 gccaacagaa agacaaacag tcttatcggg acctcaaaga agtaactcct gaagggctcc
      781 aaatggtaaa gaaaaacttt gagtgggttg cagagagagt agagttgctt ttgaaatcag
      841 aaagtcagtg cagggttgta gtgttgatgg gctctacttc tgatcttggt cactgtgaaa
      901 aaatcaagaa ggcctgtgga aattttggca ttccatgtga acttcgagta acatctgcgc
      961 ataaaggacc agatgaaact ctgaggatta aagctgagta tgaaggggat ggcattccta
     1021 ctgtatttgt ggcagtggca ggcagaagta atggtttggg accagtgatg tctgggaaca
     1081 ctgcatatcc agttatcagc tgtcctcccc tcacaccaga ctggggagtt caggatgtgt
     1141 ggtcttctct tcgactaccc agtggtcttg gctgttcaac cgtactttct ccagaaggat
     1201 cagctcaatt tgctgctcag atatttgggt taagcaacca tttggtatgg agcaaactgc
     1261 gagcaagcat tttgaacaca tggatttcct tgaagcaggc tgacaagaaa atcagagaat
     1321 gtaatttata agaaagaatg ccattgaatt ttttagggga aaaactacaa atttctaatt
     1381 tagctgaagg aaaatcaagc aagatgaaaa ggtaatttta aattagagaa cacaaataaa
     1441 atgtattagt gaataaatgc ttctctagat ccatattaat aaacatgagc atctaacccc
     1501 tcctttctta ggctagacac caagatattt cagccagcct ttatcattcc tcttacttta
     1561 tcctttttcc ttaagtattg gtggtcacta ctattgagtt tcttccttaa cactgattaa
     1621 atgatcttaa ctccctcagc taaaactggc attactgact cccagctata tttctccaga
     1681 cttgcatttt tttttttttt tttgagacag ggtctcactg tcgcccaggc tggagtgcag
     1741 tggcgtgatc tcagttcact gctgctttcc ctcctgggct caagcagttc tcccacctca
     1801 gcctctcgac taacagggac tataatcttg cagcaccatg ccgagctaat tttatttttt
     1861 gtagagatga gctctcacta tgtcacccag gttcgtctca aactcctgaa ccctagtaat
     1921 tctcctatct cagcctccca aagtgctagg gttacagaca tgagccactg tgcctgtcta
     1981 gacttgtact ttcaactgtc catttctccc tgtctgtccc atgggcactc atgaaaaaac
     2041 agaatgctcc caactttatt catcttccaa gcctgtagct cttggtatac tcactgttgc
     2101 aagtcagaag cttgatttca tcattgatgt ttttctcacg tttcacatct cactcatcac
     2161 caagtcatgt tggtgttaat ttctgattaa cccttgaatt taccgtcttc tcatcctctg
     2221 tacaaaagcc tcaagtgagg gtcaaattca acattatcct gatctagaca gcccccattc
     2281 tcaatccacc cttttccaag ttgattgccc aaggacttct aacaataaac tctcttttgc
     2341 accacagact tctttgaaaa tatacatgct gttgaccctc tctgtagaaa accgcacaca
     2401 taaaacttac caacagattt cattggttct tgggttctcc cgaagcctat ccatggttta
     2461 tagattaaga attgatgagg tagctgggca cagtggctca cacctacgat cacagcactt
     2521 cgggaggctg aagcaagcag atcacttgag gtcaggagtt tgagaccagc ctggccaaca
     2581 tggtgaaacc ctgtctctac taaaaataca aaaagtagcc agccgtgatg acaggcacct
     2641 gtaatcccag ctactcggga ggctgaggca tgagaattgc ttgaacccgg gaggcggagg
     2701 ttgcagtgag cctagatcat gccactgcac tccaacctgg gcagcagagc aagactctgt
     2761 ctcaaaaggg gaaaaaaaaa attgctgatg tgacccatga agggaactca ttttcctcgt
     2821 aattttggac tgccacacat tggtaccttt agttctctga aggcccacgt ttttatcatt
     2881 aagacctatt tgttagctag tagagcttta tgttcgctgt ccatgaaacc ttctgtaacc
     2941 acagtgacta caagtagttc tttctctatt gaattattag gtccagaata gaagatgtca
     3001 ttgtacactt tatttccctc acactgtgtt atgctctgat gtgctatgct tagctatctg
     3061 tcagagatta gtaaattata aaactcatgt gtactactta agtttatatc ttatgctagt
     3121 ttataagaac aattaaaagg acttagaaga ttaactttgg tttcatggtc tctgaagtca
     3181 ctgactgcta tttcagcttg tttaccctta cctagcatta agactccatc tacttctgtg
     3241 cagtatatga aaatttttaa actttcattt agactggtgg ataggactga ccattacaaa
     3301 ttgtcgttat caattttttt tccttttttt ttttaagagc caagttctca ctgtctccca
     3361 ggctggagtg cagtggcatg attatggctc cctgcagcct tgaactcctg gactcaagct
     3421 gcagcctctc gagtagctgg gtgcatgtgc taccacaccc aattatgaat ttcatcatta
     3481 gtttcttagt agagtccaca tgtcctcagt agtaagttca tcagtgctaa atatttgaag
     3541 gtatttctac tgttttgtaa aagtaactta agcctacctg gtctgctatc ttttgagtat
     3601 ttatactttc tacgggcttg taggtaaaca taaaaagaga aaaaatatcc caataataca
     3661 gtttttaacc ttttatgata aagacatgct tagaattgct gttaagcttt ctgagattta
     3721 accactgaaa ctaagtaaaa gacaaagcac ttaggtaaag cttcattcag tatccattca
     3781 cccaatactg gtttgattct agggcctagg aaaataggac tgagcaaagc ccttgtccag
     3841 atggaactta tgttttagag gggaaaacaa accataaaaa ggtaaacagt ataaaatcag
     3901 gaaaggataa atgtatatga agaatcaaaa tgaggacggt gatggggata agaggggaag
     3961 gtttttgagg agagcagagc aatgatgtaa aagcaagaca cacagatagg gaaatagctt
     4021 tccatactaa gggaatggga aataaagctg agttttgcct tgaggacctc caaacatgag
     4081 aattgctaga gctctgtgaa caaggatgag agtggaagac aatataagca aaggctacat
     4141 cacttagggc ctataggcca cactgaagtg tgacaggaaa aactcagttt gagcagaggc
     4201 ttgacatact taacatattt aaaggttctc tggctgttgt gtggacaaga ggagaagcag
     4261 agattagtta agaggctatt gtagcccagg tgagggatga tgtatgatct tcaacatgtc
     4321 taattttttt gtgcctcaat ttcatgaaat gaaaatgcga ctaataccac ctcataaagt
     4381 tgtgagaatt acatgagtca atatatgtaa ggcccatcat ggcacacaaa tgtgttatgt
     4441 aatatccatt tggcagactg aagaacaaca gtatgaatgg aattcattca ccatgagaat
     4501 tacctggaat tctctgggca tggtagctca tgcctgtaat cccagcactt tgggtggccg
     4561 aggcaggtgg atcacctgag atcaggagtt cgagaccagc ctgaccaaca tggagaaacc
     4621 cagtctctaa taaaaataca aaactagccg ggcatggtgg cacattcctg taatcccagc
     4681 gactcaggag gctgaggcag gagaatcgct tgaacctggg aagcggaggt tgtggtgagc
     4741 cgaggttgcg ccattgtact ccagcctggg caacaagagc aaaactctgt ttcaaaaaaa
     4801 aagaaagaaa gaaaattacc tggaattcaa tattgccatc ggctgattta atttctaata
     4861 tgaagaaagg ggcagtgtga tgtgccacgg agcatccaca acctgccatt tcagcccagc
     4921 caaccttaga aagccattga aaagagttgt ttttaatggt gtttttacat ccagcttccc
     4981 acacctcaaa tacttggggt ggaattgtta atctcacatt gcagtacaat gaaaatagtg
     5041 gaatggaaat caagttataa aatggagcta aatatttctt ctgcttgcct ctgagttgat
     5101 aagataccat aagatactgt acatgaggct gggcgcggtg gctcacgtct tatttcttct
     5161 gcttgcctct gagttgacaa gataccataa gatactgtac atgaggctgg gtgcagtggc
     5221 tcacgcctgt aatcccagca ctttgggagg gtgaggtggg cagatcacct gaggtcggga
     5281 gttcaagacc agcctgactg acatggagaa accccctctt tactaaaaat acaaaattag
     5341 ccaggcatgg tggtgcatgc ctataattcc aactactcgg gaggctgagg caggagaatc
     5401 gcttgaacct ggaaggcaga ggttgtggtg agctgagatc gaaccattgc actccagcct
     5461 gggcaacaag agcgaaaatc tgtcgccaaa aaaaaaaaaa aaaagatact gtacatggaa
     5521 gcttctcagg ctaaatccat taatataaaa atacattgtg gatactgatg agatggctaa
     5581 ttctgtcaac ttgactaggc tacgggatgc cttgatagct ggtcaaacaa catttctagg
     5641 tacatctgtg atggtgtttc tggaagagac tagcacttga atcagtagac ttgagtaaag
     5701 aagactgcct tcacccatgt gggtgagcgt catctaatcc attgagggcc tgaatagaac
     5761 aaaaaagggg aagaagggtg aactgctggg acatccattt cgtgccccca gatgttggtg
     5821 ctcctggtcc tcaggccttc agactaggac ttaacgttat tgcctcccct gattctcaag
     5881 ccctcgggtt tggaactaca ctggctttcc tgggccttca gcctgcagaa ggcagactgt
     5941 gggacttcac ctccattttg cagagccaat ttctcataat ctgtacatat cctattggtt
     6001 ctgtattttt tagagaacaa atacagccta ttatgtatat ataagaccct gggaatgcaa
     6061 agatgaacaa aattaacctt ctgctctcaa tgaatcttgg aagtctccag aggcagacaa
     6121 tttcaaaaca ccgtatatag tcttaatatg gaattaacaa tagggtattg tgaatacaca
     6181 aaagtaggaa ggactctgat ctctagaaaa caattgtata ctgtgaatga aaaagactaa
     6241 ttctccacag tctatactca atctctctta cctttccata attttcttca gcaaacttat
     6301 taccaccaaa catagtacat gtttatttat tacccatctc tcccaactag aaaataaatg
     6361 tattacactg g
//
