LOCUS       NM_024516               3874 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1),
            mRNA.
ACCESSION   NM_024516
VERSION     NM_024516.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3874)
  AUTHORS   Li,Y., Han,J., Zhang,Y., Cao,F., Liu,Z., Li,S., Wu,J., Hu,C.,
            Wang,Y., Shuai,J., Chen,J., Cao,L., Li,D., Shi,P., Tian,C.,
            Zhang,J., Dou,Y., Li,G., Chen,Y. and Lei,M.
  TITLE     Structural basis for activity regulation of MLL family
            methyltransferases
  JOURNAL   Nature 530 (7591), 447-452 (2016)
   PUBMED   26886794
REFERENCE   3  (bases 1 to 3874)
  AUTHORS   Takeshita,T., Yamamoto-Ibusuki,M., Yamamoto,Y., Omoto,Y., Honda,Y.,
            Iyama,K., Zhang,Z. and Iwase,H.
  TITLE     PTIP associated protein 1, PA1, is an independent prognostic factor
            for lymphnode negative breast cancer
  JOURNAL   PLoS One 8 (11), e80552 (2013)
   PUBMED   24260416
  REMARK    GeneRIF: PTIP associated protein 1, PA1, is an independent
            prognostic factor for lymphnode negative breast cancer.
            GeneRIF: PA1 expression was observed in both nucleus (mainly)and
            cytoplasm from breast cancer tissue samples. PA1 nuclear expression
            was correlated with postmenopausal, smaller tumor size, negative
            Ki67, positive AR and positive ERbeta. PA1 nuclear positive cases
            seemed to have a longer survival than negative ones for RFS. For
            those patients without lymphnode metastasis PA1 was found to be an
            independent prognostic factor for RFS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3874)
  AUTHORS   van Nuland,R., Smits,A.H., Pallaki,P., Jansen,P.W., Vermeulen,M.
            and Timmers,H.T.
  TITLE     Quantitative dissection and stoichiometry determination of the
            human SET1/MLL histone methyltransferase complexes
  JOURNAL   Mol Cell Biol 33 (10), 2067-2077 (2013)
   PUBMED   23508102
REFERENCE   5  (bases 1 to 3874)
  AUTHORS   Zhang,Z., Sun,Y., Cho,Y.W., Chow,C.C. and Simons,S.S. Jr.
  TITLE     PA1 protein, a new competitive decelerator acting at more than one
            step to impede glucocorticoid receptor-mediated transactivation
  JOURNAL   J Biol Chem 288 (1), 42-58 (2013)
   PUBMED   23161582
  REMARK    GeneRIF: PA1 is a new competitive decelerator of GR transactivation
            and can act at more than one molecularly defined step in a manner
            that depends upon the specific gene
REFERENCE   6  (bases 1 to 3874)
  AUTHORS   Gong,Z., Cho,Y.W., Kim,J.E., Ge,K. and Chen,J.
  TITLE     Accumulation of Pax2 transactivation domain interaction protein
            (PTIP) at sites of DNA breaks via RNF8-dependent pathway is
            required for cell survival after DNA damage
  JOURNAL   J Biol Chem 284 (11), 7284-7293 (2009)
   PUBMED   19124460
  REMARK    GeneRIF: subset of PTIP.PA1 complex is recruited to DNA damage
            sites via the RNF8-dependent pathway and is required for cell
            survival in response to DNA damage.
REFERENCE   7  (bases 1 to 3874)
  AUTHORS   Liang,J., Zhang,H., Zhang,Y., Zhang,Y. and Shang,Y.
  TITLE     GAS, a new glutamate-rich protein, interacts differentially with
            SRCs and is involved in oestrogen receptor function
  JOURNAL   EMBO Rep 10 (1), 51-57 (2009)
   PUBMED   19039327
  REMARK    GeneRIF: GAS is a new transcription cofactor
REFERENCE   8  (bases 1 to 3874)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
  REMARK    GeneRIF: PA1 (C16orf53) binds PTIP directly and requires PTIP for
            interaction with the MLL3- and MLL4-containing histone H3 K4
            methyltransferase complex.
REFERENCE   9  (bases 1 to 3874)
  AUTHORS   Issaeva,I., Zonis,Y., Rozovskaia,T., Orlovsky,K., Croce,C.M.,
            Nakamura,T., Mazo,A., Eisenbach,L. and Canaani,E.
  TITLE     Knockdown of ALR (MLL2) reveals ALR target genes and leads to
            alterations in cell adhesion and growth
  JOURNAL   Mol Cell Biol 27 (5), 1889-1903 (2007)
   PUBMED   17178841
REFERENCE   10 (bases 1 to 3874)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009133.7, AL549915.3, BC003640.2, AC120114.2 and CA455544.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024516.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.161716.1,
                                           SRR1803612.147832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320330.8/ ENSP00000326519.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC009133.7         49183-49237         c
            56-511              AL549915.3         4-459
            512-1502            BC003640.2         153-1143
            1503-3550           AC009133.7         43224-45271         c
            3551-3778           AC120114.2         237-464
            3779-3874           CA455544.1         81-176
FEATURES             Location/Qualifiers
     source          1..3874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3874
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /note="PAXIP1 associated glutamate rich protein 1"
                     /db_xref="GeneID:79447"
                     /db_xref="HGNC:HGNC:28707"
                     /db_xref="MIM:612033"
     exon            1..856
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1139
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /note="glutamate-rich coactivator interacting with
                     SRC1/NCOA1; PAXIP1-associated protein 1; PTIP-associated 1
                     protein; PTIP-associated protein 1; glutamate-rich
                     coactivator associated with SRC1"
                     /codon_start=1
                     /product="PAXIP1-associated glutamate-rich protein 1"
                     /protein_id="NP_078792.1"
                     /db_xref="CCDS:CCDS10655.1"
                     /db_xref="GeneID:79447"
                     /db_xref="HGNC:HGNC:28707"
                     /db_xref="MIM:612033"
                     /translation="MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAG
                     KAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADG
                     QPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEE
                     KPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQI
                     LRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY"
     exon            857..939
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..3874
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /note="hexamer: AATAAA"
     polyA_site      1502
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
                     /note="major polyA site"
     polyA_site      3874
                     /gene="PAGR1"
                     /gene_synonym="C16orf53; GAS; PA1"
ORIGIN      
        1 aggtgcgtac ggcatctgac ttgacgtggc ccacaactga aaggtctggg gagaaggcgc
       61 cgtgtccggg tgtggagagg ggcgtcgtgg aagcgagaag agtggcccgt ccctctcctc
      121 cccctttccc tctttcggaa agtggtttct gcggggcccg ggagcctcgg agtaccgaac
      181 ctcgatctcc ggggcggggt ccttggtggg gactgagcgc cccctcccgg ggacgggcgg
      241 tctggccgcg gagtcccctg cgggagcgtg attggctgga aacggtcccg aacccccagg
      301 ggagcccgat ccctggggga ccctggcttc ggactccagt atctgtcgtc gcagggtccc
      361 tgccctagtg gcctatgtcc cttgctcggg gccatggaga cactgcggcc agtacggcgg
      421 cgcctctgtc tgaagaaggg gaagtgacct ccggcctcca ggctctggcc gtggaggata
      481 ccggaggccc ctctgcctcg gccggtaagg ccgaggacga gggggaagga ggccgagagg
      541 agaccgagcg tgaggggtcc gggggcgagg aggcgcaggg agaagtcccc agcgctgggg
      601 gagaagagcc tgccgaggag gactccgagg actggtgcgt gccctgcagc gacgaggagg
      661 tggagctgcc tgcggatggg cagccctgga tgcccccgcc ctccgaaatc cagcggctct
      721 atgaactgct ggctgcccac ggtactctgg agctgcaagc cgagatcctg ccccgccggc
      781 ctcccacgcc ggaggcccag agcgaagagg agagatccga tgaggagccg gaggccaaag
      841 aagaggaaga ggaaaaacca cacatgccca cggaatttga ttttgatgat gagccagtga
      901 caccaaagga ctccctgatt gaccggagac gcaccccagg aagctcagcc cggagccaga
      961 aacgggaggc ccgcctggac aaggtgctgt cggacatgaa gagacacaag aagctggagg
     1021 agcagatcct tcgtaccggg agggacctct tcagcctgga ctcggaggac cccagccccg
     1081 ccagcccccc actccgatcc tccgggagta gtctcttccc tcggcagcgg aaatactgat
     1141 tcccactgct cctgcctcta gggtgcagtg tccgtacctg ctggagcctg ggccctcctt
     1201 ccccagccca gacattgaga aacttgggaa gaagagagaa acctcaagct cccaaacagc
     1261 acgttgcggg aaagaggaag agagagtgtg agtgtgtgtg tgtgtttttt ctattgaaca
     1321 cctgtagagt gtgtgtgtgt gttttctatt gaacacctat agagagagtg tgtgtgtttt
     1381 ctattgaaca tctatataga gagagtgtgt gagtgtgtgt tttctattga acacctattc
     1441 agagacctgg actgaatttt ctgagtctga aataaaagat gcagagctat catctcttaa
     1501 aaggaggggc tgtagctgta gctcaacagt taggccccac ttgaagggag aggcagaatt
     1561 gtactcaccc agattggaaa atgaaagcca gatgggtaga ggtgccctca gttagcacct
     1621 gtcccatctc gggccctcca actcctccca gtcccactcc agtgcagcca gctggctcca
     1681 aggtagaaac ccatgagcac tcagggagca gtgtgccttc agctgcagca gaagcagccc
     1741 ggaggataaa atgagaacca gctgcacacg ggccctttaa ctcccaagcc ccacccctgg
     1801 gcttggcctg ccttgccctg ccgggaagtg atccccaagg cagggtgaga gttccccatc
     1861 tgaggcgttt gttgcagcta cctgcacttc tagatgtgag tacattgtac tagcccccca
     1921 aaccccaaat caggggcaga tctttgtatc ccttgaggct ctctttagtc ctgtcttgct
     1981 ttgaagggcc ttgcttctgc tggggcaggg aaaacatgtc tgaatcagag tggggaagga
     2041 ggatgggtgg tggctttgct tttggaggtt tcactttcca atagttggga gtcttctggg
     2101 ttttgaagta aaggcagatt aacaccaaca ccggtccccc acccccctgc aactctcagg
     2161 cctctctctg acttcagggt cccacctggg aaatcaggtg gggaacctta cagggtcatt
     2221 cagaccccat cttagcccta gatcggtgct tgctctactc acctgcactg tcctggggac
     2281 ctgggctctg gcctgtcacc ttgagctcca agaatgtgac ctgtacccat tcaggcccct
     2341 taactctgac agatgagggt ttcttactcc tccatgcagg gctgggccag ctgttggtct
     2401 cagtcgatca ttcaggaagt cattagcaga gtgatttcca gaaggcgtag aatttagtga
     2461 ccaaggttct ttcctttttg ggaggagaaa gtgaaaacta ggatgctcag ctggacccac
     2521 cagcctgaga ttctggggat tttagagctg tcccttgggg agccaagcac ttgggggtgg
     2581 aggtgatagc gaggctgatg gcccctgtgt tctcagctct ctgcctgggt agcccctggg
     2641 tgatggggga gaggccagct gtcacgtggg gtatcaggtg gctctgccag aaactccctt
     2701 ggcacacaga gcactgggtc ggccctcggg tgtggctgtt tgggcaggac agccctctgt
     2761 atgtagcctt gagcaggtag gggggccacc ttgagtgggt ggcccagaga cagcctcagg
     2821 gctccaaggt aacggggtgc tcaggttatc ttgggtgctg ccctcccagg ttctggggga
     2881 gcagaggctg ggcgctggcc caacttacag gaaacactca cctttgaact gccattagca
     2941 ccatctgggc agtacacagc cccacccagg tcctctagtt cttgttctcg gcttagaatc
     3001 tttgtgtttc tgcctgagaa gccactgcct cctagtttgt ggtctctaca gttatagcca
     3061 ggttggactt ccggctccgt cctttgataa ctgtgtgctc ttgggcaaat ttcttaactt
     3121 gcaggttctt gtgaggataa catgagttaa ttgagggcac ttaacactac ctggcacaga
     3181 ttaagctcat ctgaagtggg agctgttact taggggcgtt tgcctagaac acagggtcca
     3241 gaggctctct cccggaaact tagacccagt gagtcagaag tgaggcctgc aaaaagcagc
     3301 aggagtgggg ttaagaattc cagcctaggg ctggatgcgg tggctcaggc ctgtaatccc
     3361 agtactttgg gaggcccgaa tgggaggatg gcttgaggcc aggagttcca gaccagcctg
     3421 agcaacatag cgagaccctg tctctgtttg tgtgtgtgtg gttggggttt tgtttttttt
     3481 ttttttttaa agaattatag ctcagtccta tgattaggca agttgagaaa atattgatga
     3541 agatcagggg tgctgaagcc tggttcctgg ggtcgcttct gatctaggcg gttcttgcct
     3601 ctggtgactg gtgttaattg gcaggagtgg gaggagggag gacaagtgga agtctaggct
     3661 ggctgagctg ttctgtctcg aaaagttcct aaaactgtgc tgctttaaaa aaaaaaaaag
     3721 taatttatga gacacattct caatttccat taatcatctc ctaaaggggg taaaccagga
     3781 agccgctggg tgaaaacagg ctgttggcaa ttcctgagtc atgtgaccca ttctctaaag
     3841 actagaatat ttaacttaaa tcagtgagaa actc
//
