LOCUS       NM_001013435             553 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens PAGE family member 5 (PAGE5), transcript variant 2,
            mRNA.
ACCESSION   NM_001013435
VERSION     NM_001013435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 553)
  AUTHORS   Nylund,C., Rappu,P., Pakula,E., Heino,A., Laato,L., Elo,L.L.,
            Vihinen,P., Pyrhonen,S., Owen,G.R., Larjava,H., Kallajoki,M. and
            Heino,J.
  TITLE     Melanoma-associated cancer-testis antigen 16 (CT16) regulates the
            expression of apoptotic and antiapoptotic genes and promotes cell
            survival
  JOURNAL   PLoS One 7 (9), e45382 (2012)
   PUBMED   23028975
  REMARK    GeneRIF: Results indicate that CT16 promotes the survival of
            melanoma cells and is therefore a potential target for future drug
            development.
REFERENCE   3  (bases 1 to 553)
  AUTHORS   Rappu,P., Nylund,C., Ristiniemi,N., Kulpakko,J., Vihinen,P.,
            Hernberg,M., Mirtti,T., Alanen,K., Kallajoki,M., Vuoristo,M.S.,
            Pyrhonen,S. and Heino,J.
  TITLE     Detection of melanoma-derived cancer-testis antigen CT16 in patient
            sera by a novel immunoassay
  JOURNAL   Int J Cancer 128 (10), 2382-2392 (2011)
   PUBMED   20658534
REFERENCE   4  (bases 1 to 553)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 553)
  AUTHORS   Hellman,M., Tossavainen,H., Rappu,P., Heino,J. and Permi,P.
  TITLE     Characterization of intrinsically disordered prostate associated
            gene (PAGE5) at single residue resolution by NMR spectroscopy
  JOURNAL   PLoS One 6 (11), e26633 (2011)
   PUBMED   22073178
REFERENCE   6  (bases 1 to 553)
  AUTHORS   Takagaki,K., Katsuma,S., Horio,T., Kaminishi,Y., Hada,Y.,
            Tanaka,T., Ohgi,T. and Yano,J.
  TITLE     cDNA microarray analysis of altered gene expression in
            Ara-C-treated leukemia cells
  JOURNAL   Biochem Biophys Res Commun 309 (2), 351-358 (2003)
   PUBMED   12951057
REFERENCE   7  (bases 1 to 553)
  AUTHORS   Zendman,A.J., Van Kraats,A.A., Weidle,U.H., Ruiter,D.J. and Van
            Muijen,G.N.
  TITLE     The XAGE family of cancer/testis-associated genes: alignment and
            expression profile in normal tissues, melanoma lesions and Ewing's
            sarcoma
  JOURNAL   Int J Cancer 99 (3), 361-369 (2002)
   PUBMED   11992404
REFERENCE   8  (bases 1 to 553)
  AUTHORS   Scanlan,M.J., Gordon,C.M., Williamson,B., Lee,S.Y., Chen,Y.T.,
            Stockert,E., Jungbluth,A., Ritter,G., Jager,D., Jager,E., Knuth,A.
            and Old,L.J.
  TITLE     Identification of cancer/testis genes by database mining and mRNA
            expression analysis
  JOURNAL   Int J Cancer 98 (4), 485-492 (2002)
   PUBMED   11920606
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158819.14, BP429046.1 and
            BQ437151.1.
            
            On Jul 12, 2018 this sequence version replaced NM_001013435.2.
            
            Summary: This gene is a member of family of proteins that are
            expressed in a variety of tumors and in some fetal and reproductive
            tissues. The encoded protein may protect cells from programmed cell
            death. Multiple alternatively spliced transcript variants encoding
            distinct isoforms have been found. [provided by RefSeq, Jan 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG476118.1, BE896256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374955.8/ ENSP00000364093.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL158819.14        41376-41376
            2-13                BP429046.1         5-16
            14-553              BQ437151.1         1-540
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..553
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /note="PAGE family member 5"
                     /db_xref="GeneID:90737"
                     /db_xref="HGNC:HGNC:29992"
                     /db_xref="MIM:301009"
     exon            1..107
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            108..196
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..448
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cancer/testis antigen family 16, member 1; cancer/testis
                     antigen family 16, member 2; P antigen family, member 5
                     (prostate associated); g antigen family E member 1;
                     cancer/testis antigen 16.1; prostate-associated gene 5
                     protein; P antigen family member 5"
                     /codon_start=1
                     /product="P antigen family member 5 isoform 2"
                     /protein_id="NP_001013453.1"
                     /db_xref="CCDS:CCDS35306.1"
                     /db_xref="GeneID:90737"
                     /db_xref="HGNC:HGNC:29992"
                     /db_xref="MIM:301009"
                     /translation="MSEHVTRSQSSERGNDQESSQPVGPVIVQQPTEEKRQEEEPPTD
                     NQGIAPSGEIKNEGAPAVQGTDVEAFQQELALLKIEDAPGDGPDVREGTLPTFDPTKV
                     LEAGEGQL"
     exon            197..305
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            306..431
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            432..553
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      526..531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /note="hexamer: AATAAA"
     polyA_site      553
                     /gene="PAGE5"
                     /gene_synonym="CT16; CT16.1; CT16.2; GAGEE1; PAGE-5"
                     /note="major polyA site"
ORIGIN      
        1 cttctgtcta ggcagagctc tgcaaggaga ggttgtgtct tcgttctttc cgccatcttc
       61 gttctttcca acatcttcgt tctttctcac tgaccgagac tcagccgtga gagatatgag
      121 tgagcatgta acaagatccc aatcctcaga aagaggaaat gaccaagagt cttcccagcc
      181 agttggacct gtgattgtcc agcagcccac tgaggaaaaa cgtcaagaag aggaaccacc
      241 aactgataat cagggtattg cacctagtgg ggagatcaaa aatgaaggag cacctgctgt
      301 tcaagggact gatgtggaag cttttcaaca ggaactggct ctgcttaaga tagaggatgc
      361 acctggagat ggtcctgatg tcagggaggg gactctgccc acttttgatc ccactaaagt
      421 gctggaagca ggtgaagggc aactataggt ttaaaccaag acaaatgaag actgaaacca
      481 agaatattgt tcttatgctg gaaatttgac tgctaacatt ctcttaataa agttttacag
      541 ttttctgcaa aga
//
