LOCUS       NM_007003                790 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens PAGE family member 4 (PAGE4), transcript variant 1,
            mRNA.
ACCESSION   NM_007003
VERSION     NM_007003.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 790)
  AUTHORS   Li,Y., Liu,J., Liu,D., Wang,Z., Zhou,Y., Yang,S., Guo,F., Yang,L.
            and Zhang,X.
  TITLE     The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the
            Development of Benign Prostatic Hyperplasia under Oxidative Stress
  JOURNAL   Oxid Med Cell Longev 2022, 7041739 (2022)
   PUBMED   35633887
  REMARK    GeneRIF: The Prostate-Associated Gene 4 (PAGE4) Could Play a Role
            in the Development of Benign Prostatic Hyperplasia under Oxidative
            Stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 790)
  AUTHORS   Fu,S., Liu,T., Lv,C., Fu,C., Zeng,R., Kakehi,Y., Kulkarni,P.,
            Getzenberg,R.H. and Zeng,Y.
  TITLE     Stromal-epithelial interactions in prostate cancer: Overexpression
            of PAGE4 in stromal cells inhibits the invasive ability of
            epithelial cells
  JOURNAL   J Cell Biochem 121 (11), 4406-4418 (2020)
   PUBMED   32003504
  REMARK    GeneRIF: Stromal-epithelial interactions in prostate cancer:
            Overexpression of PAGE4 in stromal cells inhibits the invasive
            ability of epithelial cells.
REFERENCE   3  (bases 1 to 790)
  AUTHORS   Koirala,S., Klein,J., Zheng,Y., Glenn,N.O., Eisemann,T., Fon
            Tacer,K., Miller,D.J., Kulak,O., Lu,M., Finkelstein,D.B., Neale,G.,
            Tillman,H., Vogel,P., Strand,D.W., Lum,L., Brautigam,C.A.,
            Pascal,J.M., Clements,W.K. and Potts,P.R.
  TITLE     Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway by PAGE4
            Inhibition of Tankyrase
  JOURNAL   Cell Rep 32 (3), 107922 (2020)
   PUBMED   32698014
  REMARK    GeneRIF: Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway
            by PAGE4 Inhibition of Tankyrase.
REFERENCE   4  (bases 1 to 790)
  AUTHORS   Lv,C., Fu,S., Dong,Q., Yu,Z., Zhang,G., Kong,C., Fu,C. and Zeng,Y.
  TITLE     PAGE4 promotes prostate cancer cells survive under oxidative stress
            through modulating MAPK/JNK/ERK pathway
  JOURNAL   J Exp Clin Cancer Res 38 (1), 24 (2019)
   PUBMED   30658679
  REMARK    GeneRIF: PAGE4 protects PCa cells from DNA damage and apoptosis
            under oxidative stress by modulating MAPK signalling pathway. PAGE4
            expression may serve as a prognostic biomarker for clinical
            applications.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 790)
  AUTHORS   Rajagopalan,K., Qiu,R., Mooney,S.M., Rao,S., Shiraishi,T.,
            Sacho,E., Huang,H., Shapiro,E., Weninger,K.R. and Kulkarni,P.
  TITLE     The Stress-response protein prostate-associated gene 4, interacts
            with c-Jun and potentiates its transactivation
  JOURNAL   Biochim Biophys Acta 1842 (2), 154-163 (2014)
   PUBMED   24263171
  REMARK    GeneRIF: Data suggest that disrupting prostate-associated gene 4
            (PAGE4)/c-Jun interaction using small molecules could be a novel
            strategy to treat prostate cancer.
REFERENCE   6  (bases 1 to 790)
  AUTHORS   Sampson,N., Ruiz,C., Zenzmaier,C., Bubendorf,L. and Berger,P.
  TITLE     PAGE4 positivity is associated with attenuated AR signaling and
            predicts patient survival in hormone-naive prostate cancer
  JOURNAL   Am J Pathol 181 (4), 1443-1454 (2012)
   PUBMED   22885105
  REMARK    GeneRIF: Dysregulation of epithelial PAGE4 modulates AR signaling.
REFERENCE   7  (bases 1 to 790)
  AUTHORS   Zeng,Y., He,Y., Yang,F., Mooney,S.M., Getzenberg,R.H., Orban,J. and
            Kulkarni,P.
  TITLE     The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a
            highly intrinsically disordered protein
  JOURNAL   J Biol Chem 286 (16), 13985-13994 (2011)
   PUBMED   21357425
  REMARK    GeneRIF: PAGE4 is a highly intrinsically disordered protein with an
            anti-apoptotic function
REFERENCE   8  (bases 1 to 790)
  AUTHORS   Kong,U., Koo,J., Choi,K., Park,J. and Chang,H.
  TITLE     The expression of GAGE gene can predict aggressive biologic
            behavior of intestinal type of stomach cancer
  JOURNAL   Hepatogastroenterology 51 (59), 1519-1523 (2004)
   PUBMED   15362791
  REMARK    GeneRIF: These results suggest that GAGE gene might have an
            important role in the development and progression of intestinal
            type of stomach cancer and the detection of GAGE mRNA may be
            eligible to the panel of molecular markers for aggressive behavior.
REFERENCE   9  (bases 1 to 790)
  AUTHORS   Iavarone,C., Wolfgang,C., Kumar,V., Duray,P., Willingham,M.,
            Pastan,I. and Bera,T.K.
  TITLE     PAGE4 is a cytoplasmic protein that is expressed in normal prostate
            and in prostate cancers
  JOURNAL   Mol Cancer Ther 1 (5), 329-335 (2002)
   PUBMED   12489849
  REMARK    GeneRIF: PAGE4 mRNA is expressed only in the cytoplasm of
            epithelial cells of normal and prostate-cancer specimens
REFERENCE   10 (bases 1 to 790)
  AUTHORS   Brinkmann,U., Vasmatzis,G., Lee,B., Yerushalmi,N., Essand,M. and
            Pastan,I.
  TITLE     PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in
            normal and neoplastic prostate, testis, and uterus
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10757-10762 (1998)
   PUBMED   9724777
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG435968.1, DA841276.1,
            AC231644.3 and AL548759.3.
            
            On Jan 15, 2016 this sequence version replaced NM_007003.3.
            
            Summary: This gene is a member of the GAGE family. The GAGE genes
            are expressed in a variety of tumors and in some fetal and
            reproductive tissues. This gene is strongly expressed in prostate
            and prostate cancer. It is also expressed in other male and female
            reproductive tissues including testis, fallopian tube, uterus, and
            placenta, as well as in testicular cancer and uterine cancer. The
            protein encoded by this gene shares sequence similarity with other
            GAGE/PAGE proteins, and also belongs to a family of CT
            (cancer-testis) antigens. The protein may play a role in benign and
            malignant prostate diseases. A related pseudogene is located on
            chromosome 7. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA838759.1, DA841276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218068.7/ ENSP00000218068.6
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BG435968.1         2-19
            19-504              DA841276.1         1-486
            505-566             AC231644.3         32993-33054         c
            567-790             AL548759.3         518-741
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..790
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /note="PAGE family member 4"
                     /db_xref="GeneID:9506"
                     /db_xref="HGNC:HGNC:4108"
                     /db_xref="MIM:300287"
     exon            1..49
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            50..157
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..388
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /note="prostate-associated gene protein 4; g antigen
                     family C member 1; P antigen family, member 4 (prostate
                     associated)"
                     /codon_start=1
                     /product="P antigen family member 4"
                     /protein_id="NP_008934.1"
                     /db_xref="CCDS:CCDS35274.1"
                     /db_xref="GeneID:9506"
                     /db_xref="HGNC:HGNC:4108"
                     /db_xref="MIM:300287"
                     /translation="MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEP
                     GQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP
                     "
     exon            158..245
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            246..371
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            372..790
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      469..474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /note="hexamer: AATAAA"
     polyA_site      495
                     /gene="PAGE4"
                     /gene_synonym="CT16.7; GAGE-9; GAGEC1; JM-27; JM27;
                     PAGE-1; PAGE-4"
                     /note="major polyA site"
ORIGIN      
        1 gccacttctc ttcccttcat tcttcgccag gctctctgct gactcaagtt cttcagttca
       61 cgatcttcta gttgcagcga tgagtgcacg agtgagatca agatccagag gaagaggaga
      121 tggtcaggag gctcccgatg tggttgcatt cgtggctccc ggtgaatctc agcaagagga
      181 accaccaact gacaatcagg atattgaacc tggacaagag agagaaggaa cacctccgat
      241 cgaagaacgt aaagtagaag gtgattgcca ggaaatggat ctggaaaaga ctcggagtga
      301 gcgtggagat ggctctgatg taaaagagaa gactccacct aatcctaagc atgctaagac
      361 taaagaagca ggagatgggc agccataagt taaaaagaag acaagctgaa gctacacaca
      421 tggctgatgt cacattgaaa atgtgactga aaatttgaaa attctctcaa taaagtttga
      481 gttttctctg aagaagtcat gcgtgtcttt tgtaaaattt attcctagga aattgacact
      541 attgtaaatg gtatctttaa aaaatccttg tgttctgttt agagctggta tatatttttg
      601 tatactgatt ttgtgttggg caacattgct aaacttgcct attctgttgg tttatcccta
      661 cgtccttttg gattttctcc atacacaatc ataccacatg taaataatga taattctgtt
      721 ttttcctttt gaggctttgt actttcattt ctggtcctta tgacactggc cagacccctc
      781 cagtacaatg
//
