LOCUS       NM_003785                659 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PAGE family member 1 (PAGE1), mRNA.
ACCESSION   NM_003785
VERSION     NM_003785.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 659)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 659)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 659)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 659)
  AUTHORS   De Backer,O., Arden,K.C., Boretti,M., Vantomme,V., De Smet,C.,
            Czekay,S., Viars,C.S., De Plaen,E., Brasseur,F., Chomez,P., Van den
            Eynde,B., Boon,T. and van der Bruggen,P.
  TITLE     Characterization of the GAGE genes that are expressed in various
            human cancers and in normal testis
  JOURNAL   Cancer Res 59 (13), 3157-3165 (1999)
   PUBMED   10397259
REFERENCE   5  (bases 1 to 659)
  AUTHORS   Brinkmann,U., Vasmatzis,G., Lee,B., Yerushalmi,N., Essand,M. and
            Pastan,I.
  TITLE     PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in
            normal and neoplastic prostate, testis, and uterus
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10757-10762 (1998)
   PUBMED   9724777
REFERENCE   6  (bases 1 to 659)
  AUTHORS   Chen,M.E., Lin,S.H., Chung,L.W. and Sikes,R.A.
  TITLE     Isolation and characterization of PAGE-1 and GAGE-7. New genes
            expressed in the LNCaP prostate cancer progression model that share
            homology with melanoma-associated antigens
  JOURNAL   J Biol Chem 273 (28), 17618-17625 (1998)
   PUBMED   9651357
REFERENCE   7  (bases 1 to 659)
  AUTHORS   Van den Eynde,B., Peeters,O., De Backer,O., Gaugler,B., Lucas,S.
            and Boon,T.
  TITLE     A new family of genes coding for an antigen recognized by
            autologous cytolytic T lymphocytes on a human melanoma
  JOURNAL   J Exp Med 182 (3), 689-698 (1995)
   PUBMED   7544395
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU941413.1, BC004861.2 and
            AC231643.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003785.3.
            
            Summary: This gene belongs to a family of genes that are expressed
            in a variety of tumors but not in normal tissues, except for the
            testis. Unlike the other gene family members, this gene does not
            encode an antigenic peptide. Nothing is presently known about the
            function of this protein. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG333742.1, SRR5189664.177738.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376150.4/ ENSP00000365320.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU941413.1         12-29
            19-656              BC004861.2         1-638
            657-659             AC231643.3         57686-57688
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..659
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /note="PAGE family member 1"
                     /db_xref="GeneID:8712"
                     /db_xref="HGNC:HGNC:4107"
                     /db_xref="MIM:300288"
     exon            1..116
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..187
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..565
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /note="prostate associated gene 1; G antigen, family B, 1
                     (prostate associated); G antigen family B member 1; G
                     antigen 9; prostate-associated gene 1 protein; P antigen
                     family, member 1 (prostate associated)"
                     /codon_start=1
                     /product="P antigen family member 1"
                     /protein_id="NP_003776.2"
                     /db_xref="CCDS:CCDS14327.1"
                     /db_xref="GeneID:8712"
                     /db_xref="HGNC:HGNC:4107"
                     /db_xref="MIM:300288"
                     /translation="MGFLRRLIYRRRPMIYVESSEESSDEQPDEVESPTQSQDSTPAE
                     EREDEGASAAQGQEPEADSQELVQPKTGCELGDGPDTKRVCLRNEEQMKLPAEGPEPE
                     ADSQEQVHPKTGCERGDGPDVQELGLPNPEEVKTPEEDEGQSQP"
     exon            188..290
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..416
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..542
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..659
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /note="hexamer: AATAAA"
     polyA_site      659
                     /gene="PAGE1"
                     /gene_synonym="AL5; CT16.3; GAGE-9; GAGEB1; PAGE-1"
                     /note="major polyA site"
ORIGIN      
        1 gagaacgcca gggagctgtg agagtgtgca gtcgcgttcc tgctgtccgg acactttttt
       61 cctctactga gactcatctg gtagatccgc aggccagtcc tcccaggggc tgaagttgtg
      121 aaatatgggt tttctaagaa gattaatcta tcggcgtaga ccaatgatct atgtagaatc
      181 ttctgaggag tccagtgatg agcaacctga cgaagtggaa tcaccaactc aaagtcagga
      241 ttctacacct gctgaagaga gagaggatga gggagcatct gcagctcaag ggcaggagcc
      301 tgaagctgat agccaggaac tggttcagcc aaagactggg tgtgagcttg gagatggtcc
      361 tgataccaag agggtgtgcc tgcgaaatga agagcagatg aaactgcccg cagaagggcc
      421 agagcctgaa gcggatagcc aggaacaggt tcacccgaag actgggtgtg agcgcggaga
      481 tggtcctgat gtccaggagt tgggcctgcc aaatccagag gaggtgaaaa cacctgagga
      541 agatgaaggg caatcacagc cttaaaagaa gacacgctga aatggttcag gctgctcctg
      601 tgttggaaat ttgaccatta aaattctccc aataaagctt tacagccttc tgcaaagaa
//
