LOCUS       NM_018440              10744 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens phosphoprotein membrane anchor with glycosphingolipid
            microdomains 1 (PAG1), mRNA.
ACCESSION   NM_018440 NM_001007549 XM_496979
VERSION     NM_018440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10744)
  AUTHORS   Sun,Y., Yang,X., Guan,S., Ma,T., Jiang,Z., Gao,M., Xu,Y. and
            Cong,B.
  TITLE     The role of phosphoprotein associated with
            glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the
            progression of oral squamous cell carcinoma
  JOURNAL   Arch Oral Biol 156, 105810 (2023)
   PUBMED   37852106
  REMARK    GeneRIF: The role of phosphoprotein associated with
            glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the
            progression of oral squamous cell carcinoma.
REFERENCE   2  (bases 1 to 10744)
  AUTHORS   Strazza,M., Azoulay-Alfaguter,I., Peled,M., Adam,K. and Mor,A.
  TITLE     Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory
            signaling in human T cells
  JOURNAL   Commun Biol 4 (1), 672 (2021)
   PUBMED   34083754
  REMARK    GeneRIF: Transmembrane adaptor protein PAG is a mediator of PD-1
            inhibitory signaling in human T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10744)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 10744)
  AUTHORS   Lin,J.J., Fan,J.J., Ge,X.J. and Sha,H.B.
  TITLE     PAG1 stimulates proliferation and metastasis of nasopharyngeal
            carcinoma through downregulating PTEN
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (21), 11096-11104 (2020)
   PUBMED   33215426
  REMARK    GeneRIF: PAG1 stimulates proliferation and metastasis of
            nasopharyngeal carcinoma through downregulating PTEN.
REFERENCE   5  (bases 1 to 10744)
  AUTHORS   Foltz,L., Palacios-Moreno,J., Mayfield,M., Kinch,S., Dillon,J.,
            Syrenne,J., Levy,T. and Grimes,M.
  TITLE     PAG1 directs SRC-family kinase intracellular localization to
            mediate receptor tyrosine kinase-induced differentiation
  JOURNAL   Mol Biol Cell 31 (20), 2269-2282 (2020)
   PUBMED   32726167
  REMARK    GeneRIF: PAG1 directs SRC-family kinase intracellular localization
            to mediate receptor tyrosine kinase-induced differentiation.
REFERENCE   6  (bases 1 to 10744)
  AUTHORS   Tedoldi,S., Paterson,J.C., Hansmann,M.L., Natkunam,Y., Rudiger,T.,
            Angelisova,P., Du,M.Q., Roberton,H., Roncador,G., Sanchez,L.,
            Pozzobon,M., Masir,N., Barry,R., Pileri,S., Mason,D.Y.,
            Marafioti,T. and Horejsi,V.
  TITLE     Transmembrane adaptor molecules: a new category of lymphoid-cell
            markers
  JOURNAL   Blood 107 (1), 213-221 (2006)
   PUBMED   16160011
REFERENCE   7  (bases 1 to 10744)
  AUTHORS   Ren,Y., Meng,S., Mei,L., Zhao,Z.J., Jove,R. and Wu,J.
  TITLE     Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and
            Src activation in response to epidermal growth factor
  JOURNAL   J Biol Chem 279 (9), 8497-8505 (2004)
   PUBMED   14665621
REFERENCE   8  (bases 1 to 10744)
  AUTHORS   Brdickova,N., Brdicka,T., Andera,L., Spicka,J., Angelisova,P.,
            Milgram,S.L. and Horejsi,V.
  TITLE     Interaction between two adapter proteins, PAG and EBP50: a possible
            link between membrane rafts and actin cytoskeleton
  JOURNAL   FEBS Lett 507 (2), 133-136 (2001)
   PUBMED   11684085
REFERENCE   9  (bases 1 to 10744)
  AUTHORS   Brdicka,T., Pavlistova,D., Leo,A., Bruyns,E., Korinek,V.,
            Angelisova,P., Scherer,J., Shevchenko,A., Hilgert,I., Cerny,J.,
            Drbal,K., Kuramitsu,Y., Kornacker,B., Horejsi,V. and Schraven,B.
  TITLE     Phosphoprotein associated with glycosphingolipid-enriched
            microdomains (PAG), a novel ubiquitously expressed transmembrane
            adaptor protein, binds the protein tyrosine kinase csk and is
            involved in regulation of T cell activation
  JOURNAL   J Exp Med 191 (9), 1591-1604 (2000)
   PUBMED   10790433
REFERENCE   10 (bases 1 to 10744)
  AUTHORS   Wen,S.T. and Van Etten,R.A.
  TITLE     The PAG gene product, a stress-induced protein with antioxidant
            properties, is an Abl SH3-binding protein and a physiological
            inhibitor of c-Abl tyrosine kinase activity
  JOURNAL   Genes Dev 11 (19), 2456-2467 (1997)
   PUBMED   9334312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB960651.1, BX426120.2,
            AK000680.1, BC090931.1, AC012533.11 and AA766638.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018440.3.
            
            Summary: The protein encoded by this gene is a type III
            transmembrane adaptor protein that binds to the tyrosine kinase csk
            protein. It is thought to be involved in the regulation of T cell
            activation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289818.1, SRR1660805.105152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220597.4/ ENSP00000220597.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               CB960651.1         28-444
            418-632             BX426120.2         423-637
            633-776             AK000680.1         26-169
            777-3281            BC090931.1         103-2607
            3282-10543          AC012533.11        138470-145731       c
            10544-10744         AA766638.1         16-216              c
FEATURES             Location/Qualifiers
     source          1..10744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..10744
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /note="phosphoprotein membrane anchor with
                     glycosphingolipid microdomains 1"
                     /db_xref="GeneID:55824"
                     /db_xref="HGNC:HGNC:30043"
                     /db_xref="MIM:605767"
     exon            1..478
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            479..537
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            538..631
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            632..836
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             712..2010
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /note="Csk-binding protein; transmembrane phosphoprotein
                     Cbp; transmembrane adaptor protein PAG; phosphoprotein
                     associated with glycosphingolipid microdomains 1;
                     transmembrane adapter protein PAG"
                     /codon_start=1
                     /product="phosphoprotein associated with
                     glycosphingolipid-enriched microdomains 1"
                     /protein_id="NP_060910.3"
                     /db_xref="CCDS:CCDS6227.1"
                     /db_xref="GeneID:55824"
                     /db_xref="HGNC:HGNC:30043"
                     /db_xref="MIM:605767"
                     /translation="MGPAGSLLGSGQMQITLWGSLAAVAIFFVITFLIFLCSSCDREK
                     KPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPASSEQNGALTNGDILSEDSTLTCM
                     QHYEEVQTSASDLLDSQDSTGKPKCHQSRELPRIPPESAVDTMLTARSVDGDQGLGME
                     GPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQT
                     EGKAEFAEYASVDRNKKCRQSVNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEG
                     GEAEESATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQLVNKSGQSL
                     TVPESTYTSIQGDPQRSPSSCNDLYATVKDFEKTPNSTLPPAGRPSEEPEPDYEAIQT
                     LNREEEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL"
     exon            837..888
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            889..985
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1587
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1647
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..10744
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6416..6421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /note="hexamer: AATAAA"
     polyA_site      6438
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
     regulatory      10722..10727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /note="hexamer: AATAAA"
     polyA_site      10744
                     /gene="PAG1"
                     /gene_synonym="CBP; PAG"
                     /note="major polyA site"
ORIGIN      
        1 attctccgcg gcgcggcggc gagtgctggc tgcggtaccc tcccgctcgc ttgtccgtct
       61 gcgcgcccgc gatgtgacca gccgactggg ggcgggctgg cggctctgcc tgcggcagcg
      121 catcggtttt tctcctggca ggtccctaat tgagccgtga ttcccttgga gccagagaca
      181 cccaccaggg gctcggagcg ccgcgctccg gggctggagg cagctgcagc gctcgggtcc
      241 gcgcggccgg gtgcagtagc ctcagtccca gccgccgcct cgctgagtcg tgtgccctgg
      301 cgaatgcccg gcgcccggca cagctgagcc aaggcgactg gtgcagagcg gcggcgcctg
      361 gtcctgcact tgccgctgct gccgggctgt gccggggcgg cggcgctgcg cgccggagtt
      421 tgcagaggct gcctccgagc gccgtccgcc aggaagactc cctgcctcct gagtcccaaa
      481 aacacgagat ttttctccta tttcagcagt tggccacaac ttcattgctg ggaaaaggcc
      541 aagaaagaag agagaactct caccacaaca tttcaaaggg aatacattgc cagaacttgg
      601 aatactctac tggacaaaca tttcctccaa ggacacagct ctctgcctcc atgtcaccac
      661 ctttgaagga ctgactgatt ccctcggctg gtgccagtgc ctgctcctgc catggggccc
      721 gcggggagcc tgctgggcag cggacagatg cagatcaccc tgtggggaag tctggctgct
      781 gtcgccattt tcttcgtcat caccttcctc atcttcctgt gctctagttg tgacagggaa
      841 aagaagccgc gacagcatag tggggaccat gagaacctga tgaacgtgcc ttcagacaag
      901 gagatgttca gccgttcagt tactagcctg gcaacagatg ctcctgccag cagtgagcag
      961 aatggggcac tcaccaatgg ggacattctt tcagaggaca gtactctgac ctgcatgcag
     1021 cattacgagg aagtccagac atcggcctcg gatctgctgg attcccagga cagcacaggg
     1081 aaaccaaaat gtcatcagag tcgggagctg cccagaatcc ctcccgagag cgcagtggat
     1141 accatgctca cggcgagaag tgtggacggg gaccaggggc tggggatgga agggccctat
     1201 gaagtgctca aggacagctc ctcccaagaa aacatggtgg aggactgctt gtatgaaact
     1261 gtgaaagaga tcaaggaggt ggctgcagct gcacacctgg agaaaggcca cagtggcaag
     1321 gcaaaatcta cttctgcctc gaaagagctc ccagggcccc agactgaagg caaagctgag
     1381 tttgctgaat atgcctcggt ggacagaaac aaaaaatgtc gtcaaagtgt taatgtagag
     1441 agtatccttg gaaattcatg tgatccagaa gaggaggccc caccacctgt ccctgttaag
     1501 cttctggacg agaatgaaaa ccttcaggag aaggaagggg gagaggcgga agagagtgcc
     1561 acagacacga ccagtgaaac taacaagaga tttagctcat tgtcatacaa gtctcgggaa
     1621 gaagacccca ctctcacaga agaagagatc tcagctatgt actcatcagt aaataaacct
     1681 ggacagttag tgaataaatc ggggcagtcg cttacagttc cggagtccac ctacacctcc
     1741 attcaagggg acccacagag gtcaccctcc tcctgtaatg atctctatgc tactgttaaa
     1801 gacttcgaaa aaactccaaa cagcacactt ccaccagcag ggaggcccag cgaggagcca
     1861 gagcctgatt atgaagcgat acagactctc aacagagagg aagaaaaggc caccctgggg
     1921 accaatggcc accacggtct cgtcccaaag gagaacgact acgagagcat aagtgacttg
     1981 cagcaaggca gagatattac caggctctag caacccagaa gacaaccctg ggtagcctgt
     2041 gatcagtgtc tggagacgtt tcttctgtgg aagagaagaa gtgacacaaa cctatacttc
     2101 atatgctgct ttagtcacct gaagatggtt ggagaggccc tgtcgactgt tctcccagtt
     2161 gttcagtttc tgagacagag aggtacggac taggctgcac ctgagtgtgc ccctgcctgc
     2221 cagatggaca ggtacaccca agcacatctc cctgctgcac cctcaccacc cacaaaagat
     2281 cccagctgtc agtggtctca tctcattagt gaggaaagcc aagctgtatg gaaaagctgc
     2341 actcaccaag gaccacaatg cccccggcct aaagtactgc cattcagaaa agcaggtttt
     2401 tcttcctctc tttccttttc tctgtctgct actgacttta aggctttttc ccccttgaaa
     2461 tgtccagatt cctgtggttc atcccaagga aattttcaca caaagcttgg cctttgccct
     2521 caatataggt gttttaggat ggtgacaaac catggctgct gctttctgcc cagctcgcca
     2581 gtcctcccca aagagttgcg catcagcacc tggggatctg gaccctgcgg gtgaagggat
     2641 ggggagggac gtccctggag tctcttctgt ctttgttcct tcttattttg gcattcgata
     2701 tcagcagcct ctccccaaag tacttgaagt cagttttaga tgctttattt tatttttcta
     2761 gtcaaaaacg tgtttccccc agtgtttgaa aactcgtccg aatcttttca gtattttcca
     2821 tgagtattgt ggtacttcta gacttgttta agcccagaac tcattccttc aaaacagaga
     2881 gccttaatct ttatgttggg acacagacca catatttgga cggcagccat gcatccatcg
     2941 ctgaagggct gtggacatga atgtgtattt cccatggtct ccgctgccca caccaacagt
     3001 gtggcatctc ataagttaac tgctacccta aggtaatcta agattaaaat gtaaacattt
     3061 atttttgtta tgtaagttta taagatgttt tatgttcaat gcctaatttc tcaaaagtgc
     3121 cagaaaaaaa tgtatattag ctattttgat tttatgtaca atgatttata ctctcctttt
     3181 gaaaagatac cataaagcac ataagctaga tcactacaag gagctgttat cttttttcta
     3241 atcaagtgtt taaaacactg atggttttta aagactcacc tttttaaatg gtacttggag
     3301 ctcctgattc aaattaccta gaccccctag agaaataaat ggaatataca taaataatca
     3361 ttttcagtgg tttatggtgg gcaatattgc aatatttgaa atggtaaaaa tggaaagaag
     3421 aacaaaatat gatgagaggt ggctgtgaat tataaacctc ataaaagtgt cataattcca
     3481 ttaaggttta attatatttt ttcagaaaac agtgatgaat tctgtagtcc agtgcttgcc
     3541 aatgcaaatt gcctattgga atcttcttcc tatattttac aaacatcagt ggctgaaata
     3601 gctcagagta agagctcagc ctggtttgaa tttaatcatc tctttagatc ttataaggcc
     3661 agcattagga aacttgttca cttttcattt tcaaaggagc ctagttgaag tgctattatg
     3721 agtgtgggct atggaaagac agcttttcct acactgataa agaaaaaaaa tgaggaaatt
     3781 atttcatccc cttgtgacat ctgtgacttt ttggatttaa taatcttgct gtttttcctc
     3841 tttatgacaa agaatataat tgggaggatg aagtgtctta aaaattgtag agaccagctc
     3901 actggaatgt ttttccatcc ctgtattcat ggcttgactt tgtgactgct ctacactgca
     3961 tgtctgacat tgcagagtga gctatgttga ggtaaactgg ttggttgtca ttattttgca
     4021 atcagcctgg tctctcccat gaagatgtcg tgtgcataag cacaatcatc actgattaga
     4081 agatcacagc agaataccct tggattagag agaagttcgt accttgcatt tctctgaatt
     4141 ctagtctctc ataagcactg ctttgctgga tgattttcac tgctttgtgt taatgacttt
     4201 gagcgatctc tcacatgatg gggttcttta gtacatggta acagccatgt catcttacac
     4261 acctagcatt gtgaatgctg tagtgacatc ctttataggc accttacagc tcaaaacttt
     4321 tgtttcattt catgccttac ttatcaaaaa ggcaggaaag taggtatgat ctctaaagta
     4381 aaaaaaaaaa aaaaaaaaaa actttttata gaaagctcat aaataatcat gtcattttgc
     4441 aattttgtta ccaaaatttc ccccaagagt tttcaaatat tagttctgca atgtggctat
     4501 gaaatatgca ctgaaatata ccttttaatt tgagaaccag tggttagaat aagctgtgat
     4561 ataaagtatt ttcagtgtac ttttaaagga actataaggc cctccagcat aaacgctaaa
     4621 agaatagatg gtagcacagg ccatgagggc tgggggagag aagcagagtg aaccttagaa
     4681 agatggctca gctatttgga gcactggata ttttactgaa gttatttact gaggcaccat
     4741 cactgttttg actgtacagt atagtttttc ataaatttca tcacatttac tttgttcaga
     4801 atctgggctt gaatctttga gttggacaaa agcctatggt ttcttttaaa aagtttcatc
     4861 ttgagctaat gctacagttt aaataaaatg tatgaaaggt agttatcaaa aacaatttgt
     4921 atatttaaaa ttctattttg acatccattt tttacagcga attatagcag gttatgtgaa
     4981 atttaaaaat aaattttagg aaattttttt atcttgtaag taagaattat aaatctatct
     5041 cagttaaaag taggatcttt gtttttattc agatattttg aaagtttaga agcattttgt
     5101 atgctacttt ggtatttctt aagtatagtc agcaggaaag ggtaacctgt tttatgcaaa
     5161 atttttttaa tttgtcaaat gtttttagtg tgtctacttt ctgaaatagt ctcaatatcc
     5221 tgtctgtatc ctaggcagat aactacacaa gaacaaaacg ctatatagaa aagaaaatat
     5281 ttgaggaaat cttaaattcc ataagaaagt aattcttgca agaatgttgg ctacatattt
     5341 ttttttctgt cctgaataaa ttacatcatt aggtctgttg aagcttttga agctaccact
     5401 attctttctg ggataaaggc taattactga tttatctgcc ctcaaaatcc cagagttaat
     5461 tctaattgag tactaaatta acagtaagta gttaacacag agaactaaaa tttaaccgca
     5521 ttatatcact gtatatattt ctcatgattt ttgctaatta gagcatttac ttaaccagta
     5581 ataaactaca cacacacaca cacacacaca cacgtatacg tgtgtgtgtg tatatacttg
     5641 gctctgacac aactctggtg cttaattagg atatgttcta ttatgtattt tgaatgttta
     5701 tcctgctagt gtgatgaact tttgttggaa aagcagaatt agaaggaaca gtttttcaat
     5761 cagtttcatt tggtaattac aggaaaacct tgagttgctc taatttaatt tttccaatta
     5821 atacatttag actttaaatt gcatccgtaa ttctcttggc tgaaaaacag tggtatttta
     5881 agacagtttt gttatacatg tgacttactt ttgactcagc ctgagaggag gaaatgtaaa
     5941 gagataagag atttggccca aagcagcaag agactagtaa ccttgagcca ggacgaagcc
     6001 aagacaacgt gactcccaag tagcaggagc agaggtcggt cacctgtggc attctgtttc
     6061 attccctttt aaaattatga gactttatag gcagtgtaaa acatcagcag gcagcgatgt
     6121 gataggatgt gcgaaaaagc tggtctgata ccatggctat aattacagag ctttagttca
     6181 attaggattt tgtaaatgag caaatgacct ttttttccag tgccccttgt aatagttaat
     6241 atgagtccat gcaatcttgt gatgccattc tcctgaaggt gttgatttct ggtacccagc
     6301 cagcttagct ttggctgctg gaagcacagt aggtactgat gattacttcc tggaaatctt
     6361 gacaggctta ttgtactgtg taatggggaa aagttaaagt ataatgtttg gtgttaataa
     6421 atgactgatg tgaaaatagg aacatgtgtc tttaatatca aatatggctt tatttgcagt
     6481 gaaatctaaa ttccttattc tacagtagta ttttcttgcc ctgtgttgta tattttccta
     6541 aatacatttt tcctgacagt ggctttaggc cagttgaaca cacttagact gaaagtgttt
     6601 aacttaaaga gatcagtcca gaaaccatga taaattagaa tctttatctg gaattaccaa
     6661 attaaaattt aaaatcatgg tccagaagag aacaaacatt catggttttt tttatcctac
     6721 tgctcatttt taggtctgtg tttacatcta gtctctacta tttgtgaagt atgtcattat
     6781 ttttttcaag ttcttctttg acttaactga aaaataatat tccaaattct taatgtaaca
     6841 tgaaaagaga aatacaattt ttgcttaaaa gacatttttt aaaaagcgtt caattcagta
     6901 atcatttctg ttaatacagg aagttttttt ggcttgccag ttatatactg tgggtatttt
     6961 ttaaaatgtg ctacccttgg gttgtctcat atcaccttgc gtaatcatgt attacaaagg
     7021 ttgataattg tcatttctca gatgtctgta tgttacattg gcagcagtaa aatgttttaa
     7081 tgttgttacc ttttaaataa ttgtgttgta ttaacatgcc tcatattttc tggggaaact
     7141 tgaaatatat ctaaacaaaa aaggtctgtt ataaatagga attggcattt cattgttaat
     7201 gttttttcct cataaaaata gttacaccaa aagtgacata ttgtctatta catgggccca
     7261 atcagtatta aagtactccc cttactcaaa aatattaaaa aataattcat gacacttagt
     7321 agcattttca ttgattgttt caaaagatct tcataatggt caaattgtcc aattcacaaa
     7381 agagtgagaa agttgttttc agtactggga atttttaaac cttagtttta agaccaaaaa
     7441 tatctcttat tagcttgaac attttgtgat tacttttccc tccccggatc tagtcctttt
     7501 aaggagtaag tctaaagaat gaggccatga agtcactatt tcctcccacc tcagtttgtc
     7561 tcctggtact tagctggcct atcgctttgt gtggcaatac ccctgggtcg cttccccact
     7621 cagccttctg tatctgctgt tcacaggaca tgccattatg tctttccagt acggatcaca
     7681 gtgctgccat atcacagacc ctgccagccg gcacagaacc atgcctcgtc acagctctgc
     7741 ccaactcaca ggctgccaag atgaggccac aggtccacct agggcggcag atgctggtgc
     7801 tatttgtcac gacttttgcc aaaacatgta cactgttgct cacatctttc gtaagaatgg
     7861 ttgacactaa ggggccatgg aaaagcactt ttaaaaaatt atgtggtgga atcaaactca
     7921 cagaggcaga aatgttagtg ccgtgctcta accaagtaag cttagtgttc cccacagtga
     7981 tctgtatctg gcctgagtct cctcaagcag caacccccac tgtccagcat gtggaaggta
     8041 gatccttatg acaacaccag acccatagtt accaggaaag aaaaaggaag ctgagtgttg
     8101 tgaaggggaa gaaatccttt ttataagaag taatcatttt taggccgggt gcagtggctc
     8161 atgcctgtaa tcccagcact ttgggaggct gagacaggtg gatcacttga ggtcaggagt
     8221 ttgagacctg cctggccaac atgatgaaac cctgtctcta ctaaaaatgc aaaaaaaatt
     8281 agccaggcat ggtggcatgt gcctgtagtc ccaactactc aggaggctga ggcaggagaa
     8341 tcacttgaac ctgggaggca gaggttgcaa tgagctgaga tcgcaacact gcactccagc
     8401 ctgggcgaca gagcaagact ccatctcaaa aacaaaaaca aaaaaaaaac ctttttaaag
     8461 taaattgagt gtaaaatgtt ttcaccatga agccattgca ccctctcccc caggaaacag
     8521 tgcctaagga tgatgtcaag ttacagccag tttgctctga tcccccagga cctaagaaaa
     8581 ctgtgagtgc ttcagcatgc aaaggtagag ctaccagata aggagaataa cttggccatt
     8641 tatagcaaac tgcctgactt tggagtgaga aaccaagcac cttctaggtc ctaggatagg
     8701 tgaattggag gtgcagctgc tgaagttccc attttctaca tacttcagga gccagggtgt
     8761 ttcatttggt tttgtaaaac tttgctgtaa gtcatcacag ttaattcttt gaatggacat
     8821 tttagagtgt aacttttttt caaaattagc agaacagata tctctgctca ttctctttat
     8881 acatttagtt ttttaaagtt cccctagtat acctgttagg cactctaaat aggacacagt
     8941 taaagctaaa agaaggacca gttgctccct agagcctaca gttcagaact atcttgttgt
     9001 catgtcctgg tttggtttgg tttgttttta actcaacaag ttggaaacca tgagtttaaa
     9061 gcaaactatt tccttttctt aagcttaaag agaatttttt ttttaatctt tagctcctca
     9121 tttaggtagt gaaggcttcc ctgaaagaca gcagtgccct tctctggaag aagaggctgg
     9181 gaccaaaagc ctgagtctat gggttgagga ttttgagcat tcctttgaca agcttctatg
     9241 tatttttaat ataagactca taaatgaacc tgatgtggtg ttcatgaccc atcccttaag
     9301 catgcttgct ttttttaact ttactttttg agtatagtac ttgtcttgtt tttcctggag
     9361 ccatgctagg atttaattcc tatgtgccac tacccgccca tgtcctggaa gatggccatg
     9421 cctgcagcaa tgctcatgtc ttgaggagaa gcaatgtgaa aagcatcagg aaagctgaac
     9481 cttacgttca agtcagcaaa catttgtgag cattctagta tgcttgcgac cttgacactt
     9541 tttaaaaatt atctttttat ttgcttcgag tatcaaccgt atagttgact ctagtggggc
     9601 gaagggagca gagatgagag caaaattcag acttgctgcc cctgtgtgtc tcagttctca
     9661 tgtctctctg agaaatgtgt tggcccaatt ccctatctgc cactctgagt ctcttgagta
     9721 aatgtgtgta aatgagaaaa attatctcaa agatttaact tattatttag atattttctt
     9781 ctttttaaac tcaggaataa acctggtttg tagataatat aatatggcta ctagagctat
     9841 aattgagtag gtgactagaa gcattttttc aaatatattt cttgtaaaga catctacttt
     9901 gttttaacta ggaaaagaaa ctcctcatat taaaataaac atttccataa gcactttcta
     9961 gaagagtgta gcatccatct accatccatc ccagaatgtt tgtatcttgc tcatagtatt
    10021 tcaaaaattt ttatgggtga aaaaaatgca cttttttatt tattggaaaa gtgtagagtt
    10081 attgaattaa attctcaagt gggacaattt agtgtaaagg gaaacatggg ttttggagac
    10141 aagagcacag ggctgtggtc cctgttccag cattgacttt actatgtgac ctcgagcaaa
    10201 tgatttaact tctctgtgcc tcagtttctc catatacaaa atggggataa tgatactaac
    10261 cattgcctac ctcatagaga tgttatgggg acaaacgaaa taatagagat aagcacgaat
    10321 gctttcaact cttcggaaga aaggtgctat ataaattgaa gttgtgtttt taatgatcca
    10381 attattaatt atgtttaggg tttaaataac aatactgtta gtcatgttaa gaataagttt
    10441 tgttttgatg catatttcca cttctcttct gtggccagat cttgatcatt caaccagtaa
    10501 tggtacctga ggaactgaaa tgggtatttg ttttcgtatg tttctgccag tagtatttca
    10561 attgaatatc cagaaaagac tggagtttaa cttgtaatat cttatagttt acatgtaata
    10621 aaacttattc aagctatata taaaagtatg attacatgta aatagcaggt atgttgtaat
    10681 taaaggcact tatcaaattg tctttgttct tttttaattg taataaaagt cagttttaca
    10741 taaa
//
