LOCUS       NM_002571                992 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens progestagen associated endometrial protein (PAEP),
            transcript variant 2, mRNA.
ACCESSION   NM_002571
VERSION     NM_002571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 992)
  AUTHORS   Lob,S., Vattai,A., Kuhn,C., Schmoeckel,E., Mahner,S., Wockel,A.,
            Kolben,T., Keil,C., Jeschke,U. and Vilsmaier,T.
  TITLE     Pregnancy Zone Protein (PZP) is significantly upregulated in the
            decidua of recurrent and spontaneous miscarriage and negatively
            correlated to Glycodelin A (GdA)
  JOURNAL   J Reprod Immunol 143, 103267 (2021)
   PUBMED   33388716
  REMARK    GeneRIF: Pregnancy Zone Protein (PZP) is significantly upregulated
            in the decidua of recurrent and spontaneous miscarriage and
            negatively correlated to Glycodelin A (GdA).
REFERENCE   2  (bases 1 to 992)
  AUTHORS   Hautala,L.C., Pang,P.C., Antonopoulos,A., Pasanen,A., Lee,C.L.,
            Chiu,P.C.N., Yeung,W.S.B., Loukovaara,M., Butzow,R., Haslam,S.M.,
            Dell,A. and Koistinen,H.
  TITLE     Altered glycosylation of glycodelin in endometrial carcinoma
  JOURNAL   Lab Invest 100 (7), 1014-1025 (2020)
   PUBMED   32205858
  REMARK    GeneRIF: Altered glycosylation of glycodelin in endometrial
            carcinoma.
REFERENCE   3  (bases 1 to 992)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 992)
  AUTHORS   Hansen,Y.B.L., Myrhoj,V. and Sorensen,S.
  TITLE     Glycodelin is internalized by peripheral monocytes
  JOURNAL   J Reprod Immunol 138, 103102 (2020)
   PUBMED   32120159
  REMARK    GeneRIF: Glycodelin is internalized by peripheral monocytes.
REFERENCE   5  (bases 1 to 992)
  AUTHORS   Dixit,A. and Karande,A.A.
  TITLE     Glycodelin regulates the numbers and function of peripheral natural
            killer cells
  JOURNAL   J Reprod Immunol 137, 102625 (2020)
   PUBMED   31730930
  REMARK    GeneRIF: Glycodelin regulates the numbers and function of
            peripheral natural killer cells.
REFERENCE   6  (bases 1 to 992)
  AUTHORS   Garde,J., Bell,S.C. and Eperon,I.C.
  TITLE     Multiple forms of mRNA encoding human pregnancy-associated
            endometrial alpha 2-globulin, a beta-lactoglobulin homologue
  JOURNAL   Proc Natl Acad Sci U S A 88 (6), 2456-2460 (1991)
   PUBMED   2006183
REFERENCE   7  (bases 1 to 992)
  AUTHORS   Van Cong,N., Vaisse,C., Gross,M.S., Slim,R., Milgrom,E. and
            Bernheim,A.
  TITLE     The human placental protein 14 (PP14) gene is localized on
            chromosome 9q34
  JOURNAL   Hum Genet 86 (5), 515-518 (1991)
   PUBMED   2016092
REFERENCE   8  (bases 1 to 992)
  AUTHORS   Vaisse,C., Atger,M., Potier,B. and Milgrom,E.
  TITLE     Human placental protein 14 gene: sequence and characterization of a
            short duplication
  JOURNAL   DNA Cell Biol 9 (6), 401-413 (1990)
   PUBMED   2206398
REFERENCE   9  (bases 1 to 992)
  AUTHORS   Check,J.H., Nowroozi,K., Chase,J.S., Vaze,M., Joshi,S. and
            Baker,A.F.
  TITLE     Serum progestagen-associated endometrial protein (PEP) levels in
            conception versus nonconception cycles following in vitro
            fertilization-embryo transfer
  JOURNAL   J In Vitro Fert Embryo Transf 7 (3), 134-136 (1990)
   PUBMED   2380618
REFERENCE   10 (bases 1 to 992)
  AUTHORS   Wood,P.L., Iffland,C.A., Allen,E., Bentick,B., Burton,P., Shaw,R.W.
            and Bell,S.C.
  TITLE     Serum levels of pregnancy-associated endometrial alpha 2-globulin
            (alpha 2-PEG), a glycosylated beta-lactoglobulin homologue, in
            successful and unsuccessful assisted conception
  JOURNAL   Hum Reprod 5 (4), 421-426 (1990)
   PUBMED   2113930
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK311813.1, J04129.1,
            AL050169.1 and AL354761.17.
            
            On Nov 22, 2018 this sequence version replaced NM_002571.3.
            
            Summary: This gene is a member of the kernel lipocalin superfamily
            whose members share relatively low sequence similarity but have
            highly conserved exon/intron structure and three-dimensional
            protein folding. Most lipocalins are clustered on the long arm of
            chromosome 9. The encoded glycoprotein has been previously referred
            to as pregnancy-associated endometrial alpha-2-globulin, placental
            protein 14, and glycodelin, but has been officially named
            progestagen-associated endometrial protein. Three distinct forms,
            with identical protein backbones but different glycosylation
            profiles, are found in amniotic fluid, follicular fluid and seminal
            plasma of the reproductive system. These glycoproteins have
            distinct and essential roles in regulating a uterine environment
            suitable for pregnancy and in the timing and occurrence of the
            appropriate sequence of events in the fertilization process.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) uses an alternate, in-frame
            splice site in the 3' UTR, compared to variant 1. It encodes the
            same protein as variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04129.1, BX358014.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479141.6/ ENSP00000417898.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK311813.1         1-2
            3-329               J04129.1           1-327
            330-421             AK311813.1         330-421
            422-742             J04129.1           420-740
            743-813             AL050169.1         751-821
            814-992             AL354761.17        7981-8159
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..992
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /note="progestagen associated endometrial protein"
                     /db_xref="GeneID:5047"
                     /db_xref="HGNC:HGNC:8573"
                     /db_xref="MIM:173310"
     exon            1..142
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..589
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; PP14 protein (placental protein 14); alpha
                     uterine protein; glycodelin-S; glycodelin-F;
                     progesterone-associated endometrial protein; glycodelin-A;
                     progestagen-associated endometrial protein (placental
                     protein 14, pregnancy-associated endometrial a; PEG;
                     pregnancy-associated endometrial alpha-2 globulin;
                     zona-binding inhibitory factor-1"
                     /codon_start=1
                     /product="glycodelin isoform 1 precursor"
                     /protein_id="NP_002562.2"
                     /db_xref="CCDS:CCDS35173.1"
                     /db_xref="GeneID:5047"
                     /db_xref="HGNC:HGNC:8573"
                     /db_xref="MIM:173310"
                     /translation="MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMAT
                     NNISLMATLKAPLRVHITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKI
                     NYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRP
                     LPRHLWYLLDLKQMEEPCRF"
     exon            143..282
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..356
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..467
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..572
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..589
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..992
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      795..800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /note="hexamer: AATAAA"
     polyA_site      813
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /note="major polyA site"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
                     /note="hexamer: AACAAA"
     polyA_site      992
                     /gene="PAEP"
                     /gene_synonym="GD; GdA; GdF; GdS; PAEG; PEP; PP14; ZIF-1"
ORIGIN      
        1 agcatccctc tggctccaga gctcagagcc acccacagcc gcagccatgc tgtgcctcct
       61 gctcaccctg ggcgtggccc tggtctgtgg tgtcccggcc atggacatcc cccagaccaa
      121 gcaggacctg gagctcccaa agttggcagg gacctggcac tccatggcca tggcgaccaa
      181 caacatctcc ctcatggcga cactgaaggc ccctctgagg gtccacatca cctcactgtt
      241 gcccaccccc gaggacaacc tggagatcgt tctgcacaga tgggagaaca acagctgtgt
      301 tgagaagaag gtccttggag agaagactga gaatccaaag aagttcaaga tcaactatac
      361 ggtggcgaac gaggccacgc tgctcgatac tgactacgac aatttcctgt ttctctgcct
      421 acaggacacc accaccccca tccagagcat gatgtgccag tacctggcca gagtcctggt
      481 ggaggacgat gagatcatgc agggattcat cagggctttc aggcccctgc ccaggcacct
      541 atggtacttg ctggacttga aacagatgga agagccgtgc cgtttctagc tcacctccgc
      601 ctccaggaag accagactcc cacccttcca cacctccaga gcagtgggac ttcctcctgc
      661 cctttcaaag aataaccaca gctcagaaga cgatgacgtg gtcatctgtg tcgccatccc
      721 cttcctgctg cacacctgca ccacggccat ggggaggctg ctccctgggg gcagagtctc
      781 tggcagaggt tattaataaa cccttggagc atgtcctgtc tggatgcgca gccactgctg
      841 ggtgtgggat tcagggacga gggcctgggg tcggggcagg cccaggccac cgcctggcag
      901 aaccggagct cctacagacc catgggcagc ttctggtgga gaaaatacct caagtttctt
      961 atctacaaaa caaaagggtc cactttcaca aa
//
