LOCUS       NM_012387               2267 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens peptidyl arginine deiminase 4 (PADI4), mRNA.
ACCESSION   NM_012387
VERSION     NM_012387.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Araujo-Abad,S., Rizzuti,B., Soto-Conde,L., Vidal,M., Abian,O.,
            Velazquez-Campoy,A., Neira,J.L. and de Juan Romero,C.
  TITLE     Citrullinating enzyme PADI4 and transcriptional repressor RING1B
            bind in cancer cells
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133163 (2024)
   PUBMED   38878927
  REMARK    GeneRIF: Citrullinating enzyme PADI4 and transcriptional repressor
            RING1B bind in cancer cells.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Martinod,K., Denorme,F., Meyers,S., Crescente,M., Van Bruggen,S.,
            Stroobants,M., Siegel,P.M., Grandhi,R., Glatz,K. and Witsch,T.
  TITLE     Involvement of peptidylarginine deiminase 4 in eosinophil
            extracellular trap formation and contribution to citrullinated
            histone signal in thrombi
  JOURNAL   J Thromb Haemost 22 (6), 1649-1659 (2024)
   PUBMED   38395360
  REMARK    GeneRIF: Involvement of peptidylarginine deiminase 4 in eosinophil
            extracellular trap formation and contribution to citrullinated
            histone signal in thrombi.
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Bashir,K., Chaudhary,A., Aslam,M., Fatima,I. and Sarwar,R.
  TITLE     Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and
            HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population
  JOURNAL   Biochem Genet 62 (3), 1840-1856 (2024)
   PUBMED   37751115
  REMARK    GeneRIF: Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033)
            and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani
            Population.
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Osei-Amponsa,V., Chandravanshi,M., Lu,X., Magidson,V., Das,S.,
            Andresson,T., Dyba,M., Sabbasani,V.R., Swenson,R.E., Fromont,C.,
            Shrestha,B., Zhao,Y., Clapp,M.E., Chari,R. and Walters,K.J.
  TITLE     hRpn13 shapes the proteome and transcriptome through epigenetic
            factors HDAC8, PADI4, and transcription factor NF-kappaB p50
  JOURNAL   Mol Cell 84 (3), 522-537 (2024)
   PUBMED   38151017
  REMARK    GeneRIF: hRpn13 shapes the proteome and transcriptome through
            epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB
            p50.
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Nava-Quiroz,K.J., Rojas-Serrano,J., Perez-Rubio,G.,
            Buendia-Roldan,I., Mejia,M., Fernandez-Lopez,J.C.,
            Rodriguez-Henriquez,P., Ayala-Alcantar,N., Ramos-Martinez,E.,
            Lopez-Flores,L.A., Del Angel-Pablo,A.D. and Falfan-Valencia,R.
  TITLE     Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated
            with Interstitial Lung Disease Susceptibility in Rheumatoid
            Arthritis Patients
  JOURNAL   Cells 12 (18), 2235 (2023)
   PUBMED   37759458
  REMARK    GeneRIF: Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are
            Associated with Interstitial Lung Disease Susceptibility in
            Rheumatoid Arthritis Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Barton,A., Bowes,J., Eyre,S., Spreckley,K., Hinks,A., John,S. and
            Worthington,J.
  TITLE     A functional haplotype of the PADI4 gene associated with rheumatoid
            arthritis in a Japanese population is not associated in a United
            Kingdom population
  JOURNAL   Arthritis Rheum 50 (4), 1117-1121 (2004)
   PUBMED   15077293
  REMARK    GeneRIF: A PADI4 susceptibility haplotype associated with RA in a
            Japanese population is not associated with RA in a UK population
            but other genes involved in the citrullinating pathway remain
            strong candidate
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Suzuki,A., Yamada,R., Chang,X., Tokuhiro,S., Sawada,T., Suzuki,M.,
            Nagasaki,M., Nakayama-Hamada,M., Kawaida,R., Ono,M., Ohtsuki,M.,
            Furukawa,H., Yoshino,S., Yukioka,M., Tohma,S., Matsubara,T.,
            Wakitani,S., Teshima,R., Nishioka,Y., Sekine,A., Iida,A.,
            Takahashi,A., Tsunoda,T., Nakamura,Y. and Yamamoto,K.
  TITLE     Functional haplotypes of PADI4, encoding citrullinating enzyme
            peptidylarginine deiminase 4, are associated with rheumatoid
            arthritis
  JOURNAL   Nat Genet 34 (4), 395-402 (2003)
   PUBMED   12833157
  REMARK    GeneRIF: identified a haplotype of PADI4 associated with
            susceptibility to rheumatoid arthritis that affected stability of
            transcripts and was associated with levels of antibody to
            citrullinated peptide in sera from individuals with rheumatoid
            arthritis
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Nakashima,K., Hagiwara,T. and Yamada,M.
  TITLE     Nuclear localization of peptidylarginine deiminase V and histone
            deimination in granulocytes
  JOURNAL   J Biol Chem 277 (51), 49562-49568 (2002)
   PUBMED   12393868
  REMARK    GeneRIF: PAD V is localized in the nucleus in Hela cells
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Asaga,H., Nakashima,K., Senshu,T., Ishigami,A. and Yamada,M.
  TITLE     Immunocytochemical localization of peptidylarginine deiminase in
            human eosinophils and neutrophils
  JOURNAL   J Leukoc Biol 70 (1), 46-51 (2001)
   PUBMED   11435484
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Nakashima,K., Hagiwara,T., Ishigami,A., Nagata,S., Asaga,H.,
            Kuramoto,M., Senshu,T. and Yamada,M.
  TITLE     Molecular characterization of peptidylarginine deiminase in HL-60
            cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)
  JOURNAL   J Biol Chem 274 (39), 27786-27792 (1999)
   PUBMED   10488123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314839.1, AB017919.1 and
            AC004824.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012387.2.
            
            Summary: This gene is a member of a gene family which encodes
            enzymes responsible for the conversion of arginine residues to
            citrulline residues. This gene may play a role in granulocyte and
            macrophage development leading to inflammation and immune response.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017919.1, SRR1803615.231330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375448.4/ ENSP00000364597.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-765               AK314839.1         3-767
            766-1174            AB017919.1         766-1174
            1175-2018           AK314839.1         1177-2020
            2019-2263           AB017919.1         2019-2263
            2264-2267           AC004824.3         98316-98319         c
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2267
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /note="peptidyl arginine deiminase 4"
                     /db_xref="GeneID:23569"
                     /db_xref="HGNC:HGNC:18368"
                     /db_xref="MIM:605347"
     exon            1..118
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2018
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /EC_number="3.5.3.15"
                     /note="peptidyl arginine deiminase, type V; HL-60 PAD;
                     PADI-H protein; protein-arginine deiminase type IV;
                     peptidyl arginine deiminase, type IV"
                     /codon_start=1
                     /product="protein-arginine deiminase type-4"
                     /protein_id="NP_036519.2"
                     /db_xref="CCDS:CCDS180.1"
                     /db_xref="GeneID:23569"
                     /db_xref="HGNC:HGNC:18368"
                     /db_xref="MIM:605347"
                     /translation="MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINA
                     SPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTP
                     PVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLE
                     SSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATR
                     GKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSN
                     LELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKL
                     TICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYV
                     TRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDF
                     LSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEG
                     HGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIID
                     IPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLG
                     LQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP"
     exon            119..299
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            300..366
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..434
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            435..552
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            553..678
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            679..857
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            858..961
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1073
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1181
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1336
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1481
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1584
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1655
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1784
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2267
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /note="hexamer: AATAAA"
     polyA_site      2267
                     /gene="PADI4"
                     /gene_synonym="PAD; PAD4; PADI5; PDI4; PDI5"
                     /note="major polyA site"
ORIGIN      
        1 agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag
       61 agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct
      121 ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata
      181 ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc
      241 ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg
      301 ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg
      361 gggtggaaat ctccttgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag
      421 ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg
      481 tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc
      541 ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg
      601 acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga
      661 gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca
      721 agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg
      781 aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc
      841 tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc
      901 gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca
      961 gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt
     1021 gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa
     1081 tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa
     1141 ggaacagagg cctgaaggag tttcccatca aacgcgtgat gggtccagat tttggctatg
     1201 taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag
     1261 tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg
     1321 acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca
     1381 gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg
     1441 tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg
     1501 ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg
     1561 ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa
     1621 acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc
     1681 tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca
     1741 agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc
     1801 tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc
     1861 tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg
     1921 acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa
     1981 agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc
     2041 tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa
     2101 tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg
     2161 atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct
     2221 gctctaagaa gctgcaataa agttttttta agtcactttg tacatga
//
