LOCUS       NM_016233               3189 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens peptidyl arginine deiminase 3 (PADI3), mRNA.
ACCESSION   NM_016233
VERSION     NM_016233.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Chai,Z., Zhu,C., Wang,X., Zheng,Y., Han,F., Xie,Q. and Liu,C.
  TITLE     PADI3 inhibits epithelial-mesenchymal transition by targeting
            CKS1-induced signal transduction in colon cancer
  JOURNAL   J Cancer Res Ther 20 (4), 1323-1333 (2024)
   PUBMED   39206995
  REMARK    GeneRIF: PADI3 inhibits epithelial-mesenchymal transition by
            targeting CKS1-induced signal transduction in colon cancer.
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Rechiche,O., Lee,T.V. and Lott,J.S.
  TITLE     Structural characterization of human peptidyl-arginine deiminase
            type III by X-ray crystallography
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 10), 334-340 (2021)
   PUBMED   34605437
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Funabashi,K., Sawata,M., Nagai,A., Akimoto,M., Mashimo,R.,
            Takahara,H., Kizawa,K., Thompson,P.R., Ite,K., Kitanishi,K. and
            Unno,M.
  TITLE     Structures of human peptidylarginine deiminase type III provide
            insights into substrate recognition and inhibitor design
  JOURNAL   Arch Biochem Biophys 708, 108911 (2021)
   PUBMED   33971157
  REMARK    GeneRIF: Structures of human peptidylarginine deiminase type III
            provide insights into substrate recognition and inhibitor design.
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Coassolo,S., Davidson,G., Negroni,L., Gambi,G., Daujat,S.,
            Romier,C. and Davidson,I.
  TITLE     Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates
            glycolysis and cancer cell proliferation
  JOURNAL   Nat Commun 12 (1), 1718 (2021)
   PUBMED   33741961
  REMARK    GeneRIF: Citrullination of pyruvate kinase M2 by PADI1 and PADI3
            regulates glycolysis and cancer cell proliferation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Uysal-Onganer,P., D'Alessio,S., Mortoglou,M., Kraev,I. and Lange,S.
  TITLE     Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine,
            PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic
            Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion
            and Modulation of Extracellular Vesicle Signatures
  JOURNAL   Int J Mol Sci 22 (3), 1396 (2021)
   PUBMED   33573274
  REMARK    GeneRIF: Peptidylarginine Deiminase Inhibitor Application, Using
            Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in
            Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer
            Invasion and Modulation of Extracellular Vesicle Signatures.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Chavanas,S., Mechin,M.C., Takahara,H., Kawada,A., Nachat,R.,
            Serre,G. and Simon,M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   8  (bases 1 to 3189)
  AUTHORS   Iida,A. and Nakamura,Y.
  TITLE     Identification of 45 novel SNPs in the 83-kb region containing
            peptidylarginine deiminase types 1 and 3 loci on chromosomal band
            1p36.13
  JOURNAL   J Hum Genet 49 (7), 387-390 (2004)
   PUBMED   15150696
  REMARK    GeneRIF: peptidylarginine deiminase types 1 and 3 loci map to
            chromosomal band 1p36.13
REFERENCE   9  (bases 1 to 3189)
  AUTHORS   Vossenaar,E.R., Zendman,A.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     PAD, a growing family of citrullinating enzymes: genes, features
            and involvement in disease
  JOURNAL   Bioessays 25 (11), 1106-1118 (2003)
   PUBMED   14579251
  REMARK    Review article
REFERENCE   10 (bases 1 to 3189)
  AUTHORS   Kanno,T., Kawada,A., Yamanouchi,J., Yosida-Noro,C., Yoshiki,A.,
            Shiraiwa,M., Kusakabe,M., Manabe,M., Tezuka,T. and Takahara,H.
  TITLE     Human peptidylarginine deiminase type III: molecular cloning and
            nucleotide sequence of the cDNA, properties of the recombinant
            enzyme, and immunohistochemical localization in human skin
  JOURNAL   J Invest Dermatol 115 (5), 813-823 (2000)
   PUBMED   11069618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590644.14 and BC041592.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 18, 2007 this sequence version replaced NM_016233.1.
            
            Summary: This gene encodes a member of the peptidyl arginine
            deiminase family of enzymes, which catalyze the post-translational
            deimination of proteins by converting arginine residues into
            citrullines in the presence of calcium ions. The family members
            have distinct substrate specificities and tissue-specific
            expression patterns. The type III enzyme modulates hair structural
            proteins, such as filaggrin in the hair follicle and trichohyalin
            in the inner root sheath, during hair follicle formation. Together
            with the type I enzyme, this enzyme may also play a role in
            terminal differentiation of the epidermis. This gene exists in a
            cluster with four other paralogous genes. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041592.1, AB026831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375460.3/ ENSP00000364609.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL590644.14        93612-93625
            15-2926             BC041592.1         1-2912
            2927-3063           AL590644.14        128485-128621
            3064-3189           BC041592.1         3050-3175
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3189
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /note="peptidyl arginine deiminase 3"
                     /db_xref="GeneID:51702"
                     /db_xref="HGNC:HGNC:18337"
                     /db_xref="MIM:606755"
     exon            1..132
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2035
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /EC_number="3.5.3.15"
                     /note="protein-arginine deiminase type III;
                     peptidylarginine deiminase III; peptidyl arginine
                     deiminase, type III"
                     /codon_start=1
                     /product="protein-arginine deiminase type-3"
                     /protein_id="NP_057317.2"
                     /db_xref="CCDS:CCDS179.1"
                     /db_xref="GeneID:51702"
                     /db_xref="HGNC:HGNC:18337"
                     /db_xref="MIM:606755"
                     /translation="MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYG
                     TPGVDIYISPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEP
                     LPLAYAVLYLTCVDISLDCDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPS
                     CDVQDNCDQHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICG
                     PEDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSN
                     EDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVDAVAELARKAGCKL
                     TICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQDFPYKRILGPDFGYV
                     TREPRDRSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSSGRRVTQVVRDFL
                     HAQKVQPPVELFVDWLAVGHVDEFLSFVPAPDGKGFRMLLASPGACFKLFQEKQKCGH
                     GRALLFQGVVDDEQVKTISINQVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDI
                     IDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPL
                     GLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWWNMVP"
     exon            133..313
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..386
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..448
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..566
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..692
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..871
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..975
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1087
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1195
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1347
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1492
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1595
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1675
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1801
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..3189
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="PADI3"
                     /gene_synonym="PAD3; PDI3; UHS1"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt
       61 gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt
      121 ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg
      181 cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg
      241 gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct
      301 caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta
      361 tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg
      421 aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg
      481 cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg
      541 tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac
      601 gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga
      661 tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag
      721 gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga
      781 gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt
      841 ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga
      901 cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga
      961 ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc
     1021 caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg
     1081 gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt
     1141 ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc
     1201 agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt
     1261 tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag
     1321 gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg
     1381 ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc
     1441 cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg
     1501 gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg
     1561 ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc
     1621 catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg
     1681 catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat
     1741 tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt
     1801 ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat
     1861 caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca
     1921 ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg
     1981 caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag
     2041 ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga
     2101 caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg
     2161 accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg
     2221 gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc
     2281 tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg
     2341 gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg
     2401 tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca
     2461 gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa
     2521 agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca
     2581 cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg
     2641 agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg
     2701 atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa
     2761 gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca
     2821 taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag
     2881 aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct
     2941 ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct
     3001 gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg
     3061 gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag
     3121 ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag
     3181 aaacacaaa
//
