LOCUS       NM_016223               1873 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein kinase C and casein kinase substrate in
            neurons 3 (PACSIN3), transcript variant 2, mRNA.
ACCESSION   NM_016223 XM_005252880
VERSION     NM_016223.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Tanaka,M., Nanba,D., Mori,S., Shiba,F., Ishiguro,H., Yoshino,K.,
            Matsuura,N. and Higashiyama,S.
  TITLE     ADAM binding protein Eve-1 is required for ectodomain shedding of
            epidermal growth factor receptor ligands
  JOURNAL   J Biol Chem 279 (40), 41950-41959 (2004)
   PUBMED   15280379
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Kessels,M.M. and Qualmann,B.
  TITLE     The syndapin protein family: linking membrane trafficking with the
            cytoskeleton
  JOURNAL   J Cell Sci 117 (Pt 15), 3077-3086 (2004)
   PUBMED   15226389
  REMARK    Review article
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Mori,S., Tanaka,M., Nanba,D., Nishiwaki,E., Ishiguro,H.,
            Higashiyama,S. and Matsuura,N.
  TITLE     PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain
            shedding of heparin-binding epidermal growth factor-like growth
            factor
  JOURNAL   J Biol Chem 278 (46), 46029-46034 (2003)
   PUBMED   12952982
  REMARK    GeneRIF: PACSIN3 has a novel function as an up-regulator in the
            signaling of proHB-EGF shedding induced by TPA and angiotensin II
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Sumoy,L., Pluvinet,R., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the
            pacsin-syndapin-FAP52 gene family
  JOURNAL   Gene 262 (1-2), 199-205 (2001)
   PUBMED   11179684
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI601317.1, BC011889.2 and
            BC007914.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016223.4.
            
            Summary: This gene is a member of the protein kinase C and casein
            kinase substrate in neurons family. The encoded protein is involved
            in linking the actin cytoskeleton with vesicle formation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF242530.1, BC007914.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298838.11/ ENSP00000298838.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BI601317.1         33-59
            28-1861             BC011889.2         1-1834
            1862-1873           BC007914.2         1816-1827
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1873
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 3"
                     /db_xref="GeneID:29763"
                     /db_xref="HGNC:HGNC:8572"
                     /db_xref="MIM:606513"
     exon            1..86
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            87..152
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            153..243
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1464
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /note="syndapin III; SH3 domain-containing protein 6511"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 3"
                     /protein_id="NP_057307.2"
                     /db_xref="CCDS:CCDS31481.1"
                     /db_xref="GeneID:29763"
                     /db_xref="HGNC:HGNC:8572"
                     /db_xref="MIM:606513"
                     /translation="MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQ
                     ERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKL
                     QGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAA
                     RKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTP
                     RYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAAS
                     DEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDG
                     TAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLK
                     MSEEDEQGWCQGQLQSGRIGLYPANYVECVGA"
     exon            244..400
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            401..636
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            637..792
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            793..968
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1089
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1226
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1348
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1873
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /note="hexamer: ATTAAA"
     polyA_site      1873
                     /gene="PACSIN3"
                     /gene_synonym="SDPIII"
                     /note="major polyA site"
ORIGIN      
        1 aggccgcggc gcgggcccag gagcggcagg actcgggccg gagcgtggcc ggacccccac
       61 ccgccgaggg gcccagggag gacgcggcag agtcacggtg gcagcattga gagttggaca
      121 cccgggtcct tgaagtgatc tctaggcccc agccccaaat ccgccaccat tccgtgctgc
      181 ggggacacca tggctccaga agaggacgct ggaggggagg ccttaggggg cagtttctgg
      241 gaggctggca actacaggcg cacggtacag cgggtggagg acgggcaccg gctgtgcggg
      301 gacctggtca gctgcttcca ggagcgcgcc cgcatcgaga aggcttatgc ccagcagttg
      361 gctgactggg cccgaaagtg gagggggacc gtggagaagg gcccccagta tggcacactg
      421 gagaaggcct ggcatgcctt tttcacggcg gctgagcggc tgagcgcgct gcacctggag
      481 gtgcgggaga agctgcaagg gcaggacagt gagcgggtgc gcgcctggca gcggggggct
      541 ttccaccggc ctgtgctggg cggcttccgc gagagccggg cggccgagga cggcttccgc
      601 aaggcccaga agccctggct gaagaggctg aaggaggttg aggcttccaa gaaaagctac
      661 cacgcagccc ggaaggatga gaagaccgcc cagacgaggg agagccacgc aaaggcagac
      721 agcgccgtct cccaggagca gctgcgcaaa ctgcaggaac gggtggaacg ctgtgccaag
      781 gaggccgaga agacaaaagc tcagtatgag cagacgctgg cagagctgca tcgctacact
      841 ccacgctaca tggaggacat ggaacaggcc tttgagacct gccaggccgc cgagcgccag
      901 cggcttcttt tcttcaagga tatgctgctc accttacacc agcacctgga cctttccagc
      961 agtgagaagt tccatgaact ccaccgtgac ttgcaccagg gcattgaggc agccagtgac
     1021 gaagaggatc tgcgctggtg gcgcagcacc cacgggccag gcatggccat gaactggcca
     1081 cagttcgagg agtggtcctt ggacacacag aggacaatca gccggaaaga gaagggtggc
     1141 cggagccctg atgaggttac cctgaccagc attgtgccta caagagatgg caccgcaccc
     1201 ccaccccagt ccccggggtc cccaggcacg gggcaggatg aggagtggtc agatgaagag
     1261 agtccccgga aggctgccac cggggttcgg gtgagggcac tctatgacta cgctggccag
     1321 gaagctgatg agctgagctt ccgagcaggg gaggagctgc tgaagatgag tgaggaggac
     1381 gagcagggct ggtgccaagg ccagttgcag agtggccgca ttggcctgta ccctgccaac
     1441 tacgtggagt gtgtgggcgc ctgagtgtcc tgacagccct tctgcaacgt ttacccaccc
     1501 tggttcagag cccagcttct cctggagagc cggaccctca gggccctgaa ccgtcgctct
     1561 ctggctgctc ctctgtccct tgagggagga agtcctggga cccagggagg ggaggggcct
     1621 ttgtctaggg aagggactgg tagggaaggg acgagtctag gctgagggca agatgggagg
     1681 tcagaggtga cagaagcgtt caggggtgcc tgggcctccc caggagctgt ggactcagtt
     1741 cctgacctct gctttggggt tcctggggtg ggcttggggt gagtgtagtt ctggcctagc
     1801 agcaccctct tgtggcttgt tctagcgtgt attaaaactt gacacacacc cacacacaaa
     1861 aacaaaaaca cca
//
