LOCUS       NM_020804               4286 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens protein kinase C and casein kinase substrate in
            neurons 1 (PACSIN1), transcript variant 1, mRNA.
ACCESSION   NM_020804
VERSION     NM_020804.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4286)
  AUTHORS   Liu,Z., Li,X., Muhammad,A., Sun,Q., Zhang,Q., Wang,Y., Wang,Y.,
            Ren,J. and Wang,D.
  TITLE     PACSIN1 promotes immunosuppression in gastric cancer by degrading
            MHC-I
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (10), 1473-1482 (2024)
   PUBMED   38826133
  REMARK    GeneRIF: PACSIN1 promotes immunosuppression in gastric cancer by
            degrading MHC-I.
REFERENCE   2  (bases 1 to 4286)
  AUTHORS   Xie,C., Zhou,H., Athanasopoulos,V., Shen,Q., Zhang,Y., Meng,X.,
            Burgio,G., Arsov,T., Lungu,A.C., Zhang,P., Qin,Y., Ma,J., Wu,X.,
            Jiang,X., Ding,H., Meng,Y., Shen,N., He,Y. and Vinuesa,C.G.
  TITLE     De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role
            for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation
  JOURNAL   Arthritis Rheumatol 75 (6), 1058-1071 (2023)
   PUBMED   36622335
  REMARK    GeneRIF: De Novo PACSIN1 Gene Variant Found in Childhood Lupus and
            a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7
            Activation.
REFERENCE   3  (bases 1 to 4286)
  AUTHORS   Regan,P., Mitchell,S.J., Kim,S.C., Lee,Y., Yi,J.H., Barbati,S.A.,
            Shaw,C. and Cho,K.
  TITLE     Regulation of Synapse Weakening through Interactions of the
            Microtubule Associated Protein Tau with PACSIN1
  JOURNAL   J Neurosci 41 (34), 7162-7170 (2021)
   PUBMED   34290082
  REMARK    GeneRIF: Regulation of Synapse Weakening through Interactions of
            the Microtubule Associated Protein Tau with PACSIN1.
REFERENCE   4  (bases 1 to 4286)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4286)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4286)
  AUTHORS   Zucconi,A., Dente,L., Santonico,E., Castagnoli,L. and Cesareni,G.
  TITLE     Selection of ligands by panning of domain libraries displayed on
            phage lambda reveals new potential partners of synaptojanin 1
  JOURNAL   J Mol Biol 307 (5), 1329-1339 (2001)
   PUBMED   11292345
REFERENCE   7  (bases 1 to 4286)
  AUTHORS   Sumoy,L., Pluvinet,R., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the
            pacsin-syndapin-FAP52 gene family
  JOURNAL   Gene 262 (1-2), 199-205 (2001)
   PUBMED   11179684
REFERENCE   8  (bases 1 to 4286)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   9  (bases 1 to 4286)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 4286)
  AUTHORS   Qualmann,B., Roos,J., DiGregorio,P.J. and Kelly,R.B.
  TITLE     Syndapin I, a synaptic dynamin-binding protein that associates with
            the neural Wiskott-Aldrich syndrome protein
  JOURNAL   Mol Biol Cell 10 (2), 501-513 (1999)
   PUBMED   9950691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP211882.1, AL157372.18 and AL834211.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020804.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834211.1, AB037800.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244458.7/ ENSP00000244458.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               BP211882.1         16-175
            161-161             AL157372.18        51522-51522
            162-2814            AL834211.1         110-2762
            2815-2815           AL157372.18        119038-119038
            2816-3972           AL834211.1         2764-3920
            3973-3973           AL157372.18        120196-120196
            3974-4286           AL834211.1         3922-4234
FEATURES             Location/Qualifiers
     source          1..4286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..4286
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 1"
                     /db_xref="GeneID:29993"
                     /db_xref="HGNC:HGNC:8570"
                     /db_xref="MIM:606512"
     exon            1..195
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            196..321
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1593
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /note="syndapin I; syndapin-1"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 1"
                     /protein_id="NP_065855.1"
                     /db_xref="CCDS:CCDS4793.1"
                     /db_xref="GeneID:29993"
                     /db_xref="HGNC:HGNC:8570"
                     /db_xref="MIM:606512"
                     /translation="MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMN
                     CVQERAKIEKAYGQQLTDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVK
                     NNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAY
                     HLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGK
                     TTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIR
                     GADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGA
                     VESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRA
                     LYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI"
     exon            322..478
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            479..714
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            715..870
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1046
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1167
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1295
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1483
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..4286
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4264..4269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /note="hexamer: GATAAA"
     polyA_site      4286
                     /gene="PACSIN1"
                     /gene_synonym="SDPI"
                     /note="major polyA site"
ORIGIN      
        1 atccttcccc cctctccgcc tcagctctga ccttcctcct tcccgcagcc ccggcgagat
       61 cccagagcga cgcggtggcg gcggcagcgc cagccccctc ctcccccggg aagtcggccg
      121 ggcttgaggc cgggccccag acgtcccgct tcgccccgag tcgccgccga tggtccccgg
      181 agctcctgcc cccagtgcat gagcagccga gcctgctaac cgcagctccg cacttgtcca
      241 tccccctgcg gctacaccat gtccagctcc tacgatgagg cctcactggc gccagaggag
      301 accaccgaca gcttctggga ggtggggaac tacaagcgga ccgtgaagcg catcgatgac
      361 ggccaccgtc tatgcaacga cctgatgaac tgcgtgcagg agcgcgccaa gatcgagaag
      421 gcgtacgggc agcagctcac cgactgggcc aagcgttggc gccagctcat cgagaaaggc
      481 ccacagtatg gcagcctgga gcgggcctgg ggtgccataa tgacagaggc agacaaggtg
      541 agcgagctgc accaggaggt gaagaacaat ctgctgaatg aggacctgga gaaggtgaag
      601 aactggcaga aggacgccta tcacaagcag atcatgggtg gcttcaagga gacgaaggag
      661 gctgaagatg gcttccgcaa ggcccagaag ccttgggcca agaagatgaa ggagctggag
      721 gcagccaaga aggcctacca tttggcttgc aaagaggaaa agctggccat gacacgggag
      781 atgaacagca agacggagca atcggtcaca cctgagcagc aaaagaagct gcaggacaaa
      841 gtggacaagt gcaagcagga tgtgcagaag acacaggaga agtatgagaa agtgctggaa
      901 gatgtgggca agaccacacc ccagtacatg gagaacatgg agcaggtgtt tgagcaatgc
      961 cagcaatttg aggaaaagcg gctggtcttc ctcaaggagg tgctgctgga catcaaacgg
     1021 cacctcaacc tggctgagaa cagcagctac atccatgtgt accgtgagct ggagcaggcc
     1081 atccgggggg ctgatgccca ggaagacctc agatggttcc gcagcaccag tggccccggc
     1141 atgcccatga actggcccca gtttgaggag tggaacccag accttcctca caccaccacc
     1201 aagaaggaga aacagcctaa gaaggcagag ggagtggcgc tgaccaatgc cactggggcg
     1261 gtagagtcca catcccaggc tggggaccgc ggcagtgtta gcagctacga cagaggccag
     1321 ccctacgcca ccgagtggtc agacgacgag agtgggaacc cctttggggg cagtgagacc
     1381 aacgggggcg ccaacccctt tgaggacgac tccaagggag tgcgcgtgcg ggcactctac
     1441 gactatgacg gccaggagca ggacgagctc agctttaagg ccggagacga actcaccaag
     1501 ctgggcgagg aggatgagca gggctggtgc cgtgggcggc tggacagcgg gcagctgggc
     1561 ctctaccctg ccaactacgt ggaggctatc tagaggcccc ctccctccat actcccgtca
     1621 ctcctcccca ctgccgcccc tcccctccca ctctcgtctc cttcccctcg ccatagagtt
     1681 ccagacatat tttccgatca agcttttatt tttttaaaag tcaaaacaga acaaaacaaa
     1741 gtatgcagag acagagcatt tgcagggcca cctggaggct ggggtgctgg ggcttggggt
     1801 ggccccaggg taggtaacag tcttaggact tagcccaaca tcacaacatc tgctcttcgg
     1861 gttccaccaa agagtctcct gagccctgag ggatggatgt ctcctgaccc ttccaccccg
     1921 cctcactccc tccgtcccac tccactccag gctgccggca cctgccccat tccctggcct
     1981 ggtttcctaa cctcttcttc ctcccctgcc ctgcttccct tcctccacca ccctgctctc
     2041 aaaggcctcc tctccagacc cctggaaggg aggcttcccc atctttagtt ttccactctg
     2101 ccccggggag cacccttcta ctcctagcca cgtcccttgg gaccggtggg actggaggag
     2161 gaacggtcac cctcctcccc catggaggtt tccaggggtc ccccagacat gaaagagggg
     2221 tgagctggag gaagtcatgg tgtcactggg gtacaggagg gtgaatgaag ggcatgcagg
     2281 ccctcagccc gggctgtgcc agccctccca gccccaggcc catctgaggg accaagacgc
     2341 tgttacgcag gcccttcttt ccagctatca gcactttcag catcggctct tcagcagatc
     2401 caaaccccct cagcaacttg cagaggacct gtcccctctc aaaagtcccc tggcctaggg
     2461 tggggacccc caaacctacg gcaaagccag caacagtagc agcctgctcc catttgctgg
     2521 ggaggagatc atcttgttcc cctggccccc cactctccct ccatgtccat ccaaaaacca
     2581 taaaatcact gggttccaca tcagcctcca tgaggccaag ccttgtacct gcaaggctct
     2641 tggcctaacc attcctctgt cctcttctct ggcctgcctg gggagcccgt gaaggccgca
     2701 cgggtgcctc cagcctgaga catcagggga gagcctgcag ctgagttcag cagaaaggag
     2761 gaatcctggc cctcaggaag aagatagtca catgtttttc ttccttgtcc ccacggcccc
     2821 cagaacaaca ttctccctgc tggcagccct tccatgtctc caaacctggg tcagagtgaa
     2881 aggacctttg ggggtgggtg ggagcaaagg gcccacctgc tggttggtga aagcagtggt
     2941 gccggagtgc taggtaccgc acgagagggt gcgggggctt gggaagcaga ccagggttgg
     3001 acaaaacccc atgagggcgg ggagctggaa gaaaagtctc ttggggacct ctggggcaag
     3061 gagctgagaa gtcctgcagc accaggtgag acttgcttac agtggatgcc acttctaggc
     3121 ctctggaccg cagatgccct cctccctcct gcacacctgg cctcctgggc ctccaggtaa
     3181 agagagagag ccagcccagc cctgtttccc ctcagtcctc ctttgctcct gctgcttctc
     3241 ccaacagccc actgttagga ggtagtagac cccagcctca aggctctgac cttcttcatg
     3301 tgggcacaga gggtcctgac actctggcag ggcctgagct ggggcaggcc tccctcaggg
     3361 ccaggggcga tggcaccccg gggacaggca gacctccttc ctgccgtcag cacccccttc
     3421 cttatcactg tctggtctcc gagcttcggc tgcagcctga ggtgtgtcct gggctcctca
     3481 gagcctgaag caagcttttg gaagcctgca gtcctcccag ctccagtgca gaagcctctc
     3541 tctccagcct ttccccaggc aggagttggg gttgggggcc tctgtccctc atcgcttacc
     3601 ttggaaaggt gggaagctgg caatctgcac cttggggcct gggctccccc tctctgtgcc
     3661 agcggcttcc cagcacctgg gaggggctgc agccccagct ggactccagc ctgtccctct
     3721 tagcactcta gctgcccact ccagggcagg gactcgaaac cccctccgtc ctgagcagcc
     3781 acctccaggg ccctgtttgg gaccactctc tcagtcccca ggtcctcagg gccccagagc
     3841 gggagggtct cctacctgga agtccccctg agctccaggg cccagcccta cctgccagtg
     3901 ctggtgtcag ggcactcaac accgagtgtg ggggccacgc cccttgccat gcccacggcc
     3961 tcctcctgta gctcctgcct gcacccacga tgctgcacgg gcccgccctg gtggggctcg
     4021 gcgagtaatg tgttttgtcc ccagttaacc accattctgc ggcctggttc tgcaaggaac
     4081 cagggctgcc ccaccgcccg ccgtctgccg ccctaggctt cctgactcca ttagttccga
     4141 cacttgtgaa actccgagaa gtgctgtggt ctcagcaatg cacctgtttt gtacatgatt
     4201 gtgtaattta aaggtatata aatacaaata tatatatata tcagttgtga ttgtatgact
     4261 gtggataaaa tccagaactg tgtcaa
//
