LOCUS       NM_001100913            6361 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phosphofurin acidic cluster sorting protein 2 (PACS2),
            transcript variant 1, mRNA.
ACCESSION   NM_001100913
VERSION     NM_001100913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6361)
  AUTHORS   Stoian,A., Bajko,Z., Balasa,R., Andone,S., Stoian,M., Ormenisan,I.,
            Muntean,C. and Banescu,C.
  TITLE     Characteristics of Developmental and Epileptic Encephalopathy
            Associated with PACS2 p.Glu209Lys Pathogenic Variant-Our Experience
            and Systematic Review of the Literature
  JOURNAL   Biomolecules 14 (3), 270 (2024)
   PUBMED   38540691
  REMARK    GeneRIF: Characteristics of Developmental and Epileptic
            Encephalopathy Associated with PACS2 p.Glu209Lys Pathogenic
            Variant-Our Experience and Systematic Review of the Literature.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6361)
  AUTHORS   Liu,S., Han,S., Wang,C., Chen,H., Xu,Q., Feng,S., Wang,Y., Yao,J.,
            Zhou,Q., Tang,X., Lin,L., Hu,L., Davidson,A.J., Yang,B., Ye,C.,
            Yang,F., Mao,J., Tong,C., Chen,J. and Jiang,H.
  TITLE     MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in
            Diabetic Kidney Disease via the PACS-2-Dependent Mechanism
  JOURNAL   Int J Biol Sci 20 (2), 569-584 (2024)
   PUBMED   38169625
  REMARK    GeneRIF: MAPK1 Mediates MAM Disruption and Mitochondrial
            Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent
            Mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6361)
  AUTHORS   Mei,R., Wu,M. and Ren,F.
  TITLE     Knockdown of circ_0002194 protects against oxidized low-density
            lipoprotein-induced cell damage via the regulation of the
            miR-637/PACS2 axis in human vascular endothelial cells
  JOURNAL   Interact Cardiovasc Thorac Surg 35 (4) (2022)
   PUBMED   35951762
  REMARK    GeneRIF: Knockdown of circ_0002194 protects against oxidized
            low-density lipoprotein-induced cell damage via the regulation of
            the miR-637/PACS2 axis in human vascular endothelial cells.
REFERENCE   4  (bases 1 to 6361)
  AUTHORS   Sorokina,E.A., Reis,L.M., Thompson,S., Agre,K.,
            Babovic-Vuksanovic,D., Ellingson,M.S., Hasadsri,L., van Bever,Y.
            and Semina,E.V.
  TITLE     WDR37 syndrome: identification of a distinct new cluster of
            disease-associated variants and functional analyses of mutant
            proteins
  JOURNAL   Hum Genet 140 (12), 1775-1789 (2021)
   PUBMED   34642815
REFERENCE   5  (bases 1 to 6361)
  AUTHORS   Wu,M.J., Hu,C.H., Ma,J.H., Hu,J.S., Liu,Z.S. and Sun,D.
  TITLE     [Early infantile epileptic encephalopathy caused by PACS2 gene
            variation: three cases report and literature review]
  JOURNAL   Zhonghua Er Ke Za Zhi 59 (7), 594-599 (2021)
   PUBMED   34405643
  REMARK    GeneRIF: [Early infantile epileptic encephalopathy caused by PACS2
            gene variation: three cases report and literature review].
            Review article
REFERENCE   6  (bases 1 to 6361)
  AUTHORS   Aslan,J.E., You,H., Williamson,D.M., Endig,J., Youker,R.T.,
            Thomas,L., Shu,H., Du,Y., Milewski,R.L., Brush,M.H., Possemato,A.,
            Sprott,K., Fu,H., Greis,K.D., Runckel,D.N., Vogel,A. and Thomas,G.
  TITLE     Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates
            membrane traffic with TRAIL-induced apoptosis
  JOURNAL   Mol Cell 34 (4), 497-509 (2009)
   PUBMED   19481529
  REMARK    GeneRIF: Results identify PACS-2 as an essential TRAIL effector,
            and show that Akt cooperates with 14-3-3 to regulate the
            homeostatic and apoptotic properties of PACS-2 that mediate TRAIL
            action.
REFERENCE   7  (bases 1 to 6361)
  AUTHORS   Myhill,N., Lynes,E.M., Nanji,J.A., Blagoveshchenskaya,A.D., Fei,H.,
            Carmine Simmen,K., Cooper,T.J., Thomas,G. and Simmen,T.
  TITLE     The subcellular distribution of calnexin is mediated by PACS-2
  JOURNAL   Mol Biol Cell 19 (7), 2777-2788 (2008)
   PUBMED   18417615
  REMARK    GeneRIF: the phosphorylation state of the calnexin cytosolic domain
            and its interaction with PACS-2 sort the chaperone between domains
            of the ER and the plasma membrane
REFERENCE   8  (bases 1 to 6361)
  AUTHORS   Atkins,K.M., Thomas,L., Youker,R.T., Harriff,M.J., Pissani,F.,
            You,H. and Thomas,G.
  TITLE     HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that
            triggers major histocompatibility complex class I (MHC-I)
            down-regulation: analysis using short interfering RNA and knock-out
            mice
  JOURNAL   J Biol Chem 283 (17), 11772-11784 (2008)
   PUBMED   18296443
  REMARK    GeneRIF: PACS-2 is required for Nef action and sorting of itinerant
            membrane cargo in the TGN/endosomal system
REFERENCE   9  (bases 1 to 6361)
  AUTHORS   Simmen,T., Aslan,J.E., Blagoveshchenskaya,A.D., Thomas,L., Wan,L.,
            Xiang,Y., Feliciangeli,S.F., Hung,C.H., Crump,C.M. and Thomas,G.
  TITLE     PACS-2 controls endoplasmic reticulum-mitochondria communication
            and Bid-mediated apoptosis
  JOURNAL   EMBO J 24 (4), 717-729 (2005)
   PUBMED   15692567
  REMARK    GeneRIF: PACS-2 as a novel sorting protein that links the
            endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
            Erratum:[EMBO J. 2005 Mar 23;24(6):1301]
REFERENCE   10 (bases 1 to 6361)
  AUTHORS   Kottgen,M., Benzing,T., Simmen,T., Tauber,R., Buchholz,B.,
            Feliciangeli,S., Huber,T.B., Schermer,B., Kramer-Zucker,A.,
            Hopker,K., Simmen,K.C., Tschucke,C.C., Sandford,R., Kim,E.,
            Thomas,G. and Walz,G.
  TITLE     Trafficking of TRPP2 by PACS proteins represents a novel mechanism
            of ion channel regulation
  JOURNAL   EMBO J 24 (4), 705-716 (2005)
   PUBMED   15692563
  REMARK    GeneRIF: subcellular localization and function of polycystin-2 are
            directed by phosphofurin acidic cluster sorting protein (PACS)-1
            and PACS-2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB011174.1, AL928654.1 and CA423467.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001100913.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447393.6/ ENSP00000393559.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3424              AB011174.1         5-3428
            3425-6352           AL928654.1         73629-76556
            6353-6361           CA423467.1         19-27               c
FEATURES             Location/Qualifiers
     source          1..6361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..6361
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="phosphofurin acidic cluster sorting protein 2"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
     exon            1..290
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2886
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PACS1-like protein"
                     /codon_start=1
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform 1"
                     /protein_id="NP_001094383.2"
                     /db_xref="CCDS:CCDS45178.2"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
                     /translation="MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSL
                     TLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPH
                     FLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLCSSIK
                     EAPVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASDDAVQ
                     GQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPA
                     EHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTE
                     IGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPE
                     AEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNER
                     ANSLDNERCPDARSQLQVQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFL
                     SDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSA
                     ILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNK
                     LEAQSAVQDTPDIVSRITQYIAGANCAHQLPIAEAMLTYKQKRKKHFHFDFTLSPDEE
                     SSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGTLSSTPPSASPAAKEASPTPPS
                     SPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSL
                     QVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICT
                     ARQQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF"
     exon            291..378
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            379..468
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            469..594
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            595..757
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            758..831
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            832..912
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            913..972
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1130
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1221
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1296
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1439
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1584
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1689
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1796
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1951
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2062
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2171
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2204
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2247
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2290
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2426
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2653
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2767
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..6361
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="hexamer: AATAAA"
     polyA_site      3420
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="major polyA site"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="hexamer: AATACA"
     polyA_site      3469
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="major polyA site"
     regulatory      6341..6346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="hexamer: AATAAA"
     polyA_site      6361
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcgtc gccgcccgcg ggcctgtccg acgccggggc ccggcccgtc ccctccgccg
       61 cccggcagcc atgtgaccgc gccgccgccc tccgcgcgcc cggcccgccc gccgcgcgtc
      121 cgcggcccgg ccgcagcccc aggccgccga gggagcggcg gggccggcgc catggccgag
      181 cgaggccgcc tcggcctccc cggcgcgccc ggcgcgctca acacgcccgt gcccatgaac
      241 ctgttcgcca cctgggaggt ggacggctcc agccccagct gcgtgcccag gttgtgcagc
      301 ctgactctga agaagctggt ggtcttcaag gagctggaga aggagctgat ctccgtggtg
      361 atcgctgtca agatgcaggg ctccaaacga atcctgcggt cccatgagat tgtgctgccc
      421 cccagtggac aagtggagac agacctggcc ctgaccttct ccttgcagta tcctcacttc
      481 ttgaagaggg aaggcaacaa gcttcagatc atgctgcagc gcagaaagcg ctacaagaac
      541 agaaccatcc tgggctacaa gacgctggcc gcgggctcca tcagcatggc tgaggtgatg
      601 caacacccgt ctgaaggtgg ccaggtgctg agcctctgca gcagcatcaa ggaggccccc
      661 gtcaaggcgg ccgagatctg gatcgcctcc ctgtccagcc agcccattga ccacgaagac
      721 agcaccatgc aggccggccc caaggccaag tccacggata actactccga ggaggagtat
      781 gagagcttct cctccgagca ggaggccagt gacgacgccg tgcaggggca ggacttggac
      841 gaggacgact ttgacgtggg gaagccgaag aagcagcgga gatcgattgt aagaacgacg
      901 tccatgacca ggcaacagaa cttcaagcag aaagtggtag cgctgctgcg gaggttcaaa
      961 gtgtccgacg aggtcctgga ctcggagcag gaccctgcgg agcacatccc cgaggcagag
     1021 gaggacctgg acctcctgta tgacaccctg gacatggagc accccagcga cagcggcccc
     1081 gacatggagg atgacgacag cgtcctcagc acccccaagc cgaagctgcg gccatacttt
     1141 gaaggcctgt cgcactcgag ctcgcagacg gagattggga gcatccacag cgcccgcagc
     1201 cacaaggagc ccccaagccc ggctgacgtg cccgagaaga cgcggtccct gggaggcagg
     1261 cagccgagcg acagtgtctc tgacacggtg gccctcggtg tgccaggccc gagggagcac
     1321 cctggacagc ctgaggacag ccccgaggct gaggcctcca ccctggatgt gttcacggag
     1381 aggctgccgc ccagcgggag gatcaccaag acagagtccc ttgtcatccc ctccaccagg
     1441 tccgagggga agcaggctgg ccgacggggc cggagcacat ccttgaagga gcggcaggca
     1501 gcacggcccc agaatgagcg ggccaacagc ctggacaacg agcgctgccc ggacgcccgg
     1561 agccagctac aggtgcagct gcagatcccc aggaagactg tgtatgacca gctcaaccac
     1621 atcctcatct ccgatgacca gcttcccgaa aacatcatcc ttgtcaacac ctcggactgg
     1681 caggggcagt tcctctccga cgtcctgcag aggcacacgc tccccgtggt gtgcacgtgc
     1741 tctcctgcgg acgtccaggc ggccttcagc accatcgtct cacggataca gagatactgc
     1801 aactgcaatt cccagccccc gacccccgtg aagatcgccg tggcgggagc gcagcattac
     1861 ctcagtgcca tcctgcggct ctttgtggag cagctgtccc acaagacacc cgactggctc
     1921 ggctacatgc gcttcctggt catcccactg ggctcccacc ccgtggccag gtacctaggc
     1981 tccgtggact accgctacaa caacttcttc caggacctgg cctggagaga cctgttcaac
     2041 aagctggagg cccagagtgc ggtacaggac acgccagaca ttgtgtcacg catcacgcag
     2101 tacatcgcag gggccaactg tgcccaccag ctccccatcg cagaggccat gctgacctac
     2161 aagcagaaga ggaaaaagca ttttcatttt gactttaccc taagccctga cgaagagtcc
     2221 tcccaaaagt tcattccctt tgtcggggtt gtgaaggttg gaattgtgga gccatcctcg
     2281 gccacatcag gcgactcgga cgacgcggcc ccctcgggct ctggcacgct ctcctccacc
     2341 ccgccgtccg catctcctgc ggccaaggag gcctcaccca ccccgccctc ctccccgtcg
     2401 gtgagcggag gcctgtcctc ccccagccag ggtgtcggcg ccgagctgat ggggctgcag
     2461 gtggactact ggacggcagc acagcctgcg gacaggaaga gggacgccga gaagaaggac
     2521 ctgcctgtca ccaaaaacac gctcaagtgc actttccggt ccctccaggt cagcaggctg
     2581 cccagcagcg gcgaggctgc agccacgccc accatgtcca tgaccgtggt caccaaggag
     2641 aagaacaaga aggtgatgtt tctgcccaag aaagcgaagg acaaggacgt ggagtctaag
     2701 agccagtgca ttgagggcat cagccggctc atctgcactg ccaggcagca gcagaacatg
     2761 ctgcgggtcc tcatcgacgg cgtggagtgc agcgacgtca agttcttcca gctggccgcg
     2821 cagtggtcct cgcacgtgaa gcacttcccc atctgcatct tcggacactc caaggccacc
     2881 ttctagcccc acccaccagg gggcccacct cctgccccat gctgtgaggg gcccagctgc
     2941 atttctgtta acatttcagt ttactacaga gacagacgct taaaacacaa agagaaacag
     3001 tcttaagtat gaatgtgctc acaacgtgga aactaacggg ggagctcctg ccaggagccg
     3061 aataactgct ctgcttatta acccgaacgt tcggcccggg gctgggaagc cagaaggacg
     3121 atgctgagcc atggatcgcg gaaggcgtcc tctggcctca ggagccaccc agagcctcac
     3181 aggctgagtt cttgcctctg tgtcctgtcc ttcctggaag tcaggactct gcttcctcag
     3241 ggagcccggg gaaggcggag ctcagtggcc acaggccgag ggccatgggg ccgctcagtc
     3301 ccgttggggt tgtcctgagt tgagcctggg ggggccgtcc tgcccgccta agagatgccc
     3361 ccagcaccgc acactcgtgg ttcccaataa actcctgcct gcggcggagg ttttatagca
     3421 gcagatattt ttaatgcttt tcaatacatg ttctaatgta gctgccaaac atgttgctct
     3481 tctgaagtcc ccctggggct gggcagagcc agcagagcct gcccccactt ccccagcccc
     3541 tgccccaccc cgcctcacac cttccccact ctcaggctgt tcttgaaaca ccatgaggct
     3601 tctgcgtgta gtccctgccc caaacttagc aagcacaggg gcctccacag cccaggtggc
     3661 cccagaaaat gttccagagc ccagcttggt acatagtgag atgctgctgg ggttggcctg
     3721 aggtgggggc cacttcctcc accccagtgg gtatgtctga ggtcagccat ggggatatct
     3781 gggttgagat tcaggttttg gtgaatatgg ggcaggcgtc cagatgtgtt tgtgtcacct
     3841 gctgcaacgc tgtagccaat gaagattcca gcgggatggc ctgaccagcg gggccggcac
     3901 tttggagccg tgggtgcagc caggtacccc gtgcagggcc tgggaggctc tccaggccac
     3961 agtcctcaga gcgtgttggg tcccatgttg tgtgtgggtt ccatgccctc cacacagcag
     4021 gagagggctt ccctgaccac acctgccccc tcagtcctgc ttctccccag taagcctgca
     4081 ctgtggggtc tccataggag gagctgggga agctggggcc ctcccagggg tcctgatcga
     4141 ccctgggggc tcttggcctg gtttcgtaag atggagcact gcaaaaggcc atgctcagaa
     4201 agcaaacgca gggcagggtg ggcctcgagc cggggctgga ggggtctcca cccttgctgg
     4261 cctgagagat ggcccacatt tcttacttgt gaccgccctg ctcttcctgg ccgccccccc
     4321 caggtggctg aacagggtga ttttgttgtg gtgaggggcc aggatgtggc ctggtgtgca
     4381 gcctcagctc cctgggttca ggcctcagag gtagcctgtg tgcaggaggc agagccccag
     4441 cccctcccag ccagagcccc tccacaccag ggactcctcc ttcacctggg accaggagcc
     4501 tggggcacac cccagggtgg gggagagggt aggaaggtct cccattgaat cctggcttca
     4561 ggctctgccc cgagaagtgt ctgcggtgag ggtgtgagcc ccgggctgat ggcctctgac
     4621 cccggcaaca ggtgggaccc tgactgactc gttcagctgc ccccaagctg ggctgcagag
     4681 catctgtttt tctgctctcc agtttctttt cttttttttt tttttttttt ttgagatgga
     4741 gtcttgctct gttgcccagg ctggagtgca gtggcatgat ctcagctcac tgcagcctcc
     4801 gtctcccagg ttcaagcagt tctcctgcct cagcctcccg agtagctggg attacaggcg
     4861 tgtgccacca cacctggcta ttttttttgt atttttagta gagatggggt tttgccatgt
     4921 tggccaggct ggtcttgaac tcctgacctc aagtgatcca cccgcctcgg cctcccaaag
     4981 tgctgggatt acaggcgtga gtcaccgcgt cctgcctgct cttcctgttt ctttcccaag
     5041 ggtcacactc agtagggaga tgaaggtgga aacatccttg ctgtggcttt ctggcctcag
     5101 agcaggtttt agaggaaggg gccacaggct gcctagtgca tcctggctgt gggcagcccc
     5161 tttcctggag ccctcctgcc taccccgtac ctcccatctg gctgcacagc tccatcctta
     5221 gccacgcaag gggagaacat gggcagagtc tccatccagc agctgggggt tctggtggca
     5281 ctccctgtgc ccctgctgct gctgggctgt gggtctgccc tgcacccagg agccccacgg
     5341 tccatccccc acaccatgcc cagcaccagg gaggttgggc agacaagacc tgggccatgc
     5401 cagccctctg tgcctcggtt ttcccactgg ttacacagga tggtcgcatt ttccctgcct
     5461 acctcacaga gctgttctga gggtgcatgg aggagcactc tgtcccacca aggacaacta
     5521 gaaaccaaag ccatctgaca gccagtgcgg taagggcggg ggatgtgtgt gtgaggtgtg
     5581 cacacccccc gagaacctgg ccctggactg gcctcacagg acaggaggca gccccttgta
     5641 gagctagggc tcagccccat cagtctcaaa ggttaagcca ccagtcacca ccgaggcacc
     5701 cctcaggcct ggtggccact gtccactatt acgtagacag accccaccct cacccaggcc
     5761 agctgtgggc cagtcccgcc ctgcaatctg gtctgctgcc ttcctcttcc atgttggtcc
     5821 ccttggccac tgtctctggg catgcaagcc agtgtcctgg ttcagtgcct cggccagagc
     5881 tggggcagga gaggggcctc tgggtgagag ctgggggtgt ctctgcaggg tactggcagc
     5941 cttgccacac tgtcctcatt cccagatgga aagacctgag tgcctctcgc cttcctccgg
     6001 gaatgaattc ctcatgaaaa tgaccaggcc acttcttccg agggccaggc cgccccctcc
     6061 ccgagacctg tcctgccgtc cgcgggtgtg tggcctgtag gggactgaga gctgggcttg
     6121 ctgggcacct ctggaatctg accctgtggg ccaaagaagc accactgtag tttctgcaga
     6181 cccccatgcg gttcattgtg cattgtttgg tttctaggat gtatgtgttg ctagtttttt
     6241 ttaatgaaac cctggattaa tgtaaatagc tttttgggga acggattcta atgtcacgta
     6301 tgtgaccgtg tggactattt caaggtgctg atgcaacact aataaacctg gaggggccgg
     6361 c
//
