LOCUS       NM_001258345            6309 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens parkin coregulated like (PACRGL), transcript variant
            3, mRNA.
ACCESSION   NM_001258345
VERSION     NM_001258345.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6309)
  AUTHORS   Khan,N., Pelletier,D., McAlear,T.S., Croteau,N., Veyron,S.,
            Bayne,A.N., Black,C., Ichikawa,M., Khalifa,A.A.Z., Chaaban,S.,
            Kurinov,I., Brouhard,G., Bechstedt,S., Bui,K.H. and Trempe,J.F.
  TITLE     Crystal structure of human PACRG in complex with MEIG1 reveals
            roles in axoneme formation and tubulin binding
  JOURNAL   Structure 29 (6), 572-586 (2021)
   PUBMED   33529594
REFERENCE   2  (bases 1 to 6309)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6309)
  AUTHORS   Shang,A., Gu,C., Wang,W., Wang,X., Sun,J., Zeng,B., Chen,C.,
            Chang,W., Ping,Y., Ji,P., Wu,J., Quan,W., Yao,Y., Zhou,Y., Sun,Z.
            and Li,D.
  TITLE     Exosomal circPACRGL promotes progression of colorectal cancer via
            the miR-142-3p/miR-506-3p- TGF-beta1 axis
  JOURNAL   Mol Cancer 19 (1), 117 (2020)
   PUBMED   32713345
  REMARK    GeneRIF: Exosomal circPACRGL promotes progression of colorectal
            cancer via the miR-142-3p/miR-506-3p- TGF-beta1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6309)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6309)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC339941.1, AK291544.1, BM763154.1, CF121351.1, BU674750.1,
            AC104065.3 and BX104331.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001258345.2.
            
            Transcript Variant: This variant (3) contains an alternate exon in
            the 3' coding region, but maintains the reading frame, compared to
            variant 1. The encoded isoform (3) is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291544.1, ERR3218367.1138247.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503585.6/ ENSP00000423881.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DC339941.1         46-46
            2-682               AK291544.1         3-683
            683-683             BM763154.1         683-683
            684-1537            AK291544.1         685-1538
            1538-1866           CF121351.1         395-723
            1867-2109           BU674750.1         18-260              c
            2110-6020           AC104065.3         66308-70218
            6021-6309           BX104331.1         12-300              c
FEATURES             Location/Qualifiers
     source          1..6309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.31"
     gene            1..6309
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /note="parkin coregulated like"
                     /db_xref="GeneID:133015"
                     /db_xref="HGNC:HGNC:28442"
     exon            1..330
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            331..398
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1093
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /note="isoform 3 is encoded by transcript variant 3;
                     PACRG-like protein; PARK2 co-regulated like; PARK2
                     coregulated like"
                     /codon_start=1
                     /product="PACRG-like protein isoform 3"
                     /protein_id="NP_001245274.1"
                     /db_xref="CCDS:CCDS58895.1"
                     /db_xref="GeneID:133015"
                     /db_xref="HGNC:HGNC:28442"
                     /translation="MQKSEGSGGTQLKNRATGNYDQRTSSSTQLKHRNAVQGSKSSLS
                     TSSPESARKLHPRPSDKLNPKTINPFGEQSRVPSAFAAIYSKGGIPCRLVHGSVKHRL
                     QWECPPESLSFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVKGAPEKAIPLLPRLI
                     PVLKAALVHSDDEVFERGLNALVQLSVVVGPSLNDHLKHLLTSLSKRLMDKKFKEPIT
                     SALQKLEQHGGSGSLSIIKSKIPTYCSICC"
     exon            399..553
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            554..621
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            622..712
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            713..847
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            848..955
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1036
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..6309
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /note="hexamer: ATTAAA"
     polyA_site      2109
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /note="major polyA site"
     regulatory      6288..6293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
                     /note="hexamer: ATTAAA"
     polyA_site      6309
                     /gene="PACRGL"
                     /gene_synonym="C4orf28"
ORIGIN      
        1 atttccccaa acgcaggcgc tcggtggcgg tagccgcggt tgttggccga ccgagtgccg
       61 gtcataagcc ccccccggtg gggggcagct ggtgtgcgga tcgcggcggg agagaggcgc
      121 ggtaggaacg ggtccccgga gccgtgaacc gcgggtacag gtgtcctgtc tgcgctctct
      181 gccaagccgg cttgcttcct gatctgttgc tagggccgct ggaccccgtt gctaaggacc
      241 cttgagatcg tgagcgcttg gagtgtaccc ctcctttcct ggggtagagg gtcagtcgag
      301 agtagccttc gttaacctta attgaaactg gagtgaaagg gaagcaatgc agaaatcaga
      361 gggctctgga ggtacacagt tgaaaaacag agcaacaggt aactatgatc aaaggacatc
      421 atcaagcaca cagttaaaac acaggaatgc agttcaggga agcaaatcct cattgtcaac
      481 cagttctcca gagtctgcaa gaaaacttca tcctagacca agtgataaac tgaaccctaa
      541 aacaattaat ccgtttggtg aacagtcacg agtgccttct gcatttgcag ctatttactc
      601 taaaggaggt attccttgca gattggtaca tggttcagta aaacacagat tacagtggga
      661 atgtcctcct gaaagtcttt catttgatcc acttcttatt actttagctg agggtctgag
      721 agagactaag catccataca cttttgtgtc aaaggagggt tttagagaat tacttttggt
      781 caaaggtgct cctgaaaaag ctattccttt gctacctaga ctgattcctg tgctaaaggc
      841 agctctggtc cattcggatg atgaagtgtt tgaaagagga ttgaatgctc tagttcagct
      901 aagtgtcgtt gttggtcctt ctctaaacga ccatctgaag catctgctta caagcctttc
      961 caagagatta atggacaaga aattcaaaga gccaatcacc agcgcattac aaaagctaga
     1021 gcaacatggt ggaagtggga gccttagcat catcaaatct aaaattccaa catactgctc
     1081 catatgctgt tgaagaaggg agccaacaaa aattgttttt tctacctgtt gacgtgtcaa
     1141 gcactaactg tgggtactca tttattttat tcttttgtaa atcacagcca ccattcatta
     1201 tttactaggt taagatgaat agacactgaa tcaaagttat tcatcaacaa aaaagaacag
     1261 ttactaatgg aaagttatta aaataagttc tataagagta caattttgag gtttattttt
     1321 tgtattttta ttatttgtgc gaagaaccat tattgagttt gcaagataag atgtatttgt
     1381 attttctagt gtctttttat ttataacaac acttttttgg caatcagttt gtagctgtgc
     1441 ccttattttt atagatagtt tgccatttct tgggtttaat gtttaacaag gctatagaag
     1501 tttaaaatag tggacaaatg tttgtgaata cacttttaaa aaattgtttt aaaagagaaa
     1561 agcggtcttg ctttgttgcc cagactggag tgcagtggca taatcatagc tcaccgcaag
     1621 cctcaaattt ttgtgctcag atgatccttt tcatctcagc ctcctgatta gctgggacta
     1681 taggcgtgtg ccaccatgcc cagctaattt tgaaatttgc ttgtagagat gggatctcac
     1741 tctgttgtcc aggctggtct cagaattctg gtgagtgatc ctcccacagt ggacttccaa
     1801 agtgctggga ttacaggtgt gagccaccat gcctggcccc atgaatacac tactaatatt
     1861 atttgtaaat atgtatttta taatgtacaa tgcttggaaa attttcagag tattctagtt
     1921 taaaaaattt tttctaattc tgtaaattct attacaagta tgttgtttat tacaactcat
     1981 tacaactacc taaattttag gtgttaactg tatttaagta aatgtgttat ttttgcattt
     2041 catagccaga aaatactgat gttcacttaa agatattcag caattaaaat gttaaaactt
     2101 gtacatgcat tcattgattt tgttgtgctt atgtttagca atttttaaga agcttttaaa
     2161 atataatata gacatagttc agaattttga tgtaatagaa gcaattccct ctggctacaa
     2221 cagctgcctg cctgctggcc ttgcttttac ctgttttcat tgcattgagc accatccaga
     2281 gctatctgcc atctagaaag tactgtaaga tttaattaat tacaaaattt cttggaaaag
     2341 acctgtaaca tagacagtag agttataaac attttatttt gcttttattt tttctttttg
     2401 aaatacaaaa tgtgcacatt gagtttacac aaacacgtga tggcaaattt cagtgtacat
     2461 gtattgtact actcttaatt tctacactgg tgatagcagg gcagctttca acatcctatc
     2521 tctacaccag aatagatacc tgatttattg ttgcaaagac agttgcaaat ttcctccttc
     2581 tgtagcctct tggtctttgt gatatttcta caaaacaggg acgatgtgtg tggctttagt
     2641 aatgtggcaa ctttacagtt ttggctaaga tgattaaaaa taatctgaat tatgatgagc
     2701 taaatcatac tgtaatctgg attagttgtt gagcacttat tttctactaa atcttggtag
     2761 tagttgtcaa tgtaatggaa ccactggtgc tttcaaagtg aattttgctt gctaattttg
     2821 cttgctgttt gttcttagta gacagtgggg tagtcaaggt ttctttcttt gtccctgaat
     2881 ggcttgtaat ataaataaac atgctgtaag gaagtcaggg gaaagaggac agatttggcc
     2941 tttaatgctg ttaggattac ttgttattaa gcattactat atactggagg atagatatcc
     3001 tgaccctttg catatgtctg taaacatcct tgttttgttt gatgccttct tcaacttcca
     3061 cttaatgatt gatactaatg attgatacaa tagaaaacag cctgtaagaa agattgaaca
     3121 aatccaaaat tattatatag gccttggctg taacatatta tggaaaatta aatgcttatt
     3181 aaaataagtt ttattaggca tatgctgata tctgataata aactaatttt taaatgttta
     3241 ataattttta aatgtttaaa aatgccagat aaaactaatt tctaacagaa ggtgggaagg
     3301 ccatagaaac tggaactatg tgttttttta attgttgtaa tcttgtttcc ttaaagtata
     3361 taaatggaat ttaaatggaa ttacagcatt caaacatgaa aattaattta atttctggaa
     3421 attaaatgca gatgtcacta tattagaaaa ccattcaaaa tcctaggact gaatacatac
     3481 aaatgagtag caaaaaacac tgatatttta aaatcactga tatgtgaaag cctcaataat
     3541 cccatggcta aggaaccaat aaaactatat gccagattct attacttttg aatattcaca
     3601 gagtatgaaa tgagttagac catcccctga actcagtggc attatgaaaa ggatgcaaat
     3661 ttataactga aagctcaaat cttttgggga ttgctttata ttaaaacaaa gcttgtttgc
     3721 ataatatgct tcagtgtcaa gctgagcaat ctatgctaaa agtggtagct ccaactttaa
     3781 gggtggtaga atagttcaca tttgtctgtt ggattcagga tctatttgac aagttaaatc
     3841 acattttcaa agagctgcat ggagcgcatt atgttttcat cctgtaaggg agaaacacag
     3901 agcgattaaa ttcagcatat ctgcaaggaa aagtacacta ttttgcccct gagtattgcc
     3961 tcctcccatc aaccacctca accacctatg ccaaaagctc aaatattaag tgtttgcaaa
     4021 tgtaaatgcc attctattct atccattttc cacatagatg actatgaagg acccatttta
     4081 tattttgtgg agtctattga ccaggcatta aaccacttta tttaaatctt tacttggtat
     4141 taatagagga tatttctcaa atcataatgc caaaatggaa actacagagg tgcagaggtg
     4201 tgtcaaagca aatgagaatt ttggcattct atgtagatca caggccaaat cacacagact
     4261 tttatacagg tacaaggaaa atttgtgtgt atgagccagc agttcatgaa gattggaggc
     4321 tggcgcatag gaggcagggt ggtggattaa gaggtaacat gtttgcagta atcatctctc
     4381 tttctgtctg ctagttatgg ctaaagctgc atggcctgaa ggagccttta aaaatgaatg
     4441 gtctctcaat tacagagaaa gaattgggga gcagaaacca ctgctcagtg gctgtgttca
     4501 gtttagcata ttctttagaa atgagttagg ggacagactt tgggcattat tggagcactt
     4561 gtcagttgca tgtgaatagc acttactgag ctgtttatgg tagtggtaaa tggtggctga
     4621 accaataatg gcttccactg ctagaaacca agtaacatca ccgtcaagca gcttaatgtc
     4681 accaaattaa ttctctcaaa gaccactgca tggaaatcca agttgagaga caagcagaca
     4741 tccagaaaag taagaacaac aatttaaaaa taaagagaaa aactaaagaa acaacggatt
     4801 tctttgtttt caggattatt tgaaaaattc tttttttctt tttttagttt tgaggcagag
     4861 tctatttctg ttgcccatca ttctggagtg cagtggcaca atcatggctc aacagggatc
     4921 aagtgatctt cctgcctcag cctcccaagt agctgagact tcagccacgt gccaccgtgc
     4981 ccagctaact taattttttt ttgtagagat agatagggtc ttgctatgtt gcccacattg
     5041 gactcaaaat cctggcctta agttatcttc ccgcctcagc ctcccatagt gctgggatta
     5101 cagttgtgag ctactgtacc aggccttaac aatttttaac tgtggttctg cccacacatc
     5161 aagtcaaata attctaagta agctaacact ggtttctttg ataacaggct actacctgga
     5221 gttctcttca gagaaaattt tccactgttt attttttgtg actgaagacc attagtgagt
     5281 tcagtcaaag agccatttct tgtccacata cactaaaaca atgacttttc tcttagaaat
     5341 cagatagaag cttggcctgt tgtgatgcca tacttggcta tctaggaatt ctaatgctgt
     5401 ggagatatga tagataatat atgagtgatg ctaagttttg gcaaagagca attcaaatct
     5461 catgtatgtt ttatcctcca tgaatactct ctaaggaatt tgggaatcaa cacagtacat
     5521 gtacaacttt tgtatcccca gggtttcctc catagcctga ctcagtgggc actctaaatg
     5581 ttgattatgt aattggtgct tgttttcaga gtggtaggct tatgctgcat gttgtagaag
     5641 tggtaaactt aggcatatga tctctatatt tcgcccagtt catggtagct agctgctaat
     5701 actcagttta gctgttatga tagctgaatt gatagttatt acactttcat tacttacttt
     5761 ttggcagctt tcaatgaact catctatggt aacaacccca tctttatttt tgtccatttt
     5821 ctgttcagga agaaaacaaa aattgtattt agacttatcc cttaataccc tcacacctgg
     5881 accaaatgag ctgaagctga taaaaagaaa acctagctgc ttatttattt cacgtggagg
     5941 aactgtttca gagcaggaac cagcagtttt ttagagataa aaatgatagg gccaaatgct
     6001 tctggctttt cccttttcaa tataatgtgg tgaagatgta gagtcactct gtcctaggta
     6061 aaatcccacc ttctagatgt gacagagctt gcgcaatttg ctgaaacttt cagagcttgc
     6121 tttttgtctc atctgtaaaa tgagattaat gaggatttat aggattcttg taaaaactga
     6181 atgaaaacaa aacttgtgaa acatgagaac tgtttagtgt tgtatcttgg atttagtgaa
     6241 tgttcaataa atgcagttat cagcattgta aattcaaaac caaagctatt aaattaatag
     6301 gatgctaaa
//
