LOCUS       NM_001080379            1549 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens parkin coregulated (PACRG), transcript variant 3,
            mRNA.
ACCESSION   NM_001080379
VERSION     NM_001080379.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Bangera,M., Dungdung,A., Prabhu,S. and Sirajuddin,M.
  TITLE     Doublet microtubule inner junction protein FAP20 recruits tubulin
            to the microtubule lattice
  JOURNAL   Structure 31 (12), 1535-1544 (2023)
   PUBMED   37816351
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Khan,N., Pelletier,D., McAlear,T.S., Croteau,N., Veyron,S.,
            Bayne,A.N., Black,C., Ichikawa,M., Khalifa,A.A.Z., Chaaban,S.,
            Kurinov,I., Brouhard,G., Bechstedt,S., Bui,K.H. and Trempe,J.F.
  TITLE     Crystal structure of human PACRG in complex with MEIG1 reveals
            roles in axoneme formation and tubulin binding
  JOURNAL   Structure 29 (6), 572-586 (2021)
   PUBMED   33529594
  REMARK    GeneRIF: Crystal structure of human PACRG in complex with MEIG1
            reveals roles in axoneme formation and tubulin binding.
REFERENCE   4  (bases 1 to 1549)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1549)
  AUTHORS   Zheng,P.F., Yin,R.X., Wei,B.L., Liu,C.X., Deng,G.X. and Guan,Y.Z.
  TITLE     Associations of PRKN-PACRG SNPs and G x G and G x E interactions
            with the risk of hyperlipidaemia
  JOURNAL   Sci Rep 10 (1), 13010 (2020)
   PUBMED   32747620
  REMARK    GeneRIF: Associations of PRKN-PACRG SNPs and G x G and G x E
            interactions with the risk of hyperlipidaemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1549)
  AUTHORS   Mira,M.T., Alcais,A., Nguyen,V.T., Moraes,M.O., Di Flumeri,C.,
            Vu,H.T., Mai,C.P., Nguyen,T.H., Nguyen,N.B., Pham,X.K., Sarno,E.N.,
            Alter,A., Montpetit,A., Moraes,M.E., Moraes,J.R., Dore,C.,
            Gallant,C.J., Lepage,P., Verner,A., Van De Vosse,E., Hudson,T.J.,
            Abel,L. and Schurr,E.
  TITLE     Susceptibility to leprosy is associated with PARK2 and PACRG
  JOURNAL   Nature 427 (6975), 636-640 (2004)
   PUBMED   14737177
  REMARK    GeneRIF: Variants in the regulatory region shared by PARK2 and
            PACRG therefore act as common risk factors for leprosy
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1549)
  AUTHORS   Imai,Y., Soda,M., Murakami,T., Shoji,M., Abe,K. and Takahashi,R.
  TITLE     A product of the human gene adjacent to parkin is a component of
            Lewy bodies and suppresses Pael receptor-induced cell death
  JOURNAL   J Biol Chem 278 (51), 51901-51910 (2003)
   PUBMED   14532270
  REMARK    GeneRIF: Glup/PACRG forms a large molecular chaperone complex,
            suppresses cell death induced by accumulation of unfolded Pael
            receptor, facilitates the formation of Pael-R inclusions,and is a
            component of Lewy bodies in Parkinson's disease
REFERENCE   8  (bases 1 to 1549)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 1549)
  AUTHORS   Mira,M.T., Alcais,A., Van Thuc,N., Thai,V.H., Huong,N.T., Ba,N.N.,
            Verner,A., Hudson,T.J., Abel,L. and Schurr,E.
  TITLE     Chromosome 6q25 is linked to susceptibility to leprosy in a
            Vietnamese population
  JOURNAL   Nat Genet 33 (3), 412-415 (2003)
   PUBMED   12577057
REFERENCE   10 (bases 1 to 1549)
  AUTHORS   West,A.B., Lockhart,P.J., O'Farell,C. and Farrer,M.J.
  TITLE     Identification of a novel gene linked to parkin via a
            bi-directional promoter
  JOURNAL   J Mol Biol 326 (1), 11-19 (2003)
   PUBMED   12547187
  REMARK    GeneRIF: PACRG is linked to parkin via a bi-directional promoter
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF546872.1, BC044227.1 and
            AL031121.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001080379.1.
            
            Summary: This gene encodes a protein that is conserved across
            metazoans. In vertebrates, this gene is linked in a head-to-head
            arrangement with the adjacent parkin gene, which is associated with
            autosomal recessive juvenile Parkinson's disease. These genes are
            co-regulated in various tissues and they share a bi-directional
            promoter. Both genes are associated with susceptibility to leprosy.
            The parkin co-regulated gene protein forms a large molecular
            complex with chaperones, including heat shock proteins 70 and 90,
            and chaperonin components. This protein is also a component of Lewy
            bodies in Parkinson's disease patients, and it suppresses unfolded
            Pael receptor-induced neuronal cell death. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an exon at its 5' end
            and an in-frame internal exon, compared to variant 1. These
            differences produce a unique 5' UTR and a protein (isoform 2) that
            is shorter than isoform 1. Both variants 2 and 3 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF546872.1, BC030642.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366888.7/ ENSP00000355854.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1360              AF546872.1         5-1364
            1361-1541           BC044227.1         1310-1490
            1542-1549           AL031121.5         110473-110480
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q26"
     gene            1..1549
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="parkin coregulated"
                     /db_xref="GeneID:135138"
                     /db_xref="HGNC:HGNC:19152"
                     /db_xref="MIM:608427"
     exon            1..418
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1036
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="isoform 2 is encoded by transcript variant 3;
                     parkin co-regulated gene protein; molecular
                     chaperone/chaperonin-binding protein; PARK2 co-regulated;
                     PARK2 coregulated"
                     /codon_start=1
                     /product="parkin coregulated gene protein isoform 2"
                     /protein_id="NP_001073848.1"
                     /db_xref="CCDS:CCDS43524.1"
                     /db_xref="GeneID:135138"
                     /db_xref="HGNC:HGNC:19152"
                     /db_xref="MIM:608427"
                     /translation="MVAEKETLSLNKCPDKMPKRTKLLAQQPLPVHQPHSLVSEGFTV
                     KAMMKNSVVRGPPAAGAFKERPTKPTAFRKFYERGDFPIALEHDSKGNKIAWKVEIEK
                     LDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEHGGNKILPVLPQLIIPIKNALNLR
                     NRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMNVNSGDGIDYSQQKR
                     ENIGDLIQETLEAFERYGGENAFINIKYVVPTYESCLLN"
     exon            419..553
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /inference="alignment:Splign:2.1.0"
     exon            554..725
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /inference="alignment:Splign:2.1.0"
     exon            726..875
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1549
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="hexamer: CATAAA"
     polyA_site      1236
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="hexamer: AATAAA"
     polyA_site      1360
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="major polyA site"
     regulatory      1523..1528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
                     /note="hexamer: AATAAA"
     polyA_site      1549
                     /gene="PACRG"
                     /gene_synonym="BUG21; GLUP; HAK005771; PACRG2.1; PARK2CRG;
                     pf12"
ORIGIN      
        1 gcttagcaac cgggaggctt acctttggaa gcttgttgca gctctagcca aggtcctgcc
       61 ctcttcccgc cccgccccta gggtccagct cccttcacct aggagctgcc aaacatctgg
      121 atcaacctgg gcactacgag gggttgaatt tctaccatta tcgcgccttt tgatattttt
      181 ttccagacct cctgctcaca tccgtaaagc ccactgattc ttttactaca ctttttatga
      241 gaacaagaca ttttctagga agatggtggc agaaaaagag accctgagct taaacaaatg
      301 cccagacaag atgccgaaga ggaccaagct gctggcacaa cagccgctcc cggtgcacca
      361 gcctcactct ctggtttctg agggtttcac agtcaaagcc atgatgaaaa actcagtcgt
      421 gagaggccct ccagctgcag gggcatttaa agaaagacca accaagccca cagcatttcg
      481 aaaattctat gagcgaggtg acttcccaat tgcccttgag catgattcga aaggaaacaa
      541 aatcgcctgg aaggtagaaa ttgagaagct ggattaccat cattatctgc ctctgttttt
      601 tgatgggctt tgtgaaatga catttcccta tgagtttttt gctcggcaag gaatccacga
      661 catgctggaa cacggtggga acaagatcct acctgtcctt ccacagctca ttatcccgat
      721 aaaaaatgcc ttgaacctcc gaaaccgaca ggtcatctgt gtcactctca aggtcctcca
      781 gcatctggtt gtgtcagctg agatggtggg caaggccttg gtgccttatt accgtcaaat
      841 cctccctgtc ctgaacatct ttaagaatat gaatgtgaac tccggagacg gcattgacta
      901 cagccagcag aagagggaga acattgggga cttgatccag gagacactgg aggccttcga
      961 gcgctacgga ggagaaaatg cctttatcaa cattaagtac gtggtcccaa cctacgagtc
     1021 ttgcttgcta aactaacagt ggcagcagct gggacttgaa acctcccgtt ggtgttggga
     1081 tcatctgtct ctgttgcttt tagcatctca ttccttgtga cttccacagc tttcttttct
     1141 acagctgcta aaatagtggc ttatgggcca ttggactgtt agccctattg agagcaaggc
     1201 tttccaatac ataaatagtg tctgtttctt agattacaat agtgtactgt gcttatttgt
     1261 tctaagagaa gaattgcttc tttatacagc tccgacagaa gcaggagtcc gagttaaacc
     1321 ttcagttgta tagacaataa actataattt tcatatgcaa ttcagcaatt gctgttctgt
     1381 gtgtgcctgc cctgggggtg atgtcagagg ttgtaaggga agagtttatg ctgactgctt
     1441 actaggtgtt tgtcatggaa gagaagcatg ggttcagcag tgcctctcta gcagctgtgc
     1501 ggaataatgt gctttgacat tcaataaaac tgttgaatct atattccaa
//
