LOCUS       NM_001080487            1314 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens PABPN1 like, cytoplasmic (PABPN1L), transcript variant
            1, mRNA.
ACCESSION   NM_001080487 XM_017023230 XM_372648
VERSION     NM_001080487.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1314)
  AUTHORS   Zhu,Z., Chen,B., Na,R., Fang,W., Zhang,W., Zhou,Q., Zhou,S.,
            Lei,H., Huang,A., Chen,T., Ni,D., Gu,Y., Liu,J., Rao,Y. and Fang,F.
  TITLE     Heritability of human visual contour integration-an integrated
            genomic study
  JOURNAL   Eur J Hum Genet 27 (12), 1867-1875 (2019)
   PUBMED   31363184
  REMARK    GeneRIF: Gene-level analysis further revealed a significant
            genome-wide association of a microRNA-encoding gene MIR1178 in both
            the discovery and replication cohorts. Another gene poly(A)-binding
            protein nuclear 1 like, cytoplasmic (PABPN1L) showed suggestive
            significance in the discovery cohort (p < 1 x 10(-4)) and was
            replicated in the replication cohort (p = 0.009).
REFERENCE   2  (bases 1 to 1314)
  AUTHORS   Sakugawa,N., Miyamoto,T., Sato,H., Ishikawa,M., Horikawa,M.,
            Hayashi,H., Ishikawa,M. and Sengoku,K.
  TITLE     Isolation of the human ePAB and ePABP2 cDNAs and analysis of the
            expression patterns
  JOURNAL   J Assist Reprod Genet 25 (5), 215-221 (2008)
   PUBMED   18483763
  REMARK    GeneRIF: Unique PABP2 gene plays a critical role in human embryo
            cleavage; cDNA has been isolated and sequenced.
REFERENCE   3  (bases 1 to 1314)
  AUTHORS   Cosson,B., Braun,F., Paillard,L., Blackshear,P. and Beverley
            Osborne,H.
  TITLE     Identification of a novel Xenopus laevis poly (A) binding protein
  JOURNAL   Biol Cell 96 (7), 519-527 (2004)
   PUBMED   15380618
REFERENCE   4  (bases 1 to 1314)
  AUTHORS   Good,P.J., Abler,L., Herring,D. and Sheets,M.D.
  TITLE     Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new
            family of cytoplasmic poly(A) binding proteins expressed during the
            early stages of vertebrate development
  JOURNAL   Genesis 38 (4), 166-175 (2004)
   PUBMED   15083517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092384.5.
            
            On Jul 16, 2021 this sequence version replaced NM_001080487.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU190484.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419291.7/ ENSP00000408598.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AC092384.5         99112-99420         c
            310-445             AC092384.5         98566-98701         c
            446-513             AC092384.5         98323-98390         c
            514-620             AC092384.5         97782-97888         c
            621-708             AC092384.5         97613-97700         c
            709-851             AC092384.5         96997-97139         c
            852-1314            AC092384.5         96093-96555         c
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..1314
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /note="PABPN1 like, cytoplasmic"
                     /db_xref="GeneID:390748"
                     /db_xref="HGNC:HGNC:37237"
     exon            1..309
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..891
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     embryonic polyadenylate-binding protein 2; poly(A) binding
                     protein nuclear 1 like, cytoplasmic; ePABP-2; embryonic
                     poly(A)-binding protein 2; poly(A)-binding protein
                     nuclear-like 1; embryonic poly(A)-binding protein type II"
                     /codon_start=1
                     /product="embryonic polyadenylate-binding protein 2
                     isoform 1"
                     /protein_id="NP_001073956.2"
                     /db_xref="CCDS:CCDS45547.2"
                     /db_xref="GeneID:390748"
                     /db_xref="HGNC:HGNC:37237"
                     /translation="MWPFPSRSLFPPPTQAWLQTVSSDPEAQGWGAWNETKEILGPEG
                     GEGKEEKEEEEDAEEDQDGDAGFLLSLLEQENLAECPLPDQELEAIKMKVCAMEQAEG
                     TPRPPGVQQQAEEEEGTAAGQLLSPETVGCPLSGTPEEKVEADHRSVYVGNVDYGGSA
                     EELEAHFSRCGEVHRVTILCDKFSGHPKGYAYIEFATKGSVQAAVELDQSLFRGRVIK
                     VLPKRTNFPGISSTDRGGLRGHPGSRGAPFPHSGLQGRPRLRPQGQNRARGKFSPWFS
                     PY"
     exon            310..445
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..513
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..620
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..708
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..851
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1314
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1314
                     /gene="PABPN1L"
                     /gene_synonym="ePABP2; PABPNL1"
                     /note="major polyA site"
ORIGIN      
        1 gaggggagtg gaggggaggc ctcgcctggc ccaccttcct cctgcccctc taccatgtgg
       61 cccttcccga gccgctctct cttcccaccc ccgactcagg cctggctcca gacggtctcc
      121 tcagaccctg aggcccaggg ctggggggcc tggaacgaga ccaaggagat tctggggcca
      181 gagggtgggg aagggaagga ggagaaagag gaggaagagg atgcagagga agaccaggat
      241 ggggatgcag gctttctgct gtctctgctg gagcaagaga acctggctga gtgcccattg
      301 cctgaccagg agctggaggc catcaagatg aaggtgtgtg ccatggagca ggccgagggg
      361 acgccacggc ctccaggagt gcagcaacag gccgaggaag aggagggcac cgcggccggg
      421 cagctgctga gccctgagac cgtgggctgc cccctctctg ggacccccga ggagaaggtg
      481 gaggctgacc acagatccgt ctacgtgggc aacgtggact acgggggctc cgccgaggag
      541 ctggaggccc acttcagccg ctgtggggag gtccaccgag tcacgatcct gtgtgacaag
      601 ttctctggac accccaaggg ttatgcctac atagagtttg ccaccaaggg ctccgtgcag
      661 gccgccgtgg agctggacca gagcctcttc cggggccggg tcatcaaggt gctgccgaaa
      721 agaaccaact tccctgggat cagctccaca gaccgcgggg gccttcgagg acacccaggc
      781 tccagggggg cacccttccc ccacagcggc ctccagggca ggccccggct cagaccacaa
      841 gggcagaacc gggcccgtgg aaaattctca ccatggtttt caccgtatta aagggaagac
      901 ccgattttga gagaggggct ggggcctgga tcaggagtaa accacttgtg ctccatcctg
      961 gggctggggc agggagtggc gcgggggcga ggccagagga gaggggtgtc cagagcagcc
     1021 actggccccc tcttggcggg gggatggccc agtagggcct tgtatggtgg tccagaccca
     1081 aggccacagc cacgagtcac agccacggcc cggtggtgag cctggcatgg gccccacggg
     1141 gatctgcggg gctctgggtg ttgagggagg ggaggagcag agtcccaggc agtgccaggc
     1201 cagcttgggg ttggcatgct cagctcttca actaagtcat tttaagaaaa atagaaacgt
     1261 gtgtcttaat ggtgaagcat aaattattaa acttgggctc tttttaaaag caaa
//
