LOCUS       NM_080832               3206 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens poly(A) binding protein cytoplasmic 5 (PABPC5), mRNA.
ACCESSION   NM_080832 XM_937772
VERSION     NM_080832.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Kazak,L., Reyes,A., Duncan,A.L., Rorbach,J., Wood,S.R.,
            Brea-Calvo,G., Gammage,P.A., Robinson,A.J., Minczuk,M. and
            Holt,I.J.
  TITLE     Alternative translation initiation augments the human mitochondrial
            proteome
  JOURNAL   Nucleic Acids Res 41 (4), 2354-2369 (2013)
   PUBMED   23275553
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Bhattacharjee,R.B. and Bag,J.
  TITLE     Depletion of nuclear poly(A) binding protein PABPN1 produces a
            compensatory response by cytoplasmic PABP4 and PABP5 in cultured
            human cells
  JOURNAL   PLoS One 7 (12), e53036 (2012)
   PUBMED   23300856
  REMARK    GeneRIF: although function of PABPN1 may be compensated by nuclear
            translocation of PABP4 and perhaps by increase the cytoplasmic
            abundance of PABP5, these were not sufficient to prevent apoptosis
            of cells. PABPN1 may have an anti apoptotic role in mammalian cells
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Blanco,P., Sargent,C.A., Boucher,C.A., Howell,G., Ross,M. and
            Affara,N.A.
  TITLE     A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific
            subinterval in the Xq21.3/Yp11.2 homology block of the human sex
            chromosomes
  JOURNAL   Genomics 74 (1), 1-11 (2001)
   PUBMED   11374897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662874.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_080832.2.
            
            Summary: This gene encodes a protein that binds to the polyA tail
            found at the 3' end of most eukaryotic mRNAs. It is thought to play
            a role in the regulation of mRNA metabolic processes in the
            cytoplasm. This gene is located in a gene-poor region within the
            X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2
            homology block. It is located close to translocation breakpoints
            associated with premature ovarian failure, and is therefore a
            potential candidate gene for this disorder. [provided by RefSeq,
            May 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.80719.1,
                                           SRR3476690.607773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312600.4/ ENSP00000308012.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL662874.9         51560-51615
            57-3206             AL662874.9         52156-55305
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.31"
     gene            1..3206
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /note="poly(A) binding protein cytoplasmic 5"
                     /db_xref="GeneID:140886"
                     /db_xref="HGNC:HGNC:13629"
                     /db_xref="MIM:300407"
     exon            1..56
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /inference="alignment:Splign:2.1.0"
     exon            57..3206
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1348
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /codon_start=1
                     /product="polyadenylate-binding protein 5"
                     /protein_id="NP_543022.1"
                     /db_xref="CCDS:CCDS14460.1"
                     /db_xref="GeneID:140886"
                     /db_xref="HGNC:HGNC:13629"
                     /db_xref="MIM:300407"
                     /translation="MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPL
                     RFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRK
                     SGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANR
                     AIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNIGDDIDDEKLKEL
                     FCEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQK
                     KIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETINDEKLKEEFSSFGSISRAKVM
                     MEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVTLGQARRRC"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2325
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /note="major polyA site"
     regulatory      3183..3188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="PABPC5"
                     /gene_synonym="PABP5"
ORIGIN      
        1 agtctctccg gacctgcctc gagcctcagg ctgctgaaat caccgcgcct cactcgcctc
       61 gacagtgatt ctgagtctgc ttttagcttc cttttgcctg ccttggcttt ttctgttcgt
      121 gaacagctgt ttggcccata gcttagagaa agcagccttt tttctcttca aagagaacct
      181 cctcccagtg ctcagagaga tggggagcgg ggagcctaat cctgctggca agaaaaagaa
      241 gtatctcaag gccgctctgt acgtgggtga cttggaccca gatgtcaccg aggacatgct
      301 ctataagaag ttcaggcctg ctggccctct gcgattcacc cgaatctgcc gtgatccggt
      361 gacccgcagc cccctgggct atgggtatgt taacttccgc tttcccgcgg atgcagagtg
      421 ggccttgaac accatgaatt ttgatttgat taatggaaaa ccattccgcc ttatgtggtc
      481 tcagccagat gaccgcttaa gaaagtctgg agtgggaaat atattcatca aaaacctgga
      541 caaatccata gacaataggg ccctgtttta cttattttct gcttttggga acattctgtc
      601 ctgcaaagtc gtatgcgatg acaacggctc taagggttat gcctatgttc actttgacag
      661 cctggccgct gccaatagag ccatctggca catgaatgga gtgcggctca acaaccgcca
      721 ggtgtatgtt ggcagattca aattcccaga agagcgggcg gctgaggtca gaaccaggga
      781 tagagcaact ttcaccaatg ttttcgttaa aaacattgga gacgacatag atgacgaaaa
      841 actgaaggaa cttttctgtg aatatgggcc aactgagagt gttaaagtaa taagagatgc
      901 cagtgggaaa tctaaaggct ttggatttgt gagatatgag acacacgagg ctgcccaaaa
      961 ggctgtgcta gacttgcatg gaaagtccat cgatggaaaa gtcctctatg tagggcgagc
     1021 acagaagaaa attgaacgcc tggctgagtt gaggcggaga tttgaacggc tgaggttaaa
     1081 agaaaaaagt cggcccccag gggtgcctat ctatattaag aacttggatg agacaatcaa
     1141 tgatgaaaaa ctgaaggagg aattttcttc ctttgggtca attagtcggg ccaaagtgat
     1201 gatggaagtg gggcaaggca aaggatttgg tgtggtctgc ttttcctctt ttgaagaggc
     1261 taccaaagca gtggatgaga tgaatggccg catagtgggc tccaagcccc tgcatgtcac
     1321 cctgggccag gccaggcgca ggtgctgaga ataagaatgc tcagtttgtt tcagccttag
     1381 ttggtgcctc cttagtttgg gctcctttgt gataaggggt tattttatgc taattcacaa
     1441 gttttttttt gaagtgaatt cttttgaaaa aaaaatgcaa aactagaaaa ctttattcat
     1501 tttagaatag aacataattt ctaactgtaa aattgtcatt ttgtactttt tttgatgtaa
     1561 tatccttaga aatctgtaga ataaagtgta ttcctccact tttttttcct gaacagtcaa
     1621 ggtgaggcaa ttgattgagt atatttccct tcttatttca gtaatactct attttttttc
     1681 atgaaaatgt caacatggtt cttctgaatc tatcacagtg aaaagttcta acttgttttt
     1741 gagaagtcag tacagcaggg gaaaacatat gtgatgcaat taacatctgc ataatttcac
     1801 ttaaaattat tatgcaaaaa tgaatgtttt ttcaaaaaat gtgaaatgta ttttattttc
     1861 tttatttgta ttcttgtttc attttttaat atgttgtgaa catgctacag atttgatagt
     1921 acttttgact aaatgttggg agtggtcgta ttaacttctt gcccaaagaa gtaagcatat
     1981 tggtgttttc tcaattagtc actgagaaaa ttaacacttt aggcagtggc tatttaaagt
     2041 aggaattgca tcttaaaaac ctttcctaag agatttggta tgtgaggata ctttcagtac
     2101 cactcctacc attcattttt ctaaattcct tagtacatat acttggatca tgttaaatta
     2161 acaagaaaga tgaataactg cgctgaattg cctttaccta taaataattt aatattttac
     2221 cttcgggttt tatcaactgt caatataaaa ggcagtactc cacagaatga tgttgaaaaa
     2281 cttcttcgaa gaacaccttc tattaaactt gttatctctt gtaaattatt gtgtgtgtcc
     2341 ttttgataat attcacaggt gtttcaaagg taaggaatag gttgtctctt ggattaagtc
     2401 atatgcctcc agccattata tgagaactgt gaaaccaata tggttttctt tatgtcttgg
     2461 ctgcttgaaa attaaaaaaa aaaaaggttt gttcaatatt gccgttacat ttattagcct
     2521 gtaatttcta aattggagat tctctacatt tcacttgcag tttcctgttc tcctcattgc
     2581 ctgccttcca ttcatattac acttattttt ctattttttg tattaccttt ttaaaaatat
     2641 ataccagttc aagtcctttt aggaagaaga aaatacctaa tttatgtaaa atttaaataa
     2701 ttactttttt ataatatgat tcacttatgc cacagattca acattagaat atgttttatc
     2761 tctactgtca gttttattac cttatataca aatcttcatt ttcatacata gtacaatgta
     2821 aatatataac tttgttaaca cttttgttag ctctttgacc ataaaataat gacaataagc
     2881 tgtttctatg tatttgttta tctacaaatt acaggtttat ccatttgcaa atattttcaa
     2941 aatggaaatc actgtttata ttgattataa acataagaca tgctcattgt aaaaaatgta
     3001 cacaaggcag aaggaagtaa aatttccaca gttcagaaat accacaatta atattttcaa
     3061 tgtgtaaata tcttttcata atttttccta cgtatacaca aacattttga ccaaaaatcc
     3121 acactatatg tactgttctg tatttttaat tttaaactga acaataatca tcttttcctg
     3181 acaataaata tcaatctcta tcatca
//
