LOCUS       NM_001114734            4985 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens poly(A) binding protein cytoplasmic 4 like (PABPC4L),
            transcript variant 1, mRNA.
ACCESSION   NM_001114734 NR_003550
VERSION     NM_001114734.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4985)
  AUTHORS   Aslam,M., Ullah,A., Paramasivam,N., Kandasamy,N., Naureen,S.,
            Badshah,M., Khan,K., Wajid,M., Abbasi,R., Eils,R., Brockmann,M.A.,
            Schlesner,M., Ahmad,N. and von Engelhardt,J.
  TITLE     Segregation and potential functional impact of a rare stop-gain
            PABPC4L variant in familial atypical Parkinsonism
  JOURNAL   Sci Rep 9 (1), 13576 (2019)
   PUBMED   31537871
  REMARK    GeneRIF: Segregation and potential functional impact of a rare
            stop-gain PABPC4L variant in familial atypical Parkinsonism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4985)
  AUTHORS   Randall,J.C., Winkler,T.W., Kutalik,Z., Berndt,S.I., Jackson,A.U.,
            Monda,K.L., Kilpelainen,T.O., Esko,T., Magi,R., Li,S.,
            Workalemahu,T., Feitosa,M.F., Croteau-Chonka,D.C., Day,F.R.,
            Fall,T., Ferreira,T., Gustafsson,S., Locke,A.E., Mathieson,I.,
            Scherag,A., Vedantam,S., Wood,A.R., Liang,L., Steinthorsdottir,V.,
            Thorleifsson,G., Dermitzakis,E.T., Dimas,A.S., Karpe,F., Min,J.L.,
            Nicholson,G., Clegg,D.J., Person,T., Krohn,J.P., Bauer,S.,
            Buechler,C., Eisinger,K., Bonnefond,A., Froguel,P., Hottenga,J.J.,
            Prokopenko,I., Waite,L.L., Harris,T.B., Smith,A.V., Shuldiner,A.R.,
            McArdle,W.L., Caulfield,M.J., Munroe,P.B., Gronberg,H., Chen,Y.D.,
            Li,G., Beckmann,J.S., Johnson,T., Thorsteinsdottir,U.,
            Teder-Laving,M., Khaw,K.T., Wareham,N.J., Zhao,J.H., Amin,N.,
            Oostra,B.A., Kraja,A.T., Province,M.A., Cupples,L.A.,
            Heard-Costa,N.L., Kaprio,J., Ripatti,S., Surakka,I., Collins,F.S.,
            Saramies,J., Tuomilehto,J., Jula,A., Salomaa,V., Erdmann,J.,
            Hengstenberg,C., Loley,C., Schunkert,H., Lamina,C., Wichmann,H.E.,
            Albrecht,E., Gieger,C., Hicks,A.A., Johansson,A., Pramstaller,P.P.,
            Kathiresan,S., Speliotes,E.K., Penninx,B., Hartikainen,A.L.,
            Jarvelin,M.R., Gyllensten,U., Boomsma,D.I., Campbell,H.,
            Wilson,J.F., Chanock,S.J., Farrall,M., Goel,A., Medina-Gomez,C.,
            Rivadeneira,F., Estrada,K., Uitterlinden,A.G., Hofman,A.,
            Zillikens,M.C., den Heijer,M., Kiemeney,L.A., Maschio,A., Hall,P.,
            Tyrer,J., Teumer,A., Volzke,H., Kovacs,P., Tonjes,A., Mangino,M.,
            Spector,T.D., Hayward,C., Rudan,I., Hall,A.S., Samani,N.J.,
            Attwood,A.P., Sambrook,J.G., Hung,J., Palmer,L.J., Lokki,M.L.,
            Sinisalo,J., Boucher,G., Huikuri,H., Lorentzon,M., Ohlsson,C.,
            Eklund,N., Eriksson,J.G., Barlassina,C., Rivolta,C., Nolte,I.M.,
            Snieder,H., Van der Klauw,M.M., Van Vliet-Ostaptchouk,J.V.,
            Gejman,P.V., Shi,J., Jacobs,K.B., Wang,Z., Bakker,S.J., Mateo
            Leach,I., Navis,G., van der Harst,P., Martin,N.G., Medland,S.E.,
            Montgomery,G.W., Yang,J., Chasman,D.I., Ridker,P.M., Rose,L.M.,
            Lehtimaki,T., Raitakari,O., Absher,D., Iribarren,C., Basart,H.,
            Hovingh,K.G., Hypponen,E., Power,C., Anderson,D., Beilby,J.P.,
            Hui,J., Jolley,J., Sager,H., Bornstein,S.R., Schwarz,P.E.,
            Kristiansson,K., Perola,M., Lindstrom,J., Swift,A.J., Uusitupa,M.,
            Atalay,M., Lakka,T.A., Rauramaa,R., Bolton,J.L., Fowkes,G.,
            Fraser,R.M., Price,J.F., Fischer,K., Krjuta Kov,K., Metspalu,A.,
            Mihailov,E., Langenberg,C., Luan,J., Ong,K.K., Chines,P.S.,
            Keinanen-Kiukaanniemi,S.M., Saaristo,T.E., Edkins,S., Franks,P.W.,
            Hallmans,G., Shungin,D., Morris,A.D., Palmer,C.N., Erbel,R.,
            Moebus,S., Nothen,M.M., Pechlivanis,S., Hveem,K., Narisu,N.,
            Hamsten,A., Humphries,S.E., Strawbridge,R.J., Tremoli,E.,
            Grallert,H., Thorand,B., Illig,T., Koenig,W., Muller-Nurasyid,M.,
            Peters,A., Boehm,B.O., Kleber,M.E., Marz,W., Winkelmann,B.R.,
            Kuusisto,J., Laakso,M., Arveiler,D., Cesana,G., Kuulasmaa,K.,
            Virtamo,J., Yarnell,J.W., Kuh,D., Wong,A., Lind,L., de Faire,U.,
            Gigante,B., Magnusson,P.K., Pedersen,N.L., Dedoussis,G.,
            Dimitriou,M., Kolovou,G., Kanoni,S., Stirrups,K., Bonnycastle,L.L.,
            Njolstad,I., Wilsgaard,T., Ganna,A., Rehnberg,E., Hingorani,A.,
            Kivimaki,M., Kumari,M., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunians,T., Hunter,D., Ingelsson,E., Kaplan,R., Mohlke,K.L.,
            O'Connell,J.R., Schlessinger,D., Strachan,D.P., Stefansson,K., van
            Duijn,C.M., Abecasis,G.R., McCarthy,M.I., Hirschhorn,J.N., Qi,L.,
            Loos,R.J., Lindgren,C.M., North,K.E. and Heid,I.M.
  CONSRTM   DIAGRAM Consortium; MAGIC Investigators
  TITLE     Sex-stratified genome-wide association studies including 270,000
            individuals show sexual dimorphism in genetic loci for
            anthropometric traits
  JOURNAL   PLoS Genet 9 (6), e1003500 (2013)
   PUBMED   23754948
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015631.10, DR005318.1 and BX648831.1.
            
            On May 24, 2018 this sequence version replaced NM_001114734.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1839220.1,
                                           SRR18074967.536178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000421491.4/
                                                ENSP00000463233.1
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC015631.10        63961-64001         c
            42-531              DR005318.1         1-490
            532-955             AC015631.10        62575-62998         c
            956-4985            BX648831.1         1-4030
FEATURES             Location/Qualifiers
     source          1..4985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.3"
     gene            1..4985
                     /gene="PABPC4L"
                     /note="poly(A) binding protein cytoplasmic 4 like"
                     /db_xref="GeneID:132430"
                     /db_xref="HGNC:HGNC:31955"
     exon            1..72
                     /gene="PABPC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            73..4985
                     /gene="PABPC4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1411
                     /gene="PABPC4L"
                     /note="PABP-4-like"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4-like"
                     /protein_id="NP_001108206.3"
                     /db_xref="CCDS:CCDS47135.1"
                     /db_xref="GeneID:132430"
                     /db_xref="HGNC:HGNC:31955"
                     /translation="MNVAAKYRMASLYVGDLHADVTEDLLFRKFSTVGPVLSIRICRD
                     QVTRRSLGYAYVNFLQLADAQKALDTMNFDIIKGKSIRLMWSQRDAYLRRSGIGNVFI
                     KNLDKSIDNKTLYEHFSAFGKILSSKVMSDDQGSKGYAFVHFQNQSAADRAIEEMNGK
                     LLKGCKVFVGRFKNRKDREAELRSKASEFTNVYIKNFGGDMDDERLKDVFSKYGKTLS
                     VKVMTDSSGKSKGFGFVSFDSHEAAKKAVEEMNGRDINGQLIFVGRAQKKVERQAELK
                     QMFEQLKRERIRGCQGVKLYIKNLDDTIDDEKLRNEFSSFGSISRVKVMQEEGQSKGF
                     GLICFSSPEDATKAMTEMNGRILGSKPLSIALAQRH"
     regulatory      4958..4963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC4L"
                     /note="hexamer: AATAAA"
     polyA_site      4985
                     /gene="PABPC4L"
                     /note="major polyA site"
ORIGIN      
        1 acttggcagc gagtgcgcgg gaagttcagc gcgcgagttc cgggcttccc gcccgcccgc
       61 agacgaccgc cgttctgttg ccgcgtccta ggagggccag attggtggct gtggggactt
      121 ttggatgagg gtgttgcctg agctggggga gtcgtgtctg aactccattg cttggccttt
      181 gtgtggtgat cccgaggcct ccacacttga accgggccaa agctgtgacc tagtatcccc
      241 ccacagggat tgctcaaaga actccagggg acaaactcac agtggcaagg acaaggagat
      301 gaatgtagca gccaagtacc gcatggcctc cctgtatgtg ggtgacttac atgcagatgt
      361 caccgaggac ctgctgttca ggaagttcag cactgtgggg cctgtgctgt ccatccgcat
      421 ttgcagggac caggtcaccc gccgctctct gggctatgcc tacgtgaact tcttgcagct
      481 ggctgatgcc cagaaggcgc tggacacaat gaactttgac atcataaaag gcaaatccat
      541 ccgtctcatg tggtctcagc gcgatgccta cttgaggaga tctggaattg ggaacgtatt
      601 catcaagaat ctggacaaat ctatcgataa caaaaccctt tatgaacatt tttcagcttt
      661 tggaaagatc ctttcctcca aggtgatgag tgatgatcaa ggctccaagg gctatgcatt
      721 tgtgcacttt cagaaccaga gtgctgcaga cagggccatt gaggagatga atggaaaact
      781 actcaagggc tgcaaggtgt ttgttggcag attcaaaaac cgaaaagatc gtgaagctga
      841 actcagaagc aaagccagtg aattcaccaa tgtttacata aaaaactttg gaggtgacat
      901 ggatgatgag agattgaagg acgttttcag caaatatggc aaaactctga gtgttaaggt
      961 gatgacagat tccagtggga aatccaaagg ctttggcttt gtgagttttg atagccatga
     1021 ggctgccaag aaagctgttg aagaaatgaa tggaagggac ataaatgggc agctgatttt
     1081 tgtaggccgg gctcaaaaga aagtcgagcg acaggctgag ttaaagcaaa tgtttgagca
     1141 gctgaaaagg gaacgaattc gtgggtgcca gggggtaaaa ctctatatta agaaccttga
     1201 tgacaccatc gatgatgaaa aactacgaaa cgaattttct tcatttggat caattagcag
     1261 agttaaggta atgcaggaag aggggcagag caaagggttt ggcttgatct gcttctcctc
     1321 tcctgaggat gctactaaag caatgactga gatgaatggc cgcatcttgg gctccaaacc
     1381 tcttagcatt gccttggccc agagacacta ggaaagaaaa acgtaccttt ccagctagta
     1441 tctgcagcag gtgggagaat gatagtgatc tctgcctgaa ttgacctcag taaatttcat
     1501 attccacatg atgggtgctt agtttagtaa actttatgat aaaacgtttt ttatacaaag
     1561 ccattttttt tcttttgtgg aaaaatagat ggagcttagt tcattttaca gaggcacatt
     1621 ttctaatttt aatattgcac atttttctta ttttgatatg ttcatagcaa taagtataaa
     1681 tagatatatt tttacatttg aaccaaatga aatgaggtaa ttatttgaat ttattgcata
     1741 tttattattt tagtaatatt gctagcttta atttcttcta tgaaaatatg ctcaaaatag
     1801 ttcttacaac taaagattcc aaagtatttt taccaacaga aattttctaa tttttcatcc
     1861 aagttttgag aaatcaaact tttagaaatt tatagtacga atttaaagac ctaatttcat
     1921 tttgaattaa tgcttaaaat agtcagatat agttgaattt cttttaaatt tatatcctga
     1981 catgcttgtt tttcggatgg tttaaattaa gatgatggaa gtttttaatg ttgcctaaaa
     2041 actggcttta tgtgttttgt tctttccatt agttgactat aattcaggta cttactagtt
     2101 aatctaaatt gtaacttgca ctgtaaaacc ttaacttcta cattccttaa gttataaatc
     2161 tgttatcaac tcaggtgatc caaagttggc ctggtcttaa atctcttcat acctatatgg
     2221 cttaatatat tatcttaaat ttttaccaga tgctaatatt atgaaaatca tacatacaga
     2281 ttatagaaat tctgtttaaa aacttttaaa atctctttta tattgttttg tgtagtgatt
     2341 ttctcttagg gttcagaaaa gtaagttcct ctatttttat gtactcacat ctccttttat
     2401 tagaatgtgg cagctatgga acccattaag gttcactttt agccttcatt gatcagaaac
     2461 actgattgat tttctgatga attgaagtta catcacttat tctgttttct agcataattt
     2521 ttagtttaga accattcccc tattttcctt gctctcctgc ctttcatcta tattcctcag
     2581 ctttttaaaa tactttctaa aggatttttt tatgttggct tttaatatgt gctgcttcaa
     2641 atccatttgg aaatcgaggc aagagttatt taattacatt taaataattg ctttacaaat
     2701 tctgattcat accaaaggta tctagcaagc aagtgctttt gtttttactg ttttcatatt
     2761 tttacttggc ttagtttttt ctcataacta ttattcacat tctctatttc atatattact
     2821 aatataaaag aaatagtaaa atattttttg gcaatacctc agcttatgaa tgagaaaaat
     2881 ttgttgcctt ttatttttat agaaattata tgtatattct ttgcacattt tctaaaatga
     2941 aaatctttta gtccataaaa aattatggac aatgaaaaaa ttaaaagaat ttgcatataa
     3001 ttgtattatg caaaccaatt ccctattata atttgttaca tatttttcta tttttttctc
     3061 tctctacata tatacaccta ggtaatttaa gaaaaatagg ataatattac aaatgttgtt
     3121 tgaaattgct ttcttaaaca atatgctatg gtcaactttt atgctcacaa taattatttg
     3181 tcttataatc tgagtgactt ttatgttttg ttcaatgact gtaccaaaat ataactaatt
     3241 tcttattgat aaacttcttg ttgctagata atttcttcct tttttcttct tcctctgtca
     3301 taaataactt ggagattaac atccttgcga acttatatat gcaaatatat ctattttctt
     3361 aagaaaatgt ttagaagtag aattaatggt taaaaaagaa tcaattttaa aaagtaattt
     3421 tgataaatat tgcttaaatg ctgtccagaa tacttgtggc acttacattt ccattgtcat
     3481 tgtaggagaa tgcctatttc catatgctcc aagaaacaag ggtttttttt aagctgttgg
     3541 tcaattcaac atgatatgta aaacaaacca tttcatcatt gctttatttc acttttgtaa
     3601 attacaaaag ttaaacagta tttgtgtact cactgaccat ttgtattttc atacttataa
     3661 gttaatgtct catgatcata atttattttc ctgttggggt gttttttatt tacatggatt
     3721 tttagatttc tttgcatatt atgactacat tttagacttt tccccctgat atttcactgt
     3781 ctttatagtt ttgaaggtta ttccaaaatt gaatgttaag ctggaaagtt ttagtattct
     3841 actgaaatgg ctttgatgtc atgcttcaaa atattttgaa cactttaaat acatatattc
     3901 acacaaatat atatacaccc acacaattta tctgtattgt gtttatgact ttcagatttt
     3961 catattctca atgcttctaa ctaaaatttt ggttcataaa aagtatctta tataaaacct
     4021 atagtaaata ttttaaaaat gtgcttttcc atttttaata acatgtattt tggtaaatac
     4081 ttgattcaga gagccaatga attagagttg gcatatgagt ttcacataga ttcttatact
     4141 aggtaagtat ttaccaaaac atgtatcaga agcagaaagt tgttaaaaag gtttaccaga
     4201 caacaagact ggaaagtgta ttaagtgtgc ctggccttga catcttgttc tggataatct
     4261 agtctacatc ttaatttagg aaagctaatc tgtaaaactg ttcaaatatt tgaacaatat
     4321 ttgataatgc ttacataatc tttcaagata atatcaggaa acagagttct ttcatgtatg
     4381 taagtagtta ataggacata acatcagatg tctagatgaa ttatagctat ggcttaatta
     4441 cacaataatc tgccttctta gtagaaattg cttatttcca gcatttgctg taaaaaaaaa
     4501 aaagacagtc agtttacaaa aatatacaat cctatggatt taatttattt aaattttgtt
     4561 cattctaatt ttttttggtg cgtgataata gcaagttatc ttagttgaaa atagagattc
     4621 attcattaaa gaatattaaa tcttttgtgc ccaagtgcct taataaataa gtagaatctt
     4681 aacttttctg ataagcattc cagtaaaagc taatgtacat agatatgcct tgagccactg
     4741 tttctacttt cacccttctc tccacacata ttgccacgtc tgctgtgtag ttacctgctt
     4801 acatgtacag ccatttcaat aaatgtattc ttttaacatt ttatctttta aatttcaaat
     4861 aggaatttat agttggtaaa aataaaaatt ttaaagtgat ttaatattgt cattttcatg
     4921 ttctcaatat tgttatagat ccactgagaa aatgtcaaat aaaatctaat atttcaaagg
     4981 tgaaa
//
