LOCUS       NM_001135653            3142 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens poly(A) binding protein cytoplasmic 4 (PABPC4),
            transcript variant 1, mRNA.
ACCESSION   NM_001135653
VERSION     NM_001135653.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3142)
  AUTHORS   Jiao,Y., Kong,N., Wang,H., Sun,D., Dong,S., Chen,X., Zheng,H.,
            Tong,W., Yu,H., Yu,L., Huang,Y., Wang,H., Sui,B., Zhao,L., Liao,Y.,
            Zhang,W., Tong,G. and Shan,T.
  TITLE     PABPC4 Broadly Inhibits Coronavirus Replication by Degrading
            Nucleocapsid Protein through Selective Autophagy
  JOURNAL   Microbiol Spectr 9 (2), e0090821 (2021)
   PUBMED   34612687
  REMARK    GeneRIF: PABPC4 Broadly Inhibits Coronavirus Replication by
            Degrading Nucleocapsid Protein through Selective Autophagy.
REFERENCE   2  (bases 1 to 3142)
  AUTHORS   Holcomb,D., Alexaki,A., Hernandez,N., Hunt,R., Laurie,K., Kames,J.,
            Hamasaki-Katagiri,N., Komar,A.A., DiCuccio,M. and Kimchi-Sarfaty,C.
  TITLE     Gene variants of coagulation related proteins that interact with
            SARS-CoV-2
  JOURNAL   PLoS Comput Biol 17 (3), e1008805 (2021)
   PUBMED   33730015
  REMARK    GeneRIF: Gene variants of coagulation related proteins that
            interact with SARS-CoV-2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3142)
  AUTHORS   Jiang,X., Wang,G., Liu,Y., Mei,C., Yao,Y., Wu,X., Chen,X., Ma,W.,
            Li,K., Zhang,Z. and Yuan,Y.
  TITLE     A novel long non-coding RNA RP11-286H15.1 represses hepatocellular
            carcinoma progression by promoting ubiquitination of PABPC4
  JOURNAL   Cancer Lett 499, 109-121 (2021)
   PUBMED   33259899
  REMARK    GeneRIF: A novel long non-coding RNA RP11-286H15.1 represses
            hepatocellular carcinoma progression by promoting ubiquitination of
            PABPC4.
REFERENCE   4  (bases 1 to 3142)
  AUTHORS   Meola,N., Domanski,M., Karadoulama,E., Chen,Y., Gentil,C.,
            Pultz,D., Vitting-Seerup,K., Lykke-Andersen,S., Andersen,J.S.,
            Sandelin,A. and Jensen,T.H.
  TITLE     Identification of a Nuclear Exosome Decay Pathway for Processed
            Transcripts
  JOURNAL   Mol Cell 64 (3), 520-533 (2016)
   PUBMED   27871484
REFERENCE   5  (bases 1 to 3142)
  AUTHORS   Wu,J., Yin,R.X., Guo,T., Lin,Q.Z., Shen,S.W., Sun,J.Q., Shi,G.Y.,
            Wu,J.Z., Yang,D.Z. and Lin,W.X.
  TITLE     Gender-specific association between the cytoplasmic poly(A) binding
            protein 4 rs4660293 single nucleotide polymorphism and serum lipid
            levels
  JOURNAL   Mol Med Rep 12 (3), 3476-3486 (2015)
   PUBMED   26005159
  REMARK    GeneRIF: The PABPC4 rs4660293 SNP is associated with serum lipid
            levels.
REFERENCE   6  (bases 1 to 3142)
  AUTHORS   Hinz,T., Flindt,S., Marx,A., Janssen,O. and Kabelitz,D.
  TITLE     Inhibition of protein synthesis by the T cell receptor-inducible
            human TDAG51 gene product
  JOURNAL   Cell Signal 13 (5), 345-352 (2001)
   PUBMED   11369516
REFERENCE   7  (bases 1 to 3142)
  AUTHORS   Feral,C., Mattei,M.G., Pawlak,A. and Guellaen,G.
  TITLE     Chromosomal localization of three human poly(A)-binding protein
            genes and four related pseudogenes
  JOURNAL   Hum Genet 105 (4), 347-353 (1999)
   PUBMED   10543404
REFERENCE   8  (bases 1 to 3142)
  AUTHORS   Hoshino,S., Imai,M., Kobayashi,T., Uchida,N. and Katada,T.
  TITLE     The eukaryotic polypeptide chain releasing factor (eRF3/GSPT)
            carrying the translation termination signal to the 3'-Poly(A) tail
            of mRNA. Direct association of erf3/GSPT with polyadenylate-binding
            protein
  JOURNAL   J Biol Chem 274 (24), 16677-16680 (1999)
   PUBMED   10358005
REFERENCE   9  (bases 1 to 3142)
  AUTHORS   Houng,A.K., Maggini,L., Clement,C.Y. and Reed,G.L.
  TITLE     Identification and structure of activated-platelet protein-1, a
            protein with RNA-binding domain motifs that is expressed by
            activated platelets
  JOURNAL   Eur J Biochem 243 (1-2), 209-218 (1997)
   PUBMED   9030741
REFERENCE   10 (bases 1 to 3142)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC094755.1 and BC029969.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135653.1.
            
            Summary: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail
            present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or
            IPABP (inducible PABP) was isolated as an activation-induced T-cell
            mRNA encoding a protein. Activation of T cells increased PABPC4
            mRNA levels in T cells approximately 5-fold. PABPC4 contains 4
            RNA-binding domains and proline-rich C terminus. PABPC4 is
            localized primarily to the cytoplasm. It is suggested that PABPC4
            might be necessary for regulation of stability of labile mRNA
            species in activated T cells. PABPC4 was also identified as an
            antigen, APP1 (activated-platelet protein-1), expressed on
            thrombin-activated rabbit platelets. PABPC4 may also be involved in
            the regulation of protein translation in platelets and
            megakaryocytes or may participate in the binding or stabilization
            of polyadenylates in platelet dense granules. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. This protein has also been found to interact with
            coronavirus nucleocapsid proteins and is thought to inhibit
            coronavirus replication. [provided by RefSeq, Nov 2021].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094755.1, SRR1163655.446230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000372858.8/ ENSP00000361949.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3020              BC094755.1         1-3020
            3021-3142           BC029969.1         2632-2753
FEATURES             Location/Qualifiers
     source          1..3142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..3142
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /note="poly(A) binding protein cytoplasmic 4"
                     /db_xref="GeneID:8761"
                     /db_xref="HGNC:HGNC:8557"
                     /db_xref="MIM:603407"
     exon            1..1032
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             840..2822
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inducible poly(A)-binding protein; polyadenylate-binding
                     protein 4; PABP-4; poly(A)-binding protein 4;
                     activated-platelet protein 1; poly(A) binding protein,
                     cytoplasmic 4 (inducible form)"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 1"
                     /protein_id="NP_001129125.1"
                     /db_xref="CCDS:CCDS44115.1"
                     /db_xref="GeneID:8761"
                     /db_xref="HGNC:HGNC:8557"
                     /db_xref="MIM:603407"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTL
                     SVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SAIRQSGPRPTLRHLAPTGNAPASRGLPTTTQRVGSECPDRLAMDFGGAGAAQQGLTD
                     SCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQG
                     QEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLES
                     PESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS"
     exon            1033..1226
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1342
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1482
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1577
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1715
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1811
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2084
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2172
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2292
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2379
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2507
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2601
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2732
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2835
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..3142
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /note="hexamer: AAGAAA"
     polyA_site      3142
                     /gene="PABPC4"
                     /gene_synonym="APP-1; APP1; iPABP; PABP4"
                     /note="major polyA site"
ORIGIN      
        1 ctctctccgc cccgggtcgc tgccgcctcc gccgctttcg ggcttcgcag cctgaggaaa
       61 aaaagagaaa aagataaaaa aaatctgaaa acgcttcaaa atcctgaaaa aaaaaaagga
      121 aaagaaaaaa cgaatcctcg gagaacccgc ggggaagtca ctttcgtacg cttccggcct
      181 gccccgcgcc cgccgccgca gcgcttggcg tccgtcggtc tccgtccgtc ggtccggggg
      241 tgagccgccc gcccggcccg ccgtgccctc cccccgctcg ggccccgagc cccgcgcccc
      301 gcgcctgccc cggcgcacca cgtgtccgtg ctgcccttcg ccgcccgccc ggggctcgcc
      361 gagtcggcgc ccacaaagat ttggtttccc tctgccccgg cggttgtaat cttaaaccgc
      421 cggagcccga ggcctatatt tatagagaaa cgcgtgtccc cgaggccgcc gtgggcagcg
      481 tccggtcgcc tcttaaagga tttttaccct tcggaagggg attccccgtt taattttttt
      541 cctactttga ttttttgaaa tttggagctt cgcaccagga ccgcggagaa gtgcaaagtc
      601 gcggggaggg ccgtattgtg cggagagcct tttgtctgcg gtgctgcggc cgtgggagcc
      661 ggcccccgcc tcccgtttcc gtcccgtctc caagcccgcc gactccagct cgtcctcgcc
      721 gcgccggtgc cacctgtgag ccgcggcgcg ggcccgggct ccgaaggcgc ccctttgtcc
      781 tgcggcgggc ccgataagaa gtcctcctgg cggggctcgg ggtggtgggg ggcggggaga
      841 tgaacgctgc ggccagcagc taccccatgg cctccctgta cgtgggcgac ctgcattcgg
      901 acgtcaccga ggccatgctg tacgaaaagt tcagccccgc ggggcctgtg ctgtccatcc
      961 gggtctgccg cgatatgatc acccgccgct ccctgggcta tgcctacgtc aacttccagc
     1021 agccggccga cgctgagcgg gctttggaca ccatgaactt tgatgtgatt aagggaaagc
     1081 caatccgcat catgtggtct cagagggatc cctctttgag aaaatctggt gtgggaaacg
     1141 tcttcatcaa gaacctggac aaatctatag ataacaaggc actttatgat actttttctg
     1201 cttttggaaa catactgtcc tgcaaggtgg tgtgtgatga gaacggctct aagggttatg
     1261 cctttgtcca cttcgagacc caagaggctg ccgacaaggc catcgagaag atgaatggca
     1321 tgctcctcaa tgaccgcaaa gtatttgtgg gcagattcaa gtctcgcaaa gagcgggaag
     1381 ctgagcttgg agccaaagcc aaggaattca ccaatgttta tatcaaaaac tttggggaag
     1441 aggtggatga tgagagtctg aaagagctat tcagtcagtt tggtaagacc ctaagtgtca
     1501 aggtgatgag agatcccaat gggaaatcca aaggctttgg ctttgtgagt tacgaaaaac
     1561 acgaggatgc caataaggct gtggaagaga tgaatggaaa agaaataagt ggtaaaatca
     1621 tatttgtagg ccgtgcacaa aagaaagtag aacggcaggc agagttaaaa cggaaatttg
     1681 aacagttgaa acaggagaga attagtcgat atcagggggt gaatctctac attaagaact
     1741 tggatgacac tattgatgat gagaaattaa ggaaagaatt ttctcctttt ggatcaatta
     1801 ccagtgctaa ggtaatgctg gaggatggaa gaagcaaagg gtttggcttc gtctgcttct
     1861 catctcctga agaagcaacc aaagcagtca ctgagatgaa tggacgcatt gtgggctcca
     1921 agccactata tgttgccctg gcccagagga aggaagagag aaaggctcac ctgaccaacc
     1981 agtatatgca acgagtggct ggaatgagag cacttcctgc caatgccatc ttaaatcagt
     2041 tccagcctgc agcgggtggc tactttgtgc cagcagtccc acaggctcag ggaaggcctc
     2101 catattatac acctaaccag ttagcacaga tgaggcctaa tccacgctgg cagcaaggtg
     2161 ggagacctca aggcttccaa ggaatgccaa gtgctatacg ccagtctggg cctcgtccaa
     2221 ctcttcgcca tctggctcca actggtaatg ctccggcctc tcgtggcctc cctactacca
     2281 ctcagagagt cgggtctgag tgcccggacc gcttggctat ggactttggt ggggctggtg
     2341 ccgcccagca agggctgact gacagctgcc agtctggagg cgttcccaca gctgtgcaga
     2401 acttagcgcc acgcgctgct gttgctgctg ctgctccccg ggctgttgcc ccctacaaat
     2461 acgcctccag tgtccgcagc cctcatcctg ccatacagcc tctgcaggca ccccagcctg
     2521 cggtccatgt gcaggggcag gagccactga ctgcctccat gctggctgca gcaccccccc
     2581 aggaacagaa gcagatgctg ggagaacgct tgttcccact catccaaaca atgcattcaa
     2641 atctggctgg gaagatcacg ggaatgctgc tggagataga caactctgag ctgctgcaca
     2701 tgttagagtc ccccgagtct ctccgctcca aggtggatga agctgtagca gttctacagg
     2761 ctcatcatgc caagaaagaa gctgcccaga aggtgggcgc tgttgctgct gctacctctt
     2821 agacaaggaa aaaccgattc aaaagccaaa taacccctta tggaattcaa ctcaaggttt
     2881 gaagacttcc tagcttgtcc tatggacctc aacaccaagg attacaaatt gcaaatttaa
     2941 taggtcattt tgtatcaaaa ggtcaattat gaagcaccta gaatttttca attatacgaa
     3001 tatgttcttt gggttctgct gtggcccaga cagtgttaac ttttttttta ttgtgggttt
     3061 tgattttttc ccccagaaat tggttttatt tgatgtaccc aagtcttacg tttcccaata
     3121 aagaaaaaaa atctccataa aa
//
