LOCUS       NM_030979               3119 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens poly(A) binding protein cytoplasmic 3 (PABPC3), mRNA.
ACCESSION   NM_030979
VERSION     NM_030979.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Ozturk,S., Sozen,B., Uysal,F., Bassorgun,I.C., Usta,M.F.,
            Akkoyunlu,G. and Demir,N.
  TITLE     The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are
            differentially expressed in infertile men with non-obstructive
            azoospermia
  JOURNAL   J Assist Reprod Genet 33 (3), 335-348 (2016)
   PUBMED   26843391
  REMARK    GeneRIF: PABPC3 decreased expression in in infertile men with
            non-obstructive azoospermia
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Feral,C., Guellaen,G. and Pawlak,A.
  TITLE     Human testis expresses a specific poly(A)-binding protein
  JOURNAL   Nucleic Acids Res 29 (9), 1872-1883 (2001)
   PUBMED   11328870
  REMARK    GeneRIF: molecular cloning and expression in testis
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Feral,C., Mattei,M.G., Pawlak,A. and Guellaen,G.
  TITLE     Chromosomal localization of three human poly(A)-binding protein
            genes and four related pseudogenes
  JOURNAL   Hum Genet 105 (4), 347-353 (1999)
   PUBMED   10543404
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Hoshino,S., Imai,M., Kobayashi,T., Uchida,N. and Katada,T.
  TITLE     The eukaryotic polypeptide chain releasing factor (eRF3/GSPT)
            carrying the translation termination signal to the 3'-Poly(A) tail
            of mRNA. Direct association of erf3/GSPT with polyadenylate-binding
            protein
  JOURNAL   J Biol Chem 274 (24), 16677-16680 (1999)
   PUBMED   10358005
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Morris,C.M. and Bodger,M.P.
  TITLE     Localization of the human poly(A)-binding protein gene (PAB1) to
            chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ
            hybridization
  JOURNAL   Genomics 15 (1), 209-211 (1993)
   PUBMED   8432538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359757.21.
            
            On Jul 27, 2020 this sequence version replaced NM_030979.2.
            
            Summary: Messenger RNA stability and translation initiation are
            extensively under the control of poly(A)-binding proteins (PABP).
            See PABPC1 (MIM 604679) for background information.[supplied by
            OMIM, Jul 2002].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC045608.1, AF132026.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281589.5/ ENSP00000281589.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3119              AL359757.21        66477-69595
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..3119
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="poly(A) binding protein cytoplasmic 3"
                     /db_xref="GeneID:5042"
                     /db_xref="HGNC:HGNC:8556"
                     /db_xref="MIM:604680"
     exon            1..3119
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1959
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="poly(A)-binding protein-like 3; testis-specific
                     poly(A)-binding protein (PABP); testis-specific
                     poly(A)-binding protein 3; testis PABP; PABP-3"
                     /codon_start=1
                     /product="polyadenylate-binding protein 3"
                     /protein_id="NP_112241.2"
                     /db_xref="CCDS:CCDS9311.1"
                     /db_xref="GeneID:5042"
                     /db_xref="HGNC:HGNC:8556"
                     /db_xref="MIM:604680"
                     /translation="MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICR
                     DLITSGSSNYAYVNFQHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIF
                     VKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNG
                     MLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPAL
                     SVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTEL
                     KRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAV
                     PNQRAPPSGYFMTAVPQTQNHAAYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRP
                     GAPRVPFSTMRPASSQVPRVMSTQRVANTSTQTVGPRPAAAAAAAATPAVRTVPRYKY
                     AAGVRNPQQHRNAQPQVTMQQLAVHVQGQETLTASRLASAPPQKQKQMLGERLFPLIQ
                     AMHPTLAGKITGMLLEIDNSELLYMLESPESLRSKVDEAVAVLQAHQAKEATQKAVNS
                     ATGVPTV"
     polyA_site      2048
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="major polyA site"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
     regulatory      2075..2080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="hexamer: AATAAA"
     polyA_site      2083
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
     polyA_site      2094
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="hexamer: AATACA"
     polyA_site      2703
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
                     /note="hexamer: AATAAA"
     polyA_site      3119
                     /gene="PABPC3"
                     /gene_synonym="PABP3; PABPL3; tPABP"
ORIGIN      
        1 acgcgctcta ctcctgtaac ggaaaggtcg cggcttgtgt gcctgcgggc agccgtgccg
       61 agaatgaacc ccagcacccc cagctaccca acggcctcgc tctacgtggg ggacctccac
      121 cccgacgtga ctgaggcgat gctctacgag aagttcagcc cggcagggcc catcctctcc
      181 atccggatct gcagggactt gatcaccagc ggctcctcca actacgcgta tgtgaacttc
      241 cagcatacga aggacgcgga gcatgctctg gacaccatga attttgatgt tataaagggc
      301 aagccagtac gcatcatgtg gtctcagcgt gatccatcac ttcgaaaaag tggagtgggc
      361 aacatattcg ttaaaaatct ggataagtcc attaataata aagcactgta tgatacagtt
      421 tctgcttttg gtaacatcct ttcgtgtaac gtggtttgtg atgaaaatgg ttccaagggt
      481 tatggatttg tacactttga gacacacgaa gcagctgaaa gagctattaa aaaaatgaac
      541 ggaatgctcc taaatggtcg caaagtattt gttggacaat ttaagtctcg taaagaacga
      601 gaagctgaac ttggagctag ggcaaaagag ttccccaatg tttacatcaa gaattttgga
      661 gaagacatgg atgatgagcg ccttaaggat ctctttggca agttcgggcc cgccttaagt
      721 gtgaaagtaa tgaccgatga aagtggaaaa tccaaaggat ttggatttgt aagctttgaa
      781 aggcatgaag atgcacagaa agctgtagat gagatgaatg gaaaggagct caatggaaaa
      841 caaatttacg ttggtcgagc tcagaaaaaa gtggaacggc agacggaact taagcgcaca
      901 tttgaacaga tgaagcaaga taggatcacc agataccagg ttgttaatct ttatgtgaaa
      961 aatcttgatg atggtattga tgatgaacgt ctccggaaag cgttttctcc atttggtaca
     1021 atcactagtg caaaggttat gatggaaggt ggtcgcagca aagggtttgg ttttgtatgt
     1081 ttctcctccc cagaagaagc cactaaagca gttacagaaa tgaacggtag aattgtggcc
     1141 acaaagccat tgtatgtagc tttagctcag cgcaaagaag agcgccaggc ttacctcact
     1201 aacgagtata tgcagagaat ggcaagtgta cgagctgtgc ccaaccagcg agcacctcct
     1261 tcaggttact tcatgacagc tgtcccacag actcagaacc atgctgcata ctatcctcct
     1321 agccaaattg ctcgactaag accaagtcct cgctggactg ctcagggtgc cagacctcat
     1381 ccattccaaa ataagcccag tgctatccgc ccaggtgctc ctagagtacc atttagtact
     1441 atgagaccag cttcttcaca ggttccacga gtcatgtcaa cgcagcgtgt tgctaacaca
     1501 tcaacacaga cagtgggtcc acgtcctgca gctgctgctg ctgctgcagc tacccctgct
     1561 gtgcgcacgg ttccacggta taaatatgct gcgggagttc gcaatcctca gcaacatcgt
     1621 aatgcacagc cacaagttac aatgcaacag cttgctgttc atgtacaagg tcaggaaact
     1681 ttgactgcct ccaggttggc atctgcccct cctcaaaagc aaaagcaaat gttaggtgaa
     1741 cggctctttc ctcttattca agccatgcac cctactcttg ctgggaaaat cactggcatg
     1801 ttgttggaga ttgataattc agaacttctt tatatgctcg agtctccaga gtcactccgt
     1861 tctaaggttg atgaagctgt agctgtacta caagcccacc aagctaaaga ggctacccag
     1921 aaagcagtta acagtgctac cggtgttcca actgtttaaa attgatcaga gaccacgaaa
     1981 agaaatttgt gcttcaccga agaaaaatat ctaaacatcg agaaactatg ggaaaaaaaa
     2041 ttgcaaaatc taaaataaaa aatgcaaaat ctaaaataaa aaatggaaag gaaactttga
     2101 accttatgta ccgagcaaat gcaaggtcta gcaaatataa tgctagtcct agattactta
     2161 ttgatttaaa aacaaaaaaa agattactta attttgattt aaaaacaaaa aatcgtaaaa
     2221 tacaaaaacc agttaatgtt ttgtagaccc tgggaaaaga attttcagca aagtacaaaa
     2281 atttaaagca ttcctttaat tttttaattc tttactgtgg aatagctcaa aatgtccatt
     2341 ctgttttaag taacagaatt gataactgag caaggaaaca tggtttggat tataaaattc
     2401 ttgctttaat aaaaatttct taaacagtga aaaaaagaaa aatcatcaat tttactaata
     2461 gtctttcttt acattttcta ttattctatc tcccactata tttcaaatat gaaaatcact
     2521 ttttcaccaa aattttaggt ctttacataa tagtgtttat ttttaatatt cataaatgaa
     2581 aatatgcaat gacaaaatag taattataaa ttcagtaaca tttgttcaaa attgtaagac
     2641 aattattaat ttatactgca ttatttttaa ataaaaaata aatacatagt tttaaaaatc
     2701 taattgaaca ggaggctaaa catggttctg atcacagaga taatcacttt taatcatttg
     2761 gttttagtgt ttctggtagt tgattttctt caataataat tgtacatagt tatttcttgg
     2821 tttatcaatt ttgtaattta actattgact tcctgctgta acaaataagg atatgtttca
     2881 tctacctctt cccaccatcc ctcctcctcc tcccaatata atttatcact acttgtagct
     2941 cctttattgg taatattaat taatataaat atttataatt aatgttacac ctagtgaatt
     3001 gtataaaagg acagcccatt tgagcattct cctttaagat gagtagaggc tgtgacattg
     3061 cactacatag aaatataatt ataccatatt actttgcaat aaactatgta ttatagaga
//
