LOCUS       NM_002568               2861 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.
ACCESSION   NM_002568
VERSION     NM_002568.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Wang,Y., Shi,N., Zhang,H., Luo,J., Yan,H., Hou,H., Guan,Z., Zhao,L.
            and Duan,M.
  TITLE     LINC01197 inhibits influenza A virus replication by serving as a
            PABPC1 decoy
  JOURNAL   Vet Res 55 (1), 121 (2024)
   PUBMED   39334466
  REMARK    GeneRIF: LINC01197 inhibits influenza A virus replication by
            serving as a PABPC1 decoy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Silva,A.L., Ribeiro,P., Inacio,A., Liebhaber,S.A. and Romao,L.
  TITLE     Proximity of the poly(A)-binding protein to a premature termination
            codon inhibits mammalian nonsense-mediated mRNA decay
  JOURNAL   RNA 14 (3), 563-576 (2008)
   PUBMED   18230761
  REMARK    GeneRIF: Nonsense-mediated decay-sensitive mRNA can be stabilized
            by tethering the cytoplasmic poly(A) binding protein 1, PABPC1, at
            a premature termination codon-proximal position.
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Siddiqui,N., Mangus,D.A., Chang,T.C., Palermino,J.M., Shyu,A.B. and
            Gehring,K.
  TITLE     Poly(A) nuclease interacts with the C-terminal domain of
            polyadenylate-binding protein domain from poly(A)-binding protein
  JOURNAL   J Biol Chem 282 (34), 25067-25075 (2007)
   PUBMED   17595167
  REMARK    GeneRIF: the poly(A) nuclease interacts with the C-terminal domain
            of polyadenylate-binding protein domain from poly(A)-binding
            protein
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Kahvejian,A., Svitkin,Y.V., Sukarieh,R., M'Boutchou,M.N. and
            Sonenberg,N.
  TITLE     Mammalian poly(A)-binding protein is a eukaryotic translation
            initiation factor, which acts via multiple mechanisms
  JOURNAL   Genes Dev 19 (1), 104-113 (2005)
   PUBMED   15630022
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Mangus,D.A., Evans,M.C. and Jacobson,A.
  TITLE     Poly(A)-binding proteins: multifunctional scaffolds for the
            post-transcriptional control of gene expression
  JOURNAL   Genome Biol 4 (7), 223 (2003)
   PUBMED   12844354
  REMARK    Review article
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Grosset,C., Chen,C.Y., Xu,N., Sonenberg,N., Jacquemin-Sablon,H. and
            Shyu,A.B.
  TITLE     A mechanism for translationally coupled mRNA turnover: interaction
            between the poly(A) tail and a c-fos RNA coding determinant via a
            protein complex
  JOURNAL   Cell 103 (1), 29-40 (2000)
   PUBMED   11051545
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Feral,C., Mattei,M.G., Pawlak,A. and Guellaen,G.
  TITLE     Chromosomal localization of three human poly(A)-binding protein
            genes and four related pseudogenes
  JOURNAL   Hum Genet 105 (4), 347-353 (1999)
   PUBMED   10543404
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Deo,R.C., Bonanno,J.B., Sonenberg,N. and Burley,S.K.
  TITLE     Recognition of polyadenylate RNA by the poly(A)-binding protein
  JOURNAL   Cell 98 (6), 835-845 (1999)
   PUBMED   10499800
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Afonina,E., Stauber,R. and Pavlakis,G.N.
  TITLE     The human poly(A)-binding protein 1 shuttles between the nucleus
            and the cytoplasm
  JOURNAL   J Biol Chem 273 (21), 13015-13021 (1998)
   PUBMED   9582337
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Grange,T., de Sa,C.M., Oddos,J. and Pictet,R.
  TITLE     Human mRNA polyadenylate binding protein: evolutionary conservation
            of a nucleic acid binding motif
  JOURNAL   Nucleic Acids Res 15 (12), 4771-4787 (1987)
   PUBMED   2885805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AP001205.3, AK130523.1 and AL135187.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002568.3.
            
            Summary: This gene encodes a poly(A) binding protein. The protein
            shuttles between the nucleus and cytoplasm and binds to the 3'
            poly(A) tail of eukaryotic messenger RNAs via RNA-recognition
            motifs. The binding of this protein to poly(A) promotes ribosome
            recruitment and translation initiation; it is also required for
            poly(A) shortening which is the first step in mRNA decay. The gene
            is part of a small gene family including three protein-coding genes
            and several pseudogenes.[provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041863.1, SRR11853567.29436.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318607.10/ ENSP00000313007.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AP001205.3         130570-130570       c
            2-2622              AK130523.1         1-2621
            2623-2861           AL135187.1         185-423
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..2861
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /note="poly(A) binding protein cytoplasmic 1"
                     /db_xref="GeneID:26986"
                     /db_xref="HGNC:HGNC:8554"
                     /db_xref="MIM:604679"
     exon            1..698
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..2416
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /note="poly(A) binding protein, cytoplasmic 2"
                     /codon_start=1
                     /product="polyadenylate-binding protein 1"
                     /protein_id="NP_002559.2"
                     /db_xref="CCDS:CCDS6289.1"
                     /db_xref="GeneID:26986"
                     /db_xref="HGNC:HGNC:8554"
                     /db_xref="MIM:604679"
                     /translation="MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPAL
                     SVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTEL
                     KRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAV
                     PNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNM
                     PGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTV
                     PQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERL
                     FPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQ
                     KAVNSATGVPTV"
     exon            699..892
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1008
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1148
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1243
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1381
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1477
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1750
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1841
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1952
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2107
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2192
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2323
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2417
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2861
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2840..2845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /note="hexamer: AATAAA"
     polyA_site      2861
                     /gene="PABPC1"
                     /gene_synonym="PAB1; PABP; PABP1; PABPC2; PABPL1"
                     /note="major polyA site"
ORIGIN      
        1 ccccttctcc ccggcggtta gtgctgagag tgcggagtgt gtgctccggg ctcggaacac
       61 acatttatta ttaaaaaatc caaaaaaaat ctaaaaaaat cttttaaaaa accccaaaaa
      121 aatttacaaa aaatccgcgt ctcccccgcc ggagactttt attttttttc ttcctctttt
      181 ataaaataac ccggtgaagc agccgagacc gacccgcccg cccgcggccc cgcagcagct
      241 ccaagaagga accaagagac cgaggccttc ccgctgcccg gacccgacac cgccaccctc
      301 gctccccgcc ggcagccggc agccagcggc agtggatcga ccccgttctg cggccgttga
      361 gtagttttca attccggttg atttttgtcc ctctgcgctt gctccccgct cccctccccc
      421 cggctccggc ccccagcccc ggcactcgct ctcctcctct cacggaaagg tcgcggcctg
      481 tggccctgcg ggcagccgtg ccgagatgaa ccccagtgcc cccagctacc ccatggcctc
      541 gctctacgtg ggggacctcc accccgacgt gaccgaggcg atgctctacg agaagttcag
      601 cccggccggg cccatcctct ccatccgggt ctgcagggac atgatcaccc gccgctcctt
      661 gggctacgcg tatgtgaact tccagcagcc ggcggacgcg gagcgtgctt tggacaccat
      721 gaattttgat gttataaagg gcaagccagt acgcatcatg tggtctcagc gtgatccatc
      781 acttcgcaaa agtggagtag gcaacatatt cattaaaaat ctggacaaat ccattgataa
      841 taaagcactg tatgatacat tttctgcttt tggtaacatc ctttcatgta aggtggtttg
      901 tgatgaaaat ggttccaagg gctatggatt tgtacacttt gagacgcagg aagcagctga
      961 aagagctatt gaaaaaatga atggaatgct cctaaatgat cgcaaagtat ttgttggacg
     1021 atttaagtct cgtaaagaac gagaagctga acttggagct agggcaaaag aattcaccaa
     1081 tgtttacatc aagaattttg gagaagacat ggatgatgag cgccttaagg atctctttgg
     1141 caagtttggg cctgccttaa gtgtgaaagt aatgactgat gaaagtggaa aatccaaagg
     1201 atttggattt gtaagctttg aaaggcatga agatgcacag aaagctgtgg atgagatgaa
     1261 cggaaaggag ctcaatggaa aacaaattta tgttggtcga gctcagaaaa aggtggaacg
     1321 gcagacggaa cttaagcgca aatttgaaca gatgaaacaa gataggatca ccagatacca
     1381 gggtgttaat ctttatgtga aaaatcttga tgatggtatt gatgatgaac gtctccggaa
     1441 agagttttct ccatttggta caatcactag tgcaaaggtt atgatggagg gtggtcgcag
     1501 caaagggttt ggttttgtat gtttctcctc cccagaagaa gccactaaag cagttacaga
     1561 aatgaacggt agaattgtgg ccacaaagcc attgtatgta gctttagctc agcgcaaaga
     1621 agagcgccag gctcacctca ctaaccagta tatgcagaga atggcaagtg tacgagctgt
     1681 tcccaaccct gtaatcaacc cctaccagcc agcacctcct tcaggttact tcatggcagc
     1741 tatcccacag actcagaacc gtgctgcata ctatcctcct agccaaattg ctcaactaag
     1801 accaagtcct cgctggactg ctcagggtgc cagacctcat ccattccaaa atatgcccgg
     1861 tgctatccgc ccagctgctc ctagaccacc atttagtact atgagaccag cttcttcaca
     1921 ggttccacga gtcatgtcaa cacagcgtgt tgctaacaca tcaacacaga caatgggtcc
     1981 acgtcctgca gctgcagccg ctgcagctac tcctgctgtc cgcaccgttc cacagtataa
     2041 atatgctgca ggagttcgca atcctcagca acatcttaat gcacagccac aagttacaat
     2101 gcaacagcct gctgttcatg tacaaggtca ggaacctttg actgcttcca tgttggcatc
     2161 tgcccctcct caagagcaaa agcaaatgtt gggtgaacgg ctgtttcctc ttattcaagc
     2221 catgcaccct actcttgctg gtaaaatcac tggcatgttg ttggagattg ataattcaga
     2281 acttcttcat atgctcgagt ctccagagtc actccgttct aaggttgatg aagctgtagc
     2341 tgtactacaa gcccaccaag ctaaagaggc tgcccagaaa gcagttaaca gtgccaccgg
     2401 tgttccaact gtttaaaatt gatcagggac catgaaaaga aacttgtgct tcaccgaaga
     2461 aaaatatcta aacatcgaaa aacttaaata ttatggaaaa aaaacattgc aaaatataaa
     2521 ataaataaaa aaaggaaagg aaactttgaa ccttatgtac cgagcaaatg ccaggtctag
     2581 caaacataat gctagtccta gattacttat tgatttaaaa acaaaaaaac acaaaaaaat
     2641 agtaaaatat aaaaacaaat taatgtttta tagaccctgg gaaaaagaat tttcagcaaa
     2701 gtacaaaaat ttaaagcatt cctttcttta attttgtaat tctttactgt ggaatagctc
     2761 agaatgtcag ttctgtttta agtaacagaa ttgataactg agcaaggaaa cgtaatttgg
     2821 attataaaat tcttgcttta ataaaaattc cttaaacagt g
//
