LOCUS       NM_001387468            4377 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens PABIR family member 2 (PABIR2), transcript variant 13,
            mRNA.
ACCESSION   NM_001387468 XM_006724730
VERSION     NM_001387468.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4377)
  AUTHORS   Sato,T., Fujii,R., Konomi,K., Yagishita,N., Aratani,S., Araya,N.,
            Aono,H., Yudoh,K., Suzuki,N., Beppu,M., Yamano,Y., Nishioka,K. and
            Nakajima,T.
  TITLE     Overexpression of SPACIA1/SAAL1, a newly identified gene that is
            involved in synoviocyte proliferation, accelerates the progression
            of synovitis in mice and humans
  JOURNAL   Arthritis Rheum 63 (12), 3833-3842 (2011)
   PUBMED   22127701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691477.9 and AL672032.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 5, 2020 this sequence version replaced XM_006724730.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.35597.1,
                                           SRR14038192.3844754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343004.10/ ENSP00000339207.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1098              AL691477.9         18882-19979         c
            1099-1177           AL691477.9         16589-16667         c
            1178-1234           AL691477.9         12354-12410         c
            1235-1278           AL691477.9         11997-12040         c
            1279-1333           AL691477.9         11859-11913         c
            1334-1435           AL691477.9         11504-11605         c
            1436-1497           AL691477.9         10246-10307         c
            1498-1562           AL691477.9         8660-8724           c
            1563-1659           AL691477.9         4595-4691           c
            1660-4377           AL672032.6         199657-202374       c
FEATURES             Location/Qualifiers
     source          1..4377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..4377
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /note="PABIR family member 2"
                     /db_xref="GeneID:159090"
                     /db_xref="HGNC:HGNC:30490"
     exon            1..1098
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1001..1804
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /note="isoform 13 is encoded by transcript variant 13;
                     synoviocyte proliferation associated in collagen-induced
                     arthritis 2; protein FAM122B; family with sequence
                     similarity 122B"
                     /codon_start=1
                     /product="PABIR family member 2 isoform 13"
                     /protein_id="NP_001374397.1"
                     /db_xref="CCDS:CCDS94668.1"
                     /db_xref="GeneID:159090"
                     /db_xref="HGNC:HGNC:30490"
                     /translation="MAQEKMELDLEPDTSYGGTLRRSSSAPLIHGLSDLSQVFQPYTL
                     RTRRNSTTIMSRHSLLLSSSPNRIPSSRLHQIKREEGLDMVNRETAHEREMQTAMQIS
                     QSWDESLSLSDSDFDKPEKLYSPKRIDFTPVSPAPSPTRGFGKMFVSSSGLPPSPVPS
                     PRRFSSRRSQSPVKCIRPSVLGPLKRKGEMETESQPKRLFQGTTNMLSPDAAQLSDLS
                     SCSDILDGSSSSSGLSSDPLAKGSATAESPVACSNSCSSFILMDDLSPK"
     exon            1099..1177
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1234
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1278
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1333
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1435
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1497
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1562
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1659
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..4377
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4348..4353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /note="hexamer: AATAAA"
     polyA_site      4377
                     /gene="PABIR2"
                     /gene_synonym="FAM122B; SPACIA2"
                     /note="major polyA site"
ORIGIN      
        1 aggacccgat gggtgcccgg acgcggaaga actggcccag cggaggttcc cgcttctgaa
       61 gcgtgggagg cggaagagac tgcaggttgt agattttggt cttggcccca acgggttccc
      121 ccagaccatt agaacccgag agaggaagag gaggcaccgc ggcggcggct gagaggccga
      181 acccccaacc tgtcctcgag gcgggagggg ggcagggagg ggagaagcac cgatcccagg
      241 gctgaggagc ctccgggacc gggtccggga gcatgggggg ctggaccggg tccccgagca
      301 tggggagctg gagccgccaa ggccgcccgg ccgggtccta cccgactgtc aggtcctcgg
      361 tgctagcgct gcccgggcag ccgcagcatc tgtagcccgg ccccgcttgt ggtcctcagc
      421 cggaaagata gcagcatgag ttccgccgct gcctagtttc ctccccctcc tcttctccct
      481 cctctctcct cttcccagac cacctccttc tttcccgccc ctgcgcttct tttcccttac
      541 cctctgtcct cctccctccc ctctgccctc tcccttcccc tccctcctcc gcccccttcc
      601 tctccctttc ccccctctgc cctcctctta tcctctctgt cctcctgctt ttccacctat
      661 ccttttccct ccctcttccc tcctccctcc atccttgttt tccctccatc cttctttcct
      721 tcatcctttt ccttcattct gtcaccttcc accactacct cttcgtcctc ctctcctgcc
      781 tcaccatcat cctcccttcc tcatcatcat cctccttccc tcctcctctc ctacttttct
      841 ccgcccccag cccccgcccc cgtccccaag cctccgcccc ttagcccccg cccccagctg
      901 ccagtcccca gcagctcagt cctgcagtga gagtcttggg agtccatagc taagcaccag
      961 gagctgagca ctgcccgctg tgcctgcctg caagtctgac atggctcagg agaaaatgga
     1021 gctggacctt gagcctgaca catcttatgg gggaaccctg aggagatcca gcagcgctcc
     1081 cctaatccat gggctcagtg acctttcaca ggttttccaa ccttacacac ttagaactcg
     1141 gaggaatagt acaacaatta tgagccgtca cagcctgttg ctgtcatcct cacctaatcg
     1201 tattcctagt agcagactgc atcagatcaa aagggaagaa ggcctggata tggtgaacag
     1261 agaaactgca catgaaaggg aaatgcaaac ggcaatgcag ataagccaat catgggatga
     1321 gagcttgagc ctgagtgaca gtgattttga caagccggag aaattatatt ctcctaagag
     1381 aattgacttc actccagttt ctccagcacc ttcacccacc aggggattcg gaaagatgtt
     1441 cgtgagcagc agtggattgc caccaagtcc agttcccagt ccaagacgat tttcaagcag
     1501 gagaagtcag agtccagtca agtgcattag acccagtgtt cttggtcctc ttaaaagaaa
     1561 aggtgaaatg gagacagaaa gtcagcccaa gagactcttc caaggcacta ccaatatgtt
     1621 atctccagat gccgcgcaac tgtctgatct cagttcatgt tcagatattt tggatggcag
     1681 tagtagcagc agtggcttat cctcagaccc gctggctaaa ggcagcgcta ccgcagagtc
     1741 tccagtagca tgctccaatt catgctcttc gttcatcttg atggatgatc tctcacccaa
     1801 gtgacttaac catttctgat tcaacgtttt aactgctgtt tcctacataa aatgtttagt
     1861 ggggaacgca gagaactttg atccataatg aggattaaag ttttacagat ttcacacatt
     1921 ctgatgctat tattactctt tggcatctct cttctccaaa gttcaatttt gtgagcctag
     1981 tgaccttact agtatctggt tttgctgatc tcattttgga tttagtgatt aaatctcaaa
     2041 tgctgatttt tgattgctta gaggaatctt ttttcttagt gcctcaaaaa acacctattt
     2101 tgagtctata catttaagaa aggcactgat gtgtattgcc tttaatggtc cttttccgca
     2161 gcagtgatat gacagatttg atcagaaatt ctcttgcttg agagattttt ttttgtcctc
     2221 tgttgactac atagtttcaa atctctcttt atttcatgat gatatataaa ttgcttttaa
     2281 ttatattaaa tttttatttt tctgcatcag cttcaagtac attattttgt ttccctttcc
     2341 tgtttgagcc gcttatgcca tttctcacag aggggaagaa atacgtagtt gctttcatta
     2401 ctcttattgc ttctttgctg ttggggtgtg tgaagtgagc attgatttta gtgctgagaa
     2461 tgtaaacgga cttacaggat gcttggatta gtcatcacag gttcttatga ctttgctacc
     2521 acagttgata tatttctcct caaacctgtt gccctaagga atatataaaa tattgttgat
     2581 atttctaggt ggtgttatca aggagaagaa attcctgcct tgaccagatg tgtggagcat
     2641 ctacaaatga atgaatagtt atttacacac aaaccactgt gtacaaaagc gtccatggag
     2701 ctgtcagtgt ctcgagtggt attatgaggc ctcaggtgcc ttggggtaca ttgtcatgct
     2761 ataagggatg tatatcataa ggtatggtgg aagaggggcc ttatgtgaat gattgccaca
     2821 tactgtttct gttgctgctt tttttccgat tcctttttgt cattggattt gtttgttttg
     2881 tcatgtggtg aatggtgttt tagttattgt gttgctgcca gaatcagaat ccagttcttg
     2941 ttcttactgc cttatagtta ttgtgttgcc accagaatca gaatccagtt cttgttcata
     3001 ctgccttgta gtgagggcag tttaatatct acaaagaagc ttttagaagc tgaaaaagtc
     3061 aatgtgattg tgcattctgc ttttaagaag ctgtttcagc tatgaactgt gtatgtgcta
     3121 taagtgtgag gtaccataag ttatttaatt tttaaaagag gaaactcctg agtgagctgt
     3181 ttaagaaatc tgagtgtgat ctattgttac gttatttata actaggtaaa atgtctgtcg
     3241 tgatagattt cttttaacgt tcagatactg tggttgggtt gtctatattt aatatgcaga
     3301 tttgcctgct ggaatcataa tccattttta agtgaatgta agaaatgaaa actactgcat
     3361 ttgtgtcttt tgaaggcaag gatccttgga ttttaaagga agagtatgtg ctttgaaggc
     3421 actcagagac tagtaatagc atatggtttg aagggaaacc cattctcttt caattacaag
     3481 agagcatcac ttagcgtgca gtacttctgt tacagcatcc gatgtgtcct ttattttaaa
     3541 ttgtaaccat aacagccatt aatggcttta tttcttgtat tgctctcatc tgggaaaagt
     3601 ctctacttct tcaaacgtaa cataaatcta ttatgaagct tgtcccctag tatgccatta
     3661 taaagaaaaa attcttcgat ggtatgcagt gtatctattc tgtttgtaaa agatcatgtc
     3721 aaaatgttct gcctctataa tgataataga tggttttgtc tttcaggata tttatccacc
     3781 tactgtcttc tttgccttaa agggacactt ggccatcatt tttaggctcg aacttaacac
     3841 tgttaagaaa taactgaaat atgatggtat ttacattaat ttttgaaatt caatggtggg
     3901 atagaattag gtcaggaaat ggaagttgtt ccaatggtgt gagaactagg agacaagatg
     3961 attcacttta ttatttaaac caagcttcat ttttagtttt tgttgtttaa atggactgga
     4021 aagttaagtt tttgcaggga ttgttttgaa ataaagagat atgctaactc acagatgaac
     4081 tttgttaaga cccctttatt tttatataaa gtctaatatt tgaaaagcga ttgttataaa
     4141 gtaaaattct ctcttcctat tctaatatat atcatatatt tcaggcttct atttgaaaac
     4201 aggtataaga gatgatatga tacaacccta tagataatgt tttttgcttg attgacttat
     4261 ataatcactg tttcatgatt actgcttttg gaataatagg aagttttgtg aaatgctggc
     4321 cttgtgtata tcttagaatg caaatttaat aaagtgtgta tacatgcata aaattta
//
