LOCUS       NM_138333               5502 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting
            phosphatase regulator 1 (PABIR1), mRNA.
ACCESSION   NM_138333
VERSION     NM_138333.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5502)
  AUTHORS   Wasserman,J.S., Faezov,B., Patel,K.R., Kurimchak,A.M.,
            Palacio,S.M., Glass,D.J., Fowle,H., McEwan,B.C., Xu,Q., Zhao,Z.,
            Cressey,L., Johnson,N., Duncan,J.S., Kettenbach,A.N., Dunbrack,R.L.
            Jr. and Grana,X.
  TITLE     FAM122A ensures cell cycle interphase progression and checkpoint
            control by inhibiting B55alpha/PP2A through helical motifs
  JOURNAL   Nat Commun 15 (1), 5776 (2024)
   PUBMED   38982062
  REMARK    GeneRIF: FAM122A ensures cell cycle interphase progression and
            checkpoint control by inhibiting B55alpha/PP2A through helical
            motifs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5502)
  AUTHORS   Padi,S.K.R., Vos,M.R., Godek,R.J., Fuller,J.R., Kruse,T.,
            Hein,J.B., Nilsson,J., Kelker,M.S., Page,R. and Peti,W.
  TITLE     Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19
  JOURNAL   Nature 625 (7993), 195-203 (2024)
   PUBMED   38123684
REFERENCE   3  (bases 1 to 5502)
  AUTHORS   Liu,M.H., Zhang,X.C., Chen,J., Yang,Y.S., Wang,Y.Q., Zheng,J.K.,
            Chen,G.Q. and Huang,Y.
  TITLE     FAM122A is required for hematopoietic stem cell function
  JOURNAL   Leukemia 35 (7), 2130-2134 (2021)
   PUBMED   33262527
  REMARK    GeneRIF: FAM122A is required for hematopoietic stem cell function.
REFERENCE   4  (bases 1 to 5502)
  AUTHORS   Li,F., Kozono,D., Deraska,P., Branigan,T., Dunn,C., Zheng,X.F.,
            Parmar,K., Nguyen,H., DeCaprio,J., Shapiro,G.I., Chowdhury,D. and
            D'Andrea,A.D.
  TITLE     CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes
            Replication Stress
  JOURNAL   Mol Cell 80 (3), 410-422 (2020)
   PUBMED   33108758
REFERENCE   5  (bases 1 to 5502)
  AUTHORS   Wang,Y.Q., Yang,Y.S., Chen,J., Liu,M.H., Chen,G.Q. and Huang,Y.
  TITLE     FAM122A maintains DNA stability possibly through the regulation of
            topoisomerase IIalpha expression
  JOURNAL   Exp Cell Res 396 (1), 112242 (2020)
   PUBMED   32866497
  REMARK    GeneRIF: FAM122A maintains DNA stability possibly through the
            regulation of topoisomerase IIalpha expression.
REFERENCE   6  (bases 1 to 5502)
  AUTHORS   Madeira,F., Tinti,M., Murugesan,G., Berrett,E., Stafford,M.,
            Toth,R., Cole,C., MacKintosh,C. and Barton,G.J.
  TITLE     14-3-3-Pred: improved methods to predict 14-3-3-binding
            phosphopeptides
  JOURNAL   Bioinformatics 31 (14), 2276-2283 (2015)
   PUBMED   25735772
REFERENCE   7  (bases 1 to 5502)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 5502)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   9  (bases 1 to 5502)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 5502)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013062.1, AL354794.16 and BX110658.1.
            
            On Jul 24, 2018 this sequence version replaced NM_138333.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803615.172247.1,
                                        SRR1803617.141716.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394264.7/ ENSP00000377807.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1258              BC013062.1         11-1268
            1259-5116           AL354794.16        97499-101356
            5117-5502           BX110658.1         2-387
FEATURES             Location/Qualifiers
     source          1..5502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..5502
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A)
                     interacting phosphatase regulator 1"
                     /db_xref="GeneID:116224"
                     /db_xref="HGNC:HGNC:23490"
                     /db_xref="MIM:617249"
     exon            1..5502
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..964
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="protein FAM122A; family with sequence similarity
                     122A; PABIR family member 1"
                     /codon_start=1
                     /product="PPP2R1A-PPP2R2A-interacting phosphatase
                     regulator 1"
                     /protein_id="NP_612206.5"
                     /db_xref="CCDS:CCDS6623.3"
                     /db_xref="GeneID:116224"
                     /db_xref="HGNC:HGNC:23490"
                     /db_xref="MIM:617249"
                     /translation="MAQEKMELDLELPPGTGGSPAEGGGSGGGGGLRRSNSAPLIHGL
                     SDTSPVFQAEAPSARRNSTTFPSRHGLLLPASPVRMHSSRLHQIKQEEGMDLINRETV
                     HEREVQTAMQISHSWEESFSLSDNDVEKSASPKRIDFIPVSPAPSPTRGIGKQCFSPS
                     LQSFVSSNGLPPSPIPSPTTRFTTRRSQSPINCIRPSVLGPLKRKCEMETEYQPKRFF
                     QGITNMLSSDVAQLSDPGVCVSSDTLDGNSSSAGSSCNSPAKVSTTTDSPVSPAQAAS
                     PFIPLDELSSK"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: AATACA"
     polyA_site      1255
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="major polyA site"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: AGTAAA"
     polyA_site      1353
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="major polyA site"
     regulatory      3520..3525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: TATAAA"
     polyA_site      3538
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="major polyA site"
     regulatory      4278..4283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: AATAAA"
     polyA_site      4304
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: ATTAAA"
     polyA_site      4363
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="major polyA site"
     regulatory      4506..4511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: AATAAA"
     polyA_site      4544
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
     regulatory      5476..5481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
                     /note="hexamer: AATAAA"
     polyA_site      5502
                     /gene="PABIR1"
                     /gene_synonym="C9orf42; FAM122A"
ORIGIN      
        1 agattctcgg tggcggcggc agcggcggcg gccctggact gcggggaatg ggaatcctag
       61 gtccctgact gagcacctcc cccgcctccc tgcccccgac atggctcagg agaagatgga
      121 gctagacctg gagctgcctc cgggtacggg cgggagcccg gcggagggcg gtggcagcgg
      181 cggcggcggg ggcctcagga ggtctaacag cgcccccctg atccacggcc tcagtgacac
      241 ttcgccggtg ttccaggccg aggcgccgag cgccaggcgg aacagcacaa cgttcccgag
      301 ccgccacggc ctgctgctgc cggcctcccc tgtccgcatg cacagcagcc gcttgcacca
      361 gatcaaacaa gaagagggca tggacttgat caaccgagag acggtccacg aacgggaggt
      421 gcagaccgca atgcagataa gccactcctg ggaggaaagt ttcagcctga gtgacaacga
      481 cgtggagaaa tccgcctccc ccaagcgcat cgatttcatt cctgtgtcac cagcaccgtc
      541 acccactcgg ggaattggga agcagtgttt ttcgccatcc ttgcaaagtt ttgtaagtag
      601 caacggattg cctccaagcc ctattcccag cccaacgacc cgatttacca cccggagaag
      661 ccagagcccc atcaattgca ttagaccaag tgttcttgga ccattgaaaa gaaaatgtga
      721 aatggaaact gaatatcagc caaagagatt tttccagggc atcaccaaca tgctttcttc
      781 tgacgttgca cagctgtcag atcctggtgt gtgtgtatct tcggataccc ttgatggaaa
      841 cagcagcagt gccggatctt cttgtaactc accagcgaaa gtcagcacta ccaccgactc
      901 tcctgtgtca cctgcccaag cggcttctcc atttattcca ctagatgaac tttcgtctaa
      961 gtgattcact catcctgaga ctttcttttt gcagtggaga gagagaataa tctagttggg
     1021 gcaaacactg aactttgtca attaatttga ggctatttcc tatttgaccc cttttctttt
     1081 ttgaaattcc ctgaaatgat gttattctag agaacttcta tgtcaggttc ctttggatac
     1141 ccttgaattc agtgtagtaa tattttcaga cgtttcccca ataagtgtgt tgaagcatac
     1201 atctttacgc tgctaatatg tctaaataca tatgttatcc cttgattttt ttaaataact
     1261 gagagctcta tttatttatg ggattattaa gttctgatga aaatataaat gttgacttaa
     1321 tcagcatagt aaactgatgt ttaaaattcc atacttcatg cccacactaa tttttaatgt
     1381 tattttcagt ggttgccgat ttccatttga tgaagaacta tacagcttaa aaaaatacgt
     1441 tagttatatc tatctagtgg ttgtctgttt tacccaggaa ttcttggata tttagttttc
     1501 tgggtactga agtggatggg agggggaatg attaaagaac aaattataaa agtttgaaca
     1561 aatcttttca aattaagtat ataaaagtaa acttttaaga aaaacatttt taatgagatt
     1621 ttaatagtaa ttctagtcag tcatacaact ataactacta tagagaaaat aaaatttttt
     1681 cctttttttt tttaaccgga aagtgcattt gcttgggtgt aatcctaaag tgaaatggga
     1741 cagtgccttg cagtctttgc ccactataca taggctaagg ctaagctctt tgtactactg
     1801 caaacttaaa agtttttcaa atgtgggaaa cgtgtgggaa ggcttgttga actttggcgc
     1861 actcaggtaa acaatactct ctcaattgtt gatatacttt aaaatattca gttgtgcctc
     1921 agttccagaa attattgcca aacaggagcc acagcaattt ttggctactt ttctgctctg
     1981 cccatctgtc accttactgg ttttcccttg ttcaggaagg aagcagctgt ttccttgcca
     2041 acaggtccct tcctctccat ctcccaccaa actagggcac cattgattag acaaaggtac
     2101 agtgtaactt gggtttctga cagcaacaac aggactgtga attgtttaac ctctgtggtt
     2161 aaagctacag cttgagttga ctgccttggg gatgtcagtt aattaagggg tgatgatttg
     2221 caagagaaaa ttagtggaga gtcacatagg taaatcatta tttaacttag gttttcctaa
     2281 agttagaata gtcgaatgtt cttttcttta cctttacaat taagacaaaa tgtttaataa
     2341 gaatagcaaa aattttttta tattatgcat ccttatacct cacatatctt ccttaactag
     2401 atagtttgac agaaagaatg gcatacaaag aggaaagggg aaaaatgact cagaacaaga
     2461 caaaagctct gactgtttaa agttatcgct tacagagact ttaacaattt tgtggaattt
     2521 ttacaactat gagagtaaat ggaactggtc aactcttgac agttgcctca agatggagtg
     2581 aaattgcatc gagggtaaga ctgtgtccac aggtttaaaa ttctctcttc tgagtaatag
     2641 tgttcatgtg ctcccattct cgaccctgtt gttgaaattc aaacttaaat agcctgactt
     2701 cttgttgggt aacttgccct gcctccagag gtatttgaac ttcattatct tcaacacagg
     2761 aattgttaat cttctcactt cacctgttct tgcattagct caattgatgt catcactgat
     2821 ttcctaaact agaaactatg gaagcatctt tgacttttcc ttttctctgt tggattagct
     2881 taatcaccaa gtcctgtcaa cttctgaaat gaatctcaaa tttcttccct tctctatctg
     2941 ttgcccctga ttttgcctta agttcttgcc tgagtgatct cccagcctgt cttctgtctc
     3001 cttttggttc agtctttata ctgcctcttg agtaatcttt ctgaaattta aacttgatat
     3061 ttttcgccct cttgcttgaa aacttcactt gcttccccat ttcctactct ttaaggaatg
     3121 atttctttag cctcagatag aaggaccttt atgatctggc catattctga aatagcttca
     3181 atcctctcct catctctgtt ccagtataca tctttccttc ttattctgca aacattagac
     3241 cacttgatat tctttaaata tgtcatgtac ttttcttgtg tctgttcttt gggataattc
     3301 ctatcctttt cagggaggca aattgcacgt gagtttaagt atgaaggcaa tgtatacctg
     3361 ctgattgtaa aatatttaaa cattgtacat atctgtgtgg ttttaaaagt ctgcttttaa
     3421 ttatgtaaaa ttcatcttcc ctttccacag ataacttctg ttaacaactt gatatctatt
     3481 gtacaagatg tgttactggc atttccatgt atatatgtat ataaatgcag gaaaccaaca
     3541 tgtcattgac acctctcttc tttacttttc cccatatcta atcattcctc aagtcttact
     3601 gatttttatc agctagaatc tatctcctta tttctacctc tattgccact ctgatccagg
     3661 ctaccagcat ttccctctta ggcttctgaa gcaacttcct aactcccact tgtgctcctc
     3721 acactcactc tggtcggcta tccattcatt ctccatacag caactagagt cattctttta
     3781 aaattgcgga cctgatcctt ccatctccca gctgaacgct tttcatttgc ttcctgttct
     3841 catgagtatg ccaaaatgta ttaattctgg gctaggaggc cctgaggaat ttggtccttc
     3901 cctcctcccc cctcgttttc tgtgcttcgc cctcactggc ttgcctttct tttccttaaa
     3961 tacatcatgt tctctcctat tttagatcct tttccccgaa ggtatggaaa cattatttct
     4021 gtaagcttat tcttctatat agatgggaag tttttaaatc agataaggtt ctaagggcat
     4081 gtggacaatt tacgttatca tagtattgtt cataacgtcc atcattattc tgtagactgt
     4141 aagggcttac ttagctcgtg taagaattat ccttcaaaaa gcatttttaa ggtattagta
     4201 ttgctaatct ataaactttg tgcaagaagt cctaaagtca atagcaacat ttatttaaag
     4261 tacagtttgt catacttaat aaacctctgg tatattttcc tttattatgc ttgttaaaaa
     4321 cacagtataa atgggagaaa tcattaaaga tcattaactc caaggctgct ggatgttagg
     4381 acccttaagc atacttaaaa gattgattgt aatcaagaat aacttgtatc agattgcctt
     4441 ccagtgattc acatttatta gttcaaccag ttacatacct gtagcaagag accagtttat
     4501 ttggcaataa aattggggaa ggaatcaaga cttaaatgag gaaagtgagt ctgagaacat
     4561 tttttttcag ggtgtgttta tagattagta gaacaatttt gaagatctaa cagaggtggg
     4621 agtcagggga atggttgcca gacaattgaa ccaagaagat gatgatcatt tcttgagtag
     4681 caccagagaa cagaagaaag agttggcctt ggaaaggagg tctggaaact tatttttctt
     4741 ctgaaacagg agggagagtg aaaaggctag gcaaagatat ccataaatgt tgaattgatt
     4801 tgttgttgca ggggtttagg agtatggagg taggtatatg aaaagtagaa tttgtttctg
     4861 attgtgccta ttttccaatt attgaggaat ctaagataca tgaggatagg gacaggagat
     4921 catttggaag cttgagtgca gtaaaggttt aatgttgcct ctgagaatct aaaggagtaa
     4981 gttaaggaca agtagaaggc ttattaggct atgatggatg ccaggttgca gttggatggc
     5041 aggcacaagg aagtgggttg gattgactag gtttgggaat tggttaagtg ggtactaggt
     5101 aaagcccagt gtgtgaagta gttaagggtt ctgctgaaag tgtagtttga atgattggct
     5161 gaggcattga ggataagaga agggagcaga ggcttatgga ctagaccact tttttcaggg
     5221 ctttacctta tcagccatga caaagtatag agaatctggt ctcaatgtag gtctctcact
     5281 ccagcagttt tgcccacatt tttcatggct gttagagaat cagggctgaa ggcaagcctt
     5341 gagtgccact tacttggtaa aaaattgtgt cagattgctc actgtagcca agacagagtt
     5401 ctttgtggct tctgtaactt gccatccaag taaaaaaatt ttcttaaaag ttgaaatgac
     5461 ctttgtataa aaagtaataa aatacttgct atgtgtcagg ga
//
