LOCUS       NM_006191               2386 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proliferation-associated 2G4 (PA2G4), mRNA.
ACCESSION   NM_006191
VERSION     NM_006191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Marchesini,M., Gherli,A., Simoncini,E., Tor,L.M.D., Montanaro,A.,
            Thongon,N., Vento,F., Liverani,C., Cerretani,E., D'Antuono,A.,
            Pagliaro,L., Zamponi,R., Spadazzi,C., Follini,E., Cambo,B.,
            Giaimo,M., Falco,A., Sammarelli,G., Todaro,G., Bonomini,S.,
            Adami,V., Piazza,S., Corbo,C., Lorusso,B., Mezzasoma,F.,
            Lagrasta,C.A.M., Martelli,M.P., La Starza,R., Cuneo,A., Aversa,F.,
            Mecucci,C., Quaini,F., Colla,S. and Roti,G.
  TITLE     Orthogonal proteogenomic analysis identifies the druggable
            PA2G4-MYC axis in 3q26 AML
  JOURNAL   Nat Commun 15 (1), 4739 (2024)
   PUBMED   38834613
  REMARK    GeneRIF: Orthogonal proteogenomic analysis identifies the druggable
            PA2G4-MYC axis in 3q26 AML.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   He,S.W., Liang,Y.L., Zhang,Y., Liu,X., Gong,S., Ye,M.L.,
            Huang,S.Y., Tan,X.R., Zhou,S.Q., Zhao,Y., Liu,N. and Li,Y.Q.
  TITLE     LINC00173 facilitates tumor progression by stimulating
            RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma
  JOURNAL   Mol Oncol 17 (3), 518-533 (2023)
   PUBMED   36606322
  REMARK    GeneRIF: LINC00173 facilitates tumor progression by stimulating
            RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal
            carcinoma.
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Alan Harris,R., Archer,K.J., Goodarzi,M.O., York,T.P., Rogers,J.,
            Dunaif,A., McAllister,J.M. and Strauss,J.F. 3rd.
  TITLE     Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are
            associated with polycystic ovary syndrome
  JOURNAL   Gene 852, 147062 (2023)
   PUBMED   36423778
  REMARK    GeneRIF: Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and
            RAB5B are associated with polycystic ovary syndrome.
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Kim,B.S., Ko,H.R., Hwang,I., Cho,S.W. and Ahn,J.Y.
  TITLE     EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome
            system in neural development
  JOURNAL   BMB Rep 54 (8), 413-418 (2021)
   PUBMED   33691908
  REMARK    GeneRIF: EBP1 regulates Suv39H1 stability via the
            ubiquitin-proteasome system in neural development.
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Xia,X., Cheng,A., Lessor,T., Zhang,Y. and Hamburger,A.W.
  TITLE     Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb
            transcriptional regulation
  JOURNAL   J Cell Physiol 187 (2), 209-217 (2001)
   PUBMED   11268000
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Lessor,T.J. and Hamburger,A.W.
  TITLE     Regulation of the ErbB3 binding protein Ebp1 by protein kinase C
  JOURNAL   Mol Cell Endocrinol 175 (1-2), 185-191 (2001)
   PUBMED   11325528
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Lessor,T.J., Yoo,J.Y., Xia,X., Woodford,N. and Hamburger,A.W.
  TITLE     Ectopic expression of the ErbB-3 binding protein ebp1 inhibits
            growth and induces differentiation of human breast cancer cell
            lines
  JOURNAL   J Cell Physiol 183 (3), 321-329 (2000)
   PUBMED   10797306
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Yoo,J.Y., Wang,X.W., Rishi,A.K., Lessor,T., Xia,X.M.,
            Gustafson,T.A. and Hamburger,A.W.
  TITLE     Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation
            of this binding by heregulin
  JOURNAL   Br J Cancer 82 (3), 683-690 (2000)
   PUBMED   10682683
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Lamartine,J., Seri,M., Cinti,R., Heitzmann,F., Creaven,M.,
            Radomski,N., Jost,E., Lenoir,G.M., Romeo,G. and Sylla,B.S.
  TITLE     Molecular cloning and mapping of a human cDNA (PA2G4) that encodes
            a protein highly homologous to the mouse cell cycle protein p38-2G4
  JOURNAL   Cytogenet Cell Genet 78 (1), 31-35 (1997)
   PUBMED   9345902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034102.32, BC001951.1 and
            BU683753.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006191.2.
            
            Summary: This gene encodes an RNA-binding protein that is involved
            in growth regulation. This protein is present in pre-ribosomal
            ribonucleoprotein complexes and may be involved in ribosome
            assembly and the regulation of intermediate and late steps of rRNA
            processing. This protein can interact with the cytoplasmic domain
            of the ErbB3 receptor and may contribute to transducing growth
            regulatory signals. This protein is also a transcriptional
            co-repressor of androgen receptor-regulated genes and other cell
            cycle regulatory genes through its interactions with histone
            deacetylases. This protein has been implicated in growth inhibition
            and the induction of differentiation of human cancer cells. Six
            pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have
            been identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.127084.1,
                                           SRR1803611.137909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303305.11/ ENSP00000302886.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC034102.32        56681-56740         c
            61-1628             BC001951.1         1-1568
            1629-1839           AC034102.32        47936-48146         c
            1840-2386           BU683753.1         18-564              c
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..2386
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="proliferation-associated 2G4"
                     /db_xref="GeneID:5036"
                     /db_xref="HGNC:HGNC:8550"
                     /db_xref="MIM:602145"
     exon            1..267
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1364
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="ErbB-3 binding protein 1; cell cycle protein
                     p38-2G4 homolog; ErbB3-binding protein Ebp1; erbB3-binding
                     protein 1; proliferation-associated 2G4, 38kD;
                     proliferation-associated 2G4, 38kDa; ErbB-3 receptor
                     binding protein; IRES-specific cellular transacting factor
                     45"
                     /codon_start=1
                     /product="proliferation-associated protein 2G4"
                     /protein_id="NP_006182.2"
                     /db_xref="CCDS:CCDS8902.1"
                     /db_xref="GeneID:5036"
                     /db_xref="HGNC:HGNC:8550"
                     /db_xref="MIM:602145"
                     /translation="MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVS
                     VLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKE
                     GDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPG
                     NQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEF
                     EVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAM
                     PFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT
                     SGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENEA
                     GD"
     exon            268..396
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            397..502
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            503..572
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            573..665
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..729
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..808
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..887
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1021
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1116
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1244
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1298
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2386
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1598
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="major polyA site"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="major polyA site"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="hexamer: AATAAA"
     polyA_site      2386
                     /gene="PA2G4"
                     /gene_synonym="EBP1; HG4-1; ITAF45; p38-2G4"
                     /note="major polyA site"
ORIGIN      
        1 agcccgcgcg ctcgcagctt ctcgctctcg cctgcctgcc cgctcccttg cttgctcgcg
       61 ctttcgctcg ccctctcctc gaggatcgag gggactctga ccacagcctg tggctgggaa
      121 gggagacaga ggcggcggcg gctcagggga aacgaggctg cagtggtggt agtaggaaga
      181 tgtcgggcga ggacgagcaa caggagcaaa ctatcgctga ggacctggtc gtgaccaagt
      241 ataagatggg gggcgacatc gccaacaggg tacttcggtc cttggtggaa gcatctagct
      301 caggtgtgtc ggtactgagc ctgtgtgaga aaggtgatgc catgattatg gaagaaacag
      361 ggaaaatctt caagaaagaa aaggaaatga agaaaggtat tgcttttccc accagcattt
      421 cggtaaataa ctgtgtatgt cacttctccc ctttgaagag cgaccaggat tatattctca
      481 aggaaggtga cttggtaaaa attgaccttg gggtccatgt ggatggcttc atcgctaatg
      541 tagctcacac ttttgtggtt gatgtagctc aggggaccca agtaacaggg aggaaagcag
      601 atgttattaa ggcagctcac ctttgtgctg aagctgccct acgcctggtc aaacctggaa
      661 atcagaacac acaagtgaca gaagcctgga acaaagttgc ccactcattt aactgcacgc
      721 caatagaagg tatgctgtca caccagttga agcagcatgt catcgatgga gaaaaaacca
      781 ttatccagaa tcccacagac cagcagaaga aggaccatga aaaagctgaa tttgaggtac
      841 atgaagtata tgctgtggat gttctcgtca gctcaggaga gggcaaggcc aaggatgcag
      901 gacagagaac cactatttac aaacgagacc cctctaaaca gtatggactg aaaatgaaaa
      961 cttcacgtgc cttcttcagt gaggtggaaa ggcgttttga tgccatgccg tttactttaa
     1021 gagcatttga agatgagaag aaggctcgga tgggtgtggt ggagtgcgcc aaacatgaac
     1081 tgctgcaacc atttaatgtt ctctatgaga aggagggtga atttgttgcc cagtttaaat
     1141 ttacagttct gctcatgccc aatggcccca tgcggataac cagtggtccc ttcgagcctg
     1201 acctctacaa gtctgagatg gaggtccagg atgcagagct aaaggccctc ctccagagtt
     1261 ctgcaagtcg aaaaacccag aaaaagaaaa aaaagaaggc ctccaagact gcagagaatg
     1321 ccaccagtgg ggaaacatta gaagaaaatg aagctgggga ctgaggtggg tcccatctcc
     1381 ccagcttgct gctcctgcct catccccttc ccaccaaacc ccagactctg tgaagtgcag
     1441 ttcttctcca cctaggaccg ccagcagagc ggggggatct ccctgccccc accccagttc
     1501 cccaacccac tcccttccaa caacaaccag ctccaactga ctctggtctt gggaggtgag
     1561 gcttcccaac cacggaagac tactttaaat gaaaaaaaga aattgaataa taaaatcagg
     1621 agtcaaaatt catcgtcttc aagcccctct ttctagcctt ttctactact ctctgcttgg
     1681 tcaaggtttg tgccccacta cagaacaggg ctaaattagc caccaccact gaaaactcag
     1741 ccgaattttt ttataccact ctgatgtcag cattttttcc atctgtttgg ggctttttcc
     1801 tcttttttcc attctcccca aatattttat ctggcttcaa aattaagagg attatttttc
     1861 agattgtttt tattcagtgt ggccgattcc tcatctgatt caggctgtcc agtcaggccc
     1921 ctcccatttt aggagctgga gccttcattt atgaagagat tctcatctat gaaatggatc
     1981 ctcatttgta aatctttttt cttccatttt cacaaagctg taaagaaata atccatctca
     2041 accttaccct ttttctctgg agtcagtggg gtctttcctc gctccatctt acacagacct
     2101 gagctggaag ctcaactggt tttgttccct gtttgaaata ttgtgatctc cctcccatga
     2161 aagaaaaacc aagaaccaga ggcgtagact gactgaagac acaactcctg gctttctgaa
     2221 gctatggact tggattggat tgctgggggt ttgtagagaa aggtgacaaa tttcagtacc
     2281 tctggcatgc tgtcccagga aactagggct cccactaact tatgaggttt ttaaacacat
     2341 tgaaaatgac atgacattaa aataaatttg gatttgctca taatga
//
