LOCUS       NM_001303427            5074 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens P3R3URF-PIK3R3 readthrough (P3R3URF-PIK3R3), mRNA.
ACCESSION   NM_001303427
VERSION     NM_001303427.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5074)
  AUTHORS   Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R,
            Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T,
            Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K,
            Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T,
            Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T
            and Sugano S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302049.1, BX537388.1 and
            CR749649.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001303427.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring genes LOC110117498 and
            PIK3R3. The readthrough transcript encodes a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Apr 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302049.1, SRR5189667.126334.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8503,
                                      110117498
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1003              AK302049.1         1-1003
            1004-1152           BX537388.1         950-1098
            1153-1153           AK302049.1         1153-1153
            1154-2232           BX537388.1         1100-2178
            2233-2233           CR749649.1         2756-2756
            2234-5074           BX537388.1         2180-5020
FEATURES             Location/Qualifiers
     source          1..5074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..5074
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /note="P3R3URF-PIK3R3 readthrough"
                     /db_xref="GeneID:110117499"
                     /db_xref="HGNC:HGNC:54999"
     exon            1..261
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1541
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /codon_start=1
                     /product="LOC110117498-PIK3R3 readthrough"
                     /protein_id="NP_001290356.1"
                     /db_xref="GeneID:110117499"
                     /db_xref="HGNC:HGNC:54999"
                     /translation="MGPSRLVRGPRPQGMRSPYRRPGMGWPRPRFPRMFKCSRRRYQQ
                     GLRGRTASSAAINPATRAMGINNTHTDTTIVWIFPPQALPPKPPKPMTSAVPNGMKDS
                     SVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK
                     IYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKED
                     NIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQC
                     HTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDN
                     REIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEE
                     DENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHC
                     VIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR"
     exon            262..370
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..469
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..650
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..776
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..919
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1096
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1171
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1342
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..5074
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5051..5056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /note="hexamer: AATAAA"
     polyA_site      5074
                     /gene="P3R3URF-PIK3R3"
                     /gene_synonym="LOC110117498-PIK3R3"
                     /note="major polyA site"
ORIGIN      
        1 agaagctccc tgtgcccatg gggccatctc ggcttgtccg tggccctcgg ccccagggca
       61 tgcgttcccc ctaccgcagg ccaggtatgg gctggcccag gccccgattt cccaggatgt
      121 tcaagtgtag ccgcagaaga tatcaacagg gtctccgagg tcgaactgcc agcagtgcag
      181 ccatcaatcc tgccaccagg gccatgggta tcaacaacac ccacactgac accaccatag
      241 tgtggatctt cccacctcaa gctcttccac caaagccacc taagccaatg acttcagcag
      301 ttccaaatgg aatgaaggac agttctgttt ctcttcagga tgcagaatgg tactgggggg
      361 atatttcaag ggaggaggta aatgacaaat tgcgggatat gccagatggg accttcttgg
      421 tccgagatgc ctcaacaaaa atgcagggag attatacttt gactttgcgg aagggaggca
      481 ataataagtt aataaagatc tatcaccggg atggtaaata tggcttttct gatcctctga
      541 catttaattc cgtggtggag ctcattaacc actatcacca tgaatctctt gctcagtaca
      601 atcccaaact tgatgtgaag ctgatgtacc cagtgtccag ataccaacag gatcagttgg
      661 taaaagaaga taatattgat gcagtaggta aaaaactgca agaataccac tctcagtatc
      721 aggagaagag taaagagtat gataggctgt atgaagaata tactagaaca tcccaggaaa
      781 tacagatgaa gaggactgca atagaagctt ttaatgaaac aattaaaata tttgaagagc
      841 agtgtcacac acaagaacaa catagcaaag aatatattga gcgatttcgc agagagggga
      901 atgaaaagga gattgaacga attatgatga attatgataa attgaaatca cgtctgggtg
      961 agattcatga tagcaaaatg cgtctagagc aggatttgaa gaatcaagct ttggacaacc
     1021 gagaaataga taaaaaaatg aatagcatca aacctgacct gatccagctg cgaaagatcc
     1081 gagatcaaca ccttgtatgg ctcaatcaca aaggagtgag acagaaacgc ctgaatgtct
     1141 ggctgggaat taagaatgag gatgctgatg agaactattt tatcaatgag gaagatgaaa
     1201 acctgcccca ttatgatgag aaaacctggt ttgttgagga tatcaatcga gtacaagcag
     1261 aggacttgct ttatgggaaa cctgatggtg cattcttaat tcgtgagagt agcaagaaag
     1321 gatgctatgc ttgctctgtg gtggccgatg gggaagtgaa gcactgtgtg atctacagca
     1381 ctgctcgggg ctatggcttt gcagagccct acaacctgta cagctctctg aaggagctag
     1441 tgctccatta ccagcagaca tccttggttc agcacaacga ctccctcaac gtcaggcttg
     1501 cctaccctgt tcatgcacag atgccctcgc tttgcagata aagaggaagt gggaagagag
     1561 gtggttctct ggcatttttt tctacagttt ttattagact acgatgaggg cattctttct
     1621 acatagactg cttgttttgc acaagaagtg attttgtgaa tgtgaagtgg agaggccgag
     1681 cagcagccgg ccgggatggg ggcattagag gcctgaggtt ctctaggact cagccatgcc
     1741 gctgcactga catactaagc tggaagcaga tgtttttttt gaaagtctgt ttcattgggg
     1801 tttttgtttt gtttagccag acaccctcaa cagaatatta ggcttgatgg ttatagcggg
     1861 tggggttgta tttggaagcc tctgaagaga ccatgtcttt ttaaaatcta actcttgaga
     1921 gtgcagcagg ggcatggctc tgctgggagt tgtgttttgc tttggcagtc tctcttcccc
     1981 ccacgaagaa ggctgtttag gttttgtgat agaatgggat ttgatgaaaa agacaaccaa
     2041 aggaaaatgg ggaggcttgg gatttcattt aaataatcta agccaagatg ataaaaaaaa
     2101 ccttcaactg aaggtatttt gtttcttacc aacataattt aggcttcagc atctcaccag
     2161 cccctccctc tgaagaagta ttatgttcag aagccaacaa aacagtttgt tgccagacca
     2221 atgtttgatg ggaaaacgtg gcactcatag ttgaatgtat acttctgtac caaaacttga
     2281 acataaaaag actagaattt gtgagtttta gcaaacgcta aaattgatca ctgtaactaa
     2341 ccccttctgt ccttcctgcc tgtttctctg agatgaggaa tagcattctt tttgtgggga
     2401 tggtgagctt tgaatcataa aatgaagttg gtgcttgtat ggtgtttcct tagcctaaag
     2461 aatgatctgt tgtttgaaac ctttgtaact tgtttgtatg agtaaagaaa aggtgcaatg
     2521 cagtgctttt agatggcttg atataccaaa taacaatata gaacaacatt attatatgtg
     2581 cttccccaag tttaaaggcc ctgcagaaat agtaaacatg gtttaatttc ccttcatttc
     2641 cccctccttt gctggatggg gttttgggag ctataggttg ctaaggaggg gagtcagatt
     2701 gtggtcaggt gcctcagtaa atcacagacc caggggccct gtggtccagg gtgagagtca
     2761 caccacatta cacatgtgct tccatacagt ggtttctgaa gcttttgcag ggagagaaga
     2821 tggcttagtg tttagactgt tagtagaagc catctggaag cttttctctt tgcctttttt
     2881 tgtgatcctg ccattaaggc tatgtgcagt ctgccctcct gctccagtgg ccttgatttt
     2941 aggccaggaa tcttctgctc catgtggctt aagccttcca gctgagtgaa gctaggcaaa
     3001 tggagtgggg gcaggcatct attcctgccc ccatcatgcc ccacacccat cagtcaacac
     3061 tcatttgaca aatagagtcc agctgcctct gagccaatcc tgggaccata ataggctcag
     3121 agtgagtcag ctgtttgaac ccaaagctgt gcagtcaggc accctggctg agctagagaa
     3181 gccagtacct gcatcttggt ttataaggct tacagctagg aaagctctag ttctgggggt
     3241 gaaagaaaaa tattagttta cctgagcact tatttccatg acagggtcta aaatatggac
     3301 catgatgtag acacagattt ttaattttgg aaaaacctcc agttactagt gacgaggata
     3361 gaaagggaag tgcttctctt tggctttttc ttggttacac tgcagtttca ggattgggtg
     3421 agacagagac aaatgaaccc ccctctaaag tcatttaact aatagccagc acatcccttc
     3481 cccaaactgt caattgaaat cttaactgaa agttttactg aataatacca agctaattgc
     3541 tgttgggcac acctggatgg ctttgcacct ggtgttgaac ctgctgaagc aggtggatgc
     3601 tcaagattac gtgcaaggaa tccctcccat ctggtactaa aatttcagtg tgttctgagt
     3661 gtcttttaaa ccaaaatgga aatacagata cagggctgta gtattcagta atgtgtctgc
     3721 tccttgttgg gcagacacca gcggtgtgca gggagagacc aagtaccatc tttatctaca
     3781 cttgggctgg cttgtggaga agggctgctt tttttcagtc ctacattcct tcattttttt
     3841 tttcattctt gaattcattg ttttgtggga tctaagaccc aggggtcatt tgagaggttt
     3901 gacagtatct tttctgacca gttgccacat gacttgcttg accctgagcc tgtggaaatg
     3961 gcatagggac cagtctacta cccactgggc ctggtgtgta gagggggaga gggtagcaag
     4021 gtgcttctct acgcccatga cttgggagca ggtcttggcc tccttcatga gagtctagtg
     4081 ccatgtcctg tcccatgatc tggaccctgg gactgtcttg gcatcttaac tgcagtttca
     4141 atgaggcaga gggcaaagag agaccaagat cagaggggtt cattataccc ctggctagag
     4201 aacccagcta ctgacatgca agcagcttgg ggctggctgg acacaggtac taggcccatt
     4261 gtttccaggt gaagctttca tcacagaaca gtgttgtctc cacctggcct tagatggcac
     4321 gccatgattc gggcctggat agactgcctg cgtccttacc actgatctgg ccaagaatga
     4381 ggccctccca acactttcac tccctctcca agccttgatg ggacctccac ttatttaggc
     4441 ctcatgtgct ttgaagaagc tttgagagcc aatgtgtctt ccacgggtct cttttttgct
     4501 acaagtaatc agccccatgt gttctcttaa actgagaatt gcacctgggc aattcctgtt
     4561 ttctaaggtg gtctctgctg ctatttaaca acccagagta ggcctctgtg aggcttcagt
     4621 ggcctcagaa accagagggt ccagataggg ggcctgcttg ggccctctgc tgccaactgc
     4681 tcaaacctgc tttagctcca gccacttgtg gcaaacaacc tcgtttcctt acaaattcca
     4741 gcatgtgact ttggtgccgt tacttgtgaa aaatctattc tgttgtcttt gatgtgtcca
     4801 agaaaattcg tgtagtttac gtaaaaatat ctgactcaca agaaagccaa ctgtatgtct
     4861 tgtgatggga cagttcataa tgtagttgct agaccacttt acaaattgtt cttgtcacca
     4921 gatgtgttca gacattgctg tgcaattgtt ggggagggta gggggaaagg cgagaggaga
     4981 tacttattgg tctttttgtt taataccttc cccaagaggg gacagtctgg ccaacttgct
     5041 ccagtaatgc aataaagaca ttgcaataaa gtaa
//
