LOCUS       NM_006455               2352 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens prolyl 3-hydroxylase family member 4 (inactive)
            (P3H4), mRNA.
ACCESSION   NM_006455
VERSION     NM_006455.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Zhang,J., Dong,Y., Shi,Z., He,H., Chen,J., Zhang,S., Wu,W.,
            Zhang,Q., Han,C. and Hao,L.
  TITLE     P3H4 and PLOD1 expression associates with poor prognosis in bladder
            cancer
  JOURNAL   Clin Transl Oncol 24 (8), 1524-1532 (2022)
   PUBMED   35149972
  REMARK    GeneRIF: P3H4 and PLOD1 expression associates with poor prognosis
            in bladder cancer.
REFERENCE   2  (bases 1 to 2352)
  AUTHORS   Jin,X., Zhou,H., Song,J., Cui,H., Luo,Y. and Jiang,H.
  TITLE     P3H4 Overexpression Serves as a Prognostic Factor in Lung
            Adenocarcinoma
  JOURNAL   Comput Math Methods Med 2021, 9971353 (2021)
   PUBMED   34257701
  REMARK    GeneRIF: P3H4 Overexpression Serves as a Prognostic Factor in Lung
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2352)
  AUTHORS   Hao,L., Pang,K., Pang,H., Zhang,J., Zhang,Z., He,H., Zhou,R.,
            Shi,Z. and Han,C.
  TITLE     Knockdown of P3H4 inhibits proliferation and invasion of bladder
            cancer
  JOURNAL   Aging (Albany NY) 12 (3), 2156-2168 (2020)
   PUBMED   32018225
  REMARK    GeneRIF: Knockdown of P3H4 inhibits proliferation and invasion of
            bladder cancer.
REFERENCE   4  (bases 1 to 2352)
  AUTHORS   Li,W., Ye,L., Chen,Y. and Chen,P.
  TITLE     P3H4 is correlated with clinicopathological features and prognosis
            in bladder cancer
  JOURNAL   World J Surg Oncol 16 (1), 206 (2018)
   PUBMED   30322400
  REMARK    GeneRIF: High P3H4 expression is associated with bladder cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2352)
  AUTHORS   Hudson,D.M., Weis,M., Rai,J., Joeng,K.S., Dimori,M., Lee,B.H.,
            Morello,R. and Eyre,D.R.
  TITLE     P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine
            Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos
            Syndrome Type VIA
  JOURNAL   J Biol Chem 292 (9), 3877-3887 (2017)
   PUBMED   28115524
REFERENCE   6  (bases 1 to 2352)
  AUTHORS   Cavazzini,F., Magistroni,R., Furci,L., Lupo,V., Ligabue,G.,
            Granito,M., Leonelli,M., Albertazzi,A. and Cappelli,G.
  TITLE     Identification and characterization of a new autoimmune protein in
            membranous nephropathy by immunoscreening of a renal cDNA library
  JOURNAL   PLoS One 7 (11), e48845 (2012)
   PUBMED   23144993
  REMARK    GeneRIF: SC65 protein is identified as an autoimmune target in
            idiopathic membranous nephropathy.
REFERENCE   7  (bases 1 to 2352)
  AUTHORS   Foster,L.J., Rudich,A., Talior,I., Patel,N., Huang,X.,
            Furtado,L.M., Bilan,P.J., Mann,M. and Klip,A.
  TITLE     Insulin-dependent interactions of proteins with GLUT4 revealed
            through stable isotope labeling by amino acids in cell culture
            (SILAC)
  JOURNAL   J Proteome Res 5 (1), 64-75 (2006)
   PUBMED   16396496
REFERENCE   8  (bases 1 to 2352)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2352)
  AUTHORS   Fossa,A., Siebert,R., Aasheim,H.C., Maelandsmo,G.M., Berner,A.,
            Fossa,S.D., Paus,E., Smeland,E.B. and Gaudernack,G.
  TITLE     Identification of nucleolar protein No55 as a tumour-associated
            autoantigen in patients with prostate cancer
  JOURNAL   Br J Cancer 83 (6), 743-749 (2000)
   PUBMED   10952778
REFERENCE   10 (bases 1 to 2352)
  AUTHORS   Ochs,R.L., Stein,T.W. Jr., Chan,E.K., Ruutu,M. and Tan,E.M.
  TITLE     cDNA cloning and characterization of a novel nucleolar protein
  JOURNAL   Mol Biol Cell 7 (7), 1015-1024 (1996)
   PUBMED   8862517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056085.1, BC007942.2 and U47621.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006455.2.
            
            Summary: This nucleolar protein was first characterized because it
            was an autoantigen in cases on interstitial cystitis. The protein,
            with a predicted molecular weight of 50 kDa, appears to be
            localized in the particulate compartment of the interphase
            nucleolus, with a distribution distinct from that of nucleolar
            protein B23. During mitosis it is associated with chromosomes.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U47621.1, AJ250583.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393928.6/ ENSP00000377505.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1528              AK056085.1         434-1961
            1529-2027           BC007942.2         1527-2025
            2028-2352           U47621.1           2006-2330
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2352
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /note="prolyl 3-hydroxylase family member 4 (inactive)"
                     /db_xref="GeneID:10609"
                     /db_xref="HGNC:HGNC:16946"
                     /db_xref="MIM:617419"
     exon            1..496
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1348
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /note="nucleolar autoantigen (55kD); nucleolar autoantigen
                     No55; synaptonemal complex protein SC65; nucleolar
                     autoantigen, 55kDa; leprecan-like protein 4; leprecan-like
                     4; endoplasmic reticulum protein SC65; prolyl
                     3-hydroxylase family member 4 (non-enzymatic);
                     synaptonemal complex 65"
                     /codon_start=1
                     /product="endoplasmic reticulum protein SC65 precursor"
                     /protein_id="NP_006446.1"
                     /db_xref="CCDS:CCDS11408.1"
                     /db_xref="GeneID:10609"
                     /db_xref="HGNC:HGNC:16946"
                     /db_xref="MIM:617419"
                     /translation="MARVAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHAL
                     EQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPAAKPDPDGGRADEWACE
                     LRLFGRVLERAACLRRCKRTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEK
                     AVAAAYTFLQRNPKHELTAKYLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSG
                     DFRSSTEDMERALSEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCE
                     ANLTPNVGGYFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLV
                     YYRFHRARWGLEEEDFQPREEAMLYHNQTAELRELLEFTHMYLQSDDEMELEETEPPL
                     EPEDALSDAEFEGEGDYEEGMYADWWQEPDAKGDEAEAEPEPELA"
     exon            497..649
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            650..821
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            822..950
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1096
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1180
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1325
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..2352
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /note="hexamer: AATAAA"
     polyA_site      2352
                     /gene="P3H4"
                     /gene_synonym="LEPREL4; NO55; NOL55; SC65"
                     /note="major polyA site"
ORIGIN      
        1 agctcagctc cggagagccg gcggcgcggc gggcatggct cgggtggcgt gggggctgct
       61 gtggttgctg ctgggcagcg ccggggcgca gtacgagaag tacagcttcc ggggcttccc
      121 gcccgaggac ctgatgccgc tggccgcggc gtacgggcac gctctggagc agtacgaggg
      181 agagagctgg cgcgagagcg cgcgctacct ggaggcggcg ctgcggctgc accggctcct
      241 gcgcgacagc gaggccttct gccacgccaa ctgcagcggc cccgcgcccg cggccaagcc
      301 cgatcccgac ggcggccgcg cagacgagtg ggcctgcgag ctgcggctct tcggccgcgt
      361 cctggagcga gccgcctgcc tgcggcgctg caagcggacg ctgcccgcct tccaggtgcc
      421 ctacccgccg cggcagctgc tgcgtgactt ccagagccgc ctgccctacc agtacctgca
      481 ctacgcgctg ttcaaggcta accggctgga gaaggcggtg gcggcggcct acaccttcct
      541 ccagaggaac ccgaagcacg agctgaccgc caagtatctc aactactatc aggggatgct
      601 ggacgtcgcc gacgagtccc tcacggacct agaggcccag ccctacgagg ccgtgttcct
      661 ccgggctgtg aagctctaca acagcgggga tttccgcagc agcacggagg acatggagcg
      721 ggccttgtca gagtacctgg cagtctttgc ccggtgcctg gccggctgtg aaggggccca
      781 tgagcaggtg gacttcaagg acttctaccc ggccatagca gatctctttg cagagtccct
      841 gcagtgcaag gtggactgtg aggccaattt gacccccaat gtgggtggct acttcgtgga
      901 caagttcgtg gccaccatgt accactacct gcagtttgcc tactataagt tgaatgatgt
      961 gcgccaggct gcccgcagcg ccgccagcta catgctcttc gaccccaagg acagcgtcat
     1021 gcagcagaac ctggtgtatt accggttcca ccgggctcgc tggggcctgg aagaggagga
     1081 cttccagccc cgggaggagg ccatgctcta ccacaaccag accgccgagc tgcgggagct
     1141 gctggagttc acccacatgt acctgcagtc agatgatgag atggagctgg aggagacaga
     1201 accgcccctg gagcctgagg atgccctatc tgacgccgag tttgaggggg agggtgacta
     1261 cgaggagggc atgtatgctg actggtggca ggagccggat gccaagggtg acgaggccga
     1321 ggctgagcca gagcctgaac tcgcatgaga aggggacacc ccacaccgct caagcttggg
     1381 aagcctggtg ccgatggccc caccctcacc agcctgggca gcagcaagaa ctatttatta
     1441 aaaacttaag atgggccagg tgcggtggct cacacctgta atcccagcat tttgggaggc
     1501 caaggtgggt ggatcacttg aggccaggag ttcaagacca gcctggccaa catgatgaga
     1561 cctccgtctc tactaaaata cataaattag ccgggtgtgg tggcaggcgc ctgaaatccc
     1621 agctactcaa gaggctgagg caggagaatc gcttgaacct gggaggcaaa ggttgcagtg
     1681 aactgagatt gcgccaccgc actccagcct gggcgacaga gcgagactcc atctttaaaa
     1741 aaaaacaaga cgggccggca cggtggctca cgcctgtaat cccagcactg agaggccgat
     1801 cacttgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta
     1861 aaaaatacaa aaattagcca ggcatggtgg cacacacctg taatcgtagc tgaggcagga
     1921 gaatcgcctg aacccaggag gcggagcttg cagtgagccg agatcgtgcc actgcactcc
     1981 agcctgggcg acagagtgag actccatctc aaaaaaaaaa aaaaaaactt aagatggaca
     2041 cagctgactg gacccccatc ctgcctcacc catgggtgct gcaccccaga cccatcctgc
     2101 cacttctatg tctctggacc acaggatggt ggtggcattg caggttggca agtgggctga
     2161 tggggtccgc cctcctcact gctgagctcc tcacctggac agtctcctgg acaaggagtt
     2221 tccagctgct ggctggagtc tcaggccaaa ttgcagaggg tcctccaggg tcctgaagag
     2281 cactggacta agagtctagt ggttccaggg ccctgaccag taggtgctca ataaatgttt
     2341 gttgttgaat ga
//
